Curated News: Grant Funded News

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Maintaining a healthy weight during the golden years is a priority for many older adults. While previous research has shown that cutting calories can lower disease risk factors, it's unclear whether it can have a long-term positive impact on disease and disability. With a $2.1 million grant from the National Institutes of Health, researchers at Wake Forest University School of Medicine will evaluate the potential benefits of diet interventions such as time-restricted eating and caloric restriction.

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LA JOLLA, CA — Researchers at La Jolla Institute for Immunology (LJI) have at last uncovered how an enzyme called O-GlcNAc transferase (OGT) keeps cells healthy. Their findings, published in the Proceedings of the National Academies of Sciences, reveals a key aspect of cellular biology and may lead to important medical advances.

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The college is proud to announce a historic $50 million gift from the John and Marcia Price Family Foundation that will benefit future students, educational programs, research centers and entrepreneurism, as well as the construction of a new $190 million computing and engineering building on the U campus. The college will be renamed the University of Utah John and Marcia Price College of Engineering pending review and approval by the university’s Board of Trustees at its meeting on Feb. 14.

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The opportunistic bacterium Acinetobacter baumannii rarely sickens healthy people but causes serious infections in hospitalized patients. A study, in mice, from Washington University School of Medicine in St. Louis suggests that Acinetobacter can hide undetected in bladder cells and then reactivate when stimulated by medical intervention. The findings suggest that patients may bring Acinetobacter into hospitals and that screening patients could supplement current infection-control efforts.

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Twenty-seven Penn Medicine employees and medical students recently received Penn Medicine CAREs grants for projects designed to improve wellbeing, health equity, and inclusion in the region’s most diverse and underserved populations. In addition, HopePHL was selected as the Penn Medicine CAREs Community Champion for 2022.

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A team of University of Delaware researchers will use a $2 million National Institutes of Health (NIH) grant to create microrobots smaller than a human cell and work with “active matter,” exploring how to embed the rudimentary intelligence of single-cell organisms into these robotic creations.

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The article shares lessons from SUNY Geneseo’s Marine Biology course and presents a model for bringing deep-sea research into undergraduate classrooms. Access to the deep oceans is limited to a select number of researchers, in large part due to the costs of ship time.

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Researchers at Washington University School of Medicine in St. Louis have discovered that vaccinating mice against a toxin produced by the bacterium E. coli can prevent intestinal damage, a finding that suggests new ways to prevent malnutrition and stunting in children.

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Researchers at Wake Forest University School of Medicine are reporting the results of a new study that shows food-insecure families have higher health care expenditures than families that are food secure.

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Findings from a UC Davis Comprehensive Cancer Center study prompt researchers to question current cervical cancer screening guidelines for older women.

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The study will concentrate on azalea compounds, a class of fungicides widely used in agriculture and to treat human infections.

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Using a new method based upon comparing DNA mutation rates between parents and offspring, evolutionary biologists at Indiana University have for the first time revealed the average age of mothers versus fathers over the past 250,000 years, including the discovery that the age gap is shrinking, with women's average age at conception increasing from 23.2 years to 26.4 years, on average, in the past 5,000 years.

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New experiments that show that eukaryotic cells can robustly control average fluctuations in organelle size. By demonstrating that organelle sizes obey a universal scaling relationship that the scientists predict theoretically, their new framework suggests that organelles grow in random bursts from a limiting pool of building blocks.

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Columbia Engineering has won a $35 million five-year grant to establish the Center for Ubiquitous Connectivity (CUbiC) and advance energy-efficient communications technologies for addressing the vastly growing connectivity bottlenecks between data-hungry wireless devices and deluged data centers. Over the next five years, CUbiC will strive to flatten the computation-communication gap, delivering seamless Edge-to-Cloud connectivity with transformational reductions in the global system energy consumption.

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The NSF grant will fund a three-year project to create a comprehensive database for dust storms and dust events.

