Feature Channels: Pharmaceuticals

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Researchers view cells for hearing in 3D using virtual reality

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A single dose of a new influenza drug can significantly shorten the duration of the illness in teens and adults, according to a study published in the prestigious New England Journal of Medicine.

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A Roswell Park-led research team has linked the development of castration-resistant prostate cancer and resistance to treatment to a lack of androgen receptor expression in prostate cancer cells, identifying a new therapeutic target. Their findings were published in the journal Nature Communications.

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Charlotte and Emelia Dubs are just starting to toddle around their world. The 1-year-old twin girls from Conway spend their days exploring, laughing, blowing kisses and keeping their parents, Kenzie Butcher-Dubs and Morgan Dubs, on their toes.

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A new “virtual” drug development startup company, Enspire Bio, will channel the knowledge and financial resources necessary to translate basic science — the bedrock of medicine — into powerful treatments. And, in a notable departure from traditional approaches, the translation will occur in the heart of the research lab.

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Thirty to 40 percent of people with epilepsy — more than 1 million Americans — continue to experience seizures despite taking medication. Experts at the UCLA Seizure Disorder Center at UCLA Health want to change that picture. Their message to people with epilepsy as well as their doctors is simple: Referral to a full-service epilepsy center can help.

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The CAP releases position statement creating solutions for combating the opioid crisis

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Researchers from The Feinstein Institute for Medical Research have discovered that the activation of brain cells called microglia likely contributes to the memory loss and other cognitive impairments suffered by many patients with systemic lupus erythematosus (SLE). The study, which will be published September 5 in the Journal of Experimental Medicine, shows that ACE inhibitors—a class of drugs commonly used to treat hypertension—can block this process in mice and might therefore be used to preserve the memory of lupus patients.

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The Endocrine Society has confirmed the plenary program speaker line-up for ENDO 2019, the world's largest event for endocrine science and medicine. This year features a presidential plenary from Francis S. Collins, M.D., Ph.D., Director of the National Institutes of Health (NIH), the largest supporter of biomedical research in the world. Other noteworthy speakers are Robert Califf, M.D., Duke University School of Medicine and former Food & Drug Administration (FDA) Commissioner, and Cori Bargmann, Ph.D., Rockefeller University and head of the Chan Zuckerberg Initiative’s science work.

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Digital medicine platform Rx.Health, a Mount Sinai Health System spinoff and provider of RxUniverse™, recently announced that it has raised $1.8 million in seed funding.

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The Blavatnik Family Foundation and the New York Academy of Sciences today announced the three winners and six finalists of the 2018 Blavatnik Regional Awards for Young Scientists.

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Three Penn Medicine ophthalmology innovators received the 2018 António Champalimaud Vision Award for their revolutionary work leading to the first successful gene therapy to cure an inherited cause of childhood blindness.

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Wistar scientists have applied their synthetic DNA technology to engineer a novel eCD4-Ig anti-HIV agent and to enhance its potency in vivo, providing a new simple strategy for constructing complex therapeutics for infectious agents as well as for diverse implications in therapeutic delivery.

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URI Doctor of Pharmacy (PharmD) students can apply to Johnson & Wales’ Master of Science in Physician Assistant Studies (MSPAS) program after completing their fourth year of the six-year pharmacy program. Applications began in the spring.

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Craig A. Thompson, MD, MMSc , whose seminal, pioneering achievements are now a standard of care for re-vascularization of totally blocked coronary arteries, has been named director of cardiac catheterization laboratories at NYU Langone Health System .

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The Department of Defense (DoD) has awarded Brian Schmidt, DDS, MD, PhD, director of the Bluestone Center for Clinical Research at New York University College of Dentistry (NYU Dentistry) and Nigel Bunnett, PhD, professor in the Departments of Surgery and Pharmacology at Columbia University, a joint $2.4 million, three-year grant to study how receptors inside nerve cells generate chronic (long-lasting) pain. Three painful medical conditions prevalent in military personnel and veterans—headache, nerve injury, and infectious colitis—will be investigated.

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Hong Chen, assistant professor of biomedical engineering in the school of Engineering & Applied Science, and assistant professor of radiation oncology at the School of Medicine, reached across disciplines to develop a more focused drug delivery system that can target tumors lodged in the brainstem.

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Researchers from New York Institute of Technology (NYIT) have secured $426,621 in funding from the National Science Foundation (NSF) for the acquisition of a micro-computed tomography machine.

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The Mount Sinai Health System has launched a new television series called Mount Sinai Future You, featuring clinicians, researchers, and patients discussing how innovations in science, medicine, and new models of care are changing the course of health care.

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In 2014, Massachusetts lawmakers passed a law requiring a 1:1 or 2:1 patient-to-nurse staffing ratio in intensive care units (ICU) in the state, as guided by a tool that accounts for patient acuity and anticipated care intensity. The regulations were intended to ensure patient safety in the state’s ICUs, but new research led by physician-researchers at Beth Israel Deaconess Medical Center (BIDMC) and published today in Critical Care Medicine found the staffing regulations were not associated with improved patient outcomes.

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Patients with muscle-invasive bladder cancer have been shown to benefit from chemotherapy prior to surgical removal of the bladder. But which type of chemotherapy leads to the best outcomes in terms of complete response rates or cancer control? Moffitt Cancer Center researchers examined data from more than 800 surgical patients with advanced bladder cancer.

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A new international guideline has been developed to help physicians diagnosis idiopathic pulmonary fibrosis (IPF), a rare and often fatal lung disease whose cause is unknown.

