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Micro-RNA May Amplify Effectiveness of Sorafenib in Difficult Liver Cancer Cases

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Only 25% of patients respond to sorafenib treatment, so researchers have endeavored to understand its mechanism of action and discover a way to boost its effectiveness.

Science

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Placenta, Autism, UC Davis MIND Institute, DLL1, Methylation, epigentics

Placenta Provides Time Capsule for Autism Studies

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In two recent studies, researchers at UC Davis have shown that placental tissue can provide critical information about the epigenetic landscape that influences fetal development.

Medicine

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Cancer, Awards, Roth Award, Genetech, Roche, Lymphoma, Drug Development

Cancer Survivor and Noted Physician-Scientist Sandra Horning to Receive Roth Award

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Sandra Horning, MD, Chief Medical Officer and executive vice president of global development for Roche and Genentech, a member of the Roche Group, has been named the 2017 recipient of the Duane Roth Memorial Award, which will be presented February 16 at the annual Industry/Academia Translational Oncology Symposium at UC San Diego Moores Cancer Center.

Medicine

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Heart-Shaped Cells, The Power of Aspirin, Stem Cells Transplants and More in the Cancer News Source

Click here to go directly to the Cancer News Source

Medicine

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Back Pain, Nsaids, Pain Killers, spinal pain, Chiropractic, Chiropractors, Analgesic, Opioids, pain, Back Injury

Chiropractors Offer Alternative to NSAIDs for Back Pain

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People suffering from back pain should consider first trying chiropractic services and other non-drug therapies in light of a new research review that found common over-the-counter and prescription pain medications have limited effectiveness for back pain and raise the risk of side-effects, according to the American Chiropractic Association (ACA).

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Breaking Research Published in AACC’s Clinical Chemistry Journal Could Help to Combat Rise in Drivers Impaired by Edible Marijuana Consumption

Though marijuana edibles are becoming increasingly common, scant information exists on how to test drivers for impairment following their consumption. For the first time, research published today in AACC’s Clinical Chemistry journal evaluates the performance of roadside saliva tests for tetrahydrocannabinol (THC) following consumption of edibles, showing that lower THC cutoff points are needed for these tests to effectively detect marijuana ingestion.

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Constant Challenge for Discovery Propels Harvinder Gill

The Texas Tech researcher has shown how vaccines can be administered more effectively through the use of creative methods of drug delivery.

Medicine

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Pancreatic Cancer, MD Anderson Cancer Center, personalized medicine

Scientists Identify Aggressive Pancreatic Cancer Cells and Their Vulnerability

A team from The University of Texas MD Anderson Cancer Center describes this week in the journal Nature a series of preclinical experiments using patient-derived tumor xenografts (PDXs) and mouse models that point to potential treatments for patients with a rapidly-progressing and resistant subgroup of tumor cells.

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Every Diagnosis of Cancer Should Come with One of These, Says Cancer Expert

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“Every cancer diagnosis should come with a referral to genetic counseling,” says cancer expert Dr. Antonio Giordano, President of the Sbarro Health Research Organization at Temple University.

Medicine

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drug, Aging, Cell Signaling, cell signaling pathways

UNM Cancer Center Researcher Discovers New Class of Drugs to Combat Aging Diseases

Eric Prossnitz, PhD and his team uncovered new details of the aging process. They discovered an altered balance between certain signaling molecules in the smooth muscle cells of blood vessels and the heart. The team also discovered a new class of drugs that combats an important part of the aging process.

Medicine

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Genetics, armc, Nature Communications, universite de montreal, mice study, Cushing's Syndrome

A New Immunologic and Endocrine Syndrome

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After 10 years of research, a team at Université de Montréal's research centre has succeeded in deleting the Armc5 gene in experimental mice, discovering that its loss gives rise to a heretofore unidentified syndrome.

Medicine

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Fralin Life Science Institute, Virginia Tech Center for Drug Discovery, Malaria, malaria drug, Compound, Drug Resistance

Drug Discovery Researchers Awarded Grant to Refine Malaria Drug

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A research team from the Virginia Tech Center for Drug Discovery has received a $431,126 two-year grant from the National Institutes of Health to make improved versions of a promising compound called MMV008138, or 8138 for short.

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Chikungunya virus, Arthritis

Drug Combination Effective Against Chikungunya Arthritis in Mice

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Chikungunya virus causes a painful, debilitating arthritis for which there is currently no treatment. A new study has found that combining a drug for rheumatoid arthritis with one that targets the chikungunya virus can eliminate the signs of arthritis in mice in the early stage of the disease.

