Curated News: National Institutes of Health (NIH)

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Released: 31-Jul-2023 12:00 PM EDT
Duke Clinical Research Institute launches long COVID trials through NIH RECOVER Long COVID Initiative
Duke Clinical Research Institute

Today, the National Institutes of Health launched and is opening enrollment for phase 2 clinical trials that will evaluate at least four potential treatments for long COVID, with additional clinical trials to test at least seven more treatments expected in the coming months. Treatments will include drugs, biologics, medical devices and other therapies.

Newswise: Alternative cellular ‘fuels’ boost immunity
Released: 28-Jul-2023 11:05 AM EDT
Alternative cellular ‘fuels’ boost immunity
Van Andel Institute

A metabolic by-product that is more prevalent during fasting may supercharge immune cells as they fight infection and disease, reports an early stage study by Van Andel Institute scientists and collaborators.

Released: 28-Jul-2023 10:45 AM EDT
Enhanced light sensitivity may contribute to Alzheimer's 'sundowning,' disease progression
University of Virginia Health System

New Alzheimer’s research from UVA Health suggests that enhanced light sensitivity may contribute to “sundowning” – the worsening of symptoms late in the day – and spur sleep disruptions thought to contribute to the disease’s progression.

24-Jul-2023 11:10 AM EDT
CHOP and Penn Medicine Researchers Develop “In Vivo” RNA-based Gene Editing Model for Blood Disorders
Children's Hospital of Philadelphia

In a step forward in the development of genetic medicines, researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body. If translated into the clinic, this approach could expand access and reduce the cost of gene therapies for blood disorders, many of which currently require patients receive chemotherapy and a stem cell transplant. The findings were published today in the journal Science.

Newswise: Study provides new insights into Type 2 diabetes
Released: 27-Jul-2023 1:20 PM EDT
Study provides new insights into Type 2 diabetes
Texas A&M AgriLife

New insights into the underlying mechanisms of Type 2 diabetes and novel potential therapeutic targets for the disease were revealed in a recent study.

Released: 27-Jul-2023 11:55 AM EDT
Yale Scientists Develop a New Approach to Strengthen CAR-T Cell Therapy
Yale Cancer Center/Smilow Cancer Hospital

Chimeric antigen receptor (CAR)-T cells are a powerful, new form of cancer therapy that are being studied to treat blood cancers. Using a new approach, Yale Cancer Center researchers at Yale School of Medicine found a new way to substantially improve the effectiveness of CAR-T cell therapy. The new study was published in Nature Immunology on July 27.

Newswise: Transcription Factors Contribute to Subtypes of Colorectal Cancers
Released: 27-Jul-2023 11:05 AM EDT
Transcription Factors Contribute to Subtypes of Colorectal Cancers
Johns Hopkins Medicine

New research in colorectal cancers directed by investigators at the Johns Hopkins Kimmel Cancer Center suggests that expression of transcription factors — proteins that help turn specific genes on or off by binding to nearby DNA — may play a central role in the degree of DNA methylation across the genome, contributing to the development of different subtypes of these cancers. Methylation is a process in which certain chemical groups attach to areas of DNA that guide genes’ on/off switches.

Newswise: Investigators Identify Translation Gaps in Instrument That Measures Nursing Practice Environment
Released: 27-Jul-2023 11:00 AM EDT
Investigators Identify Translation Gaps in Instrument That Measures Nursing Practice Environment
University of Pennsylvania School of Nursing

Two decades ago, the Practice Environment Scale of the Nursing Work Index was published to measure the nursing practice environment. Although the instrument's use has resulted in advances in science and quality improvement efforts, its potential may be limited by the availability and quality of translations into different languages.

Released: 27-Jul-2023 10:45 AM EDT
Storing fat at the waist may NOT up diabetes risk, surprise findings indicate
University of Virginia Health System

Conventional wisdom holds that storing fat around your belly puts you at increased risk for type 2 diabetes. But surprising new findings from the University of Virginia School of Medicine suggest that naturally occurring variations in our genes can lead some people to store fat at the waist but also protect them from diabetes.

Released: 27-Jul-2023 8:15 AM EDT
NIH funds study of ultrasound with genetics to treat brain disorders
Washington University in St. Louis

Researchers have developed methods to study and manipulate areas of the brain, though many of those methods are restricted by the limited depth that light can reach within the brain. A multidisciplinary team at Washington University in St. Louis plans to overcome that limitation by integrating ultrasound with genetics to precisely modify neurons in the brain.

