In a new article published in Nature Communications, Moffitt Cancer Center researchers show how the location of the tumor and spatial constraints put on it by the surrounding tissue architecture impact genetic heterogeneity of tumors.
Researchers in the Oregon State University College of Science have taken a key step toward new drugs and vaccines for combating COVID-19 with a deep dive into one protein's interactions with SARS-CoV-2 genetic material.
Overfishing likely did not cause the Atlantic cod, an iconic species, to evolve genetically and mature earlier, according to a study led by Rutgers University and the University of Oslo – the first of its kind – with major implications for ocean conservation.
A novel mechanism has been identified that might explain why a rare mutation is associated with familial Alzheimer’s disease in a new study by investigators at the University of Chicago.
In the first study to use whole genome sequencing (WGS) to discover rare genomic variants associated with Alzheimer's disease (AD), researchers have identified 13 such variants (or mutations).
For years, research to pin down the underlying cause of Alzheimer's Disease has been focused on plaque found to be building up in the brain in AD patients.
In support of a major collaborative project to store massive amounts of data in DNA molecules, a Los Alamos National Laboratory–led team has developed a key enabling technology that translates digital binary files into the four-letter genetic alphabet needed for molecular storage.
The findings published in eLife show that men with this unstable subtype of the Y chromosome have a significantly increased risk of genomic rearrangements.
AIEC bacteria grow in a biofilm that coats cells lining the intestinal wall, protecting them from both the immune system and antibiotics. In this research, the team identified a critical protein structure on the surface of the bacteria that allow them to grow in biofilms.
Wistar scientists identified a new mechanism of transcriptional control of cellular senescence that drives the release of inflammatory molecules that influence tumor development through altering the surrounding microenvironment.
International Project Set to Boost Precision Medicine, Reduce Health Disparities
High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke. But now, scientists at Washington University School of Medicine in St. Louis have identified a gene that likely plays a causal role in coronary artery disease independent of cholesterol levels. The gene also likely has roles in related cardiovascular diseases, including high blood pressure and diabetes.
A team of University of Colorado School of Medicine researchers recently published a paper offering new insight into the role that oxygen deprivation, or hypoxia, plays in cancer development. CU Cancer Center member Joaquin Espinosa, PhD, is the senior researcher on the paper, which he hopes will help lead to more targeted treatments for cancer.
A Northwestern University-led research team has developed a novel skin-mounted sticker that absorbs sweat and then changes color to provide an accurate, easy-to-read diagnosis of cystic fibrosis within minutes.
Armonk, N.Y. and Cleveland, OH, March 30, 2021: Cleveland Clinic and IBM have announced a planned 10-year partnership to establish the Discovery Accelerator, a joint Cleveland Clinic - IBM center with the mission of fundamentally advancing the pace of discovery in healthcare and life sciences through the use of high performance computing on the hybrid cloud, artificial intelligence (AI) and quantum computing technologies.
Researchers at the Johns Hopkins Kimmel Cancer Center used machine learning techniques to detect mutational signatures in cancer patients. Their algorithm outperformed the current standard of analysis and revealed new mutational signatures associated with obesity, which is believed by cancer prevention experts to be becoming the most significant lifestyle factor contributing to cancer in the U.S. and most of the Western world.
Working with fruit flies, scientists at Johns Hopkins Medicine say they have identified a new molecular pathway that helps steer moving cells in specific directions. The set of interconnected proteins and enzymes in the pathway act as steering and rudder components that drive cells toward an “intended” rather than random destination, they say.
A new study out of the University of Chicago and the University of Illinois Urbana-Champaign in humans, chimpanzees, rhesus macaques and baboons has found key differences in early gene expression in response to pathogen exposure, highlighting the importance of choosing the right animal model for the right questions.
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the pillow, but the child can be assured of a new tooth in a few months. The same cannot be said of adults who have lost their teeth.
Guillermina (Gigi) Lozano, Ph.D., chair of Genetics at The University of Texas MD Anderson Cancer Center, has been elected to the 2021 class of Fellows of the American Association for Cancer Research (AACR) Academy in recognition of her pioneering work to describe the p53 tumor suppressor pathway, which is undermined in many cancers.
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