… hold a patent application for the investigated stem cell product “Stem cell therapy based on adipose-derived stem cells”, WO2017068140. None of the other coauthors declare conflicts of interest. LS is an advisory board member for Takeda and Kyowa …
… In this study, we generate lung cells and macrophages from the same human pluripotent stem cell (hPSC) lines and pair them to establish a co-culture system. This strategy addresses a common concern about histocompatibility when studying …
… ABCC1 encodes the ATPase cassette transporter protein multidrug resistance 1, a stem cell marker and MYCN transcriptional target conferring … 1, 2), suggesting they share a common ependymal stem cell lineage. The mismatch repair gene …
The heterogeneous nature of human CD34+ hematopoietic stem cells (HSCs) has hampered our understanding of the cellular and molecular trajectories that HSCs navigate during lineage commitment. Using various platforms including single cell …
… The objective of this study is to assess the effect of mesenchymal stem cell (MSC) therapy on SG function after radiation-induced injury. … Accumulating literature on animal studies suggests that mesenchymal stromal/stem cell (MSC) transplantation …
… We decided to focus on stem cell therapy administered within the acute phase (<2 weeks) of the timing of the TSCI, as this would be the realistic time for administration within humans. It is likely that SC therapy may involve injections within both the …
In this work, the mechanism underlying the anticancer activity of a photoactivatable Ir(III) compound of the type [Ir(CˆN) 2 (dppz)][PF 6 ] where CˆN = 1-methyl-2-(2′-thienyl)benzimidazole (complex 1) was investigated. Complex 1 photoactivated by visible light shows …
… a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms. … Taken together, our data describe one mechanism by which a transcription factor controls stem cell …
… stem cell commitment, the field’s mechanistic understanding of this phenomenon largely derives from simplified two-dimensional (2D) culture substrates. Here, we found a 3D matrix–specific mechanoresponsive mechanism for neural stem cell (NSC …
… cells remains eliciting the desired stem cell behavior once transplanted in the body. In their natural environment, stem cell fate is regulated by their … ECM ligands, as well as soluble cues, making MSN-ssDNA based biointerfaces a novel tool to …
… Importantly, we demonstrate that Aux interacts with EGFR and safeguards the activation of EGFR to maintain a proper stem cell proliferation rate. Thus, our data uncover the underlying mechanism of Aux in stem cell proliferation control and …
… This article briefly introduced the regulatory framework development, the progress in stem cell clinical researches and clinical trials of commercially developed stem cell-based products, as well as the clinical review concerns of stem cell-based products in …
In this review, we will outline dimensions in which outcome of patients with myelofibrosis undergoing curative treatment can be optimized: patient selection, transplant procedure, and posttransplant prevention or treatment of relapse. For …
… of etoposide and cytarabine [8], or intensive chemotherapy followed by autologous stem cell transplantation (IC-ASCT) [9, 10]. Thiotepa-based myeloablative chemotherapy followed by autologous stem cell transplantation (ASCT) …
… Owing to the fact that MSC-derived exosomes can further control stem cell differentiation by carrying and transferring miRNAs, stem cell-based exosome therapeutic regimens have been highlighted as effective means for cardiac …
The widespread clinical application of cord blood (CB) for hematopoietic stem cell (HSC) transplantation is limited mainly by the inadequate number of hematopoietic stem and progenitor cells (HSPCs) in single CB units, which results in unsuccessful or …
… Mesenchymal stem cell-derived EV have been shown to contain a diverse array of bioactive cargo, including proteins, nucleic acids, non-coding RNA and lipids. The lipid bilayer of the EV membrane protects the cargo from degradation and is often …
In a reelection campaign ad, Alabama Gov. Kay Ivey, claimed without proof, that the 2020 election was stolen from Donald Trump. There is still no evidence of election fraud.
