Feature Channels: Regenerative Medicine

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Released: 13-Jul-2020 9:00 AM EDT
Alliance for Regenerative Rehabilitation and Training Receives $5 Million NIH Grant to Continue Innovative Work
Health Sciences at the University of Pittsburgh

The National Institutes of Health has renewed a five-year grant for $5 million for the Alliance for Regenerative Rehabilitation and Training (AR3T) to continue its work expanding scientific knowledge, expertise and methodologies focused on science and regenerative medicine.

Newswise: University of Miami Miller School-led technology paves way for islet regeneration in human pancreas
Released: 8-Jul-2020 3:50 PM EDT
University of Miami Miller School-led technology paves way for islet regeneration in human pancreas
University of Miami Health System, Miller School of Medicine

New research published in Nature Communications uses a technology first developed at the University of Miami Miller School of Medicine to enhance the oxygenation of cultured tissues that will likely be able to conduct real-time regeneration and development studies in the human pancreas.

Newswise: How the body regulates scar tissue growth after heart attacks
Released: 3-Jul-2020 11:35 AM EDT
How the body regulates scar tissue growth after heart attacks
University of California, Los Angeles (UCLA), Health Sciences

New UCLA research conducted in mice could explain why some people suffer more extensive scarring than others after a heart attack. The study, published in the journal Cell, reveals that a protein known as type 5 collagen plays a critical role in regulating the size of scar tissue in the heart.

Newswise: WFIRM Scientists Prove Bioengineered Uteri Support Pregnancy
25-Jun-2020 1:00 PM EDT
WFIRM Scientists Prove Bioengineered Uteri Support Pregnancy
Wake Forest Baptist Health

WFIRM scientists were able to show that bioengineered uteri in an animal model developed the native tissue-like structures needed to support normal reproductive function.

Newswise: National Eye Institute establishes office of regenerative medicine
Released: 18-Jun-2020 10:20 AM EDT
National Eye Institute establishes office of regenerative medicine
NIH, National Eye Institute (NEI)

The National Eye Institute (NEI) has established an office to accelerate progress in regenerative medicine for eye disease and vision disorders.

Newswise: Putting “Super” in Natural Killer Cells
Released: 11-Jun-2020 1:20 PM EDT
Putting “Super” in Natural Killer Cells
University of California San Diego Health

Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells — a type of immune cell — with measurably stronger activity against a form of leukemia, both in vivo and in vitro.

Newswise: Lab-Grown Miniature Human Livers Successfully Transplanted in Rats
28-May-2020 11:00 AM EDT
Lab-Grown Miniature Human Livers Successfully Transplanted in Rats
Health Sciences at the University of Pittsburgh

Using skin cells from human volunteers, researchers at the University of Pittsburgh School of Medicine have created fully functional mini livers, which they then transplanted into rats. In this proof-of-concept experiment, the lab-made organs survived for four days inside their animal hosts.

Newswise: Human Growth Hormone Treatment After ACL Injury May Prevent Loss of Muscle Strength
Released: 27-May-2020 4:05 PM EDT
Human Growth Hormone Treatment After ACL Injury May Prevent Loss of Muscle Strength
Michigan Medicine - University of Michigan

A new study finds the use of HGH treatment in patients that have undergone ACL reconstructive surgery may prevent the loss of muscle strength and weakness.

Newswise: Rejuvenated fibroblasts can recover the ability to contract
Released: 26-May-2020 9:00 AM EDT
Rejuvenated fibroblasts can recover the ability to contract
National University of Singapore

A recent study from the Mechanobiology Institute at the National University of Singapore has shown that rejuvenated fibroblasts can recover their ability to self-contract. This encouraging discovery holds great potential for applications in regenerative medicine and stem cell engineering.

Released: 26-May-2020 8:55 AM EDT
Sexton Biotechnologies and Ikeda Scientific Provide Human Platelet Lysate to Japanese Regenerative Medicine Product Manufacturers
Sexton Biotechnologies

Sexton Biotechnologies pathogen reduced hPL confirmed by PMDA as human derived raw material for regen med products.

Newswise: Hackensack Meridian Health Invests in EpiBone, Inc., 
A Regenerative Medicine Company
Released: 19-May-2020 10:50 AM EDT
Hackensack Meridian Health Invests in EpiBone, Inc., A Regenerative Medicine Company
Hackensack Meridian Health

EpiBone’s Craniomaxillofacial, or EB-CMF, product is a living, anatomically correct bone graft made from a patient’s own fat-derived stem cells.

