For the first time, researchers at University of California San Diego have used rapid 3D printing technologies to create a spinal cord, then successfully implanted that scaffolding, loaded with neural stem cells, into sites of severe spinal cord injury in rats.
The collaborative research between the Kornberg School of Dentistry and the College of Engineering uses stem cells to regrow the pulp-dentin complex that makes up the center of a tooth.
Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered that squamous cell skin cancers do not require increased glucose to power their development and growth, contrary to a long-held belief about cancer metabolism. The findings could bring about a better understanding of many cancers' metabolic needs and lead to the development of more effective therapies for squamous cell skin cancer and other forms of epithelial cancer.
A special edition of National Geographic on "The Future of Medicine" highlights the innovative stem-cell science of Cedars-Sinai, showing how investigators are seeking to use stem cells and Organ-Chips to tailor personalized treatments for individual patients. Downloadable video available.
Hackensack Meridian Health Hackensack University Medical Center recently held the third annual Blood and Marrow Transplant (BMT) RN Fellowship Graduation Ceremony for nine registered nurses. The nurses are from 8PE and 8PW Blood and Marrow Transplant (BMT) units.
In experiments in rats and human cells, Johns Hopkins Medicine researchers say they have added to evidence that a cellular protein signal that drives both bone and fat formation in selected stem cells can be manipulated to favor bone building.
UC San Diego researchers have found a stem cell enzyme copy edits more than 20 tumor types, providing new therapeutic target for preventing cancer cell resistance to chemotherapy and radiation.
The healing of wounded skin in diabetes can be sped up by more than 50 percent using injections of stem cells taken from bone marrow, a new study in mice shows.
About 3.4 million Americans, or 1.2 percent of the population, have active epilepsy. Although the majority respond to medication, between 20 and 40 percent of patients with epilepsy continue to have seizures even after trying multiple anti-seizure drugs.
A team of Rutgers scientists have taken an important step toward the goal of making diseased hearts heal themselves – a new model that would reduce the need for bypass surgery, heart transplants or artificial pumping devices.
A new study by UCLA scientists shows that enhancers, snippets of DNA that contribute to gene regulation, fall into the same “insulated neighborhoods” or chromatin loops as the target gene and other gene-specific regulatory elements.
In an effort to better understand frontotemporal dementia, an international team of researchers, led by Washington University School of Medicine in St. Louis, has found that a lone mutation in a single gene that causes an inherited form of the disorder makes it harder for neurons in the brain to communicate with one another, leading to neurodegeneration.
A company in Israel has unveiled the world’s first lab-grown steak, grown in a petri dish with the taste and texture of one that comes from a cow. Jan Dutkiewicz, a postdoctoral fellow in political science at Johns Hopkins University has researched the emergence of cellular agriculture. He is available to talk about the new steak and offer perspective on the development.
Summaries of recent Fred Hutch research with links for additional background and media contacts.
Duke Health researchers have previously shown that introducing bone marrow stem cells to a bone injury can expedite healing, but the exact process was unclear. Now, the same Duke-led team believes it has pinpointed the “youth factor” inside bone marrow stem cells -- it’s the macrophage, a type of white blood cell, and the proteins it secretes that can have a rejuvenating effect on tissue. Nature Communications will publish the findings online on Dec. 5.
The National Eye Institute (NEI) awarded $25,000 to a team led by Wei Liu, Ph.D., Albert Einstein College of Medicine, for demonstrating progress toward the development of a living model of the human retina, the light-sensitive tissue at the back of the eye. The prize money was awarded for the first of two phases of the NEI 3-D Retina Organoid Challenge 2020 (3-D ROC 2020), a national initiative to generate human retina organoids from stem cells. NEI is part of the National Institutes of Health.
Umbilical cord blood stem cells that are cultured and expanded outside the body before being used for bone marrow transplant in adult blood cancer patients appear safe and restore blood count recovery faster than standard cord blood. The findings, led by a Duke Cancer Institute researcher, advance efforts to improve cord blood use among adults who have been diagnosed with blood cancers.
An international phase-2 trial of a CAR-T cell therapy—to be published on-line Dec. 1 in the New England Journal of Medicine (and presented at the ASH annual meeting in San Diego)—found that 52% of patients responded favorably to the therapy; 40% had a complete response and 12% had a partial response. One year later, 65% of those patients were relapse-free, including 79% of complete responders. The median progression-free survival “has not been reached.”
MSK experts in CAR-T therapy, immunotherapy, leukemia, lymphoma, blood and marrow stem cell transplantation, and more, are also available to comment on meeting news.
A material based on a natural product of bones and citrus fruits, called citrate, provides the extra energy stem cells need to form new bone tissue, according to a team of Penn State bioengineers.
A protein found in healing muscles of younger mice helps older animals bounce back from injury.
The American College of Rheumatology (ACR) welcomes members of the press to write about rheumatology research presented the Winter Rheumatology Symposium in Snowmass Village, CO on January 26 to February 1, 2019.
New research has identified rogue cells – namely brain and muscle cells – lurking within kidney organoids. The presence of such cells indicates that the “recipes” used to coax stem cells into becoming kidney cells inadvertently are churning out other cell types.
University of Nebraska Medical Center leading national team to determine if ruxolitinib is effective for treating a certain type of graft versus host disease (GVHD) called sclerotic. The grant is funded by Incyte, a global biopharmaceutical company.
