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Study Suggests Additional Applications for FL118 as Personalized Therapy for Cancer

Scientists from Roswell Park Cancer Institute have reported new mechanisms of action of the novel anticancer agent FL118 and new potential therapeutic targets for the agent, a camptothecin analogue.

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Meniscus Regenerated with 3D-Printed Implant

Researchers have devised a way to replace the knee’s protective lining, called the meniscus, using a personalized 3D-printed implant, or scaffold, infused with human growth factors that prompt the body to regenerate the lining on its own. The therapy, successfully tested in sheep, could provide the first effective and long-lasting repair of damaged menisci, which occur in millions of Americans each year and can lead to debilitating arthritis. The paper was published today in the online edition of Science Translational Medicine.

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Innovative “Tumor in a Dish” Turns Cells Into Cancer

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New research technique could allow better, more personalized cancer drug treatments

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Fast Modeling of Cancer Mutations

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Using CRISPR, researchers at MIT's Koch Institute have developed a new approach to rapidly model the effects of tumor cells’ genetic mutations in mice.

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Personalized Cellular Therapy Achieves Complete Remission in 90 Percent of Acute Lymphoblastic Leukemia Patients Studied

Ninety percent of children and adults with acute lymphoblastic leukemia (ALL) who had relapsed multiple times or failed to respond to standard therapies went into remission after receiving an investigational personalized cellular therapy, CTL019, developed at the Perelman School of Medicine at the University of Pennsylvania. The results are published this week in The New England Journal of Medicine.

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PTPRZ-MET Fusion Protein: A New Target for Personalized Brain Cancer Treatment

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Researchers at the University of California, San Diego School of Medicine have identified a new fusion protein found in approximately 15 percent of secondary glioblastomas or brain tumors. The finding offers new insights into the cause of this cancer and provides a therapeutic target for personalized oncologic care.

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Biologists Reprogram Skin Cells to Mimic Rare Disease

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Stem cell biologists have reprogrammed skin cells from patients with a rare genetic disorder, called familial dysautonomia, into neural crest cells that mimic and display many biological features of the disease. The research expedites the creation of these precursor cells from any patient with a neural crest-related disorder, allowing scientists to study each patient’s disorder at the cellular level.

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Growing Human GI Cells May Lead to Personalized Treatments

A method of growing human cells from tissue removed from a patient’s gastrointestinal (GI) tract eventually may help scientists develop tailor-made therapies for inflammatory bowel disease and other GI conditions. Researchers at Washington University School of Medicine in St. Louis have made cell lines from individual patients in as little as two weeks. They said the cell lines can help them understand the underlying problems in the GI tracts of individual patients and be used to test new treatments.

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Study Assesses Impact of Hourly Nursing Rounds on Patient Safety and Satisfaction

Adoption of hourly rounds schedules for nurses working in acute care hospitals may improve patient safety and overall satisfaction with care provided, according to research reported in the Journal for Healthcare Quality, the peer reviewed publication of the National Association for Healthcare Quality (NAHQ, www.nahq.org).

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New Toolkits Ease the Transition from Pediatric to Adult Health Care

The new Transitions of Care initiative spearheaded by the Endocrine Society provides interactive toolkits to help young adults who have hormone conditions navigate the shift from a pediatric to an adult health care team. The Society partnered with several health care organizations on the initiative, which offers resources for young adults, their parents and health care providers.

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