Newswise: Scientists show MRI predicts the efficacy of a stem cell therapy for brain injury
11-May-2020 12:45 PM EDT
Scientists show MRI predicts the efficacy of a stem cell therapy for brain injury
Sanford Burnham Prebys Medical Discovery Institute

Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve efficacy. The study was published in Cell Reports.

Newswise: UCLA scientists create first roadmap of human skeletal muscle development
Released: 11-May-2020 12:15 PM EDT
UCLA scientists create first roadmap of human skeletal muscle development
University of California, Los Angeles (UCLA), Health Sciences

An interdisciplinary team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA has developed a first-of-its-kind roadmap of how human skeletal muscle develops, including the formation of muscle stem cells.

Newswise: Gene therapy in mice builds muscle, reduces fat
6-May-2020 4:45 PM EDT
Gene therapy in mice builds muscle, reduces fat
Washington University in St. Louis

A new study in mice at Washington University School of Medicine in St. Louis suggests gene therapy one day may help build muscle and relieve pain in overweight patients with osteoarthritis.

Released: 8-May-2020 12:30 PM EDT
Growing back the lymph system
University of Georgia

Study provides hope for cancer-related lymphedema

Released: 23-Apr-2020 4:45 PM EDT
Pesquisa da Mayo Clinic descobre como as células-tronco reparam danos causados por ataques cardíacos
Mayo Clinic

Pesquisadores da Mayo Clinic descobriram mecanismos de cura ativados por células-tronco após um ataque cardíaco. As células-tronco restauraram o músculo cardíaco devolvendo-o ao seu estado anterior ao ataque cardíaco, fornecendo um esquema sobre como as células-tronco podem funcionar.

Newswise: Cedars-Sinai Looks to Space for Tomorrow's Stem Cell Therapies
Released: 17-Apr-2020 9:00 AM EDT
Cedars-Sinai Looks to Space for Tomorrow's Stem Cell Therapies
Cedars-Sinai

Is the future of personalized medicine out of this world? Cedars-Sinai is trying to find out by launching special stem cells into space to see if they multiply better there. The Cedars-Sinai Board of Governors Regenerative Medicine Institute is partnering with Space Tango of Lexington, Kentucky, to send induced pluripotent stem cells (iPSCs) to the International Space Station. The first flight for the project, funded by a $1.5 million award from NASA, could occur as early as next year.

Newswise: Researchers restore sight in mice by turning skin cells into light-sensing eye cells
14-Apr-2020 6:25 PM EDT
Researchers restore sight in mice by turning skin cells into light-sensing eye cells
NIH, National Eye Institute (NEI)

Researchers have discovered a technique for directly reprogramming skin cells into light-sensing rod photoreceptors used for vision, sidestepping the need for stem cells. The lab-made rods enabled blind mice to detect light after the cells were transplanted into the animals’ eyes.

Newswise: UCI clinical trial targeting retinitis pigmentosa receives $6.6M grant from California Institute for Regenerative Medicine
Released: 13-Apr-2020 3:55 PM EDT
UCI clinical trial targeting retinitis pigmentosa receives $6.6M grant from California Institute for Regenerative Medicine
University of California, Irvine

Henry J. Klassen, MD, PhD, professor and director of the Stem Cell and Retinal Generation Program at the UCI School of Medicine, Gavin Herbert Eye Institute, and founder of jCyte, Inc., was awarded a $6.6 million dollar grant from the California Institute for Regenerative Medicine (CIRM) for a clinical trial targeting retinitis pigmentosa (RP).

Newswise: UC San Diego to Advance Stem Cell Therapies in New Space Station Lab
Released: 8-Apr-2020 3:45 PM EDT
UC San Diego to Advance Stem Cell Therapies in New Space Station Lab
University of California San Diego Health

UC San Diego and Space Tango received a NASA award to develop the first dedicated stem cell research laboratory within the International Space Station.

Released: 18-Mar-2020 1:05 PM EDT
How “Pioneer” Protein Turns Stem Cells into Organs
Perelman School of Medicine at the University of Pennsylvania

Early on in each cell, a critical protein known as FoxA2 simultaneously binds to both the chromosomal proteins and the DNA, opening the flood gates for gene activation, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania. The discovery, published in Nature Genetics, helps untangle mysteries of how embryonic stem cells develop into organs.

