Non metastasis protein 2 (NME2) is a potential target for leukemia-specific immunotherapy
PreprintsTobias Däbritz, Sabine Tschiedel, Michael Cross, Dietger Niederwieser
Tobias Däbritz, Sabine Tschiedel, Michael Cross, Dietger Niederwieser
Ajeet Kumar, Ravi Bhushan, Pawan K. Dubey, Vijai Tilak, Vineeta Gupta, Nilesh Kumar, S. V.S Raju, Akhtar Ali
Hamid Aria, Mahdieh Azizi, Shima Nazem, Maryam Bahmanyar, Ali Moravej, Mohammad Hosein Pourjafarian, Babak Pezeshki, Alireza Tavassoli, Mohammad Kazem Vakil, Yaser Mansoori
Cytovale®, a medical diagnostics company focused on providing rapid and insightful tools to improve early detection of fast-moving and immune-mediated diseases, will reveal its 510(k) pending Cytovale system and 10-minute IntelliSep® sepsis risk stratification test at the American Association for Clinical Chemistry (AACC) annual meeting, where new data featuring the test will also be shared. The instrument can be seen in the Cytovale booth, no. 5045, in the exhibit hall during Clinical Lab Expo hours. The IntelliSep test was recently named an AACC Disruptive Technology Award Semifinalist and is also being featured in the Disruptive Tech area of the exhibit hall during the meeting.
Fuad Gandhi Torizal, Tia Utami, Lau Qiau You, Kousuke Inamura, Masaki Nishikawa, Yasuyuki Sakai
Louise Cheng, Kellie Veen, Francesca Froldi, Qian Dong, Edel Alvarez-Ochoa, Phuong-Khanh Nguyen, Kieran F Harvey, John P D McMullen, Owen J. Marshall, Patricia R Jusuf
Ogechi Ogoke, Daniel Guiggey, Sarah Thompson, Alexander Chiang, Tram Hoang Anh Nguyen, Daniel Berke, Cortney Ott, Allison Kalinousky, Claire Shamul, Peter Chen, Shatoni Ross, Zhaowei Chen, Pooja Srivastava, Supriya D Mahajan,
Daniel W. Simmons, David R. Shuftan, Jingxuan Guo, Kasoorelope Oguntuyo, Ghiska Ramahdita, Mary K. Munsell, Brennan Kandalaft, Missy Pear, Nathaniel Huebsch
Abstract: To develop into the central nervous system, neuroepithelial cells must first form a neural tube consisting of a series of patterned neural progenitor cells along the anterior-posterior (AP) axis. Based on studies using model organisms, it has been revealed that AP spatial regionalization is dominated by gradients of morphogens that regulate retinoic acid (RA), sonic hedgehog (SHH), bone morphogenetic proteins (BMPs), and Wingless/int1 (WNT) signaling pathways.
Genome sequencing, where scientists use laboratory methods to determine a specific organism’s genetic makeup, is becoming a common practice in insect research.
Abstract: A growing number of studies showed that single nucleotide polymorphisms (SNPs) in the human leukocyte antigen (HLA)-related genes were associated with the outcome of hematopoietic stem cell transplantation (HSCT).
Background Senescent adipose-derived stem cells (ASCs) exhibit reduced therapeutic efficacy during wound healing. Transcriptional regulation factors including long non-coding RNAs (lncRNAs) reportedly play essential roles in stem cell aging. However, the mechanisms by which lncRNAs influence mesenchymal stem cell aging have not been investigated.
Jiacong Hong, Shan Wang, Zhaopeng Cai, Peng Wang, Zhongyu Xie, Keng Chen
Giorgia Fedele, Alessandra Cazzaniga, Sara Castiglioni, Laura Locatelli, Antonella Tosoni, Manuela Nebuloni, Jeanette A.M. Maier
Lara Al Zouabi, Marine Stefanutti, Nick Riddiford, Natalia Rubanova, Mylene Bohec, Nicolas Servant, Allison J Bardin
Researchers have successfully tested a device that may one day use the chemical biomarkers in sweat to detect changes in a person’s health.
