The same complex genetics that contribute to a higher risk of type 2 diabetes may also increase the risk of developing diabetes during pregnancy among women of South Asian descent, a study published today in eLife shows.
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UC San Diego Alpha Stem Cell Clinic awarded $8M to expand clinical trials of novel stem cell therapies. The CIRM award will advance partnerships between academic and industry experts in San Diego to expedite clinical trials for patients with difficult-to-treat diseases.
Scientists looking to understand the fundamental brain mechanisms of autism spectrum disorder have found that a gene mutation known to be associated with the disorder causes an overstimulation of brain cells far greater than that seen in neuronal cells without the mutation. The Rutgers-led study, spanning seven years, employed some of the most advanced approaches available in the scientific toolbox, including growing human brain cells from stem cells and transplanting them into mouse brains.
A RUDN biologist for the first time described the genetic and other features of more than 50 strains of a bacterium that infects many crops around the world. The results will be important for plant breeding for resistance to phytopathogens
Researchers at UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) have grown ‘mini eyes', which make it possible to study and better understand the development of blindness in a rare genetic disease called Usher syndrome for the first time.
Rutgers scientists have developed a new approach to stopping viral infections: a so-called live-attenuated, replication-defective DNA virus vaccine that uses a compound known as centanamycin to generate an altered virus for vaccine development.
A team of researchers mapping a molecular atlas for ductal carcinoma in situ (DCIS) has made a major advance toward distinguishing whether the early pre-cancers in the breast will develop into invasive cancers or remain stable.
More than 20 UT Southwestern Medical Center scientists are among the 2022 Highly Cited Researchers listed in the top 1% of researchers from across the globe
UC San Diego researchers expand and deepen understanding of how genetic aberrations fuel human papilloma virus-negative head and neck cancers and, potentially, provide paths to further refinement and improvement of immune checkpoint inhibitors for HPV-negative head and neck cancers.
Many estimates of how strongly traits and diseases share genetic signals may be inflated, and therefore some genetic correlations that have been attributed to shared biology may instead represent incorrect statistical assumptions.
The goal of the project is to create a membrane-based downstream purification platform for large-scale continuous biomanufacturing of viral vectors and virus-like particles (VLPs).
It is difficult to assess brain health status and risk of cognitive impairment, particularly at the initial evaluation. To address this, researchers have developed the Brain Health Platform to quantify brain health and identify Alzheimer’s disease and related disorders.
The hypothalamus, one of the most complex brain regions in the mammalian nervous system, contains an astonishing heterogeneity of neurons that regulate endocrine, autonomic and behavioral functions.
TEAMSPORT will create a standardized approach to ordering genomic tests and adapt it for use in community cancer centers, where most cancer patients receive testing and treatment.
A teaspoon of soil contains billions of viruses and other microorganisms. In this study, scientists examined viruses in soil from Kansas prairies to sequence genetic material, identify viruses’ proteins, and look at how viruses’ activity varied under different environmental conditions. They found that some viruses were more abundant in wet soils, while others were more active.
Scientists at the University of Cologne have discovered how cells can eliminate mutated mitochondrial DNA (mtDNA). Mitochondria are the powerhouses of our cells.
Enzymes, which are crucial to controlling how cells replicate in the human body, could be the very ingredient that encourages DNA to spontaneously mutate – causing potentially permanent genetic errors, according to new research from the University of Surrey.
Cambridge scientists have used synthetic biology to create artificial enzymes programmed to target the genetic code of SARS-CoV-2 and destroy the virus, an approach that could be used to develop a new generation of antiviral drugs.
A gene recognized as the strongest risk factor for Alzheimer’s disease (AD) alters the way cholesterol moves around the brain and as we age, this altered movement likely contributes to loss of learning and memory, a team of researchers from the Icahn School of Medicine at Mount Sinai and the Massachusetts Institute of Technology (MIT) reports.
An international study led by the medical Faculty of the University of Bonn has identified a gene that plays an important role in the development of the human embryo.
Adopting some of the strategies behind successfully treating the childhood disease spinal muscular atrophy may enable development of therapies to curb the muscle decline that accompanies aging, new research suggests.
Researchers at the University of Michigan Rogel Cancer Center have identified a novel treatment approach to an aggressive type of pediatric brain cancer, using therapies already approved to treat cancer. The team developed a mouse model of pediatric glioma with a histone mutation called H3.3-G34, which allowed them to study the tumor’s biology in the presence of a functional immune system, revealing a promising outlook for long-term survival.
