Researchers at UT Southwestern Medical Center have discovered the first molecular biomarker for acquired generalized lipodystrophy (AGL), a rare disorder in which fat deposits are destroyed, causing patients to have dangerously low body fat, signs of accelerated aging, and severe metabolic diseases including diabetes and fatty liver.
Reporting in the PNAS, UNC School of Medicine researchers made the stunning discovery that telomeres contain genetic information to produce two small proteins, one of which they found is elevated in some human cancer cells, as well as cells from patients suffering from telomere-related defects.
FASEB and NIH select inaugural winners of the DataWorks! Prize, showcasing research teams' exemplary data sharing and reuse projects.
In a bid to understand why mosquitoes may be more attracted to one human than another, Johns Hopkins Medicine researchers say they have mapped specialized receptors on the insects’ nerve cells that are able to fine-tune their ability to detect particularly “welcoming” odors in human skin.
Analyzing the most extensive datasets in the U.S., researchers from the Icahn School of Medicine at Mount Sinai have revealed that vaccination against COVID-19 is associated with fewer heart attacks, strokes, and other cardiovascular issues among people who were infected with SARS-CoV-2, the virus that causes COVID-19. The research letter, “Impact of Vaccination on Major Adverse Cardiovascular Events in Patients with COVID-19 Infection,” was published in the Journal of the American College of Cardiology on February 20. The research will also be presented on March 5, 2023 in a poster session in New Orleans, LA, at the American College of Cardiology’s 72nd Annual Scientific Session Together With World Heart Federation’s World Congress of Cardiology.
Strokes are a leading cause of morbidity and mortality in the United States, as well as around the world. Various environmental and biological factors are known to affect the risks and outcomes of strokes.
Drs. Akash Patel and Tiemo Klisch, investigators at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital and faculty at Baylor College of Medicine, have found that the loss of a single copy of CDKNA/B genes can greatly accelerate the recurrence of aggressive meningiomas, portending a poor prognosis for this subset of patients.
Location, location, location is the key for psychedelic drugs that could treat mental illness by rapidly rebuilding connections between nerve cells.
Cannabidiol or CBD, a non-psychoactive component of cannabis, inhibits the metabolism of nicotine, new research has found, meaning it could help tobacco users curb the urge for that next cigarette.
UVA Health neuroscientists have discovered a potential way to disrupt the chronic inflammation responsible for multiple sclerosis.
UC San Diego researchers report that a late-stage, pre-clinical small molecule inhibitor reverses malignant hyper-editing by a protein that promotes silencing of the immune response, metastasis and therapeutic resistance in 20 different cancer types.
Two federal grants are supporting efforts at Children’s Hospital Los Angeles to develop novel therapies for this aggressive childhood brain tumor. Researchers at Children’s Hospital Los Angeles have received a nearly $1 million K08 grant from the National Institutes of Health (NIH)—as well as funding from the U.S. Department of Defense—to support studies into diffuse intrinsic pontine glioma (DIPG), a childhood brain tumor with a 0% survival rate.
The researchers looked at a ubiquitin ligase enzyme named FBXL2, known to degrade proteins at various cellular membrane compartments. They found that by attaching or detaching a fat molecule or lipid to FBXL2 — a process called palmitoylation and de-palmitoylation — they could direct where the FBXL2 went. They also discovered that in order to travel in the aqueous cellular environment for the delivery of lipid-modified FBXL2 to membrane compartments, it used a trafficking protein called PDE6D, which is known to shield the lipid modifications.
Society’s growing demand for high-voltage electrical technologies—including pulsed power systems, cars and electrified aircraft, and renewable energy applications—requires a new generation of capacitors that store and deliver large amounts of energy under intense thermal and electrical conditions. Researchers at Lawrence Berkeley National Laboratory and Scripps Research have now developed a new polymer-based device that efficiently handles record amounts of energy while withstanding extreme temperatures and electric fields.
Researchers discover a mechanism used by neurons to repair damage that occurs during neuronal activity
The National Institutes of Health has awarded $3.8 million to Texas Biomedical Research Institute to further develop a promising HIV vaccine candidate that stops the virus upon entry, before it begins rapidly spreading throughout the body.
At least 830 men, women and children were coercively sterilized in Utah, approximately 54 of whom may still be alive. They were victims of a sterilization program that lasted for fifty years in the state and targeted people confined to state institutions. Many were teenagers or younger when operated upon; at least one child was under the age of ten.
Interdisciplinary research highlighted lipid-protein interaction as a new avenue for oncology drug development, demonstrating its functionality by designing small molecule-based inhibitors to target acute myeloid leukemia.
Neighborhood redevelopment, which transforms low-income neighborhoods through rezoning, new construction and renovation, can lead to health benefits, such as greater access to fresh produce, improved housing, and more green spaces. But these advantages may not extend to all area residents. More information is needed about the impact of redevelopment, also known as urban renewal, on health, particularly if it contributes to inequities among middle-aged and older adults.
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