The National Institutes of Health has renewed a five-year grant for $5 million for the Alliance for Regenerative Rehabilitation and Training (AR3T) to continue its work expanding scientific knowledge, expertise and methodologies focused on science and regenerative medicine.
New research published in Nature Communications uses a technology first developed at the University of Miami Miller School of Medicine to enhance the oxygenation of cultured tissues that will likely be able to conduct real-time regeneration and development studies in the human pancreas.
New UCLA research conducted in mice could explain why some people suffer more extensive scarring than others after a heart attack. The study, published in the journal Cell, reveals that a protein known as type 5 collagen plays a critical role in regulating the size of scar tissue in the heart.
WFIRM scientists were able to show that bioengineered uteri in an animal model developed the native tissue-like structures needed to support normal reproductive function.
The National Eye Institute (NEI) has established an office to accelerate progress in regenerative medicine for eye disease and vision disorders.
Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells — a type of immune cell — with measurably stronger activity against a form of leukemia, both in vivo and in vitro.
Using skin cells from human volunteers, researchers at the University of Pittsburgh School of Medicine have created fully functional mini livers, which they then transplanted into rats. In this proof-of-concept experiment, the lab-made organs survived for four days inside their animal hosts.
A new study finds the use of HGH treatment in patients that have undergone ACL reconstructive surgery may prevent the loss of muscle strength and weakness.
A recent study from the Mechanobiology Institute at the National University of Singapore has shown that rejuvenated fibroblasts can recover their ability to self-contract. This encouraging discovery holds great potential for applications in regenerative medicine and stem cell engineering.
Sexton Biotechnologies pathogen reduced hPL confirmed by PMDA as human derived raw material for regen med products.
EpiBone’s Craniomaxillofacial, or EB-CMF, product is a living, anatomically correct bone graft made from a patient’s own fat-derived stem cells.
Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve efficacy. The study was published in Cell Reports.
An interdisciplinary team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA has developed a first-of-its-kind roadmap of how human skeletal muscle develops, including the formation of muscle stem cells.
A new study in mice at Washington University School of Medicine in St. Louis suggests gene therapy one day may help build muscle and relieve pain in overweight patients with osteoarthritis.
Study provides hope for cancer-related lymphedema
Pesquisadores da Mayo Clinic descobriram mecanismos de cura ativados por células-tronco após um ataque cardíaco. As células-tronco restauraram o músculo cardíaco devolvendo-o ao seu estado anterior ao ataque cardíaco, fornecendo um esquema sobre como as células-tronco podem funcionar.
Is the future of personalized medicine out of this world? Cedars-Sinai is trying to find out by launching special stem cells into space to see if they multiply better there. The Cedars-Sinai Board of Governors Regenerative Medicine Institute is partnering with Space Tango of Lexington, Kentucky, to send induced pluripotent stem cells (iPSCs) to the International Space Station. The first flight for the project, funded by a $1.5 million award from NASA, could occur as early as next year.
Researchers have discovered a technique for directly reprogramming skin cells into light-sensing rod photoreceptors used for vision, sidestepping the need for stem cells. The lab-made rods enabled blind mice to detect light after the cells were transplanted into the animals’ eyes.
Henry J. Klassen, MD, PhD, professor and director of the Stem Cell and Retinal Generation Program at the UCI School of Medicine, Gavin Herbert Eye Institute, and founder of jCyte, Inc., was awarded a $6.6 million dollar grant from the California Institute for Regenerative Medicine (CIRM) for a clinical trial targeting retinitis pigmentosa (RP).
UC San Diego and Space Tango received a NASA award to develop the first dedicated stem cell research laboratory within the International Space Station.
Early on in each cell, a critical protein known as FoxA2 simultaneously binds to both the chromosomal proteins and the DNA, opening the flood gates for gene activation, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania. The discovery, published in Nature Genetics, helps untangle mysteries of how embryonic stem cells develop into organs.
Bioengineers have created a 3D-printed scaffold designed to regenerate complex tissues composed of multiple layers of cells with different biological and mechanical properties.
Mayo Clinic researchers have uncovered stem cell-activated mechanisms of healing after a heart attack. Stem cells restored cardiac muscle back to its condition before the heart attack, in turn providing a blueprint of how stem cells may work.
Researchers from seven institutions team up to create a device combining artificial intelligence, bioelectronics and regenerative medicine for regrowing muscle tissue, especially after combat injuries.
Johns Hopkins Medicine scientists say they have successfully turned back the biological hands of time, coaxing adult human cells in the laboratory to revert to a primitive state, and unlocking their potential to replace and repair damage to blood vessels in the retina caused by diabetes. The findings from this experimental study, they say, advance regenerative medicine techniques aimed at reversing the course of diabetic retinopathy and other blinding eye diseases.
Based on proof-of-concept results from clinical trials at University of North Carolina Lineberger Comprehensive Cancer Center and Baylor College of Medicine, an investigational cellular immunotherapy for Hodgkin lymphoma has received a Regenerative Medicine Advanced Therapy designation from the U.S. Food and Drug Administration.
Researchers will use a combination of approaches involving bioelectronic devices, machine learning, and regenerative medicine in an effort to achieve precise control over the physiological processes involved in wound healing.
