Houston Methodist nanomedicine researchers have found a way to tame pancreatic cancer - one of the most aggressive and difficult to treat cancers - by delivering immunotherapy directly into the tumor with a device that is smaller than a grain of rice.
The key to understanding allergies may lie in genetic and environmental triggers as well as a person’s lifestyle. A Penn State Health physician discusses what causes seasonal allergies and how to alleviate the symptoms.
Below are some of the latest headlines in the new Avian Flu channel on Newswise.
New smart-drug treatment options for pancreatic cancer, immuno-oncology treatments and real-time immune-monitoring strategies are among the research topics to be presented by investigators at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) at the American Association for Cancer Research (AACR) annual meeting held April 14-19 at the Orange County Convention Center in Orlando, Florida.
James P. Allison, PhD, is the recipient of the 25th Herbert and Maxine Block Memorial Lectureship Award for Distinguished Achievement in Cancer. A 2018 Nobel Prize co-recipient in physiology/medicine, Allison serves as the chair of immunology and executive director of the Immunotherapy Platform at The University of Texas MD Anderson Cancer Center.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. This special edition features presentations by MD Anderson researchers at the American Association for Cancer Research (AACR) Annual Meeting 2023.
Testing the efficacy of a vaccine candidate is typically a long process, with the immune response of an animal model taking around two months. A multi-institution team is developing a method that is more than an order of magnitude faster.
20240326113011.png&width=400&height=400){kind=logo}
Researchers reporting in ACS Central Science have developed a new testing platform that encapsulates B cells — some of the most important components of the immune system — into miniature “organoids” to make vaccine screening quicker and greatly reduce the number of animals needed for testing.
Omicron subvariants of SARS-CoV-2 — the virus behind COVID-19 — have shown an uncanny knack for evading antibodies produced either by vaccines or exposure to earlier versions of the virus, leading to many breakthrough infections. However, in order to sicken people, these viral variants must also avoid “killer” T cells, immune cells that are unleashed when the immune system detects foreign pathogens.
In Brazil, a group of researchers supported by FAPESP created mutant forms of Salmonella to understand the mechanisms that favor colonization of the intestinal tract of chickens by these pathogenic bacteria and find better ways to combat the infection they cause.
New research from RUSH University reveals pathways to reducing organ injury caused by severe COVID-19 infection. What began as a study of how the common cold affected patients with certain types of kidney disease evolved to mitigating myocarditis, liver injury and severe kidney injury from COVID-19.
Researchers at Washington University School of Medicine in St. Louis have found a creative way to make a vaccine for norovirus, the leading cause of foodborne infections, by piggybacking on rotavirus, an unrelated virus for which there are already several highly effective vaccines.
Viruses are usually associated with illness. But our bodies are full of both bacteria and viruses that constantly proliferate and interact with each other in our gastrointestinal tract.
Cell secretions like proteins, antibodies, and neurotransmitters play an essential role in immune response, metabolism, and communication between cells.
Four distinguished researchers from the Abramson Cancer Center and Perelman School of Medicine at the University of Pennsylvania will receive 2023 Scientific Achievement Awards from the American Association for Cancer Research (AACR), during the AACR Annual Meeting 2023.
Ana Fernandez-Sesma, PhD, has been appointed Chair of the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Dr. Fernandez-Sesma will direct all educational and research functions of the Department, while cultivating an academic culture that advances insights into virology, vaccinology, immunology, and microbiology, and encourages innovative approaches to teaching and mentoring.
Chulalongkorn University, Thailand, and Nagoya University, Japan, in their collaboration to develop an immunotherapy method for curing cancer, reported on the progress of CAR T-cell immunotherapy innovation for treating cancer in leukemia and B-cell lymphoma patients, which can increase survival rates and reduce cancer recurrence.
Beyond vaccines, mRNA offers immense potential to fight disease, but targeting the genetic material to specific diseased cells is challenging—requiring a new method. To meet this need, researchers at the Case Western Reserve University School of Medicine, with a Global Research Fellowship award from Moderna Inc., are developing a process that essentially uses bubbles to overcome the problem.
May is Asthma and Allergy Awareness Month. Experts from the American College of Allergy, Asthma & Immunology caution that pollen season is starting earlier and lasting longer than in past decades.
South Carolina residents were more hesitant than Americans as a whole to receive the COVID-19 vaccine during the fall of 2020, report researchers in the Department of Psychiatry and Behavioral Sciences at the Medical University of South Carolina (MUSC) in the Journal of Psychiatry Research.
The study of immunotherapy for treating triple negative breast cancer might still be at its early stages of development but is full of future promise.
Research led by scientists at UCLA Jonsson Comprehensive Cancer Center found that responses to a type of immunotherapy called PD-1 checkpoint blockade in patients with advanced melanoma depended on whether or not they had previously received another immunotherapy – CTLA-4 blockade – as well as other factors.
Yale Cancer Center (YCC) and Smilow Cancer Hospital (SCH) physicians and scientists are presenting research studies at the 2023 American Association for Cancer Research (AACR) Annual Meeting at the Orange County Convention Center in Orlando, Florida, April 14 to 19th.