Newswise: Leveraging layers for enhanced tissue repair
Released: 16-Mar-2020 12:55 PM EDT
Leveraging layers for enhanced tissue repair
National Institute of Biomedical Imaging and Bioengineering

Bioengineers have created a 3D-printed scaffold designed to regenerate complex tissues composed of multiple layers of cells with different biological and mechanical properties.

Released: 12-Mar-2020 4:25 PM EDT
Mayo Clinic research discovers how stem cells repair damage from heart attacks
Mayo Clinic

Mayo Clinic researchers have uncovered stem cell-activated mechanisms of healing after a heart attack. Stem cells restored cardiac muscle back to its condition before the heart attack, in turn providing a blueprint of how stem cells may work.

Newswise: DARPA Awards $22 Million to Create ‘Smart’ Device for Healing Large Muscle Wounds
Released: 11-Mar-2020 9:00 AM EDT
DARPA Awards $22 Million to Create ‘Smart’ Device for Healing Large Muscle Wounds
Health Sciences at the University of Pittsburgh

Researchers from seven institutions team up to create a device combining artificial intelligence, bioelectronics and regenerative medicine for regrowing muscle tissue, especially after combat injuries.

Newswise: ‘Primitive’ Stem Cells Shown to Regenerate Blood Vessels in The Eye
Released: 9-Mar-2020 9:00 AM EDT
‘Primitive’ Stem Cells Shown to Regenerate Blood Vessels in The Eye
Johns Hopkins Medicine

Johns Hopkins Medicine scientists say they have successfully turned back the biological hands of time, coaxing adult human cells in the laboratory to revert to a primitive state, and unlocking their potential to replace and repair damage to blood vessels in the retina caused by diabetes. The findings from this experimental study, they say, advance regenerative medicine techniques aimed at reversing the course of diabetic retinopathy and other blinding eye diseases.

Newswise: CAR-T immunotherapy for lymphoma studied at UNC Lineberger receives fast-track designation from FDA
Released: 9-Mar-2020 8:00 AM EDT
CAR-T immunotherapy for lymphoma studied at UNC Lineberger receives fast-track designation from FDA
University of North Carolina Health Care System

Based on proof-of-concept results from clinical trials at University of North Carolina Lineberger Comprehensive Cancer Center and Baylor College of Medicine, an investigational cellular immunotherapy for Hodgkin lymphoma has received a Regenerative Medicine Advanced Therapy designation from the U.S. Food and Drug Administration.

Released: 27-Feb-2020 11:05 AM EST
UC Santa Cruz leads collaboration to speed wound healing with a novel smart bandage
University of California, Santa Cruz

Researchers will use a combination of approaches involving bioelectronic devices, machine learning, and regenerative medicine in an effort to achieve precise control over the physiological processes involved in wound healing.

Newswise:Video Embedded mount-sinai-discovers-new-drug-combo-to-induce-high-rates-of-human-beta-cell-regeneration
VIDEO
9-Feb-2020 7:05 PM EST
Mount Sinai Discovers New Drug Combo to Induce High Rates of Human Beta Cell Regeneration
Mount Sinai Health System

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a novel combination of two classes of drugs that, together, cause the highest rate of proliferation ever observed in adult human beta cells—the cells in the pancreas that produce insulin—without harming most other cells in the body. The result is an important step toward a diabetes treatment that restores the body’s ability to produce insulin.

Released: 12-Feb-2020 8:50 AM EST
Mayo Clinic研究发现了一种修复中枢神经系统疾病的分子开关
Mayo Clinic

Mayo Clinic研究人员发现,一种分子开关能在动物体内启动一种物质,从而修复多发性硬化症等疾病中的神经损伤。在动物模型中进行的早期研究有望推动这一已获得美国食品药品监督管理局批准的疗法,同时还可能促成治疗中枢神经系统疾病的新策略。

Newswise: Superior “Bio-Ink” for 3D Printing Pioneered
Released: 10-Feb-2020 2:05 PM EST
Superior “Bio-Ink” for 3D Printing Pioneered
Rutgers University-New Brunswick

Rutgers biomedical engineers have developed a “bio-ink” for 3D printed materials that could serve as scaffolds for growing human tissues to repair or replace damaged ones in the body. Their study was published in the journal Biointerphases.

