A major type of inflammatory bowel disease (IBD) may be caused in part by genetic variants that prevent beneficial bacteria in the gut from doing their job, according to a new study published today in the journal Science.
T cells use a kind of mechanical handshake, or tug test, to determine whether a cell they encounter is a foreign invader.
When It Comes to Spring Allergies, Oak Pollen More Potent Than Pine; Food Allergies of Low-Income Kids Are Poorly Managed; Flowers Not to Blame for Allergies, and More in the Allergies Channel
Pinellas County a Model for Mosquito-Borne Disease Surveillance, Scientists Unravel the Genetic Evolution of Zika Virus, Worm Infection Counters Inflammatory Bowel Disease and more in the Infectious Diseases News Source
Probiotic supplements protected female mice from the loss of bone density that occurs after having their ovaries removed, researchers at Emory University School of Medicine and Georgia State University have shown.
The addition of a house dust mite (HDM) sublingual allergen immunotherapy (SLIT) tablet to maintenance medications improved time to first moderate or severe asthma exacerbation during a period of inhaled corticosteroid (ICS) reduction among adults with HDM allergy-related asthma not well controlled by ICS, according to a study appearing in the April 26 issue of JAMA.
Evelo Biosciences and the University of Chicago have announced that they have entered into an exclusive worldwide license agreement to develop and commercialize a microbiome-based cancer immunotherapy.
While scientists have known for many years that there are cells living in the cavities surrounding various organs such as the heart, lung and liver, their function has remained unknown. A recent Cumming School of Medicine study examined these cells, and discovered they play an integral role in fast tissue repair. The study was published in the journal Cell this month.
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The April 19, 2016 issue of The Journal of the American Medical Association (JAMA) features an editorial by two Seattle Cancer Care Alliance (SCCA) medical oncologists who specialize in melanoma: Dr. Shailender Bhatia and Dr. John Thompson. Their editorial addresses the state of immunotherapy drugs, specifically PD-1 blockade, in the treatment of melanoma.
Women account for approximately half of all individuals living with HIV worldwide, and researchers wanted to identify the risk factors that increase susceptibility of women to genital infection.
Removing an immunomodulatory protein called osteopontin improves the symptoms of mice with muscular dystrophy by changing the type of macrophages acting on damaged muscle tissue, according to a paper published in The Journal of Cell Biology. The study, “Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype” by Joana Capote and colleagues, adds support to the idea that osteopontin inhibitors could be used to treat patients with Duchenne muscular dystrophy.
Dr. Sunil Hingorani, a member of the Clinical Research and Public Health Sciences divisions at Fred Hutchinson Cancer Research Center, will present recent groundbreaking developments in treating pancreas cancer with engineered T-cells at the American Association for Cancer Research Annual Meeting 2016 in New Orleans on April 16.
After a stroke, there is inflammation in the damaged part of the brain. Until now, the inflammation has been seen as a negative consequence that needs to be abolished as soon as possible. But, as it turns out, there are also some positive sides to the inflammation, and it can actually help the brain to self-repair.
Mass. General study confirms the safety of allergy shots, calls into question proposed changes in preparation standards.
Newly identified mechanism may offer ways to enhance the immune response to fight cancer or strengthen long-term protection provided by vaccines
Researchers have found antibodies to the newly discovered influenza D virus in pigs, cattle, horses, goats and sheep, but not poultry. South Dakota State University doctoral student Chithra Sreenivasan has proven that the guinea pig can be used as an animal model and is developing a way to study the virus in living cells—trachea and lung epithelial cells from swine and cattle.
Ludwig Cancer Research and the Cancer Research Institute (CRI) have launched a Phase 1/2 clinical trial of combination immunotherapy for advanced ovarian cancer. The international, multicenter trial is led by George Coukos, director of the Ludwig Institute for Cancer Research, Lausanne and Brad Monk, director of Gynecologic Oncology at St. Joseph’s Hospital and Medical Center.
Award-winning journalist Rita Baron-Faust and renowned lupus researcher, Dr. Jill Buyon, republishes updated "Autoimmune Connection: Essential Information for Women on Diagnosis, Treatment and Getting on with Your Life".
Researchers have identified a common variant in a non-coding RNA that may contribute to the intestinal inflammation that occurs in people with celiac disease. The findings point to a possible new risk factor for developing celiac disease in people with celiac disease risk genes.
Renewing a commitment to advance its reputation in lung cancer and other thoracic malignancies, NYU Langone Medical Center has announced the appointment of physician-scientist Leena Gandhi, MD, PhD, as director of thoracic medical oncology at its Laura and Isaac Perlmutter Cancer.
TESARO, Inc., an oncology focused biopharmaceutical company, and the Institute for Applied Cancer Science at The University of Texas MD Anderson Cancer Center today announced an exclusive collaboration to discover and develop small molecule product candidates against undisclosed immuno-oncology targets.
The closely related Hendra and Nipah viruses (referred to jointly as henipaviruses) are deadly cousins of the more common mumps, measles, and respiratory syncytial viruses, all members of the paramyxovirus family. Henipavirus outbreaks are on the rise, but little is known about them, partly because research has to be conducted under extreme level containment conditions.
American Autoimmune Related Diseases Association Salutes Autoimmune Heroes: Kellie Martin, Haley Ramm and Barbara Ramm
The most common immune disorder, common variable immunodeficiency disorder (CVID), is notoriously difficult to diagnose early, before serious complications develop. Genetic analysis of six families from across the U.S. and Europe has revealed that mutations in IKAROS, known for its central role in immune cell development, define a new class of CVID. Published in the New England Journal of Medicine, the results open the door to personalized health care tailored to patients with this disorder.