RareCyte Inc., ("RareCyte" or "The Company") a leading provider of Precision Biology products and services has been selected by Wellcome Leap to participate in the $50M In Utero program to create the scalable capacity to measure, model and predict gestational development, to achieve the goal of reducing global stillbirth rates by half.
Bringing together concepts from electrical engineering and bioengineering tools, Technion and MIT scientists collaborated to produce cells engineered to compute sophisticated functions – “biocomputers” of sorts.
A new paper published in Nature Communications presents research on unique peptides with anti-cancer potential.
New research findings in mouse models of one genetic risk for autism support the idea that loss of a specific gene interferes with cells in the brain whose role is to inhibit signaling.
UMSOM Researchers Report on New Findings from Heart Monitoring Systems at American Heart Association Meeting
One of every 10 patients with appendiceal cancer carries a germline genetic variant associated with cancer predisposition, according to a study in JAMA Oncology that is the first to show inherited risk factors for this rare cancer.
Our sensory urges ranging from anger to hunger are regulated by hormonal or neuronal signals. Often, these impulses appear as behavioral responses, evoked through complex biological reactions.
Eyal Gottlieb, Ph.D., has been named MD Anderson's vice president for Research. Gottlieb, an accomplished scientist and leader, will join the institution in January to uphold and expand the institution’s research excellence.
Researchers at the University of Pennsylvania’s Basser Center for BRCA at the Abramson Cancer Center have discovered factors that may make breast and ovarian cancers associated with BRCA1/2 gene mutations more likely to recur.
For the first time, scientists have used CRISPR technology to insert genes that allow immune cells to focus their attack on cancer cells, potentially leaving normal cells unharmed and increasing the effectiveness of immunotherapy.
Un nuevo estudio que se presenta en la Reunión Científica Anual del ACAAI de este año muestra que un tratamiento que usa una tecnología de edición genética de repeticiones palindrómicas cortas, agrupadas y regularmente interespaciadas logró aliviar la inflamación y reducir la frecuencia de los ataques.
For the first time, researchers have assembled a high-quality reference genome for the Nile rat, a promising model organism for diabetes research.
Tufts neuroscientist Michele Jacob studies the CTNNB1 gene, which is crucial for cell development, but a mutation in the gene can result in a developmental disorder with no cure
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microRNAs are thought to suppress protein expression in dividing cells, such as tumor cells. But new research in ACS Central Science shows that some of these molecules can elevate the expression of a particular gene in dividing human cells and in cancer cells, challenging conventional wisdom.
While the physical differences between humans and non-human primates are quite distinct, a new study reveals their brains may be remarkably similar. And yet, the smallest changes may make big differences in developmental and psychiatric disorders.
A normal process called cell competition, in which healthy tissues eliminate unhealthy cells, could be responsible for cancer relapses in patients months or years after they were declared cancer-free
Researchers have discovered the vital role of a hormone, that develops in men during puberty, in providing an early prediction of whether they could develop certain diseases in later life.
مدينة روتشستر، ولاية مينيسوتا — في دراسة جديدة من دراسات الروابط على نطاق الجينوم الخاصة بأمراض الشريان التاجي للمقيمين في قطر، لقد ألقى الباحثون الضوء على البنية الجينية للمرض في مجموعة سكانية محددة.
Desde la enfermedad de Alzheimer y el asma hasta la diabetes y los medicamentos para quimioterapia, los investigadores de Mayo Clinic están utilizando el banco biológico Sangre Por Salud Biobank en Arizona, el cual es una fuente abundante de especímenes biológicos que amplía la diversidad en la investigación médica.
Some cancer cells can deploy parallel mechanisms to evade the immune system’s defences as well as resist immunotherapy treatment, according to a new study from the Garvan Institute of Medical Research.
Scientists have discovered the cause of a rare condition within a part of the genome that has been largely unexplored in medical genetics.
A genetic test known as chromosomal microarray analysis (CMA) could help identify the cause of sudden infant death syndrome (SIDS) or its counterpart in older children, known as sudden unexplained death in childhood (SUDC), finds a study led by Boston Children’s Hospital.
The Mark and Kathie Miller Pediatric Genomics Fund will contribute $3.6 million over the next five years to support a pair of pediatric genetic research programs at the Center for Genomic Medicine (CGM) at University of Utah Health.
Tailoring the analysis of whole genome sequencing to individual patients could double the diagnostic rates of rare diseases, finds a new study led by UCL researchers.
Scientists in the U.S. and UK illuminated the molecular events underlying an inherited movement and neurodegenerative disorder known as ARSACS – Autosomal recessive spastic ataxia of Charlevoix-Saguenay, named for two Quebec valleys where the first cases were found.
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts.
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