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Wayne State's Dr. Jamesdaniel received a $1.7 million NIH grant to study cisplatin, a drug that is prescribed to 10 to 20% of cancer patients that causes hearing loss in up to 80% treated with the drug.

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Researchers report a warming climate could increase the number and intensity of tropical cyclones in the North Atlantic, potentially creating more and stronger hurricanes. Researchers also examine a possible explanation for the relatively constant number of tropical cyclones around the globe every year.

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Using the latest technologies—including both single-nuclear sequencing of mice and human liver tissue and advanced 3D glass imaging of mice to characterize key scar-producing liver cells—researchers have uncovered novel candidate drug targets for non-alcoholic fatty liver disease (NAFLD). The research was led by investigators at the Icahn School of Medicine at Mount Sinai. Utilizing these innovative methods, the investigators discovered a network of cell-to-cell communication driving scarring as liver disease advances. The findings, published online on January 4 in Science Translational Medicine, could lead to new treatments.

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Orangutans, mice, and horses are covered with it, but humans aren’t. Why we have significantly less body hair than most other mammals has long remained a mystery. But a first-of-its-kind comparison of genetic codes from 62 animals is beginning to tell the story of how people—and other mammals—lost their locks.

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A three-dose regimen of a whole-parasite vaccine against malaria – called Plasmodium falciparum sporozoite (PfSPZ) vaccine – demonstrated safety and efficacy when tested in adults living in Burkina Faso, West Africa, which has endemic malaria.

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A collaborative team of academia, industry, start-ups, and non-profits, led by Jenna Gorlewicz, Ph.D., associate professor in aerospace and mechanical engineering and associate dean of research and innovation in the School of Science and Engineering at Saint Louis University, was awarded a National Science Foundation (NSF) grant to develop technology to enhance the quality of life, employment access, and opportunities for persons with disabilities.

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Penn Medicine has received a $9.7 million grant from The Warren Alpert Foundation (WAF) that will fund continuing education efforts for genetic counselors, to ensure opportunities for continued training that will keep them on the leading edge of their profession interpreting genomic data and explaining its implications to patients.

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UTEP received a $5 million grant from NSF to provide financial support and professional development experiences to talented students in the field of computer science. The initiative will provide partial scholarships to 26 students at UTEP and to 15 students who start their college education at EPCC.

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In a new study from the Johns Hopkins Kimmel Cancer Center, researchers described a novel mechanism of tumor formation in kidney cancers.

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The foundation is investing $1.1 million in studies that hold the potential to set new standards in the prevention and treatment of age-related macular degeneration

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Hackensack Meridian Health Foundation Awarded $250,000 Grant from TD Bank to Support NJ InCK Program and Support Children’s Health

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Looking for answers about how the brain works amid age-related hearing loss, Johns Hopkins Medicine researchers say they found that old mice were less capable than young mice of “turning off” certain actively firing brain cells in the midst of ambient noise.

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For the first time, researchers at UC San Diego have shown that changes in gene expression happen almost entirely during the transcription stage while the cells are growing. The researchers have provided a simple quantitative formula linking regulatory control to mRNA and protein levels.

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After an intrepid, decade-long search, Johns Hopkins Medicine scientists say they have found a new role for a pair of enzymes that regulate genome function and, when missing or mutated, are linked to diseases such as brain tumors, blood cancers and Kleefstra syndrome — a rare genetic, neurocognitive disorder.

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Research to Prevent Blindness announces a new round of awardees who are generating critical knowledge around a host of sight-threatening conditions. With this latest round of funding, RPB has provided more than $400 million in research funding.

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In the Phase I/II CodeBreaK 100 trial, the KRAS G12C inhibitor sotorasib achieved meaningful anticancer activity with an acceptable safety profile in heavily pretreated patients with KRAS G12C-mutated metastatic pancreatic cancer, according to researchers at The University of Texas MD Anderson Cancer Center.