Released: 5-Feb-2020 2:55 PM EST
Platelet Microparticles Give Antibody Drug ‘Piggyback Ride’ to Repair Damaged Heart
North Carolina State University

Platelet microparticles are an effective way to deliver therapeutic drugs directly to the heart following a heart attack.

Newswise: Brain Links to Embryonic Immunity, Guiding Response of The
30-Jan-2020 4:25 PM EST
Brain Links to Embryonic Immunity, Guiding Response of The "Troops" That Battle Infection
Tufts University

Researchers have discovered that the brains of developing embryos provide signals to a nascent immune system that help it ward off infections and significantly improve the embryo’s ability to survive a bacterial challenge. Viable brainless frog embryos can survive for some time, but exhibit chaotic and ineffective responses.

Newswise: Study Reveals New Way to Treat Stroke Using an Already FDA-Approved Drug
Released: 29-Jan-2020 8:30 AM EST
Study Reveals New Way to Treat Stroke Using an Already FDA-Approved Drug
Florida Atlantic University

Granulocyte colony-stimulating factor (GCSF) is currently used to treat neutropenia due to chemotherapy and has been successfully used for patients who require bone marrow transplants. The study is the first to report on the neuroprotective effect of GCSF in vivo and showed that it improved neurological deficits that occur in the first few days following cerebral ischemia. GCSF improved long-term behavioral outcomes while also stimulating a neural progenitor recovery response in a mouse model.

Newswise: Parkinson's Disease May Start Before Birth
24-Jan-2020 2:05 PM EST
Parkinson's Disease May Start Before Birth
Cedars-Sinai

People who develop Parkinson's disease before age 50 may have been born with disordered brain cells that went undetected for decades, according to EMBARGOED Cedars-Sinai research that will publish Jan. 27 in the journal Nature Medicine. The research points to a drug that potentially might help correct these disease processes.

Newswise:Video Embedded researchers-regrow-damaged-nerves-with-polymer-and-protein
VIDEO
17-Jan-2020 7:00 PM EST
Researchers Regrow Damaged Nerves with Polymer and Protein
Health Sciences at the University of Pittsburgh

University of Pittsburgh researchers have created a biodegradable nerve guide – a polymer tube – filled with growth-promoting protein that can regenerate long sections of damaged nerves, without the need for transplanting stem cells or a donor nerve.

Newswise: Exosomes promote remarkable recovery in stroke
Released: 14-Jan-2020 1:40 PM EST
Exosomes promote remarkable recovery in stroke
University of Georgia

Scientists present brain-imaging data for a new stroke treatment that supported full recovery in swine, modeled with the same pattern of neurodegeneration as seen in humans with severe stroke.

Released: 10-Jan-2020 11:25 AM EST
Mayo Clinic research discovers a molecular switch for repairing central nervous system disorders
Mayo Clinic

A molecular switch has the ability to turn on a substance in animals that repairs neurological damage in disorders such as multiple sclerosis (MS), Mayo Clinic researchers discovered.

Newswise: WFIRM Scientists Push Bioprinting Capability Forward
Released: 4-Dec-2019 3:05 PM EST
WFIRM Scientists Push Bioprinting Capability Forward
Wake Forest Baptist Health

Wake Forest Institute for Regenerative Medicine (WFIRM) scientists are the first to report using bioprinting to print a tracheal tissue construct comprised of multiple different functional materials.

Released: 27-Nov-2019 9:35 AM EST
Case report: Stem cells a step toward improving motor, sensory function after spinal cord injury
Mayo Clinic

Stem cells derived from a patient's own fat offer a step toward improving — not just stabilizing — motor and sensory function of people with spinal cord injuries, according to early research from Mayo Clinic.

Released: 25-Nov-2019 10:40 AM EST
Mayo Clinic, Children's of Alabama announce rare congenital heart defect collaboration
Mayo Clinic

Mayo Clinic's Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome (HLHS) and Children's of Alabama announce their collaboration within a consortium to provide solutions for patients with hypoplastic left heart syndrome, a rare and complex form of congenital heart disease in which the left side of the heart is severely underdeveloped.

