Since 2007, clinical trials using gene therapy have resulted in often-dramatic sight restoration for dozens of children and adults who were otherwise doomed to blindness. Now, researchers have found evidence that this sight restoration leads to strengthening of visual pathways in the brain.
Stem cells are key for the continual renewal of tissues in our bodies. As such, manipulating stem cells also holds much promise for biomedicine if their regenerative capacity can be harnessed. Researchers are making headway in this area by studying stem cells in their natural environment in fruitflies.
Overdoses of opioid pain medications frequently occur in people who aren't chronic users with high prescribed opioid doses—the groups targeted by current opioid prescribing guidelines, reports a study in the August issue of Medical Care. The journal is published by Wolters Kluwer.
They may look neat, but the dangers of sunburn tattoos far outweigh the coolness factor.
Studies using magnetic resonance imaging (MRI) techniques are beginning to reveal differences in brain connectivity—the ways that different parts of the brain are connected to each other and work together—in people with autism spectrum disorders (ASD), reports a review in the Harvard Review of Psychiatry. The journal is published by Wolters Kluwer.
Benzodiazepine drugs are widely used in patients with posttraumatic stress disorder (PTSD), but available evidence suggests that they are not effective—and may even be harmful, concludes a systematic review and meta-analysis in the July Journal of Psychiatric Practice. The journal is published by Wolters Kluwer.
More than 80 percent of people with depression in the general population aren't eligible for clinical trials of antidepressant drugs, according to a study in the Journal of Psychiatric Practice. The journal is published by Wolters Kluwer.
A new partnership between Philadelphia College of Osteopathic Medicine and the Residentialist Group will help high-risk elderly stay in their homes.
Patients over 50 with ulcerative colitis (UC), a chronic disease of the colon, who undergo surgery to treat their condition live longer than those who are treated with medications, according to a new study from the Perelman School of Medicine at the University of Pennsylvania. The results are published this week in Annals of Internal Medicine.
Trusted partners leverage Wistar Science.
A single molecule called DNA-PKcs may drive metastatic processes that turn cancer from a slowly growing relatively benign disease to a killer.
Children with inflammatory bowel disease (IBD) who are doing well on specific biological medications should not be switched to recently approved "biosimilar" products, concludes an expert consensus statement of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). The statement appears in the Journal of Pediatric Gastroenterology and Nutrition, the official journal of the European Society of Paediatric Gatroenterology, Hepatology and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, published by Wolters Kluwer.
For people who use cocaine, stopping or reducing cocaine use is associated with decreased levels of endothelin-1 (ET-1)—a protein that plays a key role in the development of coronary artery disease, reports a study in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine. The journal is published by Wolters Kluwer.
For children with cleft lip and palate, the chances of undergoing secondary surgery vary depending on the center where they're treated, reports a study in Plastic and Reconstructive Surgery—Global Open®, the official open-access medical journal of the American Society of Plastic Surgeons (ASPS).
SEJ members and non-members invited to apply for up to $5,000 grant to cover environmental coverage project; 2 awards annually, apply by July 15 and November 15
The Basser Center for BRCA at Penn’s Abramson Cancer Center has announced the recipient of its third annual Basser Global Prize. The honor will go to molecular cancer expert David Livingston, MD, Emil Frei Professor of Genetics and Medicine at Harvard Medical School, and deputy director of the Dana-Farber/Harvard Cancer Center.
Fixing up abandoned buildings in the inner city doesn’t just eliminate eyesores, it can also significantly reduce crime and violence, including gun assaults, researchers from the University of Pennsylvania and Penn’s Perelman School of Medicine report in the first study to demonstrate the direct impact of building remediation efforts on crime.
It’s important to know about the causes of unrecognized, or silent, heart attacks and how to prevent them.
Penn Nursing Research Findings Show Nurses are Key to Kaiser Permanente Hospital Success
Average out-of-pocket spending for oral contraceptive pills and the intrauterine device (IUD), the two most common forms of contraception for women, has decreased significantly since the Affordable Care Act (ACA) took effect.
Many people believe that phase I trials with healthy volunteers are very risky and because they pose risks with no benefits, unethical. But how risky are such trials? Less than 1% of 11,000 healthy volunteers who participated in 394 phase I trials for new drugs experienced serious complications, according to a new meta-analysis of participants in non-cancer, phase I medication trials. In addition, none of the volunteers died or suffered persistent disabilities linked to the experimental drugs.
The Association of American Cancer Institutes (AACI) Clinical Research Initiative (CRI) will convene its seventh annual meeting July 8-9 in Chicago. The meeting will focus on immunotherapies for cancer and their impact on cancer clinical trials.