Researchers at the Icahn School of Medicine at Mount Sinai have discovered a novel combination of two classes of drugs that, together, cause the highest rate of proliferation ever observed in adult human beta cells—the cells in the pancreas that produce insulin—without harming most other cells in the body. The result is an important step toward a diabetes treatment that restores the body’s ability to produce insulin.
Mayo Clinic研究人员发现，一种分子开关能在动物体内启动一种物质，从而修复多发性硬化症等疾病中的神经损伤。在动物模型中进行的早期研究有望推动这一已获得美国食品药品监督管理局批准的疗法，同时还可能促成治疗中枢神经系统疾病的新策略。
Rutgers biomedical engineers have developed a “bio-ink” for 3D printed materials that could serve as scaffolds for growing human tissues to repair or replace damaged ones in the body. Their study was published in the journal Biointerphases.
Platelet microparticles are an effective way to deliver therapeutic drugs directly to the heart following a heart attack.
Researchers have discovered that the brains of developing embryos provide signals to a nascent immune system that help it ward off infections and significantly improve the embryo’s ability to survive a bacterial challenge. Viable brainless frog embryos can survive for some time, but exhibit chaotic and ineffective responses.
Granulocyte colony-stimulating factor (GCSF) is currently used to treat neutropenia due to chemotherapy and has been successfully used for patients who require bone marrow transplants. The study is the first to report on the neuroprotective effect of GCSF in vivo and showed that it improved neurological deficits that occur in the first few days following cerebral ischemia. GCSF improved long-term behavioral outcomes while also stimulating a neural progenitor recovery response in a mouse model.
People who develop Parkinson's disease before age 50 may have been born with disordered brain cells that went undetected for decades, according to EMBARGOED Cedars-Sinai research that will publish Jan. 27 in the journal Nature Medicine. The research points to a drug that potentially might help correct these disease processes.
University of Pittsburgh researchers have created a biodegradable nerve guide – a polymer tube – filled with growth-promoting protein that can regenerate long sections of damaged nerves, without the need for transplanting stem cells or a donor nerve.
Scientists present brain-imaging data for a new stroke treatment that supported full recovery in swine, modeled with the same pattern of neurodegeneration as seen in humans with severe stroke.
A molecular switch has the ability to turn on a substance in animals that repairs neurological damage in disorders such as multiple sclerosis (MS), Mayo Clinic researchers discovered.
Wake Forest Institute for Regenerative Medicine (WFIRM) scientists are the first to report using bioprinting to print a tracheal tissue construct comprised of multiple different functional materials.
Stem cells derived from a patient's own fat offer a step toward improving — not just stabilizing — motor and sensory function of people with spinal cord injuries, according to early research from Mayo Clinic.
Mayo Clinic's Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome (HLHS) and Children's of Alabama announce their collaboration within a consortium to provide solutions for patients with hypoplastic left heart syndrome, a rare and complex form of congenital heart disease in which the left side of the heart is severely underdeveloped.
The University of Arkansas at Little Rock announced a $750,000 grant from the U.S. Department of Defense to support the development of potentially life-saving bone regeneration technology during a Nov. 15 visit from Sen. John Boozman. The visit celebrated on-campus research initiatives that the senator championed for federal support.
A recent study published in Muscle & Nerve appears to show that needle electromyography can play a major role in reinnervation in face transplantation.
GRAND RAPIDS, Mich. (Nov. 6, 2019) — Scientists have devised a technique to sort out which heart cells can replicate and which cannot, a critical step toward treatments that may one day help the heart heal itself after injury.
Three researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received awards totaling more than $18 million from the California Institute for Regenerative Medicine, the state’s stem cell agency.
A new type of micromotor—powered by ultrasound and steered by magnets—can move around individual cells and microscopic particles in crowded environments without damaging them. In one demonstration, a micromotor pushed around silica particles to spell out letters. Researchers also controlled the micromotors to climb up microsized blocks and stairs, demonstrating their ability to move over three dimensional obstacles.
Magnetogenetics — the idea that you can use magnetic fields to control cells and activate cellular pathways — has immense potential in biomanufacturing, medicine, tissue regeneration, and biosensing. Despite its promise, the mechanism behind magnetogenetics remains largely unknown.
In a media roundtable at 11 a.m. U.S. Central on Tuesday, October 15, leading neuroscientists will summarize key science being presented at the American Neurological Association’s 2019 Annual Meeting (ANA2019). Reporters may attend in person or dial in.
Contrary to popular belief, cartilage in human joints can repair itself through a process similar to that used by creatures such as salamanders and zebrafish to regenerate limbs, researchers at Duke Health found.
The California Institute for Regenerative Medicine (CIRM) has awarded a $4.96 million grant to Sanford Burnham Prebys Professor Evan Y. Snyder, M.D., Ph.D. The funding will allow Snyder to complete pre-investigational new drug (IND)-enabling studies, a step toward securing U.S. Food & Drug Administration (FDA) approval of a human trial for neural stem cells as a potential treatment for newborns who experience oxygen and blood-flow deprivation during birth. Called perinatal hypoxic-ischemic brain injury (HII), the lack of oxygen and blood flow to the brain can cause cerebral palsy and other permanent neurological disorders.
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