Feature Channels: Immunology

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Stay informed! Keep up with the latest research on the COVID-19 virus in the Coronavirus channel on Newswise.

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Cleveland Clinic researchers analyzed genes and brain tissue of patients with Alzheimer’s and found that differences in brain immunometabolism – the interactions between the immune system and the ways cells create energy – may contribute to women’s increased risk for the disease and its severity.

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Immunotherapy using modified chimeric antigen receptor (CAR) T cells has greatly improved survival rates for relapsed and recurrent pediatric leukemia and lymphomas, but not brain and solid tumors.

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Immunologists found the difference between antibodies that react to birch pollen allergens in healthy people and patients with allergies. The authors also found out why not all classes of antibodies can protect against allergies. The results were published in Allergy.

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Clarivate calls these scientists "pioneers," noting that ranking on the Highly Cited Researchers list is a sign that a scientist has published significant findings and influenced their field of study.

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St. Jude scientists mapped the gene regulatory networks responsible for progressive differentiation states of tumor-infiltrating T cells, using a technology known as single-cell CRISPR screening to knock out or genetically perturb multiple genes potentially involved.

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The Department of Immunology and Immunotherapy and the Icahn Genomics Institute (IGI) at the Icahn School of Medicine at Mount Sinai have been awarded a $5 million grant from the National Cancer Institute (NCI) of the National Institutes of Health to establish a state-of-the-art center dedicated to the discovery and development of cutting-edge targets for cancer therapy.

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A phase 1 clinical trial conducted exclusively at Roswell Park Comprehensive Cancer Center shows that a novel treatment regimen can make immunotherapy more effective in patients with metastatic triple-negative breast cancer (mTNBC).

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The James P. Allison Institute at MD Anderson hosted its inaugural scientific symposium on Nov. 10, bringing together more than 400 leading scientists in immunotherapy and immunobiology.

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For years, researchers and clinicians have known that lupus, an autoimmune condition, occurs in women at a rate nine times higher than in men.

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Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.

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Investigators from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) presented new research findings in antiphospholipid syndrome (APS) at the American College of Rheumatology (ACR) Convergence 2023, the ACR’s annual meeting.

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The American Association of Immunologists (AAI) is pleased to announce the appointment of Gwen Fortune-Blakely, M.B.A, CAE, as its new chief membership and engagement officer.

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UT Southwestern Medical Center will lead a multi-institution effort to gather and assimilate information on the billions of sequences employed by immune receptors of the adaptive immune system. The project, funded by the National Institutes of Health, aims to improve the understanding of immunity and help facilitate the development of improved vaccines and treatments for many diseases.

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Jennifer Oyler-Yaniv is studying human diseases to learn about the immune system. She hopes that diseases such as cancer will reveal fundamental principles of how immune cells communicate

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Un nuevo estudio que se presentará en la Reunión Científica Anual del ACAAI de este año en Anaheim (California) determinó que tanto un régimen de solución salina de dosis baja como de dosis alta parecían estar asociadas a menores tasas de hospitalización en comparación con los controles en las infecciones por SARS-CoV-2.

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Un nuevo estudio que se presentará en la Reunión Científica Anual del ACAAI de este año en Anaheim (California) muestra que el 42% de los médicos de atención primaria (PCP) encuestados no estaban familiarizados con los productos biológicos para tratar el asma.

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A new study being presented at this year’s ACAAI Annual Scientific Meeting in Anaheim, Calif. shows that 42% of the primary care physicians (PCPs) surveyed were unfamiliar with asthma biologics.

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A new late breaking abstract being presented at this year’s ACAAI Annual Scientific Meeting in Anaheim, Calif. demonstrates that a specially formulated toothpaste can be successfully used for Oral Mucosal Immunotherapy (OMIT).

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PNNL scientists took thousands of measurements of firefighters in training to learn more about how the body responds to vigorous exercise.

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Analyses led by Corinne Keet, MD, PhD, at the University of North Carolina School of Medicine, of two longitudinal studies reveal how an increased level of an antibody called immunoglobin (IgE) to cow’s milk is associated to cardiovascular-related death.

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The most effective way to prevent cervical cancer is to give HPV vaccines to both boys and girls, reports a collaborative study involving researchers from Karolinska Institutet published in Cell, Host and Microbe. Beside personal immunity, such use of the vaccine also induces a herd immunity that will help to eradicate the carcinogenic virus types more quickly.

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UCLA scientists have developed a new method to engineer more powerful immune cells that can potentially be used for “off-the-shelf” cell therapy to treat challenging cancers.

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JDRF, the world’s largest nonprofit supporter of Type 1 diabetes research, has awarded a $750,000 grant to a team of Michigan State University researchers.

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Low doses of an immunotherapy taken under the tongue safely achieved desensitization to peanut allergies in children ages 1 to 4 years, according to results of a clinical trial conducted by researchers at UT Southwestern Medical Center, Children’s Medical Center Dallas, and the University of North Carolina School of Medicine.

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The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational, and clinical cancer research from MD Anderson experts. irectly into the liver for patients with metastatic uveal melanoma.

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A new pathologic scoring system that accurately assesses how much lung tumor is left after a patient receives presurgical cancer treatments can be used to predict survival, according to new research led by investigators at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center and the Mark Foundation Center for Advanced Genomics and Imaging at the Johns Hopkins University.

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Research in mice shows that the anti-inflammatory properties of exercise may arise from immune cells mobilized to counter exercise-induced inflammation. Immune cells prevent muscle damage by lowering levels of interferon, a key driver of chronic inflammation, inflammatory diseases, and aging.

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A cost-effectiveness analysis for the updated COVID-19 vaccine prepared for the CDC's vaccine panel shows cost savings from vaccinating people over age 65, and good value from vaccinating adults of all ages.

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The Icahn School of Medicine at Mount Sinai will award its 2023 Maria I. New International Prize for Biomedical Research to Jean-Laurent Casanova, MD, PhD, for revolutionizing our understanding of human infectious diseases through the discovery of genetic and immunological determinants that underpin both rare and common infectious illnesses. The prize honors medical pioneers in the tradition of Maria I. New, MD, a world-renowned researcher in pediatric genetic disorders with a special focus on endocrinology over her six-decade career. Dr. Casanova will receive a prize of $20,000 and will present the Maria I. New Distinguished Lecture during a ceremony to be held in at Icahn Mount Sinai in New York City on November 21, 2023.

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Dendritic cells play a key role in the mammalian immune system. These cells are present throughout the human body and are known to capture foreign bodies, i.e., antigens, using extendable “arms” called dendrites

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The Cancer Research Institute is proudly awarding Dr. Ananda Goldrath with the 2023 Fredrick W. Alt award for New Discoveries in Immunology.

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A novel replacement strategy termed GE x HDR 2.0: Find and Replace, developed by researchers from Bar-Ilan University and described in published today in Nature Communications, combines CRISPR-Cas9-mediated genome editing with recombinant adeno-associated serotype 6 (rAAV6) DNA donor vectors to precisely replace the RAG2 coding sequence while preserving regulatory elements.

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AAI celebrates an immunologist being given the National Medal of Technology and Innovation

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A clinical study of 11 dogs with advanced malignant melanoma demonstrated the efficacy, safety, and tolerability profile of cANK-101, a canine interleukin-12 anchored immunotherapy.

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A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die.