Inflammatory bowel disease, or IBD, describes Crohn’s disease and ulcerative colitis, two chronic diseases that cause inflammation in the intestines. IBD, which affects about 3 million adults in the United States, is an autoimmune disorder — a condition in which the body’s immune system attacks healthy tissues.
A regulatory class of human T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity, according to a new study led by Children’s Hospital of Philadelphia (CHOP). The findings, published today in Science Immunology, could pave the way for new treatments for autoimmune diseases that target the immune system selectively.
A team led by researchers at Weill Cornell Medicine, the University of Wisconsin-Madison; Scripps Research and the University of Chicago has identified an antibody that appears to block infection by all dominant variants of the virus that causes COVID-19, including Omicron, the most recent. Their discovery could lead to more potent vaccines and new antibody-based treatments.
After helping to develop and test new mRNA technologies for COVID-19 vaccines, University of Maryland School of Medicine (UMSOM) researchers and scientists are turning their attention to utilizing this innovative technology to ward off other infectious diseases like malaria and influenza.
Experts from Fred Hutchinson Cancer Center will present their latest findings on targets in RIT1-driven cancers, ROR1 CAR T-cell immunotherapy, interplay of the microbiome and genetics in colorectal cancer and more at the annual meeting of the American Association for Cancer Research, to be held April 14-19 in Orlando, Florida.
The human body is capable of creating a vast, diverse repertoire of antibodies—the Y-shaped sniffer dogs of the immune system that can find and flag foreign invaders.
Penn State College of Medicine researchers have found Black and Hispanic patients with severe allergies are less likely to get a common treatment, allergen immunotherapy, compared to white patients.
The American Association of Immunologists announces its most recent class of Distinguished Fellows
People exposed to higher levels of air pollution before the pandemic had lower antibody responses to COVID-19 vaccines, according to a study led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by “la Caixa” Foundation, in collaboration with the Germans Trias i Pujol Research Institute (IGTP).
A new survey of allergists/immunologists from the American College of Allergy, Asthma and Immunology shows that diagnosing, treating and managing hereditary angioedema can be challenging for patients and healthcare providers - including patients in rural areas. An article about the survey is published in Annals of Allergy, Asthma and Immunology, ACAAI’s scientific journal.
In a new study published in the January issue of Autophagy, they found that after traumatic brain injury, the brain’s immune system cells’ internal recycling function slowed dramatically, allowing waste products to build up and interfere with recovery from injury.
Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.
The saliva of mosquitoes infected with dengue viruses contains a substance that thwarts the human immune system and makes it easier for people to become infected with these potentially deadly viruses, new research reveals.
New research from Washington University School of Medicine in St. Louis suggests that transposable elements in various cancers potentially may be used to direct novel immunotherapies to tumors that don’t typically respond to immune-based treatments.
A study by researchers at Washington University School of Medicine in St. Louis shows that vaccinating people with updated boosters as new variants of the virus that cause COVID-19 emerge could shore up population immunity even as the virus mutates, and thereby prevent another deadly COVID-19 wave.
The findings, published in Nature Microbiology, are particularly important in understanding how and why bacterial communities defer duties to certain cells – and could lead to new ways to tackle antibiotic tolerance further down the line.
A groundbreaking human clinical trial published in the Journal of Biochemistry and Biotechnology reveals AstraGin®'s significant impact on various factors related to gut health in patients with Ulcerative Colitis (UC).
In this study led by Dana-Farber Cancer Institute, interim results of the combination of cabozantinib, a VEGF TKI, plus belzutifan, a HIF-2α inhibitor, show promising anti-tumor activity in this pre-treated patient group. The results suggest that the combination might fill and unmet need and provides a rationale for further study of combining a VEGF TKI and a HIF-2 inhibitor.
Twenty to 50 per cent of all critically ill patients contract potentially deadly infections during their stay in the intensive care unit or in hospital after being in the ICU – markedly increasing the risk of death.
Four RUSH respiratory specialists have been named top doctors by Chicago magazine.
Researchers at Carnegie Mellon University are developing lipid nanoparticles that are designed to carry mRNA specifically to the pancreas. Their study in mice could pave the way for novel therapies for intractable pancreatic diseases, such as diabetes and cancer.
More than half of patients who suffer from chronic hepatitis B have the e antigen (HBeAg)-negative form of the disease. Even after many years of antiviral treatment with nucleos(t)ide analogues (NUC), lasting immune control is almost never seen.
University of Wisconsin–Madison researchers have developed a new method for targeting tumors with cancer drugs by exploiting the clotting propensity of blood platelets.The new approach, first described March 29 in the journal Science Advances, adds to a growing set of innovative drug delivery techniques under development in the lab of Quanyin Hu, a professor in the UW–Madison School of Pharmacy.
Two independent Ludwig Cancer Research studies published in the current issue of the journal Cell show that immune cells known as neutrophils, whose abundance in the microenvironment of tumors has traditionally been associated with poor patient prognosis, can play an important role in the success of cancer immunotherapies.
New research reveals that long-underestimated neutrophils play key role in determining success of cancer immunotherapy
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right
