The antiviral therapies remdesivir, molnupiravir, and the active ingredient in Pfizer’s Paxlovid pill (nirmatrelvir), remain effective in laboratory tests against the BA.2 variant of SARS-CoV-2, the virus that causes COVID-19. The BA.2 variant also remains susceptible to at least some of the monoclonal antibodies used to treat COVID-19, such as Evusheld by AstraZeneca.
Adding the proteasome inhibitor bortezomib to chemotherapy significantly improved overall survival in children and young adults with newly diagnosed T-cell lymphoblastic lymphoma (T-LL), according to a Children’s Oncology Group (COG) study led by researchers at Children’s Hospital of Philadelphia (CHOP). This international phase 3 clinical trial also found that radiation could be eliminated in 90% of children with T-cell acute lymphoblastic leukemia (T-ALL) when the chemotherapy regimen was intensified.
Muslims’ gender values are not nearly as uniform as is often suggested. Islamic religiosity and time spent in Europe shape views on gender, but shape different gendered issues in varying ways, according to a study by Saskia Glas(verwijst naar een andere website) published today in the journal Social Forces(verwijst naar een andere website).
New research from the University of Notre Dame looks at so-called seamless garment Catholics (SGCs), or those Catholics who embrace the Church’s policy positions on both sides of the political spectrum.
Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and—when dysregulated by mutation—the emergence of blood cancers known as myeloproliferative neoplasms.
Mobile applications could provide "an uninterrupted tool for crisis response" for people experiencing suicidal thoughts and behaviors – although more research is needed to establish their effectiveness – concludes a review in the March/April issue of Harvard Review of Psychiatry. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Danish and Swedish researchers have dated the enormous Hiawatha impact crater, a 31 km-wide meteorite crater buried under a kilometer of Greenlandic ice.
Researchers have discovered a genetic variation associated with an often deadly esophageal disorder frequently found in German shepherd dogs. Researchers have developed a genetic test for the disease that German shepherd dog breeders can use to reduce the risk that puppies in future litters will develop the disease.
More than two decades of effort went into a project that has now revealed the structure of a crucial signaling molecule, opening the door to new and better drugs for some cancers.
Scientists from the Faculty of Engineering, Information and Systems at the University of Tsukuba devised a text message mediation robot that can help users control their anger when receiving upsetting news.
Endangered mountain gorillas increase the frequency they drink water as the temperature increases, suggesting a likely impact of climate change on their behavior, finds a new study published in Frontiers in Conservation Science.
Eating a balanced diet including protein from a greater variety of sources may help adults lower the risk of developing high blood pressure, according to new research published today in Hypertension, a peer-reviewed journal of the American Heart Association.
Irvine, Calif., March 10, 2022 – An analysis of Antarctica’s Pope, Smith and Kohler glaciers by researchers at the University of California, Irvine, NASA’s Jet Propulsion Laboratory, the University of Houston and other institutions has revealed an aggressive pattern of retreat connected to high melt rates of floating ice in the Amundsen Sea Embayment sector of West Antarctica.
A Cornell University physicist’s discovery could lead to the engineering of high-temp superconducting properties into materials useful for quantum computing, medical imaging.
A novel study published today in AACC’s Clinical Chemistry journal shows that a machine learning-based test detects emerging synthetic cannabinoids with greater ease than standard methods. By making it simpler to identify new synthetic cannabinoids, this innovative screening test could significantly improve the ability of health professionals and lawmakers to protect the public from these potentially dangerous designer drugs.
A Johns Hopkins Medicine study of about 50 people with Alzheimer’s disease has added to evidence that damage to the inner ear system that controls balance is a major factor in patients’ well-documented higher risk of falling.
The study, led by Moffitt Cancer Center, followed 515 patients with varying cancers. The goal was to evaluate if patients had an immune response to the Moderna mRNA-1273 vaccine and if that response differed by diagnosis and treatment.
Compared to US-born individuals, immigrants to the United States have increased financial worries – especially related to things like retirement and medical costs, reports a study in the March issue of the Journal of Psychiatric Practice. The journal is published in the Lippincott portfolio by Wolters Kluwer.
With the insertion of a little math, Sandia National Laboratories researchers have shown that neuromorphic computers, which synthetically replicate the brain’s logic, can solve more complex problems than those posed by artificial intelligence and may even earn a place in high-performance computing.
Wolters Kluwer, Health announced today that it will publish International Journal of Women’s Dermatology (IJWD) under its Lippincott open access portfolio as part of its new partnership with the Women’s Dermatologic Society (WDS).
To have a better chance of holding global warming to 1.5°C, we need to accelerate the phase-down of HFC refrigerants under the Montreal Protocol. This could also reduce pollution and improve energy access.
Climate change poses a potentially devastating economic threat to low-income cattle farmers in poor countries due to increasing heat stress on the animals. Globally, by the end of this century those producers may face financial loss between $15 and $40 billion annually.