The study reports on a newly discovered category of tRNA fragments as well as shows that all tRNAs are rich sources of very diverse short molecules whose characteristics depend on a person’s gender, population, and race and differ according to tissue and disease type.
Compilation of quotes from Pennsylvania medical associations on what 50 years of Medicare has meant to the delivery of care.
A review article published on the journal Oncotarget focusing on RB role in apoptosis provides a comprehensive overview on the role of RB proteins in the coordinated control of cell decisions.
In the first study of its kind, researchers have shown how an anti-diabetic drug can have variable effects depending on small natural differences in DNA sequence between individuals. They aim to apply this knowledge to develop personalized approaches to treating diabetes and other metabolic disorders.
While heart disease is the number one cause of death in both sexes, it poses special considerations in women—with risks often beginning in childhood and changing at different stages of life. Insights on cardiovascular disease (CVD) risk in women and girls throughout the life span are shared in a special symposium feature in the June issue of The American Journal of Medical Sciences (AJMS). The official journal of the Southern Society for Clinical Investigation (SSCI), AJMS is published by Wolters Kluwer.
Three-quarters of the population will get an itchy red rash if exposed to the urushiol oil inside poison ivy's leaves, stem and roots. One-quarter of people will not have any reaction to exposure.
Penn State Health and Catholic Health Initiatives (CHI) have completed the transfer of ownership of CHI’s affiliate, St. Joseph Regional Health Network (St. Joseph) in Reading, Pa., to Penn State Health.
Despite findings of previous studies and published guidelines, nearly two-thirds of patients with T4a larynx (”voice box”) cancer are not receiving a total laryngectomy (surgical removal of the larynx), the recommended form of treatment, and as a result, have significantly worse survival rates versus those treated with a total laryngectomy.
This unique summer reading list--voted on by the readers of JOM, the member journal of The Minerals, Metals & Materials Society--highlights books containing materials science and engineering themes.
Wolters Kluwer, a leading global provider of information and point-of-care solutions for the healthcare industry, is pleased to announce that 10 of its Lippincott Williams & Wilkins publications won 16 awards in the 27th annual APEX Awards for Publication Excellence Competition. Nursing made Incredibly Easy! won the Grand Award for Magazines, Journals & Tabloids.
Poor sleep is associated with negative mood in women with bipolar disorder, according to researchers at Penn State College of Medicine and University of Michigan Medical School.
Rather than cellular trash, half of a transfer RNA (tRNA) molecule appears to actively spur cell proliferation in breast and prostate cancers, suggesting a new role for tRNA and a possible target for a new class of therapy.
The enzyme PI3K appears to be exploited in almost every type of human cancer, making it the focus of considerable interest as a therapeutic target. However, PI3K inhibitors have only shown modest clinical activity. Now, new research The Wistar Institute shows that treatment with PI3K inhibitors alone may actually make a patient’s cancer even worse by promoting more aggressive tumor cell behavior and increasing the cancer’s potential of spreading to other organs.
Researchers studying the pediatric cancer neuroblastoma have detailed how cancer-driving mutations evolve during chemotherapy, and they hope to exploit this knowledge to design better treatments for children.
Two migraine surgery techniques targeting a specific "trigger site" are both highly effective in reducing the frequency and severity of migraine headaches, according to a randomized trial in the July issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
In recent years, a large majority of US plastic surgeons have adopted fat grafting techniques as part of their approach to facelift surgery, reports a study in the July issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
Pediatric researchers have discovered gene locations affecting bone strength in wrist bones, the most common site for fractures in children. Children with these genetic variants could especially benefit from activities and diets promoting bone strength.
For hikers, football players, endurance athletes, and a growing range of elite and recreational exercisers, the best approach to preventing potentially serious reductions in blood sodium level is to drink when thirsty, according to an updated consensus statement on exercise-associated hyponatremia (EAH). The recommendations appear in the June issue of the Clinical Journal of Sport Medicine, published by Wolters Kluwer.
Future therapies for failing hearts are likely to include stem-like cells and associated growth factors that regenerate heart muscle. Scientists have just taken an important step towards that future by identifying a stem-like “progenitor” cell that produces only heart muscle cells.
When it comes to breast cancer screening, the density of your breasts affects how well a mammogram can detect cancerous tissues.
Viruses like influenza have the ability to mutate over time, and given that the flu vaccines administered during the 2014-2015 season were largely ineffective at preventing the spread of the flu, it appears the virus that recently circulated had taken on mutations not accounted for when last year’s vaccine was developed. Now, researchers at The Wistar Institute identified specific mutations that influenza recently acquired to escape the current vaccine design.
New results in animals highlight a major safety concern regarding a class of magnetic resonance imaging (MRI) contrast agents used in millions of patients each year, according to a paper published online by the journal Investigative Radiology. The journal is published by Wolters Kluwer.
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