… Despite ongoing attempts since the 1990s, no stably defined pig epiblast-derived stem cell line has been established. Here, guided by … in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 …
Stem cell-based therapy for retinal degeneration is transitioning from the research stage to the clinical stage and is being developed as a treatment across the globe. In clinical studies on induced pluripotent stem cell (iPSC)-… of stem cell-based therapy …
… and cell types and correlate interfacial mechanical properties with stem cell expansion. Correlations suggest an impact of … stem cell proliferation, we determined the interfacial shear moduli of corresponding interfaces and correlated …
Pattern of clips taken out of context to create the implication that president is unfit for office
Here are some of the latest articles that have been added to the Clinical Trials channel on Newswise.
The conclusion that climate change is natural, therefore humans have nothing to do with it, or that we shouldn't do anything about it, is misleading.
… quite high risk of procedure-related stroke after TAVR due to the grade 4 thrombus formation in the ascending aorta, treated with TF-TAVR with the Sentinel CPS insertion. To our knowledge, the usefulness of a filter device insertion prior to …
Background The outcome of chemotherapy in patients older than 40 years with acute lymphoblastic leukaemia is poor and myeloablative allogeneic haematopoietic stem-cell transplantation (HSCT) has a high transplant-related …
… The primary endpoint of this study was a composite of cardiovascular death, stroke, myocardial infarction, all-cause readmission, major vascular complications, and new PPM implantation. Secondary outcomes were each component of the …
… We separated our assessment of stroke after TAVR into early (<30 days, Figure 2C) and late (>30 days) (Figure 2D) in order to define the … factor for stroke after TAVR but that this risk is limited to the first 30 days after the procedure. This raises …
… Autologous limbal stem cell transplantation is highly successful, but impossible in cases of complete bilateral stem cell deficiency. In these … We found that a very low amount of stem cell-like cells remained 4 weeks after the stem cell deficiency model …
… of death of any cause or stroke, all-cause mortality, stroke and rehospitalization with a focus on … cause or stroke, the analysis of the HR trend over time shows the superiority of TAVR over … Again, the HR trend over time shows a survival …
… They may arise due to accumulation of mutations in adult stem cells, uptake of mutated DNA from an apoptotic cell, occurrence of a dedifferentiating mutation within a previously differentiated somatic cell, or induction of fusion between a stem …
… stroke and TIA within 30 days after TAVR in a large single-center all-comers cohort of 1919 patients over a 10-year period with a detailed description of all detected strokes. … TAVR presented with a prior stroke and account for 19.7% of …
… quite high risk of procedure-related stroke after TAVR due to the grade 4 thrombus formation in the ascending aorta, treated with TF-TAVR with the Sentinel CPS insertion. To our knowledge, the usefulness of a filter device insertion prior to …
… To further investigate whether the implanted functionalized sodium alginate hydrogels produced bioactive stem cell transplantation beds, we performed an H&E and a Masson staining of paraffin sections of subcutaneous composite cystic tissues …
… Although rates of clinically overt cerebrovascular events associated with TAVR are reported to be low—particularly in low-risk patients [26]—… on patient population, study design, and stroke definition. As we treat more and more patients with TAVR …
… Induced pluripotent stem cell (iPSC) technology has provided a complementary experimental approach for investigating the pathogenic mechanisms implicated in PCDH19-CE during neurogenesis and studying the pathology in a more …
… Single cell technology has found a niche in stem cell biology and can be used for studying cellular diversity, identifying subpopulations in heterogeneous culture systems and stem cellbased disease models. There are many methods available for …
An article says that microplastics have been found in human blood for the first time. We rate this claim as true, although more studies are needed to determine if these substances in humans are associated with a public health risk.
… In this study, we hypothesized that several paracrine cytokines exist in stem cell culture media that may facilitate the immunomodulation of macrophages. The IL4 treatment of stem cells could lead to a greater production of those compounds which …
… of death of any cause or stroke, all-cause mortality, stroke and rehospitalization with a focus on … cause or stroke, the analysis of the HR trend over time shows the superiority of TAVR over … Again, the HR trend over time shows a survival …
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