Feature Channels: Stem Cells

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Released: 7-Mar-2023 7:00 AM EST
Ingeniería de tejidos para fortalecer corazones con malformaciones
Mayo Clinic

¿Acaso sería posible extraer células de una pequeña porción de piel y transformarlas en tejido muscular para reparar un defecto cardíaco congénito? Esta es una pregunta científica que el Dr. Timothy Nelson, y sus colaboradores esperan responder para ayudar a quienes nazcan con una cavidad malformada en el hemisferio izquierdo del corazón, una afección compleja e infrecuente conocida como síndrome del corazón izquierdo hipoplásico (HLHS, por sus siglas en inglés).

Released: 7-Mar-2023 7:00 AM EST
هندسة الأنسجة لدعم القلوب غير مكتملة النمو
Mayo Clinic

هل يمكن لخلايا مأخوذة من رقعة جلدية صغيرة أن تتحول لتصبح عضلة قلبية وتصلح عيبًا خلقيًا نادرًا بالقلب؟ هذا هو السؤال العلمي الذي يأمل تيموثي نيلسون، دكتور في الطب وحاصل على دكتوراه، والمتعاونون معه في الإجابة عليه من أجل هؤلاء الذين يولدون بحجرة قلب يسرى غير مكتملة النمو، وهي حالة مرضية نادرة ومعقدة تعرف باسم متلازمة القلب الأيسر ناقص التنسُّج.

Released: 2-Mar-2023 2:35 PM EST
Early Mayo Clinic research finds hope in stem cell therapy for perianal fistulas in patients with Crohn’s disease
Mayo Clinic

A dissolvable plug delivered stem cell therapy with few side effects in patients with single tract perianal fistulas, Mayo Clinic researchers discovered. Perianal fistulas are painful tunnels between the intestine and the skin that often do not go away with standard medical or surgical care.

Newswise: Possible treatment strategy identified for bone marrow failure syndrome
28-Feb-2023 5:40 PM EST
Possible treatment strategy identified for bone marrow failure syndrome
Washington University in St. Louis

Research led by Washington University School of Medicine in St. Louis has identified a possible treatment strategy for a rare bone marrow failure syndrome that is named poikiloderma with neutropenia. The work also may have implications for treating other bone marrow failure syndromes with similar underlying dysfunctions.

Released: 2-Mar-2023 6:00 AM EST
Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
Cell Stem Cell

Zhang et al. identified an epitranscriptomic mechanism regulating cortical neural stem cells in the embryonic mouse brain and human forebrain organoids. Specifically, Mettl8 installs m3C modification on mitochondrial tRNAThr/Ser(UNC), which regulate

Released: 2-Mar-2023 6:00 AM EST
Brain organoids restore cortical damage
Cell Stem Cell

Cortical damage is irreparable and poses a challenge to regenerative medicine. Whether brain organoids can compensate for injured brain regions remains unclear. In this issue of Cell Stem Cell, Jgamadze et al. report that human forebrain organoids t

Released: 2-Mar-2023 6:00 AM EST
Human stem cell models unravel mechanisms of somite segmentation
Cell Stem Cell

In vitro models to study human somitogenesis, the formation of the segmented body plan, have so far been limited.1 Two papers in Nature now report the creation of pluripotent stem cell (PSC)-derived 3D culture systems that recapitulate the formation

Released: 2-Mar-2023 6:00 AM EST
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering
Cell Stem Cell

Song et al. (Nature Methods, 2022) engineered a 3D model of the human outer blood-retina barrier (oBRB) that recapitulates key features of healthy and age-related macular degeneration (AMD)-affected eyes.1 We shine a spotlight on this tissue-enginee

Released: 2-Mar-2023 6:00 AM EST
Unraveling barriers to iPSC-derived CAR-T cell differentiation
Cell Stem Cell

The generation of off-the-shelf CAR-T cells from TiPSCs has been hindered by the difficulty to recapitulate adaptive T cell development and lower therapeutic efficacy compared to peripheral blood CAR-T cells. Ueda et al. address these issues in a t

Released: 2-Mar-2023 6:00 AM EST
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain
Cell Stem Cell

In this issue, Wells et al. combine genetic multiplexing (“village-in-a-dish”) and Stem-cell-derived NGN2-accelerated Progenitors (SNaPs) to evaluate genotype-phenotype relationships across 100 donors in the context of Zika virus infection in th

Released: 1-Mar-2023 6:25 PM EST
Researchers uncover how gene that increases risk of genetic heart disease works, paving way for new treatments
Murdoch Childrens Research Institute

Researchers have discovered how a gene that increases the risk of developing genetic heart disease functions, paving the way for new treatments.

Newswise:Video Embedded real-ai-will-need-biology-computers-powered-by-human-brain-cells
VIDEO
Released: 1-Mar-2023 1:15 PM EST
Real AI will need biology: Computers powered by human brain cells
Cortical Labs

The time has come to create a new kind of computer, say researchers from John Hopkins University together with Dr Brett Kagan, chief scientist at Cortical Labs in Melbourne, who recently led development of the DishBrain project, in which human cells in a petri dish learnt to play Pong.

Released: 28-Feb-2023 12:45 PM EST
Clinical trial for patients with swallowing difficulties after cancer treatment
UC Davis Health (Defunct)

UC Davis Health researchers have begun a new stem cell clinical trial to treat patients with swallowing problems. The study takes stem cells and injects them into the patient’s tongue.

Newswise: UC San Diego's Astrobiotechnology Hub to Drive Drug Discovery in Space
Released: 28-Feb-2023 11:45 AM EST
UC San Diego's Astrobiotechnology Hub to Drive Drug Discovery in Space
University of California San Diego

UC San Diego’s new Astrobiotechnology Hub brings together leaders in academia, biotechnology and aerospace industries under a united mission to advance stem cell science and commercialization in space.

   
Released: 26-Feb-2023 12:00 PM EST
Mesenchymal stem cells in ischemic tissue regeneration
World Journal of Stem Cells

Diseases caused by ischemia are one of the leading causes of death in the world. Current therapies for treating acute myocardial infarction, ischemic stroke, and critical limb ischemia do not complete recovery. Regenerative therapies opens new

Newswise: Healing the brain: Hydrogels enable neuronal tissue growth
Released: 24-Feb-2023 11:45 AM EST
Healing the brain: Hydrogels enable neuronal tissue growth
Hokkaido University

Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction.

23-Feb-2023 3:40 PM EST
Head injuries could be a risk factor for developing brain cancer
University College London

Researchers from the UCL Cancer Institute have provided important molecular understanding of how injury may contribute to the development of a relatively rare but often aggressive form of brain tumour called a glioma.

Released: 23-Feb-2023 2:20 PM EST
Thrive Bioscience Debuts New Cell Imaging Capabilities That Advance Laboratory Automation
Thrive Bioscience, Inc.

Thrive Bioscience Inc., an innovative provider of automated live cell imaging instruments and software, debuts a new integrated suite of unique and exciting capabilities that significantly advance the field of live cell imaging.

   
Newswise: Susceptibility to Pathogenic T Cells in Chronic Lung Disease May Have Genetic Basis
Released: 23-Feb-2023 12:00 PM EST
Susceptibility to Pathogenic T Cells in Chronic Lung Disease May Have Genetic Basis
University of California, San Francisco (UCSF)

UC San Francisco researchers have uncovered a surprising role for fibroblasts in the lungs in activating T cell inflammation that drives lung destruction in COPD exacerbation triggered by viral infection. They also identified a T cell subset that can be targeted to treat COPD exacerbations.



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