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… There was a statistically significant difference in the frequency of CD4+ CD95+, CD4+ CD95 Hi, and CD4+ CD95 low/med T stem cell memory (T SCM) cells between responder and nonresponder groups. However, the comparison of the …

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… The child was pretreated with modified Bu/Cy plus ATG regimen for transplantation, and underwent haploid hematopoietic stem cell … , intravenous immunoglobulin (IVIG) transfusion, stem cell transfusion and other treatments, and …

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Acute liver injury (ALI) is characterized by massive hepatocyte necrosis and subsequent recruitment of myeloid cells to liver. Mesenchymal stem cells (MSCs) have therapeutic potential for ALI through their immunoregulation on macrophages …

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… MSC, a pluripotent stem cell, has self-renewal capability and multidirectional differentiation potential, and it can be obtained from tissues, such as the umbilical cord, bone marrow and fat [24], [25]. Many experimental and clinical studies proved …

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Cell therapy using induced pluripotent stem cell (iPSC) derivatives may result in abnormal tissue generation because the cells undergo numerous cycles of mitosis before clinical application, potentially increasing the accumulation of genetic …

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… stem cell sources and differentiation lineages and is therefore useful for various stem cell–… cells and extracellular matrix components, guiding stem cell fates ex vivo is generally initiated … ultimately negatively affects the guiding efficiency of the …

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… The objective of this study is to synthesise the findings of clinical studies in order to derive evidence for use of the mesenchymal stem cell (MSC) therapy in the treatment of neurodegenerative cerebellar ataxias. In order to find relevant studies …

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… d Stem cell frequency of GS5 cells treated with Cas9 and the indicated sgRNAs as determined by limiting dilution assay. e–g Representative flow cytometry images (e) and corresponding quantification (f) (n = 3 biologically independent samples, black …

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… methylation status, which in turn compromised periodontal stem cell function including a reduction in proliferation and differentiation … co‐regulator, which plays a key role in cell proliferation, differentiation, and stem cell self‐renewal [86]. The …

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… Allogeneic hematopoietic stem cell transplantation (HSCT) can be a highly effective treatment for patients with hematological malignancies and hereditary blood disorders if a suitable HSC graft can be obtained, ideally from an HLA (human leukocyte …

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As in younger patients, allogeneic stem cell transplantation (alloHSCT) offers the best chance for durable remission in older patients (≥60 years) with acute myeloid leukemia (AML). However, defining the best treatment strategy (and in particular …

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… hold a patent application for the investigated stem cell product “Stem cell therapy based on adipose-derived stem cells”, WO2017068140. None of the other coauthors declare conflicts of interest. LS is an advisory board member for Takeda and Kyowa …

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… In this study, we generate lung cells and macrophages from the same human pluripotent stem cell (hPSC) lines and pair them to establish a co-culture system. This strategy addresses a common concern about histocompatibility when studying …

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… ABCC1 encodes the ATPase cassette transporter protein multidrug resistance 1, a stem cell marker and MYCN transcriptional target conferring … 1, 2), suggesting they share a common ependymal stem cell lineage. The mismatch repair gene …

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The heterogeneous nature of human CD34+ hematopoietic stem cells (HSCs) has hampered our understanding of the cellular and molecular trajectories that HSCs navigate during lineage commitment. Using various platforms including single cell …

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… The objective of this study is to assess the effect of mesenchymal stem cell (MSC) therapy on SG function after radiation-induced injury. … Accumulating literature on animal studies suggests that mesenchymal stromal/stem cell (MSC) transplantation …

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… We decided to focus on stem cell therapy administered within the acute phase (<2 weeks) of the timing of the TSCI, as this would be the realistic time for administration within humans. It is likely that SC therapy may involve injections within both the …

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In this work, the mechanism underlying the anticancer activity of a photoactivatable Ir(III) compound of the type [Ir(CˆN) 2 (dppz)][PF 6 ] where CˆN = 1-methyl-2-(2′-thienyl)benzimidazole (complex 1) was investigated. Complex 1 photoactivated by visible light shows …

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… a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms. … Taken together, our data describe one mechanism by which a transcription factor controls stem cell …

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Background: The poor coverage of essential maternal services, such as antenatal care (ANC) and skilled delivery care utilization, accounts for higher maternal and infant mortality in low- and middle-income countries (LMICs). Although...

