Curated News: Grant Funded News

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Gene therapy developed at St. Jude Children’s Research Hospital, University College London (UCL) and the Royal Free Hospital has transformed life for men with a severe form of hemophilia B by providing a safe, reliable source of the blood clotting protein Factor IX that has allowed some to adopt a more active lifestyle, researchers reported. The results appear in the November 20 edition of The New England Journal of Medicine.

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Case Western Reserve researchers have identified a protein mutation that alters specific gender-related tissue in males before birth and can contribute to cancer and other less life-threatening challenges. The findings appear in the November 21 edition of the Journal of Biological Chemistry.

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An international team reports on their cataloguing of the DNA regulatory regions throughout the mouse genome. Their results suggests why studies in mice cannot always be reproduced in humans. They also shed light on the function of DNA’s regulatory regions, which are often to blame for common chronic human diseases.

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What’s the best way to treat rectal cancer? Consult any of five top clinical guidelines for rectal cancer and you will get a different answer, according to a new study by researchers at the University of Michigan Comprehensive Cancer Center.

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A national effort to shave minutes off emergency heart attack treatment time has increased the chance that each patient will survive. But yet the survival rate for all patients put together hasn’t budged. It seems like a paradox. But the paradox vanishes with more detailed analysis of exactly who has been getting this treatment.

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The investigational drug Losartan, which worked better in an animal model, was equally effective to a high dose of the beta blocker, atenolol in treating Marfan syndrome, a rare genetic disease.

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As part of the four-year, $2.1 million National Science Foundation research project, data analytic teams from Georgia Tech and the University of Texas, Austin, will develop algorithms and methods to convert the electronic health records data into meaningful clinical concepts or phenotypes focused on diseases and specific health traits.

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NSU Researchers Will Study Effects Oil Spills Have on the Deep Ocean (more than 1 mile deep)

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A protein associated with poor survival in lung cancer patients will be further explored by investigators at Rutgers Cancer Institute of New Jersey to uncover its role in lung cancer development and metastasis. A recently-awarded $1.8 million grant from the National Institutes of Health to Cancer Institute of New Jersey researcher Sharon R. Pine, PhD, will support the work.

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A formal protocol for delivering emergency treatment to patients with subarachnoid hemorrhage (SAH) from ruptured aneurysms within the first few hours after bleeding occurs. Offered day and night, the protocol reduces the incidence of repeated hemorrhage during the hospital stay and improves clinical outcomes in patients with aneurysmal SAH.

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When a viral infection spread through five genetically identical mice in a row, the virus replicated faster and became more virulent or severe. But when the infection spread one-by-one through five genetically diverse mice, the virus had trouble adapting and became less virulent. The University of Utah study suggests that increased genetic diversity should be promoted in livestock and in captive-bred endangered species so as to limit their risk of getting deadly infections.

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Researchers at the University of Illinois at Chicago College of Medicine have found that a growth factor can regenerate damaged peripheral nerves without causing the growth of new blood vessels -- making it a unique candidate to treat nerve damage in areas of the body where the proliferation of blood vessels would be a drawback.

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A team of researchers from Johns Hopkins Medicine has discovered a receptor on blood vessels that causes the vessel to relax in response to light, making it potentially useful in treating vascular diseases. In addition, researchers discovered a previously unknown mechanism by which blood vessel function is regulated through light wavelength.

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Biologists long assumed that one-way air flow was a special adaptation in birds driven by the intense energy demands of flight. But now University of Utah scientists have shown that bird-like breathing also developed in green iguanas – reptiles not known for high-capacity aerobic fitness. The finding bolsters the case that unidirectional bird-like flow evolved long before the first birds.

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Newly formed B cells take the easy way out when it comes to exiting the bone marrow, according to researchers at Yale University School of Medicine.

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Members of the public in counties with higher median household incomes are more likely to step into action to perform cardiopulmonary resuscitation, or CPR, when they witness someone have a cardiac arrest, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania, which was presented today at the American Heart Association’s Resuscitation Science Symposium 2014.

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Dartmouth researchers have developed a fluorescence imaging technique that can more accurately identify receptors for targeted cancer therapies without a tissue biopsy.

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The activity of ion channel proteins that are important for cell-to-cell communication is markedly reduced during anesthesia, according to researchers from Weill Cornell Medical College.

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The Kresge Foundation has awarded Wayne State University a $100,000, one-year grant to support CitizenDetroit, a community outreach program of the Forum on Contemporary Issues in Society (FOCIS).

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New research in flies shows how cells in adult reproductive organs maintain their sexual identity. The study, published online on Nov. 13 in Developmental Cell, also identified a mutation that can switch the cells’ sexual identity. The findings could lead to new insights on how to alter cells for therapeutic purposes.