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Researchers at the Georgia Institute of Technology have developed a new graphene-based nanoelectronics platform that could be the key to finding a successor to silicon. The team may have also discovered a new quasiparticle. Their discovery could lead to manufacturing smaller, faster, more efficient, and more sustainable computer chips, and has potential implications for quantum and high-performance computing.

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Using machine learning and clinical data from electronic health records, researchers at the Icahn School of Medicine at Mount Sinai in New York constructed an in silico, or computer-derived, marker for coronary artery disease (CAD) to better measure clinically important characterizations of the disease.

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Diabetes is a leading cause of death in the United States. In 2020, Healthy Paso Del Norte reported that in El Paso, where nearly 82% of the population is Hispanic or Latino, 16.9% were diagnosed with diabetes. According to the U.S. Department of Health and Human Services Office of Minority Health, Hispanics were 1.3 times more likely than non-Hispanic whites to die from diabetes in 2018, and Hispanic adults are 70 percent more likely than non-Hispanic white adults to be diagnosed with diabetes.

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Tom Draper helped shaped the lives of virtually every resident on the Delmarva Peninsula as the owner of WBOC-TV and other broadcast stations until his sudden death in 2017. Now his legacy will continue to shape the lives of Salisbury University students through the new Thomas H. Draper Scholarship.

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NIBIB-funded researchers are developing a new method to treat pancreatic cancer. In their study, they combined an injectable radioactive gel with systemic chemotherapy in multiple mouse models of the disease. The treatment resulted in tumor regression in all evaluated models, an unprecedented result for this genetically diverse and aggressive type of cancer.

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Artificial intelligence could help doctors dynamically determine safe and effective medication dosing for unstable ICU patients. Predicting the right dose of medication that a critically ill child in the ICU will require in the future is a huge challenge for clinicians. FDA prescribing guidelines generally assume that patients are stable enough so that dosing for a given group is usually unchanged during treatment, but this ‘one size fits all’ approach to medication dosing does not accurately target the condition of each individual patient over time.

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A Sudan ebolavirus vaccine and antibody therapeutic tested at Texas Biomedical Research Institute have been sent to Uganda as part of efforts to control the outbreak there.

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Led by researchers from the University of California at Irvine, a new study reveals that a long-lived Chilean rodent, called Octodon degus (degu), is a useful and practical model of natural sporadic Alzheimer’s Disease.

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A $500,000 grant from the National Science Foundation will spur The University of Texas at El Paso’s efforts to help underserved communities across the nation become more resilient to earthquakes.

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Researchers at Memorial Sloan Kettering Cancer Center (MSKCC) in New York have discovered that common cancer treatments, such as radiotherapy or anthracycline drugs, cause long-term damage to heart tissue by activating a key inflammatory signaling pathway. The study, published December 19 in the Journal of Experimental Medicine (JEM), suggests that inhibiting this pathway could reduce the chances of cancer survivors suffering heart disease later in life.

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The University of Northern Colorado has had a lot to celebrate throughout 2022.

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UAlbany researchers recently received new funding to investigate why Black families disproportionately experience negative health outcomes in the first postpartum year. Findings from the five-year study will inform strategies aimed at improving Black maternal-infant health.

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The Computing Alliance of Hispanic-Serving Institutions, which The University of Texas at El Paso leads, received a $4.8 million grant from Google to increase the number of Hispanic students who enter and complete graduate programs in computing. The grant also will support efforts to bolster research capacity among faculty and students at CAHSI institutions that align with Google's research interests.

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Abhinav Jha, at the McKelvey School of Engineering, wants to use novel imaging to better understand how people absorb radiation therapy. His team won a four-year $2.2 million National Institutes of Health (NIH) grant for the study, which aims to guide treatment decisions.

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Mass transit, and subways in particular, are essential to the economic viability and environmental sustainability of cities across the globe. But public transit was hit hard during the COVID pandemic and subways especially experienced substantial drops in ridership.