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A translational research team led by the National University of Singapore (NUS) has harnessed CURATE.AI, a powerful artificial intelligence (AI) platform, to successfully treat a patient with advanced cancer, completely halting disease progression. This new development represents a big step forward in personalised medicine.

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A relatively simple effort to provide counseling and connect injection-drug users with resources could prove powerful against the spread of HIV in a notoriously hard-to-reach population, new research suggests.

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Inflammation is the body’s reaction to a harmful stimulus, such as infection with a virus like the flu, an injury like a cut or scrape or chronic conditions such as Crohn’s disease. Although it is a normal and important part of our immune system’s defenses, when it sticks around too long it can be

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The National Institute on Aging, part of the National Institutes of Health (NIH), has awarded Wake Forest School of Medicine researchers a five-year grant worth more than $18 million to study the connections between heart health and brain health among participants in the Multi-Ethnic Study of Atherosclerosis (MESA).

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While we appreciate the agency’s efforts to make prescription medications more affordable, we have serious concerns about a new CMS guidance to allow Medicare Part D plan sponsors to implement indication-based formulary designs that allow plans to select drugs for their formularies based only on the disease indications they want to use.

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Universities that aim to raise money for research by selling access to their biobanks to private companies should tell patients, a new survey shows – and saying what the money will be used for will likely encourage patients to donate

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A promising drug slowed brain shrinkage in progressive multiple sclerosis (MS) by nearly half, according to new research led by Cleveland Clinic. Very limited therapies are currently available for this disabling form of the disease. The definitive results of the phase 2 trial – published in the New England Journal of Medicine – showed that the drug ibudilast decreased progression of brain atrophy in progressive MS patients by 48 percent versus placebo.

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A drug shown to be effective in the treatment of babies with the rare muscle-wasting disease spinal muscular atrophy may be effective for muscle control even when treatment is started in children seven months and older, according to a study published in the August 29, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology. Previous studies focused on children younger than seven months old.

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With the support of the National Institute on Drug Abuse, scientists at Wake Forest School of Medicine have been working to find a safe, non-addictive pain killer to help fight the current opioid crisis in this country.

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A group of McMaster researchers has designed and built specialized hardware for their research using an in-house 3D printer. The new lab instrument is capable of collecting massive amounts of data that will help these researchers in their quest to discover new antibiotics.

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Over the next five years, the National Heart, Lung, and Blood Institute, part of the National Institutes of Health, will award approximately $20 million to four academic centers to launch a new national Career Development Consortium for Excellence in Glycosciences.

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Single-step nasal spray naloxone is the easiest to deliver, according to new research led by faculty at Binghamton University, State University at New York.

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Wolters Kluwer Health announced today it will begin electronic publishing of Evidence-Based Practice, the official journal of the Family Physicians Inquiries Network (FPIN). The monthly journal, which focuses on topics relevant to the daily practice of family medicine, will be curated in the Lippincott portfolio beginning in September 2018.

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Pulmonary fibrosis is one of the most common and serious types of lung disease. Now researchers have developed an in vitro lung tissue-on-a-chip system that mimics lung fibrosis, offering rapid testing of potential new anti-fibrotic treatments.

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The new Notre Dame study looks to improve detection of falsified medications before they harm patients.

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It has been almost 20 years since the human genome was first sequenced, but researchers still know little about how the genome is folded up and organized within cells. In a paper to be published August 28 in the Journal of Cell Biology, researchers from the University of Illinois at Urbana-Champaign describe a new technique that can measure the position of every single gene in the nucleus to build a 3D picture of the genome’s organization.

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Henry Ford Cancer Institute medical physicist Carri K. Glide-Hurst, Ph.D., DABR, has been elected to be a Fellow of the American Association of Physicists in Medicine (AAPM), a prestigious international organization of 8,500 medical physicists in 93 countries.

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Ketamine was approved as an anesthetic nearly 50 years ago, and the number of off-label uses for the drug in clinical settings has grown significantly over the last decade, primarily due to concerns about dependence and respiratory depression associated with traditional sedatives, such as opioids and benzodiazepines.

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Drugs most commonly prescribed to patients seen by primary care physicians are not often tested in the patients who go to these clinics, where most people receive their care, say investigators at Georgetown University Medical Center and Yale School of Medicine.

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According to a new study, about one in five children regularly use prescription medications, and nearly one in 12 of those children are at risk for experiencing a harmful drug- drug interaction.

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Scientists at Scripps Research have developed a urine diagnostic to detect the parasitic worms that cause river blindness, also called onchocerciasis, a tropical disease that afflicts 18 to 120 million people worldwide.

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Researchers at University of California San Diego School of Medicine have launched a phase Ib clinical trial to assess the safety and tolerability of cirmtuzumab, in combination with standard chemotherapy, to treat metastatic or locally advanced breast cancer that cannot be surgically removed.

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In 2013, UNC School of Medicine researchers were first to show an association between variants in gene FKBP5 and posttraumatic chronic pain. Now a new study by the same research group has confirmed this association in a cohort of more than 1,500 people of both European American and African American descent who experienced motor vehicle collision trauma.

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When disaster strikes, our local supply chains are among the first to respond. Supply chain operators provide relief by securing access to critical goods and utilities like food, medicine and electricity.

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Charles B. Berde, MD, PhD, of Boston Children’s Hospital and Harvard Medical School has been selected to receive ASRA’s 2018 John Bonica Award.

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About one in five children regularly use prescription medications, and nearly one in 12 of those children are at risk for experiencing a harmful drug-drug interaction. Adolescent girls are at highest risk.