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Looking Ahead: Precision Immunology in Cancer

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With President Obama’s recent State of the Union speech addressing the launch of a national precision medicine initiative to further tackle cancer and other diseases, Howard L. Kaufman, MD, FACS, a leading immunotherapy expert from Rutgers Cancer Institute of New Jersey, weighs in on where we stand with precision immunology and personalized medicine and what needs to be accomplished.

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President Obama Calls for a New Initiative in “Precision Medicine”. Why Do We Need It?

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Precision Medicine: Mayo Clinic Expert Describes Next Steps to Help More Patients Benefit

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“Precision medicine” is becoming a national catchphrase after President Obama highlighted it in his State of the Union address. But what exactly is it? Richard Weinshilboum, M.D., acting director of the Mayo Clinic Center for Individualized Medicine, describes this new, rapidly advancing frontier in medicine and outlines 10 changes that would speed development and help more patients benefit from a personalized approach to health care:

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Scripps Florida Scientists Move Closer to a Personalized Treatment Solution for Intellectual Disability

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Scientists from the Florida campus of The Scripps Research Institute have produced an approach that completely protects animal models against a type of genetic disruption that causes intellectual disability, including serious memory impairments and altered anxiety levels.

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New Test Helps Guide Treatment for Bone Marrow Transplant Patients with Graft vs. Host Disease

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Innovative scoring system uses “Ann Arbor GVHD score” to better predict how patients will respond, minimize side effects

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Study Suggests Additional Applications for FL118 as Personalized Therapy for Cancer

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Scientists from Roswell Park Cancer Institute have reported new mechanisms of action of the novel anticancer agent FL118 and new potential therapeutic targets for the agent, a camptothecin analogue.

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Meniscus Regenerated with 3D-Printed Implant

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Researchers have devised a way to replace the knee’s protective lining, called the meniscus, using a personalized 3D-printed implant, or scaffold, infused with human growth factors that prompt the body to regenerate the lining on its own. The therapy, successfully tested in sheep, could provide the first effective and long-lasting repair of damaged menisci, which occur in millions of Americans each year and can lead to debilitating arthritis. The paper was published today in the online edition of Science Translational Medicine.

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Innovative “Tumor in a Dish” Turns Cells Into Cancer

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New research technique could allow better, more personalized cancer drug treatments

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Fast Modeling of Cancer Mutations

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Using CRISPR, researchers at MIT's Koch Institute have developed a new approach to rapidly model the effects of tumor cells’ genetic mutations in mice.

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Personalized Cellular Therapy Achieves Complete Remission in 90 Percent of Acute Lymphoblastic Leukemia Patients Studied

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Ninety percent of children and adults with acute lymphoblastic leukemia (ALL) who had relapsed multiple times or failed to respond to standard therapies went into remission after receiving an investigational personalized cellular therapy, CTL019, developed at the Perelman School of Medicine at the University of Pennsylvania. The results are published this week in The New England Journal of Medicine.