Feature Channels: Pharmaceuticals

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Scientists at Sanford Burnham Prebys have discovered that combining immunotherapy with a drug called tumor necrosis factor (TNF) eradicated a deadly type of pediatric brain tumor in mice. The discovery, published in Nature Neuroscience, is expected to lead to a clinical trial to test the benefits of the treatment in patients. The findings also hold implications for other cancers that do not respond to immunotherapy.

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A possible new strategy for treating pancreatic cancer highlights the promise of collaboration between experts in both precision medicine and immunology. The findings from a team led by Agnieszka Witkiewicz, MD, and Erik Knudsen, PhD, at Roswell Park Comprehensive Cancer Center and published today in the journal Gut suggest a combination treatment approach that can make some breakthrough immunotherapy drugs effective for more patients with pancreatic cancer.

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New study reveals impact of COVID-19 pandemic on cancer clinical trials, published in Nature Reviews Drug Discovery

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Researchers at the Washington University School of Medicine in St. Louis are helming a global study of an estimated 30,000 health-care workers to establish whether the antimalaria drug chloroquine might prevent or reduce the severity of COVID-19 infections in such workers.

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Lowering testosterone may prevent the new coronavirus from entering lung cells and lessen COVID-19 severity, new Columbia University research suggests. A trial has now begun in three VA hospitals.

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Treatment with antivirals such as interferons may significantly improve virus clearance and reduce levels of inflammatory proteins in COVID-19 patients, according to a new study in Frontiers in Immunology.

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The NIH has launched a major clinical trial to assess the malaria drug hydroxychloroquine and antibiotic azithromycin as a treatment for COVID-19. The trial will recruit 2,000 participants at 30 sites. A Q&A with the trial’s team leader: Davey Smith, MD, of UC San Diego School of Medicine.

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Jubilance, containing Oxaloacetate (OAA), shown to improve PMS anxiety and gloominess by more than 50% in peer-reviewed clinical trial

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For the past 70 years, the best indicator of life expectancy for a patient with glioblastoma — the most common and the most aggressive brain cancer — has simply been age at diagnosis. Now, an international team of scientists has experimentally validated a predictor that is not only more accurate but also more clinically relevant: a pattern of co-occurring changes in DNA abundance levels, or copy numbers, at hundreds of thousands of sites across the whole tumor genome.

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A clinical trial led by Mount Sinai researchers has showed for the first time that combining chemotherapy and immunotherapy can slow down metastatic bladder cancer. The trial also showed that immunotherapy alone may be an option for a subset of patients with metastatic bladder cancer if their tumor expresses a high level of a protein called PD-L1 according to the study, published in The Lancet in May.

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Is personalized medicine cost-effective? Researchers have answered that question for one medical treatment, genotype-guided antiplatelet therapy for acute coronary syndrome patients with PCI. Their study uses pharmacogenomics and economic analysis of real-world clinical data.

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Research and experts on the symptoms and spread of COVID-19, impact on global trade and financial markets, public health response, search for an effective treatment, and more

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The AIDS Clinical Trials Group (ACTG) has initiated a clinical trial to evaluate whether the drug combination hydroxychloroquine and azithromycin can prevent hospitalization and death from COVID-19.

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Using supercomputers, scientists have developed for the first time a way to screen drugs through their chemical structures for induced arrhythmias.

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A small study in Greece found that the clinically approved anti-inflammatory drug anakinra, used to treat rheumatoid arthritis, improved respiratory function in patients with severe coronavirus disease 2019 (COVID-19).

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Researchers found that co-administering dephostatin and colistin in mice with a lethal Salmonella infection significantly prolonged animal survival and used a lower concentration of colistin than is normally required for treatment, thereby reducing its toxic effect.

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For the first time in over a decade, scientists have identified a first-line treatment that significantly improves survival for people with hepatocellular carcinoma, the most common type of liver cancer.

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Orange, Calif., May 13, 2020 — UCI Health will initiate a clinical study of a drug to treat critically ill COVID-19 patients who face a high mortality rate because of acute inflammation that fills their lungs with fluid, a grave condition that even mechanical ventilation cannot improve. Aviptadil, which has a 20-year history of use in human clinical trials for lung ailments, will be employed in a phase 2b/3 clinical study of COVID-19 patients suffering from acute respiratory distress syndrome, a primary cause of coronavirus-induced death, said Dr.

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To counter drug resistance Penn State engineers have developed a new approach for predicting which mutation has expanded the most in a population and should be targeted to design the most effective new drug.