Released: 26-Jul-2023 5:30 PM EDT
NIH spent $950M for basic or applied research leading to patents providing market exclusivity for drugs approved 2010-19
Bentley University

A new demonstrates that the National Institutes of Health (NIH) spent $950 million on basic or applied research associated with patents that provided manufacturers with market exclusivity.

   
Newswise: UCI neuroscientists discover a novel inhibitory cortical neuron type that is implicated in neuropsychiatric conditions
Released: 26-Jul-2023 4:05 PM EDT
UCI neuroscientists discover a novel inhibitory cortical neuron type that is implicated in neuropsychiatric conditions
University of California, Irvine

A University of California, Irvine-led team of researchers working at the Center for Neural Circuit Mapping find links between brain disorders and dysfunction of newly identified inhibitory brain cell types.

26-Jul-2023 12:40 PM EDT
Lost metabolic fitness of CAR NK cells is key mechanism of tumor resistance
University of Texas MD Anderson Cancer Center

A new study led by researchers at The University of Texas MD Anderson Cancer Center discovered loss of metabolic fitness in chimeric antigen receptor (CAR) natural killer (NK) cells is a critical mechanism of resistance, with infused cells gradually losing the ability to compete with tumor cells for nutrients, leading to tumor relapse.

Released: 25-Jul-2023 7:05 PM EDT
Older women at risk for Alzheimer’s disease may benefit from yoga
University of California, Los Angeles (UCLA), Health Sciences

Kundalini yoga, a form of yoga that focuses on breathing, meditation, and mental visualization, appeared beneficial for older women who had risk factors for Alzheimer’s disease and concerns about episodes of memory decline, according to a UCLA Health study.

Released: 25-Jul-2023 11:35 AM EDT
Older adults who identify as sexual and gender minorities experience disproportionate age-related decline
Beth Israel Deaconess Medical Center

Using an index to describe and compare frailty between older sexual and gender minority (OSGM) adults and non-OSGM participants, researchers showed that OSGM had higher rates of frailty, starting at younger ages and continuing into older age, compared to non-OSGM.

Newswise: Research pinpoints inflammation source behind atherosclerosis
Released: 25-Jul-2023 11:15 AM EDT
Research pinpoints inflammation source behind atherosclerosis
UT Southwestern Medical Center

Scientists at UT Southwestern Medical Center and Children’s Medical Center Dallas have discovered in mice how high cholesterol causes blood vessels to become inflamed, a necessary prerequisite for atherosclerosis – the “hardening of the arteries” responsible for most heart attacks and strokes. The findings, published in Nature Communications, could lead to new interventions to protect against cardiovascular diseases (CVD), the leading cause of death globally.

Released: 25-Jul-2023 7:25 AM EDT
A Common Diabetes Drug Has a Surprising Side Gig: Muscle Protector
University of Utah Health

You might not think of diabetes when you think of muscle function. But a common diabetes drug that regulates blood sugar can also prevent muscle atrophy and muscular fibrosis—which can help the elderly bounce back faster from injury or illness.

Newswise: Study explores how often children diagnosed with flu experience serious neuropsychiatric side effects
Released: 24-Jul-2023 11:40 AM EDT
Study explores how often children diagnosed with flu experience serious neuropsychiatric side effects
Vanderbilt University Medical Center

While the incidence of influenza-associated neuropsychiatric events in children in the United States is unknown, the controversy over the use of a common antiviral medication typically administered to treat flu in children has sparked concern among parents and medical professionals alike. The dilemma about whether the treatment causes neuropsychiatric events or if the infection itself is the culprit, led a group of pediatric researchers at Monroe Carell Jr.

Newswise: Research Reveals Blood Platelets Play Important Role in Kawasaki Disease
Released: 24-Jul-2023 11:30 AM EDT
Research Reveals Blood Platelets Play Important Role in Kawasaki Disease
Cedars-Sinai

Cedars-Sinai Guerin Children’s investigators have advanced our understanding of the role that blood platelets play in Kawasaki disease, a serious illness that primarily affects children younger than 5 years old and causes their blood vessels to swell.



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