Feature Channels: Stem Cells

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Released: 6-Oct-2022 12:00 PM EDT
Distinct modes of heat shock transcription factor interactions with mitotic chromosomes
Preprints

Rachel M Price, Marek A Budzyński, Junzhou Shen, Jennifer E. Mitchell, James Z.J. Kwan, Sheila S. Teves

Released: 6-Oct-2022 12:00 PM EDT
Prediction of diabetes mellitus development after kidney transplantation using patient-specific induced pluripotent stem cells
Preprints

Sun Woo Lim, Yoo Jin Shin, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang

Released: 6-Oct-2022 12:00 PM EDT
α-synuclein fibril and synaptic vesicle interactions lead to vesicle destruction and increased uptake into neurons
Preprints

Amberley D Stephens, Ana Fernandez-Villegas, Chyi Wei Chung, Oliver Vanderpoorten, Dorothea Pinotsi, Ioanna Mela, Edward Nicholas Ward, Thomas M McCoy, Robert Cubitt, Alexander F Routh, Clemens F Kaminski, Gabriele S Kaminski Schierle

Released: 6-Oct-2022 5:00 AM EDT
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes
Cell Stem Cell

By characterizing the epigenome of direct reprogramming processes, Qian and colleagues discovered common features of direct reprogramming. Particularly, Ascl1, the neuron reprogramming factor, activates a unique set of cardiac genes. Together with As

Released: 6-Oct-2022 5:00 AM EDT
Pervasive donor DNA integration defies precision gene editing of hematopoietic stem cells
Cell Stem Cell

Therapeutic gene editing based on homology-directed repair (HDR) promises to precisely recombine donor template sequences at programmed double-strand break sites. In this issue, Ferrari et al. report that commonly used AAV donors blunt hematopoietic

Released: 6-Oct-2022 5:00 AM EDT
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures
Cell Stem Cell

Three recent studies from the Zernicka-Goetz and Hanna groups (Amadei et al., 2022; Tarazi et al., 2022; Lau et al., 2022) report the development of mouse embryo-like structures from stem cells. Using a combination of stem cell-derived sources, th

Released: 6-Oct-2022 5:00 AM EDT
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination
Cell Stem Cell

Fibrosis, the pathological end stage of chronic inflammatory diseases, results from extracellular matrix deposition by fibrogenic fibroblasts. In this issue of Cell Stem Cell, Sobecki et al. (2022) develop a novel vaccination-based immunotherapy aga

Released: 5-Oct-2022 12:00 PM EDT
Inflammation drives age-induced loss of tissue resident macrophages
Preprints

Kémy Adé, Javier Saenz Coronilla, Dorian Obino, Tobias Weinberger, Caroline Kaiser, Sebastien Mella, Cheng Chen, Lida Katsimpardi, Catherine Werts, Pascal Dardenne, Yvan Lallemand, Elisa Gomez-Perdiguero

Released: 5-Oct-2022 12:00 PM EDT
Loss of the MLL3 tumor suppressor accelerates breast tumor onset via HIF1a-induced CCL2-mediated recruitment of CCR2+ regulatory T cells
Preprints

Marie Boutet, Piril Erler, Kenta Nishitani, Nicole Couturier, Zheng Zhang, Emeline Barbieux, Erik Guillen, Masako Suzuki, Gregoire Lauvau, Wenjun Guo

Released: 5-Oct-2022 12:00 PM EDT
Chemical Imaging Reveals Diverse Functions of Tricarboxylic Acid Metabolites in Root Growth and Development
Preprints

Tao Zhang, Sarah E. Noll, Jesus T. Peng, Amman Klair, Abigail Tripka, Nathan Stutzman, Casey Cheng, Richard N Zare, Alexandra Jazz Dickinson

Released: 5-Oct-2022 12:00 PM EDT
A corset of adhesions during development establishes individual neural stem cell niches and controls adult behaviour
Preprints

Agata Banach-Latapy, Vincent Rincheval, David Briand, Isabelle Guenal, Pauline Speder

Released: 5-Oct-2022 12:00 PM EDT
Newly diagnosed multiple myeloma patients with CD56 expression benefit more from autologous stem cell transplantation
Preprints

Chuanying Geng, Huixing Zhou, Huijuan Wang, Yanchen Li, Yun Leng, Zhiyao Zhang, Yuan Jian, Guangzhong Yang, Wenming Chen

Released: 5-Oct-2022 12:00 PM EDT
Human induced pluripotent stem cell culture v1
Preprints

Gurvir.Virdi Not Provided

Released: 5-Oct-2022 12:00 PM EDT
Neuron-derived exosomes trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease
Preprints