A crowdfunding campaign launched today (Tuesday 13 November) by the University of Adelaide aims to help save the Tasmanian devil, one of Australia’s most iconic but endangered animals.
CU Cancer Center study shows that cancer stem cells switch from metabolizing sugar to metabolizing protein. Turning off protein metabolism kills these cells.
An international team led by Montreal researchers discovers two proteins essential to the development of skeletal muscle.
With their new finding, Canadian scientists urge revision of decades-old dogma on protein synthesis
A Rutgers Cancer Institute of New Jersey researcher has received a $150,000 grant from the Lung Cancer Research Foundation to investigateautophagy in the development of lung cancers driven by mutations in tumor suppressors known as LKB1 and oncogene KRAS.
Rutgers scientists have created a tiny, biodegradable scaffold to transplant stem cells and deliver drugs, which may help treat Alzheimer’s and Parkinson’s diseases, aging brain degeneration, spinal cord injuries and traumatic brain injuries. Stem cell transplantation, which shows promise as a treatment for central nervous system diseases, has been hampered by low cell survival rates, incomplete differentiation of cells and limited growth of neural connections.
A paper published today (Nov. 1, 2018) in the journal Cell Stem Cell describes the global scope and economic impact of stem cell science, including the clinical, industrial and research use of the cells.
A study from Washington University School of Medicine in St. Louis offers a potential explanation for why many AML patients experience a relapse after a stem cell transplant, and suggests a therapeutic approach that may help to place relapsed patients back into remission.
Skeletal stem cells are valuable because it's thought they can heal many types of bone injury, but they're difficult to find because researchers don't know exactly what they look like or where they live.
In a study published online today by the journal Immunity, scientists at Dana-Farber Cancer Institute, Harvard Medical School, Vanderbilt University and colleagues at other institutions show how machinery within immune system T cells responds to outside signals and activates the cells to attack cancerous, infected, or otherwise diseased cells.
Iowa State University veterinary researchers are working with the Food and Drug Administration to advance an innovative in vitro model to study the oral absorption of therapeutic drugs without requiring testing on live animals. The work could lead to more efficient and safer development of new therapies for human and animal medicine.
Researchers at the University of Notre Dame studying tumors in prostate cancer models found that nitration of an amino acid can inhibit T-cell activation, thwarting the T-cell’s ability to kill cancer cells.
A team of ophthalmologists went looking for scientific evidence in support of commercially available “cell therapy” for eye diseases. Not only did they find virtually none; they instead discovered a growing number of patients are being irreparably harmed by unapproved cell therapies.
Insoo Hyun, PhD, and colleagues will identify ways of improving existing guidelines and ensuring professional accountability and responsibility in human-animal chimera research. The interdisciplinary bioethics project is supported by a three-year, $1.5 million grant from the National Human Genome Research Institute of the National Institutes of Health.
The National Stem Cell Foundation (NSCF), Summit for Stem Cell Foundation, The New York Stem Cell Foundation (NYSCF) Research Institute, and Space Tango today announced a bi-coastal research collaboration to study Parkinson's disease (PD) and primary progressive multiple sclerosis (PPMS) in microgravity.
A new method developed at Cedars-Sinai may revolutionize how severe injuries are treated by harnessing stem cells to regrow tissue damaged by major trauma, such as traffic accidents or war injuries.
Embargoed abstracts to be presented at the American Neurological Association’s 143rd Annual Meeting October 21-23, 2018 at the Hyatt Regency Atlanta are now available to journalists upon request.
New research at the 2018 ACR/ARHP Annual Meeting builds on current evidence that hematopoietic stem cell transplantation can significantly improve long-term outcomes for patients with severe scleroderma when compared to use of conventional treatment with cyclophosphamide.
Hematopoietic stem cell transplantation showed benefit in a subset of patients with systemic sclerosis who tend not to improve on immunosuppressive therapies like mycophenolate mofetil, according to new research findings presented this week at the 2018 ACR/ARHP Annual Meeting.
Vascular ultrasound is sensitive enough to use as a first-line imaging test in patients suspect to have giant cell arteritis, according to new research findings presented this week at the 2018 ACR/ARHP Annual Meeting.
Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and the Stein Eye Institute have been awarded a $5.1 million grant from the California Institute for Regenerative Medicine to advance the development of a novel therapy for blinding retinal conditions.
A team of Tufts University-led researchers has developed three-dimensional (3D) human tissue culture models for the central nervous system that mimic structural and functional features of the brain and demonstrate neural activity sustained over a period of many months.
Using a combination of computational modeling and experimental techniques, a research team has developed new information about how intercellular communication affects the differentiation of an embryonic stem cell colony over time.
UT Southwestern Professor Dr. Sean Morrison, Director of the Children’s Medical Center Research Institute (CRI) at UT Southwestern, has been elected to the National Academy of Medicine (NAM), one of the highest honors in the fields of health and medicine.
Led by Andreas H. Gomoll, MD, sports medicine surgeon at Hospital for Special Surgery (HSS), the study is looking at the effects on knee function of ReNu, an allograft product composed of human amniotic membrane and cells from the amniotic fluid.
University of Colorado Cancer Center study shows that "normal" gene CDK1 interacts with "abnormal" gene Sox2 to keep cancer stem cells "stemmy."
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