IUPUI researchers are developing a "biosensing platform" for COVID-19 that's fast, efficient, accurate and highly sensitive, which could help scientists stay on top of shifting virus variants.
A research team led by the Technical University of Munich (TUM) has succeeded for the first time in producing a molecular electric motor using the DNA origami method.
Ryota Mori, Norikatsu Miyoshi, Shiki Fujino, Tsunekazu Mizushima, Ryohei Yukimoto, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi
Fatemeh Eskandari, Samira Zolfaghari, Ayna Yazdanpanah, Rima Manafi Shabestari, Motahareh Rajabi Fomeshi, Peiman B. Milan, Jafar Kiani, Mina Soufi Zomorrod, Majid Safa
Messe Düsseldorf will participate in the AACC Clinical Lab Expo 2022 in order to promote its “MEDICAlliance” program of regional and international medical trade fairs organized around the globe.
The planning for the world’s leading medical trade fair MEDICA 2022 as well as for COMPAMED 2022, the No. 1 trade fair for suppliers of the medical technology industry, has entered the next stage. The current number of exhibitor registrations indicates that participation will surpass last year’s results (MEDICA 2021: 3,033; COMPAMED 2021: 490). Exhibitors can still register online for all segments at www.medica.de/2330 and www.compamed.de/2330 MEDICA and COMPAMED will take place concurrently from November 14 – 17, 2022 at the fairgrounds in Düsseldorf, Germany.
Robyn M Jong, Krystal Ching, Nicholas E Garelis, Alex Zilinskas, Xammy Nguyenla, Sagar Rawal, Bianca Hill, Bridget Luckie, Lillian Shallow, Jeffery S Cox, Gregory Barton, Sarah Stanley
Anja Hess, Stefan D. Gentile, Amel Ben Saad, Raza-Ur Rahman, Tim Habboub, Alan C. Mullen
So Hee Nam, Yan Lee, Hee-Jin Yang, Sung Bae Park
A University of Minnesota Twin Cities team has developed a new tool to predict and customize the rate of DNA editing, paving the way for more personalized, efficient genetic and cell therapies for diseases such as diabetes and cancer.
In ACS Nano, researchers report a nanomembrane system that harvests and purifies tiny blobs called exosomes from tears, allowing researchers to quickly analyze them for disease biomarkers. Dubbed iTEARS, the platform could enable more efficient and less invasive diagnoses for many diseases.
Neurodegenerative diseases like Alzheimer’s disease or Parkinson’s disease are caused by folding errors (misfolding) in proteins or peptides, i.e. by changes in their spatial structure. This is the result of minute deviations in the chemical composition of the biomolecules. Researchers at the Karlsruhe Institute of Technology (KIT) have developed a simple and effective method for detecting such misfolding at an early stage of the disease. Misfolding is revealed by the structure of dried residue from protein and peptide solutions.
Eliksa Therapeutics, a regenerative medicine company developing novel therapeutics for a range of debilitating diseases, announced today it has launched with investments from the University of Utah (U) and Militia Hill Ventures (MHV) to develop and commercialize multiple clinical programs using the regenerative medicine technology developed at the U.
