Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore have identified a SCC-specific protein complex activated by TP63 and SOX2 which triggers a gene cascade that promotes SCC growth.
Mayo Clinic的研究人员已经确定了三种特定的基因类型，这些基因类型会使非洲裔美国人的骨髓瘤（myeloma）诊断增加两到三倍。 研究人员还展示了DNA分析在更准确地研究种族和种族混合上的效果。 该研究结果发表在《血癌学杂志》（Blood Cancer Journal）上。
Researchers have demonstrated an integrated technique for monitoring specific biomolecules – such as growth factors – that could indicate the health of living cell cultures produced for the burgeoning field of cell-based therapeutics.
Led by Andreas H. Gomoll, MD, sports medicine surgeon at Hospital for Special Surgery (HSS), the study is looking at the effects on knee function of ReNu, an allograft product composed of human amniotic membrane and cells from the amniotic fluid.
Tamara Strauss has been living with high-grade, stage IV pancreatic neuroendocrine cancer for more than three years. Current treatments, although effective for her, are highly toxic. Tamara enrolled in a first-of-its-kind, pilot study at Moores Cancer Center at UC San Diego Health to test a personalized vaccine using her unique cancer mutations to boost an anti-tumor immune response.
University of Colorado Cancer Center study shows that "normal" gene CDK1 interacts with "abnormal" gene Sox2 to keep cancer stem cells "stemmy."
Ronald Paquette, MD, clinical director of the Cedars-Sinai Blood & Marrow Transplant Program at the Samuel Oschin Comprehensive Cancer Institute, recently was accepted as a member of the Myeloproliferative Neoplasm Research Consortium. The group is funded by the National Cancer Institute.
Biologists at Johns Hopkins University grew human retinas from scratch to determine how cells that allow people to see in color are made.
RNA methylation might prove important in regulating many aspects of beta cell behavior, such as how the cells divide or how effectively they are stimulated by blood glucose to produce insulin
UT Southwestern researchers attempting to transform supporting brain cells into neurons instead reprogrammed mature inhibitory neurons into a different type of neuron that creates the neurotransmitter lost in Parkinson’s disease.
A computational model that can track how genes are expressed in each cell type within tissue may help scientists unravel how diseases, such as cancer, progress and how they evade treatment.
New research published in Nature Communications from scientists at Huntsman Cancer Institute (HCI) at the University of Utah (U of U), in collaboration with the Stanford University School of Medicine, shows a specific protein regulates both the initiation of cancer spreading and the self-renewal of cancer cells in medulloblastoma, a type of pediatric brain cancer.
Predictors of future diabetes and cardiovascular disease for a person with obesity can be found among their body's metabolites.
With the development of an adaptive, multi-view light sheet microscope and a suite of computational tools, researchers have captured the first view of early organ development inside the mouse embryo.
In one of the largest clinical studies to ever examine the impact of using a blood test to detect treatable mutations in non-small cell lung cancer (NSCLC), researchers from the Abramson Cancer Center of the University of Pennsylvania found that they could identify significantly more mutations through liquid biopsy instead of a solid tissue biopsy alone. The findings also show that patients whose actionable mutations were detected by the blood based liquid biopsy responded favorably to targeted therapies.
In a UCI-led study, researchers found evidence that mast cells, an important group of immune cells typically associated with allergies, actually enable the body to survive fasting or intense exercise. The study was published today in Cell Metabolism.
The study published in the Journal of Neuroscience suggests the thalamus controls the development of state dependency and continuity.
A UNC School of Medicine study shows that two cystic fibrosis (CF) drugs aimed at correcting the defected CFTR protein seem to be more effective when a patient’s airway is inflamed. This is the first study to evaluate the efficacy of these drugs under inflammatory conditions relevant to CF airways.
In studies of mouse cells, Johns Hopkins researchers have found that low levels of cellular copper appear to make fat cells fatter by altering how cells process their main metabolic fuels, such as fat and sugar.
An emerging treatment known as adoptive T-cell therapy has proven effective in a Phase II clinical trial for treating progressive multifocal leukoencephalopathy (PML), a rare and often fatal brain infection sometimes observed in patients with cancer and other diseases in which the immune system is compromised. The study, led by Katy Rezvani, M.D., Ph.D., professor, Department of Stem Cell Transplantation and Cellular Therapy at The University of Texas MD Anderson Cancer Center, showed marked improvement in three PML patients infused with donor T cells targeting the BK virus. Findings were published in the Oct. 11 online issue of the New England Journal of Medicine.
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