Jinghui Zhang, PhD, elected Fellow of the International Society for Computational Biology
St. Jude Children's Research HospitalFormer Chair of Computational Biology honored with induction into Class of 2023 Fellows.
Former Chair of Computational Biology honored with induction into Class of 2023 Fellows.
Investigators at the Icahn School of Medicine at Mount Sinai have designed an innovative RNA-based strategy to activate dendritic cells—which play a key role in immune response—that eradicated tumors and prevented their recurrence in mouse models of melanoma.
Two Tufts researchers have developed and patented an approach that may lead to the ability to recreate tissue in people with loss of smell.
Programmed cell death, a fundamental biological process that facilitates the elimination of old, damaged, infected, and non-functional cells, plays a crucial role in maintaining the balance between health and disease in the human body.
A new study led by researchers at The University of Texas MD Anderson Cancer Center discovered loss of metabolic fitness in chimeric antigen receptor (CAR) natural killer (NK) cells is a critical mechanism of resistance, with infused cells gradually losing the ability to compete with tumor cells for nutrients, leading to tumor relapse.
Zymo Research Corp, a leading provider of life science technologies, has partnered with Opentrons Labworks, Inc., a leader in lab automation, to revolutionize cell-free DNA isolation and analysis.
Researchers have found that dozens of viruses respond to quorum sensing or other chemical signals from bacteria.
In-cell engineering can be a powerful tool for synthesizing functional protein crystals with promising catalytic properties.
Scientists at UT Southwestern Medical Center and Children’s Medical Center Dallas have discovered in mice how high cholesterol causes blood vessels to become inflamed, a necessary prerequisite for atherosclerosis – the “hardening of the arteries” responsible for most heart attacks and strokes. The findings, published in Nature Communications, could lead to new interventions to protect against cardiovascular diseases (CVD), the leading cause of death globally.
Taiwanese IVD (In-Vitro Diagnostic) manufacturer General Biologicals Corporation (GBC) today unveiled two CellBio™ circulating tumor cell (CTC) cancer detection products at the American Association for Clinical Chemistry Annual Scientific Meeting & Clinical Lab Expo, being held July 23-27 in Anaheim, California.
You might not think of diabetes when you think of muscle function. But a common diabetes drug that regulates blood sugar can also prevent muscle atrophy and muscular fibrosis—which can help the elderly bounce back faster from injury or illness.
A new study describes how a novel nanomaterial can treat disorders of toxic levels of hydrogen sulfide that occur in Down syndrome and many other disorders.
In an editorial, JBC says they’ll allow generative AI use in manuscript preparation but not during the review process.
A team of scientists have identified an ‘orphan’ gene—a gene with no identifiable homologous sequences in other species or lineages—in the seahorse Hippocampus abdominalis.
Base editing technology invented at Rutgers, The State University of New Jersey, and exclusively licensed to Revvity, Inc. subsidiary Horizon Discovery, has been sub-licensed to biopharmaceutical company AstraZeneca to support its creation of cell therapies for the treatment of cancer and immune-mediated diseases.
Neurobiologists from Immanuel Kant Baltic Federal University found out differences of educability level and processes of formation of spatial memory of adult male and female rats, that live together in large cages and played with toys.
Researchers have created a resource for analyzing how viruses infect human cells. The fruit fly-based toolkit provides a shortcut for assessing SARS-CoV-2 genes and understanding how they interact with human proteins, offering researchers a resource for new COVID-related drug therapies.
Uncontrollable movements, memory loss, mood changes, and forgetfulness. That are some of the symptoms of neurodegenerative diseases in which cells in the central nervous system stop working or die.
The human body consists of numerous trillions of cells, and 60 percent of the energy used within a cell is dedicated to a specific molecular machine. That machine is responsible for producing proteins, which are fundamental building blocks of the body.
Researchers from the University of Liverpool have created a biomedical compound that has the potential to stop the spread of breast cancer. A recently published paper details these early findings.
ASBMB publishes a statement expressing concerns for NIH budget cuts outlined by a House Labor HHS funding bill that could lead to lost jobs and halted research progress
UT Southwestern Medical Center biologists have developed a new stem cell-based embryo model for studying early human development, tissue formation, and differentiation, offering valuable contributions to the field of developmental biology and regenerative medicine.
A new study, which involved experiments on mice and human patients, uncovered an important communication pathway between two molecules called CEACAM1 (CC1) and TIM-3, finding that the pathway plays a crucial role in controlling the body's immune response during liver transplantation.
As molecular biologists at Boston University and as husband and wife, Ruslan Afasizhev and Inna Afasizheva, have worked together for decades.
Membraneless organelles (MLOs), also known as “biomolecular condensates,” are formed by the biological process of liquid-liquid phase separation (LLPS).
Why do nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate gastrointestinal infections by Clostridioides difficile, the leading cause of antibiotic-associated diarrhea worldwide? In a new paper published in Science Advances, researchers at Children’s Hospital of Philadelphia (CHOP) have begun to answer that question, showing that NSAIDs disrupt the mitochondria of cells lining the colon, sensitizing them to damage by pathogenic toxins.
New research suggests that targeting autoimmune inflammation associated with amyotrophic lateral sclerosis (ALS) using two drugs, one of them already approved for multiple sclerosis, could be a promising approach for treatment.
