Feature Channels: Stem Cells

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Jian Zhang, Xiao Hu, Qiao Wu, Shangqin Guo

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Haruka Miyata, Masakazu Ishii, Fumio Suehiro, Naohiro Komabashiri, Nao Ikeda, Tomoaki Sakurai, Masahiro Nishimura

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Ana Gutierrez-Franco, Mohamed N. Hassan, Loris Mularoni, Mireya Plass

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One of the hallmarks of Alzheimer’s disease is a reduction in the firing of some neurons in the brain, which contributes to the cognitive decline that patients experience. A new study from MIT shows how a type of cells called microglia contribute to this slowdown of neuron activity.

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Palikuqi et al. employ imaging of cleared intestinal tissue, transcriptional analyses, and genetic mouse models to investigate the role of lymphatic endothelial cells in the intestinal stem cell niche. The authors demonstrate that lymphatic endothel

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Goto and colleagues identify lymphatic endothelial cells (LECs) and RSPO3+GREM1+ fibroblasts (RGFs) as stromal niche components of intestinal stem cells (ISCs). LECs and RGFs sustain ISCs through the production of RSPO3 and GREM1 in homeostasis. In i

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A small-molecule cocktail reprograms human cord blood erythroblasts into induced megakaryocytes with ex vivo functionality. The four small molecules extensively remodel the chromatin and induce the dynamic network transition from erythroid master ge

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Tsai and colleagues explored the impact of the Alzheimer’s disease-associated risk gene APOE4 onto the cellular communication of neurons and microglia. Through combinatorial experiments with cells derived from CRISPR-edited APOE isogenic lines, thi

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Jing et al. combine a stroma-free differentiation system with EZH1-repression-mediated epigenetic reprogramming to generate developmentally mature iPSC-derived CAR T cells with enhanced antitumor activities.

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Talbott et al. discuss the current state of knowledge in fibroblast biology and heterogeneity, primarily focusing on fibroblasts in skin wound repair. They also consider emerging techniques in the field and evaluate limitations of existing methodolo

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In this issue of Cell Stem Cell, Victor et al. reveal that human microglia harboring the Alzheimer’s disease risk allele APOE4 have altered lipid metabolism and cellular activation. This dampens neuronal network activity, underscoring the importan

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In the current issue of Cell Stem Cell, Bogeska et al. demonstrate that repeated exposures to inflammation cause indelible and specific functional compromise and accelerated aging of long-term hematopoietic stem cells (LT-HSCs). This study proposes

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In this issue of Cell Stem Cell, Jing et al. inhibit EZH1 expression in a system that supports mature T cell development from iPSCs in vitro. The authors efficiently generate T cells that are highly functional against tumors.

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Inflammation and infection acutely suppress HSC function. However, the long-term ramifications of such challenges are unclear. This study demonstrates that murine HSCs fail to recover functional potency up to 1 year post-inflammatory/infection challe

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I Gde Rurus Suryawan, Andrianto Andrianto, Arisya Agita, Anudya Kartika Ratri, Ricardo Adrian Nugraha

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Yoshimitsu Shimomura, Masashi Nishikubo, Hayato Maruoka, Seiko Nasu, Tomomi Nishioka, Kenji Sakizono, Satoshi Mitsuyuki, Tomoyo Kubo, Naoki Okada, Daishi Nakagawa, Kimimori Kamijo, Hiroharu Imoto, Ryusuke Yamamoto, Yuya Nagai,

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Raly James Custodio, Hee Jin Kim, Jiyeon Kim, Darlene Mae Ortiz, Mikyung Kim, Danilo Buctot, Leandro Val Sayson, Hyun Jun Lee, Bung-Nyun Kim, Eugene Yi, Jae Hoon Cheong

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Adam Stabell, Shuxiong Wang, Grace Lee, Ji Ling, Sandrine Nguyen, George Sen, Qing Nie, Scott Atwood

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Helena G Asenjo, Maria Alcazar-Fabra, Mencia Espinosa, Lourdes Lopez-Onieva, Amador Gallardo, Emilia Dimitrova, Angelika Feldmann, Tomas Pachano, Jordi Martorell-Marugan, Pedro Carmona-Saez, Antonio Sanchez-Pozo, Alvaro Rada-Iglesias, Robert J Klose, David

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Michael Herriges, Maria Yampolskaya, Bibek R Thapa, Jonathan Lindstrom-Vautrin, Feiya Wang, Cheng-Lun Na, Liang Ma, McKenna M Montminy, Jessie Huang, Carlos Villacorta-Martin, Pankaj Mehta, Darrell N. Kotton

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Chunbo Li, Luopei Guo, Keqin Hua