Zhichun Chen, Chongchong Xu, Guanglu Li, Zhexing Wen, Jun Liu, Zixu Mao

Released: 4-Oct-2022 12:00 PM EDT
Single cell transcriptomics of human prenatal anterior foregut-derived organs identifies distinct developmental signatures directing commitment and specialization of the thymic epithelial stroma
Preprints

Abdulvasey Mohammed, Priscila Ferreira Slepicka, Benjamin Solomon, Kelsea M Hubka, Michael G Chavez, Christine Y Yeh, Virginia D Winn, Casey A Gifford, Purvesh Khatri, Andrew Gentles, Katja Gabrielle Weinacht

Released: 4-Oct-2022 12:00 PM EDT
In vivo generation of heart and vascular system by blastocyst complementation
Preprints

Giulia Coppiello, Paula Barlabe, Marta Moya-Jodar, Gloria Abizanda, Carolina Barreda, Elena Iglesias, Javier Linares, Estibaliz Arellano-Viera, Adrian Ruiz-Villalba, Eduardo Larequi, Xonia Carvajal-Vergara, Beatriz Pelacho, Felipe Prosper, Xabier L. Arangur

Released: 4-Oct-2022 12:00 PM EDT
Arterial cells support the development of human hematopoietic progenitors in vitro via secretion of IGFBP2.
Preprints

Paolo Petazzi, Telma Ventura, Alisha May, Francesca Paola Luongo, Helen Alice Taylor, Nicola Romanò, Lesley Margaret Forrester, Pablo Menéndez, Antonella Fidanza

Released: 3-Oct-2022 12:00 PM EDT
Establishment of a human pluripotent stem cell-derived MKX-tdTomato reporter system
Preprints

Yuki Fujisawa, Ming Lu, Daisuke Yamada, Tomoka Takao, Takeshi Takarada

Released: 3-Oct-2022 12:00 PM EDT
Integrative Cut&Tag/RNA-Seq analysis of histone variant macroH2A1-dependent orchestration of human iPSCs reprogramming
Preprints

Niccolo Liorni, Alessandro Napoli, Stefano Castellana, Sebastiano Giallongo, Daniela Rehakova, Oriana Lo Re, Irena Koutna, Tommaso Mazza, Manlio Vinciguerra

29-Sep-2022 11:15 AM EDT
Mount Sinai Study Uncovers Mechanisms of Reactive Oxygen Species in Stem Cell Function and Inflammation Prevention
Mount Sinai Health System

Mount Sinai researchers have published one of the first studies to demonstrate the importance of reactive oxygen species in maintaining stem cell function and preventing inflammation during wound repair, which could provide greater insights into the prevention and treatment of inflammatory bowel diseases (IBD), according to findings published in the journal Gut on October 3.

Released: 2-Oct-2022 12:00 PM EDT
Enteroendocrine cells protect the stem cell niche by regulating crypt metabolism in response to nutrients
Preprints

Heather A McCauley, Anne Marie Riedman, Jacob R Enriquez, Xinghao Zhang, Miki Watanabe-Chailland, J. Guillermo Sanchez, Daniel O. Kechele, Emily F. Paul, Kayle Riley, Courtney Burger, Richard A Lang, James M. Wells

Released: 1-Oct-2022 12:00 PM EDT
Temporal Extracellular Vesicle Protein Changes following Intraarticular Treatment with Integrin α10β1-selected Mesenchymal Stem Cells in Equine Osteoarthritis
Preprints

Emily J Clarke, Emily Johnson, Eva Caamano Gutierrez, Camilla Andersen, Lise Berg, Rosalind Jenkins, Casper Lindegaard, Kristina Uvebrant, Evy Lundgren-Akerlund, Agnieszka Turlo, Victoria James, Stine Jacobsen, Mandy J. Peffers

Released: 1-Oct-2022 12:00 PM EDT
Dual states of Bmi1-expressing intestinal stem cells drive epithelial development and tissue regeneration
Preprints

Nicholas R. Smith, Sidharth K. Sengupta, Patrick Conley, Nicole R. Giske, Christopher Klocke, Brett S. Walker, Noelle McPhail, John R. Swain, Yeon Jung Yoo, Ashley N. Anderson, Paige S. Davies, Nasim Sanati, Theresa N. Nguyen, Kristo

Newswise: September Research Highlights
Released: 30-Sep-2022 4:50 PM EDT
September Research Highlights
Cedars-Sinai

Here is a summary of the September research discoveries and faculty news from Cedars-Sinai.

Released: 30-Sep-2022 12:10 PM EDT
‘Love hormone’ revealed to have heart healing properties
Frontiers

The neurohormone oxytocin is well-known for promoting social bonds and generating pleasurable feelings, for example from art, exercise, or sex.

