Feature Channels: Stem Cells

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Released: 18-Jul-2023 12:00 PM EDT
Life on Earth didn’t arise as described in textbooks
University of Copenhagen, Faculty of Science

No, oxygen didn’t catalyze the swift blossoming of Earth’s first multicellular organisms. The result defies a 70-year-old assumption about what caused an explosion of oceanic fauna hundreds of millions of years ago.

Released: 18-Jul-2023 11:45 AM EDT
A key function for tight junctions in embryo models
Gladstone Institutes

As a human embryo grows, a set of molecules directs cells as they multiply and take on specific identities and spatial positions within the embryo. In one crucial step known as gastrulation, these signaling molecules guide a single layer of embryonic stem cells to form three layers of distinct cell types that will later become different parts of the body.

   
Released: 13-Jul-2023 7:00 AM EDT
Artificially grown ‘mini-brains’ without animal components bring opportunities for neuroscience
Michigan Medicine - University of Michigan

Researchers at University of Michigan developed a method to produce artificially grown miniature brains — called human brain organoids — free of animal cells that could greatly improve the way neurodegenerative conditions are studied and, eventually, treated. The work offers a solution to overcome Matrigel’s weaknesses.

Released: 10-Jul-2023 4:05 PM EDT
Hematopoietic stem cell culture technology for more effective and safer genome editing
University of Tsukuba

Hematopoietic stem cells (HSCs) are rare cells found in the bone marrow that produce red blood cells, white blood cells, and platelets.

Newswise: New Insight into How Plant Cells Divide
6-Jul-2023 1:00 PM EDT
New Insight into How Plant Cells Divide
University of California San Diego

Plant and animal stem cells both rely on the cytoskeleton to divide properly, but a new study finds that they use them in opposite ways—while animal cells pull on the cytoskeleton, plant cells push it away. Harnessing that action could help scientists engineer more resilient plants.

Newswise: CRI’s Sean Morrison elected to European Molecular Biology Organization
Released: 5-Jul-2023 12:45 PM EDT
CRI’s Sean Morrison elected to European Molecular Biology Organization
UT Southwestern Medical Center

Stem cell biologist Sean J. Morrison, Ph.D., Howard Hughes Medical Institute Investigator and founding Director and Professor of the Children’s Medical Center Research Institute at UT Southwestern (CRI), has been elected by his peers as an associate member of the European Molecular Biology Organization (EMBO).

Newswise: Sylvester Research: Remnants of ancient retrovirus may drive aggressiveness and resilience of malignant brain cancers
26-Jun-2023 8:05 PM EDT
Sylvester Research: Remnants of ancient retrovirus may drive aggressiveness and resilience of malignant brain cancers
Sylvester Comprehensive Cancer Center

A new, EMBARGOED study suggests that reactivation of an ancient retrovirus from 6 million years ago may be at least partly to blame for the aggressiveness and treatment resistance of some glioblastomas.

Newswise: Base editing shows potential superiority for curing sickle cell disease
Released: 3-Jul-2023 11:00 AM EDT
Base editing shows potential superiority for curing sickle cell disease
St. Jude Children's Research Hospital

Gene therapy that alters hemoglobin genes may be an answer to curing sickle cell disease and beta thalassemia. Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard found base editing increased fetal hemoglobin production in a new treatment.

Newswise: June Research Highlights
Released: 30-Jun-2023 2:45 PM EDT
June Research Highlights
Cedars-Sinai

A roundup of the latest medical discoveries and faculty news at Cedars-Sinai for June 2023.

Released: 27-Jun-2023 5:40 PM EDT
New model provides unprecedented window into human embryonic development
Yale University

Two to three weeks after conception, an embryo faces a critical point in its development. In the stage known as gastrulation, the transformation of embryonic cells into specialized cells begins.

Newswise: Human embryo-like models created from stem cells to understand earliest stages of human development
Released: 27-Jun-2023 11:50 AM EDT
Human embryo-like models created from stem cells to understand earliest stages of human development
University of Cambridge

Cambridge scientists have created a stem cell-derived model of the human embryo in the lab by reprogramming human stem cells. The breakthrough could help research into genetic disorders and in understanding why and how pregnancies fail.

Released: 26-Jun-2023 12:00 PM EDT
Factors affecting osteogenesis and chondrogenic differentiation of mesenchymal stem cells in osteoarthritis
World Journal of Stem Cells

Osteoarthritis (OA) is a common degenerative joint disease that often involves progressive cartilage degeneration and bone destruction of subchondral bone. At present, clinical treatment is mainly for pain relief, and there are no effective

Released: 26-Jun-2023 12:00 PM EDT
Culture and identification of neonatal rat brain-derived neural stem cells
World Journal of Stem Cells

BACKGROUNDTiming of passaging, passage number, passaging approaches and methods for cell identification are critical factors influencing the quality of neural stem cells (NSCs) culture. How to effectively culture and identify NSCs is a cont

Released: 26-Jun-2023 12:00 PM EDT
Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycin-induced focal segmental glomerulosclerosis
World Journal of Stem Cells

BACKGROUNDBone marrow-derived mesenchymal stem cells (MSCs) show podocyte-protective effects in chronic kidney disease. Calycosin (CA), a phytoestrogen, is isolated from Astragalus membranaceus with a kidney-tonifying effect. CA preconditio

Released: 26-Jun-2023 12:00 PM EDT
Potential regulatory effects of stem cell exosomes on inflammatory response in ischemic stroke treatment
World Journal of Stem Cells

The high incidence and disability rates of stroke pose a heavy burden on society. Inflammation is a significant pathological reaction that occurs after an ischemic stroke. Currently, therapeutic methods, except for intravenous thrombolysis

Released: 26-Jun-2023 12:00 PM EDT
Current overview of induced pluripotent stem cell-based blood-brain barrier-on-a-chip
World Journal of Stem Cells

BACKGROUNDInduced pluripotent stem cells (iPSCs) show great ability to differentiate into any tissue, making them attractive candidates for pathophysiological investigations. The rise of organ-on-a-chip technology in the past century has in

Released: 26-Jun-2023 12:00 PM EDT
Clinical relevance of stem cells in lung cancer
World Journal of Stem Cells

Lung cancer is the major cause of cancer-related deaths worldwide, it has one of the lowest 5-year survival rate, mainly because it is diagnosed in the late stage of the disease. Lung cancer is classified into two groups, small cell lung ca

Released: 26-Jun-2023 12:00 PM EDT
Advances of nanotechnology applied to cancer stem cells
World Journal of Stem Cells

Cancer stem cells (CSCs) are a small proportion of the cells that exist in cancer tissues. They are considered to be the culprit of tumor genesis, development, drug resistance, metastasis and recurrence because of their self-renewal, prolif

Released: 26-Jun-2023 12:00 PM EDT
Adipokines regulate mesenchymal stem cell osteogenic differentiation
World Journal of Stem Cells

Mesenchymal stem cells (MSCs) can differentiate into various tissue cell types including bone, adipose, cartilage, and muscle. Among those, osteogenic differentiation of MSCs has been widely explored in many bone tissue engineering studies.



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