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Risa Sugiura, Sayuri Hamano, Atsushi Tomokiyo, Daigaku Hasegawa, Shinichiro Yoshida, Hideki Sugii, Shoko Fujino, Orie Adachi, Masataka Kadowaki, Daiki Yamashita, Hidefumi Maeda

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In insulin-dependent diabetes, the islet β cells do not produce enough insulin and the patients must receive exogenous insulin to control blood sugar. However, there are still many deficiencies in exogenous insulin supplementation. Therefore,

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BACKGROUNDDermal papillae (DP) and outer root sheath (ORS) cells play important roles in hair growth and regeneration by regulating the activity of hair follicle (HF) cells. AIMTo investigate the effects of human mesenchymal stem cell-derived

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Mesenchymal stem cells (MSCs) have gained wide-ranging reputation in the medical research community due to their promising regenerative abilities. MSCs can be isolated from various resources mostly bone marrow, Adipose tissues and Umbilical cor

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For more than 20 years, researchers have isolated and identified postnatal dental pulp stem cells (DPSCs) from different teeth, including natal teeth, exfoliated deciduous teeth, healthy teeth, and diseased teeth. Their mesenchymal stem cell (M

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BACKGROUNDBronchopulmonary dysplasia (BPD) is not merely a chronic lung disease, but a systemic condition with multiple organs implications predominantly associated with hyperoxia exposure. Despite advances in current management strategies, lim

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Stem cell fate determination is one of the central questions in stem cell biology, and although its regulation has been studied at genomic and proteomic levels, a variety of biological activities in cells occur at the metabolic level. Metabolom

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The use of mesenchymal stem-cells (MSC) in cell therapy has received considerable attention because of their properties. These properties include high expansion and differentiation in vitro, low immunogenicity, and modulation of biological proc

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With advances in the fields of regenerative medicine, cell-free therapy has received increased attention. Exosomes have a variety of endogenous properties that provide stability for molecular transport across biological barriers to cells, as a

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Paul Wilmes, Jean-Pierre Trezzi, Velma Aho, Christian Jäger, Sebastian Schade, Annette Janzen, Oskar Hickl, Benoit Kunath, Mélanie Thomas, Kristopher Schmit, Pierre Garcia, Alessia Sciortino, Camille Martin-Gallausiaux, Rashi Halder,

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Huanping An, Yue Yu, Xuming Ren, Minghua Zeng, Yu Bai, Tao Liu, Huimei Zheng, Rong Sang, Fan Zhang, Yu Cai, YongMei Xi

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Afsane Soleimani, Mirsepehr Pedram, Fatemeh Saadinam, Mohammad Javad Rasaee, Saeed Oraee Yazdani, Masoud Soleimani

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Wejdan Salem AlQurashi, Naif I. AlJohani

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Khosrow Rezvani, Sanam Sane, Rekha Sriniva, Rashaun Potts, Morgan Eikanger, Diana Zagirova, Jessica Freeling, Casey Reihe, Ryan Antony, Brij Gupta, Douglas Lynch, Jonathan Bleeker, Hassan Turaihi, Angela Pillatzki,

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Kazuhiko Ikeda, Keiji Minakawa, Satoshi Ono, Mao Watanabe, Yuka Sato, Saki Takahashi, Sho Odawara, Kinuyo Kawabata, Koki Ueda, Kenneth Nollet, Hideki Sano, Takayuki Ikezoe, Atsushi Kikuta

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BACKGROUNDCancer stem cells (CSCs) have been implicated in tumorigenesis and tumor recurrence and metastasis are key therapeutic targets in cancer treatment. MicroRNAs display therapeutic potential by controlling the properties of CSCs; however

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In insulin-dependent diabetes, the islet β cells do not produce enough insulin and the patients must receive exogenous insulin to control blood sugar. However, there are still many deficiencies in exogenous insulin supplementation. Therefore,

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Marie Clémot, Cecilia D'Alterio, Alexa C. Kwang, D. Leanne Jones

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Marija Zivaljic, Mathieu Hubert, Ludivine Grzelak, Giulia Sansone, Uwe Maskos, Olivier Schwartz

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Hamid Aria, Mahdieh Azizi, Shima Nazem, Maryam Bahmanyar, Ali Moravej, Mohammad Hosein Pourjafarian, Babak Pezeshki, Alireza Tavassoli, Mohammad Kazem Vakil, Yaser Mansoori

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Kotaro Sasaki, Yasunari Seita, Keren Cheng, John McCarrey, Nomesh Yadu, Ian Cheeseman, Alec Bagwell, Corinna N Ross, Isamar Santana-Toro, Li-Hua Yen, Sean Vargas, Christopher S Navara, Brian P Hermann