A challenge in materials design is that in both natural and manmade materials, volume sometimes decreases, or increases, with increasing temperature. While there are mechanical explanations for this phenomenon for some specific materials, a general understanding of why this sometimes happens remains lacking.
Scoring of common genetic variants can help identify people at high risk for alcohol use disorder (AUD), according to a study in Alcoholism: Clinical and Experimental Research. With prompt intervention, it may then be possible to prevent these individuals from developing AUD. For decades, a family history of AUD − which reflects both genetic and environmental risk − has been used to assess AUD liability. However, information on family history is not always available, and not all patients with AUD would be expected to have a positive family history. Therefore, relying on family history as the primary predictor of risk misses many high-risk individuals. For complex disorders like AUD, the common genetic variants that contribute to genetic risk each have a small effect on their own. However, when evaluated together, these variants can be used to calculate polygenic risk scores (PRS) – the weighted sum of multiple risk genes across the whole genome. PRS have shown promise in evaluating ris
The University of Kentucky’s Sanders-Brown Center on Aging has been around for nearly half a century. In that time, they have built an international reputation for best-in-class research into a disease that kills more people every year than breast and prostate cancer combined – Alzheimer’s disease. There are several components to the ongoing research at Sanders-Brown, one is exploring ways to detect Alzheimer’s earlier in a person’s life.
Together with Ukrainian colleagues, IIASA researchers took a novel approach to further the understanding of the planetary burden and its dynamics caused by emissions from human activity.
Malignant Pleural Mesothelioma (MPM) is an aggressive cancer mostly related to asbestos exposure whose incidence is constantly rising, especially in low-income countries.
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CPS insertion. To our knowledge, the usefulness of a filter device insertion prior to …
Researchers at Lawrence Livermore National Laboratory and the University of California, San Francisco used machine learning models to identify cancer-related risks for poor outcomes from COVID-19, finding previously unreported links between a rare type of cancer—as well as two cancer treatment-related drugs—and an increased risk of hospitalization from COVID-19.
Radiation therapy is one of the cornerstones of cancer therapy. However, some types of tumor respond little or hardly at all to radiation. If it were possible to make tumor cells more sensitive, treatment would be more effective and gentler. Empa and ETH Zurich researchers have now succeeded in using metal oxide nanoparticles as "radiosensitizers" – and in producing them on an industrial scale.
Some patients with severe COVID-19 who are treated with extracorporeal membrane oxygenation (ECMO) may experience significant lung recovery and return to normal lives with “meaningful” long-term outcomes.
Excitons form when electrons leave their place in atoms and grab the “holes” they left behind for a brief, whirling dance. Now they’ve been stably trapped and measured, a big step in developing new technology.
Scientists at UC San Diego and Rutgers University have found intriguing new details about a previously missing critical factor in gene expression. An ancient protein called NDF found in all human tissues enhances gene activation and may be involved in diseases such as cancer.
World first research conducted by the University of South Australia has identified that the frequently used chemotherapy drug (5-FU or Fluorouracil) is 100 per cent more effective at targeting tumours (rather than surrounding tissues) when administered using an optimised liposomal formulation.
Michigan State University’s Thomas D. Sharkey published new research describing what they call a pilot light for photosynthesis. By understanding how plants stay primed to produce sugars in varying degrees of sunlight, Spartans are working toward a future when growers can raise more efficient crops used as food and biofuel.
A study led by researchers from The University of Texas MD Anderson Cancer Center showed a significant overall survival benefit with ribociclib plus endocrine therapy for postmenopausal patients with hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer. The results were published today in The New England Journal of Medicine and were first reported at the European Society for Medical Oncology (ESMO) Congress 2021.
• Compared with individuals on dialysis who were not vaccinated against COVID-19, those who had received 2 mRNA vaccine doses were 69% and 83% less likely to become infected or experience severe disease, respectively.
• There were no significant differences in vaccine effectiveness among age groups, mode of dialysis, or vaccine type.
New research, led by Dr Petra Holden from the African Climate and Development Initiative (ACDI) at the University of Cape Town (UCT), has shown how catchment restoration – through the management of alien tree infestation in the mountains of the southwestern Cape – could have lessened the impact of climate change on low river flows during the Cape Town “Day Zero” drought.
As Florida and other states become more urbanized, an increasing number of stormwater ponds are built. Florida already has 76,000 such ponds. The newer ones emit more carbon than they store, a new University of Florida study finds. Researchers hope this finding will inform policy makers and others about when, where and how to install stormwater ponds.
There is a scientific reason that humans feel better walking through the woods than strolling down a city street, according to a new publication from University of Oregon physicist Richard Taylor and an interdisciplinary team of collaborators.
As scientists around the world seek for solutions for Alzheimer’s disease, a new study reveals that two indigenous groups in the Bolivian Amazon have among the lowest rates of dementia in the world.
A new study of brain development in mice shortly after birth may provide insights into how early life events can affect wiring patterns in the brain that manifest as disease later in life – specifically such disorders as schizophrenia, epilepsy and autism.