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Background: Sleep disturbances and poor health-related quality of life (HRQoL) are common in people with rheumatoid arthritis (RA). Sleep disturbances, such as less total sleep time, more waking periods after sleep onset, and higher ...

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Background: For over a decade, digital health has held promise for enabling broader access to health information, education, and services for the general population at a lower cost. However, recent studies have shown mixed results le...

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Background: Advances in biomedical research using deep learning techniques have generated a large volume of related literature. However, there is a lack of scientometric studies that provide a bird’s-eye view of them. This absence ...

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… stem  cell commitment, the field’s mechanistic understanding of this phenomenon largely derives from simplified two-dimensional (2D) culture substrates. Here, we found a 3D matrix–specific mechanoresponsive mechanism for neural stem  cell (NSC …

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… cells remains eliciting the desired stem  cell behavior once transplanted in the body. In their natural environment, stem  cell fate is regulated by their … ECM ligands, as well as soluble cues, making MSN-ssDNA based biointerfaces a novel tool to …

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… Importantly, we demonstrate that Aux interacts with EGFR and safeguards the activation of EGFR to maintain a proper stem  cell proliferation rate. Thus, our data uncover the underlying mechanism of Aux in stem  cell proliferation control and …

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… This article briefly introduced the regulatory framework development, the progress in stem  cell clinical researches and clinical trials of commercially developed stem  cell-based products, as well as the clinical review concerns of stem  cell-based products in …

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In this review, we will outline dimensions in which outcome of patients with myelofibrosis undergoing curative treatment can be optimized: patient selection, transplant procedure, and posttransplant prevention or treatment of relapse. For …

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… of etoposide and cytarabine [8], or intensive chemotherapy followed by autologous stem  cell transplantation (IC-ASCT) [9, 10]. Thiotepa-based myeloablative chemotherapy followed by autologous stem  cell transplantation (ASCT) …

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… Owing to the fact that MSC-derived exosomes can further control stem  cell differentiation by carrying and transferring miRNAs, stem  cell-based exosome therapeutic regimens have been highlighted as effective means for cardiac …

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The widespread clinical application of cord blood (CB) for hematopoietic stem  cell (HSC) transplantation is limited mainly by the inadequate number of hematopoietic stem and progenitor cells (HSPCs) in single CB units, which results in unsuccessful or …

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… Mesenchymal stem  cell-derived EV have been shown to contain a diverse array of bioactive cargo, including proteins, nucleic acids, non-coding RNA and lipids. The lipid bilayer of the EV membrane protects the cargo from degradation and is often …

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Background: There is an increasing number of interactive web-based advance care planning (ACP) support tools, which are web-based aids in any format encouraging reflection, communication, and processing of publicly available informat...

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Background: Data journey modeling is a methodology used to establish a high-level overview of information technology (IT) infrastructure in health care systems. It allows a better understanding of sociotechnical barriers and thus inf...

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Online communication with participants, including online recruitment, electronic informed consent, and data communication, is one of the fields to which information and communication technology (ICT) has been applied in medical research. Online commu...

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Diabetes self-management education and support can improve outcomes in people with diabetes. Providing health interventions via digital modes of delivery can extend the reach of programs delivered through traditional means. The web-based version of t...

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Background: Computer-assisted treatment may reduce therapist contact and costs and promote client participation. This meta-analysis examined the efficacy and acceptability of an unguided computer-assisted therapy in patients with obs...

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Background: Prevalence rates for lifetime cannabis use and cannabis use disorder are much higher in people with attention deficit/hyperactivity disorder than in those without. CANreduce 2.0 is an intervention that is generally effect...

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Background: The application of big data resources and the development of medical collaborative networks (MCNs) boost each other. However, MCNs are often assumed to be exogenous. How big data resources affect the emergence, developmen...

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Background: Currently, selection of patients for sequential versus concurrent chemotherapy and radiation regimens lacks evidentiary support and it is based on locally optimal decisions for each step. Objective: We ai...

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Background: The applications of artificial intelligence (AI) processes have grown significantly in all medical disciplines during the last decades. Two main types of AI have been applied in medicine: symbolic AI (eg, knowledge base a...

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