Newswise — In a breakthrough that could change the future of pacemakers, Technion-Israel Institute of Technology researchers have used mechanical stimulation to “train” cardiac cells to beat at a given rate.
The team’s findings, published this week in Nature Physics, also demonstrate for the first time that direct physical contact with the cardiac cells isn’t required to synchronize their beating. As long as the cardiac cells are in the tissue being mechanically stimulated, they are trained by the stimulation, with long-lasting effects that persist even after it is stopped.
“Cell-cell communication is essential for growth, development and function,” explains Assistant Professor Shelly Tzlil, of the Technion Faculty of Mechanical Engineering. “We have shown that cells are able to communicate with each other mechanically by responding to deformations created by their neighbors. The range of mechanical communication is greater than that of electrical and chemical interactions. Another significant discovery is that the duration of cell pacing is greater when the stimulus is mechanical, indicating that mechanical communication induces long-term alterations within the cell.”
The stimulation was applied by an artificial “mechanical cell,” consisting of a tiny probe (with a 0.0025 cm tip diameter) that generated (via cyclical indenting and pulling) periodic deformations in the underlying substrate (cardiac tissue). The deformations mimicked those generated by a beating cardiac cell that was also in the tissue. After a brief 10-minute training period, the cardiac cell synchronized its beating rate with the mechanical cell. Furthermore, the cardiac cell maintained the induced beating rate for more than one hour after mechanical stimulation was stopped.
“In this study, we show that an isolated cardiac cell can be trained to beat at a given frequency by mechanically stimulating the underlying substrate,” says Tzlil, who led the study. “Mechanical communication plays an important role in cardiac physiology, and is essential for converting electrical pacing into synchronized beating. Impaired mechanical communication will lead to arrhythmias even when electrical conduction is working properly. The medical implication is that adding mechanical elements to electrical pacemakers will significantly improve their efficiency.”
The Technion-Israel Institute of Technology is a major source of the innovation and brainpower that drives the Israeli economy, and a key to Israel’s renown as the world’s “Start-Up Nation.” Its three Nobel Prize winners exemplify academic excellence. Technion people, ideas and inventions make immeasurable contributions to the world including life-saving medicine, sustainable energy, computer science, water conservation and nanotechnology. The Joan and Irwin Jacobs Technion-Cornell Institute is a vital component of Cornell Tech, and a model for graduate applied science education that is expected to transform New York City’s economy.American Technion Society (ATS) donors provide critical support for the Technion—more than $2 billion since its inception in 1940. Based in New York City, the ATS and its network of supporters across the U.S. provide funds for scholarships, fellowships, faculty recruitment and chairs, research, buildings, laboratories, classrooms and dormitories, and more.
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