Recently discovered biomarkers may provide valuable new approaches to monitoring immunosuppressive drug therapy in organ transplant recipients—with the potential for individualized therapy to reduce organ rejection and minimize side effects, according to a special article in the April issue of Therapeutic Drug Monitoring, official journal of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. The journal is published by Wolters Kluwer.
St. Jude Children’s Research Hospital scientists have identified a mechanism that might explain the link between maternal infections during pregnancy and cognitive problems in children; findings may impact clinical care.
A new study from scientists at The Scripps Research Institute describes the high-resolution structure of the HIV protein responsible for recognition and infection of host cells. The studyis the first to show this HIV protein, known as the envelope (Env) trimer, in its natural or “native” form.
A study by researchers at the University of Southampton and Southampton General Hospital, is the first to assess the prevalence of two different types of food hypersensitivity and the risk factors associated with them.
St. Jude Children’s Research Hospital scientists have discovered that an enzyme antibiotics rely on to kill bacteria also promotes survival of pneumococcus and sets the stage for serious, invasive infections
Inflammation is a Catch-22: the body needs it to eliminate invasive organisms and foreign irritants, but excessive inflammation can harm healthy cells, contributing to aging and sometimes leading to organ failure and death. Researchers at University of California, San Diego School of Medicine have discovered that a protein known as p62 acts as a molecular brake to keep inflammation in check and avoid collateral damage.
Immune cells that normally help us fight off bacterial and viral infections may play a far greater role in Alzheimer’s disease than originally thought, according to University of California, Irvine neurobiologists with the Sue & Bill Gross Stem Cell Research Center and the Institute for Memory Impairments and Neurological Disorders.
The research of two Montana State University microbiologists into how bacteria fend off attacks from viruses is included in a new paper published in the scientific journal Nature.
Scientists at the University of East Anglia are getting closer to solving the problem of antibiotic resistance.
Scientists from The Scripps Research Institute have identified a molecule that appears to be a cause of autoimmune diseases such as lupus. Elevated levels of the molecule allow self-reactive immune cells to escape into the blood stream and attack the body’s own tissues.
Small proteins that affect communication between cells play an important role in regulating inflammation that occurs during inflammatory bowel disease, according to researchers at Georgia State University, Emory University, the University of Michigan and Amgen, a biotechnology company.
A new optogenetic technology developed at UMass Medical School, called optogenetic immunomodulation, is capable of turning on immune cells to attack melanoma tumors in mice. Using near-infrared light, UMMS researchers have shown they can selectively activate an immune response by controlling the flow of calcium ions into the cell. This breakthrough could lead to less invasive, and more controlled and selective, immunotherapies for cancer treatment.
UNC School of Medicine scientists studying one of the world’s most virulent pathogens and a separate very common bacterium have discovered a new way that some bacteria can spread rapidly throughout the body – by hitchhiking on our own immune cells.
The 1,000 people in New Mexico fighting lung cancer may soon be able to breathe easier. The first of more than 10 new lung cancer clinical trials has just opened under the direction of Yanis Boumber, MD. The phase 3 clinical trial, called “Neptune,” opened January 28. It compares a combination of two immune drugs with standard chemotherapy.
Potential new approaches to treating eye diseases such as age-related macular degeneration (AMD) are described in a new study published in the February Journal of Experimental Medicine. Hongkang Xi, Menno van Lookeren Campagne, and colleagues discovered that a signaling protein, or cytokine, called IL-33, plays a key role in recruiting phagocytes to damaged retina and induces retinal degeneration. Blocking the IL-33 receptor inhibits this process and prevents injury-induced retinal degeneration.
People who have self-reported penicillin allergy may have a three times greater chance of suffering from chronic hives. And people who have chronic hives tend to self-report penicillin allergy at a three times greater rate than the general population. Authors of a new study think it's not coincidence.
For his research project to determine whether therapies can be designed to modulate the immune system to prevent vision loss and blindness in glaucoma patients, Stuart J. McKinnon, MD, PhD was awarded the 2016 Shaffer Prize for Innovative Glaucoma Research.
In a small pilot study, researchers at University of California, San Diego School of Medicine and Icahn School of Medicine at Mount Sinai determined that a simple swab to transfer vaginal microbes from a mother to her C-section-delivered newborn can alter the baby's microbial makeup (microbiome) in a way that more closely resembles the microbiome of a vaginally delivered baby.
A new study finds that providing zinc supplements to older adults in nursing homes increased their serum zinc levels and improved their immune response, providing potential protection against infection. The research group’s previous work found that nursing home residents had low zinc levels.
University of Alabama at Birmingham researchers have found a previously unknown step in the pathway that leads to asthma, a discovery that may offer new therapeutic approaches to this incurable disease. Asthma affects more than 25 million people in the United States, including about 7 million children.
Researchers have begun to explore in earnest the concept of "mixed vascular dementia," but until recently there was no reliable animal model. When Donna Wilcock of the UK Sanders-Brown Center on Aging discovered that a special diet deficient in B vitamins induced cognitive impairment in mice, she gave science the animal model it needed, plus the potential for a modifiable biomarker for vascular cognitive impairment.
Treatment of multiple sclerosis (MS) and other inflammatory diseases may benefit by new findings from a study that identified potential therapeutic targets for a devastating disease striking some 2.3 million people worldwide.
Researchers at Vanderbilt University Medical Center and the University of Texas Medical Branch in Galveston (UTMB) reported today in the journal Cell that they have isolated human monoclonal antibodies from Ebola survivors which can neutralize multiple species of the virus.
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