Newswise: UA Little Rock announces $750,000 grant for groundbreaking bone regeneration technology
Released: 22-Nov-2019 9:55 AM EST
UA Little Rock announces $750,000 grant for groundbreaking bone regeneration technology
University of Arkansas at Little Rock

The University of Arkansas at Little Rock announced a $750,000 grant from the U.S. Department of Defense to support the development of potentially life-saving bone regeneration technology during a Nov. 15 visit from Sen. John Boozman. The visit celebrated on-campus research initiatives that the senator championed for federal support.

Released: 20-Nov-2019 4:10 PM EST
Study Provides Insight to Role of Needle EMG in Face Transplantation
American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM)

A recent study published in Muscle & Nerve appears to show that needle electromyography can play a major role in reinnervation in face transplantation.

Newswise: New technique lays foundation for regenerative cardiac therapies
Released: 6-Nov-2019 2:00 PM EST
New technique lays foundation for regenerative cardiac therapies
Van Andel Institute

GRAND RAPIDS, Mich. (Nov. 6, 2019) — Scientists have devised a technique to sort out which heart cells can replicate and which cannot, a critical step toward treatments that may one day help the heart heal itself after injury.

Newswise: Three UCLA scientists receive grants totaling more than $18 million
Released: 31-Oct-2019 3:25 PM EDT
Three UCLA scientists receive grants totaling more than $18 million
University of California, Los Angeles (UCLA), Health Sciences

Three researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received awards totaling more than $18 million from the California Institute for Regenerative Medicine, the state’s stem cell agency.

Newswise:Video Embedded micromotors-push-around-single-cells-and-particles
VIDEO
23-Oct-2019 3:10 PM EDT
Micromotors push around single cells and particles
University of California San Diego

A new type of micromotor—powered by ultrasound and steered by magnets—can move around individual cells and microscopic particles in crowded environments without damaging them. In one demonstration, a micromotor pushed around silica particles to spell out letters. Researchers also controlled the micromotors to climb up microsized blocks and stairs, demonstrating their ability to move over three dimensional obstacles.

Newswise: Uncovering the Mechanisms Behind Magnetogenetics Could Advance Biomanufacturing
Released: 17-Oct-2019 10:00 AM EDT
Uncovering the Mechanisms Behind Magnetogenetics Could Advance Biomanufacturing
Rensselaer Polytechnic Institute (RPI)

Magnetogenetics — the idea that you can use magnetic fields to control cells and activate cellular pathways — has immense potential in biomanufacturing, medicine, tissue regeneration, and biosensing. Despite its promise, the mechanism behind magnetogenetics remains largely unknown.

Released: 10-Oct-2019 4:45 PM EDT
Dial In to the Cutting-edge Neuroscience at ANA2019 during the October 15 Media Roundtable
American Neurological Association (ANA)

In a media roundtable at 11 a.m. U.S. Central on Tuesday, October 15, leading neuroscientists will summarize key science being presented at the American Neurological Association’s 2019 Annual Meeting (ANA2019). Reporters may attend in person or dial in.

Newswise: Humans Have Salamander-Like Ability to Regrow Cartilage in Joints
Released: 9-Oct-2019 2:00 PM EDT
Humans Have Salamander-Like Ability to Regrow Cartilage in Joints
Duke Clinical Research Institute

Contrary to popular belief, cartilage in human joints can repair itself through a process similar to that used by creatures such as salamanders and zebrafish to regenerate limbs, researchers at Duke Health found.

Newswise: $4.96 Million CIRM Grant Awarded to Sanford Burnham Prebys to Help the Tiniest Patients
Released: 19-Aug-2019 8:00 AM EDT
$4.96 Million CIRM Grant Awarded to Sanford Burnham Prebys to Help the Tiniest Patients
Sanford Burnham Prebys Medical Discovery Institute

The California Institute for Regenerative Medicine (CIRM) has awarded a $4.96 million grant to Sanford Burnham Prebys Professor Evan Y. Snyder, M.D., Ph.D. The funding will allow Snyder to complete pre-investigational new drug (IND)-enabling studies, a step toward securing U.S. Food & Drug Administration (FDA) approval of a human trial for neural stem cells as a potential treatment for newborns who experience oxygen and blood-flow deprivation during birth. Called perinatal hypoxic-ischemic brain injury (HII), the lack of oxygen and blood flow to the brain can cause cerebral palsy and other permanent neurological disorders.


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