Newswise: Making lab-grown brain organoids ‘brainier’
Released: 29-Sep-2022 2:50 PM EDT
Making lab-grown brain organoids ‘brainier’
University of California, Los Angeles (UCLA), Health Sciences

Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA center members discovered how to create more accurate, consistent brain organoids to develop treatments for neurological disorders.

Newswise: Dietary supplementation may improve antibiotic-induced GVHD following stem cell transplants
28-Sep-2022 4:15 PM EDT
Dietary supplementation may improve antibiotic-induced GVHD following stem cell transplants
University of Texas MD Anderson Cancer Center

Researchers at The University of Texas MD Anderson Cancer Center have identified a specific gut bacterium involved in the progression of graft-versus-host disease (GVHD) after antibiotic treatment of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and discovered that nutritional supplementation can prevent antibiotic-induced GVHD in preclinical models, according to a study published today in Cell.

Released: 28-Sep-2022 12:00 PM EDT
A filamentous phage triggers antiviral responses in cystic fibrosis basal airway epithelial cells
Preprints

Medeea C Popescu, Naomi L Haddock, Elizabeth B Burgener, Laura S Rojas-Hernandez, Gernot Kaber, Aviv Hargil, Paul Bollyky, Carlos E Milla

Released: 28-Sep-2022 12:00 PM EDT
A Single-Cell Level Comparison of Human Inner Ear Organoids and the Human Cochlea and Vestibular Organs
Preprints

Wouter H. van der Valk, Edward S.A. van Beelen, Matthew R. Steinhart, Carl Nist-Lund, John C.M.J. de Groot, Peter Paul G. van Benthem, Karl R. Koehler, Heiko Locher

Released: 28-Sep-2022 12:00 PM EDT
Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin-beta receptor signaling
Preprints

Xing Feng, Ruifeng Sun, Moonyoung Lee, Xinyue Chen, Shangqin Guo, Huimin Geng, Marcus Müschen, Jungmin Choi, Joao Pedro Pereira

Released: 28-Sep-2022 12:00 PM EDT
Royal jelly maintains epidermal stem cell properties by repressing senescence
Preprints

Mariko Moriyama, Yuko Miyake, Tomomi Degawa, Nobuaki Okumura, Hiroyuki Moriyama

Newswise: Providing ‘quality assurance’ for new stem cells: Macrophages do the vetting
Released: 27-Sep-2022 4:50 PM EDT
Providing ‘quality assurance’ for new stem cells: Macrophages do the vetting
Boston Children's Hospital

Using live imaging and cellular barcoding, researchers in the Stem Cell Program at Boston Children’s Hospital have glimpsed how new stem cells — in this case, blood stem cells — are vetted for quality soon after they’re born.

Released: 27-Sep-2022 12:00 PM EDT
ESDR336 - Induced pluripotent stem cell-derived macrophages in an inflammatory skin disease model to study granuloma formation
Preprints

Lisa Kleissl, Anna Redl, Teresa Neuwirth, Ruth Dingelmaier-Hovorka, Ram Pandey, Georg Stary

Released: 27-Sep-2022 12:00 PM EDT
Antagonistic H3K79me-H3K9ac crosstalk determines elongation at housekeeping genes to promote pluripotency
Preprints

Coral K Wille, Xiaoya Zhang, Spencer Haws, John Denu, Rupa Sridharan

Released: 27-Sep-2022 12:00 PM EDT
Resolution of structural variation in diverse mouse genomes reveals chromatin remodeling due to transposable elements
Preprints

Ardian Ferraj, Peter A Audano, Parithi Balachandran, Anne Czechanski, Jacob I Flores, Alexander A Radecki, Varun Mosur, David S Gordon, Isha A Walawalkar, Evan E Eichler, Laura G Reinholdt, Christine R Beck

Released: 27-Sep-2022 12:00 PM EDT
Sleep-wake Disturbance following Allogeneic Hematopoietic Stem Cell Transplantation: Trajectory and Correlates
Preprints

Muthu Veeraputhiran, Jennifer Gernat, Naveen Yarlagadda, Milan Bimali, Ellyn E. Matthews

Released: 27-Sep-2022 12:00 PM EDT
Donor cord blood aging accelerates in recipients after transplantation
Preprints

Makoto Onizuka, Tadashi Imanishi, Kaito Harada, Yasuyuki Aoyama, Jun Amaki, Masako Toyosaki, Shinichiro Machida, Eri Kikkawa, Sanetoshi Yamada, Kazuhiko Nakabayashi, Kenichiro Hata, Ken Higashimoto, Hidenobu Soejima, Kiyoshi Ando

Released: 27-Sep-2022 12:00 PM EDT
Retrospective analysis of patients with severe combined immune deficiency: A 20-year Single center experience
Preprints

Sevim Busra Korkmaz, Selma Erol Aytekin, Huseyin Tokgoz, Sukru Guner, Ismail Reisli, Sevgi Keles



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