A set of nine scientific papers was released today in the Nature family of journals and the journal Cell Reports describing breakthroughs in creating an open framework for scientists to map the individual cells of the human body in two and three dimensions.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Investigators from Cedars-Sinai have provided new understanding of how diabetes delays wound healing in the eye, identifying for the first time two related disease-associated changes to the cornea.
A study from Binghamton University, State University of New York researchers explores how ultraviolet radiation can alter the microstructure of human skin. Particularly affected is collagen, the fibrous protein that binds together tissue, tendon, cartilage and bone throughout our bodies.
Immune system changes in the pregnant body that protect the fetus appear to extend to the brain, where a decrease in immune cells late in gestation may factor into the onset of maternal behavior, new research in rats suggests.
People who contract COVID-19 but never develop symptoms – the so-called super dodgers – may have a genetic ace up their sleeve. They’re more than twice as likely as those who become symptomatic to carry a specific gene variation that helps them obliterate the virus, according to a new study led by UC San Francisco researchers.
Prof Sei-ichi Tsujimura of the Nagoya City University and Prof Su-Ling Yeh of National Taiwan University and Kagoshima University, have discovered that our visual acuity (contrast sensitivity) can be improved by using a light with a special spectrum that can selectively stimulate melanopsin cells in the retina.
Led by Dr. Jordi Casanova and Dr. Panagiotis Giannios, a team of researchers at IRB Barcelona and IBMB(CSIC) has revealed the relationship between autophagy and polyploidy, the latter a phenomenon in which cells contain multiple copies of genetic material. In this regard, they have discovered a scenario where the level of autophagy is much higher in cells with several copies of DNA and that it can even trigger this programmed cell death.
A new study in mice suggests that having a common form of the flu during pregnancy may affect the next generation by impairing immune function in the gut. The study is published ahead of print in the American Journal of Physiology-Gastrointestinal and Liver Physiology.
A team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS), led by Assistant Professor Anand Jeyasekharan, has discovered a unique combination of oncogenes that could predict treatment resistance, and hence unfavourable outcomes, of patients with Diffuse large B cell lymphoma (DLBCL), the most common type of blood cancer in Singapore and globally.
No, oxygen didn’t catalyze the swift blossoming of Earth’s first multicellular organisms. The result defies a 70-year-old assumption about what caused an explosion of oceanic fauna hundreds of millions of years ago.
As a human embryo grows, a set of molecules directs cells as they multiply and take on specific identities and spatial positions within the embryo. In one crucial step known as gastrulation, these signaling molecules guide a single layer of embryonic stem cells to form three layers of distinct cell types that will later become different parts of the body.
Researchers from SANKEN (The Institute of Scientific and Industrial Research) and the Graduate School of Frontier Biosciences at Osaka University reported the development of a sensor to look at Pcdh interactions in live neurons, which brings us closer to understanding this mystery.
Rakuten Medical, Inc. (Rakuten Medical), a global biotechnology company developing and commercializing precision, cell-targeting photoimmunotherapy-based on its proprietary Alluminox™ platform, today announced it will host a virtual R&D Day on the preliminary safety and efficacy findings from its open-label Phase 1b/2 study of Alluminox™ treatment using ASP-1929 in combination with anti-PD-1 therapy in recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC).
Researchers from Indiana University School of Medicine had a large presence and leadership role at the 2023 Alzheimer's Association International Conference in Amsterdam, Netherlands, with involvement in more than 150 presentations at the four-day meeting. The annual conference is the largest and most influential international meeting dedicated to advancing dementia science.
Research from Sanford Burnham Prebys and the Osaka International Cancer Institute has shed new light on the anti-cancer properties of mannose, a sugar that is crucial to many physiological processes in humans and is also known to inhibit the growth of cancer cells.
Researchers have cracked how a particular type of immune cell develops in the body and protects against infection and disease. And the discovery could help in the development of more preventive treatments, according to a new study.
Giving patients with operable pancreatic cancers a three-pronged combination immunotherapy treatment consisting of the pancreatic cancer vaccine GVAX, the immune checkpoint therapy nivolumab and urelemab, an anti-CD137 agonist antibody treatment, is safe, it increases the amount of cancer-killing immune system T cells in the tumors and it appears effective when given two weeks prior to cancer-removal surgery, according to new research directed by Johns Hopkins investigators.
The neurons in our bodies are dotted with tiny pores that let essential molecules pass in and out of our cells. Neurons need these channels to send the signals that allow us to move, think, and perceive the world around us. Now, structural biologists at Cold Spring Harbor Laboratory (CSHL) have captured never-before-seen images of one of the largest pores in human neurons.
If the human cell is a nightclub, then the nucleus is a VIP lounge fiercely maintained by the nuclear pore complex. By modeling a dynamic simulation of the NPC, Beckman physicists have theorized as to why some proteins enter the nucleus more readily than others.
While pembrolizumab is an approved treatment for patients with stage III non-small cell lung cancer (NSCLC), only some patients respond to this therapy. Treatment failure, researchers say, is often caused by differences in the tumor microenvironment.
A multidisciplinary team led by Dr. Ángel R. Nebreda, Dr. María J. Macías and Dr. Modesto Orozco, all at IRB Barcelona, has developed a new type of p38 inhibitor, which preferentially impairs one of the activation pathways of this protein. In particular, these inhibitors block the self-activation (or autophosphorylation) of p38 but allow it to continue to be activated by other mechanisms.