Yihong Li, Ting Cai, Huina Liu, Yun Lei, Shun Zhang, Fuyu Sun, Jie Liu, Shao-Yu Chen, Huadong Fan
Amatullah Mir, Isaree Pitaktong, Jason Yusheng He, Katherine Nurminsky, Tyler Dunn, Sarah Koljaka, Olivia Dunn, Stephanie Ran, Daniel Rodgers, Anya Wang, Hiroshi Matsushita, Narutoshi Hibino, Wesley Shih
Siqin Bao, Baojiang Wu, Zhiqing Yang, Yijie Liu, Jianwen Li, Chen Chen, Xihe Li
Ophelie Renoult, Catherine Gratas, Noemie Joalland, Melanie Laurent--Blond, Hala Awada, Marine Bourgeois, Lisa Oliver, Sophie Chiavassa, Mikael Croyal, Francois Paris, Claire Pecqueur
Hailin Zou, Juan Luo, Yibo Guo, Peng Li
Kolby Jardine, Rebecca Dewhirst, Suman Som, Joseph Lei, Eliana Tucker, Robert Young P, Miguel Portillo-Estrada, Yu Gao, Luping Su, Silvano Fares, Cristina Castanha, Jenny Mortimer
Amanda Menzele, Hamida Aboalgasm, Robea Ballo, Asfree Gwanyanya
Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu
Wenxuan Wang, Chun Fan, Xinbo Yu, Xu Qiu, Yingzhe Hu, Shuhan Li, Xiangru Gao, Qiuxia Ji
Philipp Gmach, Marc Bathe-Peters, Narasimha Telugu, Martin J Lohse, Paolo Annibale
Tarik Hadid, Ayad Al-Katib, Jose Binongo, Gina M. Berteotti, Salman Fazal, James M. Rossetti, John Lister
Peng Ding, Chuan Gao, Youshui Gao, Delin Liu, Hao Li, Jun Xu, Xiaoyi Chen, Yigang Huang, Changqing Zhang, Ming Hao Zheng, Junjie Gao
Andrew D Duckworth, Cath Eberlein, Victoria Pollard, Richard Bethell, Joseph R Slupsky, Oliver Schon, John F Woolley, Tiffany Thorn
Ao Fang, Yifan Wang, Naiyu Guan, Lingmin Lin, Binjie Guo, Wanxiong Cai, Xiangfeng Chen, Jingjia Ye, Zeinab Abdelrahman, Shuang Jin, Bin Yu, Xiaosong Gu, Xuhua Wang
Brijesh Kumar, Katie Batic, Poornima Bhat-Nakshatri, Maggie M Granatir, Rebekah Joann Addison, Megan Szymanski, Lee Ann Baldridge, Constance J Temm, George Sandusky, Sandra K Althouse, Anna Maria Storniolo, Harikrishna Nakshatri
Guomin Li, Xu Han, Ye Wu, Wei Wang, Hong-Xia Tang, Mei-Ping Lu, Xue-Mei Tang, Yi Lin, Fan Deng, Jun Yang, Xin-Ning Wang, Cong-Cong Liu, Wen-Jie Zheng, Bing-Bing Wu, Fang Zhou
Tomoaki Iwayama, Mizuho Iwashita, Kazuya Miyashita, Hiromi Sakashita, Shuji Matsumoto, Kiwako Tomita, Phan Bhongsatiern, Tomomi Kitayama, Kentaro Ikegami, Takashi Shimbo, Katsuto Tamai, Masanori A Murayama, Shuhei Ogawa, Yoichiro Iwa
Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Kohei Fujikura, Helen Fedor, Bonnie Gambichler, Atul Deshpande, Pei-Hsun Wu, Dimitrios N Sidiropoulos, Rossin Erbe, Jacob Stern, Rena Chan, Stephen Williams, James M. Chell,
Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu
Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu
Abstract: Background: Clinical and research based genetic testing has uncovered genes that encode chromatin modifying complex components required for organogenesis. Covalent histone modifications play a key role in establishing transcriptional plasticity during development, required for cell fate specification, and have been implicated as a developmental mechanism that accounts for autism spectrum disorder (ASD) and CHD co-occurrence. ASXL3 has been identified as a high confidence ASD gene. ASXL3 is a component of the Polycomb Repressive Deubiquitination (PR-DUB) complex, which deubiquitinates histone H2A. However, the role of ASXL3 in cardiac development remains unknown.