Medicine

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Genetics, Height, Precision Medicine

Understanding the Genetics of Human Height

A large-scale international study involving more than 300 researchers, published today in Nature, heralds the discovery of 83 genetic variations controlling human height. To discover the 83 genetic variations, the research team measured the presence of 250,000 genetic variations in the study’s 700,000 participants – an enormous job. This study paves the way for precision medicine.

Medicine

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Cancer, Genetics, Drug Development

Potential New Drug Class Hits Multiple Cancer Cell Targets, Boosting Efficacy and Safety

In a new paper published this week in PNAS, researchers at the University of California San Diego School of Medicine and Moores Cancer Center, in collaboration with colleagues at Rady Children’s Hospital-San Diego, the University of Colorado School of Medicine and SignalRx, a San Diego-based biopharmaceutical company, describe a potential new class of anti-cancer drugs that inhibit two or more molecular targets at once, maximizing therapeutic efficiency and safety.

Science

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HIV, Hiv 1, Hiv Aids, HIV and AIDS, Hiv Treatment, HIV drug, Antiviral, Antiviral Drugs, Antiviral Therapeutics, Antiviral Therapies, antiviral therapy, antiretrovials, Antiretroviral, antiretroviral drug therapy, Antiretroviral Drug Treatment, Antiretroviral Drugs, Antiretroviral Regimen, antiretroviral therapies , Antiretroviral Therapy, antiretroviral the

UNMC Research Team Discovers Novel Pharmaceutic Action for HIV/AIDS

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Using a process called LASER ART (long-acting slow effective release antiretroviral therapy), a research team has discovered an unexpected pathway to open cell storage areas for antiviral drugs. The discovery could revolutionize current treatments for HIV/AIDS by extending the actions of disease-combating medicines.

Medicine

Science

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sulfur bacterium, Microbe, Halorhodospira halophila, photo-active yellow protein (PYP), structural changes, Drug Development, Proteins, Marius Schmidt, University of Wisconsin‐Milwaukee, Structural Dynamics

How a Bacterial Protein’s Structure Aids Biomedical Studies

A light-sensing protein from a salt-loving, sulfur-forming microbe has proved key to developing methods essential to advanced drug discovery, understanding human vision and other biomedical applications. In a review published this week in Structural Dynamics, by AIP Publishing, physicist Marius Schmidt of the University of Wisconsin‐Milwaukee presents a history of decades of research of this microbe and the many new technologies that have enabled these applications.

Medicine

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drug, Drug Target, Drug Targets, Disease, Protein

Drugs, Diseases and Proteins: New Archive Helps Precision Medicine, Drug Development

Tudor Oprea, MD, PhD, at UNM Comprehensive Cancer Center and his collaborators from the UK-based European Bioinformatics Institute in Hinxton and from the Institute for Cancer Research in London have created the beginnings of an open archive that links a drug’s chemical structure, its molecular biology activity and the diseases it is used to treat.

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Only FDA-Approved Device to Repair "Hole in the Heart" Condition Now Available at Baylor Heart and Vascular Services at Fort Worth

Baylor Heart and Vascular Services at Fort Worth on Tuesday, November 15, became the first program in Texas to implant the only FDA-approved device designed to prevent blood clots from entering the brain by sealing a hole in the heart. The device is designed to help reduce the risk of recurrent cryptogenic strokes in patients diagnosed with a patent foramen ovale (PFO) – a small opening between the upper chambers of the heart.

Medicine

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Society Of Toxicology, Toxicology, toxicologist, Annual Meeting, ToxExpo, data science, Precision Medicine, Epigenetic, Food Safety, Arsenic, Pesticide, Alternative Test Methods, Public Health, In Vitro, Organs-on-a-chip, Carcinogenesis, Air Pollution

Latest Research on Data Science, Precision Medicine, Epigenetics, Food Safety, Arsenic, Pesticides, Alternative Test Methods, and More Featured at SOT 56th Annual Meeting and ToxExpo

The later-in-life effects of early life exposure to inorganic arsenic, reducing the toxicity of cancer treatments, advances in organs-on-a-chip and other alternative test methods, how to translate in vitro research to real-world understanding, controversies in pesticide toxicology, and the reproductive and developmental effects of botanical dietary supplements are just a few of the cutting-edge scientific topics being explored at the Society of Toxicology (SOT) 56th Annual Meeting and ToxExpo.







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