Feature Channels: Transplantation

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Here are some of the latest articles that have been added to the Drug Resistance channel on Newswise, a free source for journalists.

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A Roundup of the Latest Medical Discoveries and Faculty News at Cedars-Sinai

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Physicians and researchers from UK HealthCare's Transplant Center and the University of Kentucky Markey Cancer Center conducted a study of patients over the age of 70 with a type of liver cancer called hepatocellular carcinoma (HCC) and how the outcomes of ablative treatments compare to liver transplants. The findings were published in the May 2022 issue of the Journal of the American College of Surgeons.

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• Kidney transplant recipients typically take the immunosuppressant drug tacrolimus to prevent rejection, and some patients experience large fluctuations in blood levels of tacrolimus even when the dose is unchanged. • In a recent study, pediatric kidney transplant recipients with such variability had higher risks of developing antibodies against the transplanted kidney, putting them at risk of rejection.

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The Organ Transplantation Division at Hackensack Meridian Hackensack University Medical Center, one of only a few certified transplant centers in New Jersey, is bringing its world-class services to satellite locations in the central and southern regions of New Jersey. Consultations, testing and follow up care of transplants are now available at Jersey Shore University Medical Center in Neptune and JFK University Medical Center in Edison.

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Adding immunotherapy to standard anti-rejection medication could change the lives of thousands of kidney transplant patients with incurable cancer, as new research shows it can reduce this risk of organ rejection and eliminate cancer in a quarter of patients.

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No more packing donor lungs on ice. UChicago Medicine is deploying a new ice-free, temperature-controlled cold storage cooler to transport donor lungs.

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Cleveland Clinic has successfully performed a first-in-the-world full multi-organ transplant to treat a patient with a rare form of appendix cancer called pseudomyxoma peritonei (PMP). Upon completion of the lifesaving transplant surgery, the patient received five digestive organs.

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Six months ago, University of Maryland School of Medicine surgeon-scientists successfully implanted a genetically modified pig heart into a 57 year-old patient with terminal heart disease in a first-of-its-kind surgery.

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“The potential for xenotransplantation to allow for an unlimited donor supply and resolve the organ shortage is now closer than ever,” according to a new paper published today in JACC: Basic to Translational Science.

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Two physician leaders from the Cedars-Sinai Comprehensive Transplant Center have been honored by two prestigious national groups.

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While many 21-year-olds celebrate their coming of age in bars and nightclubs, Andrew Solis is celebrating freedom by finally going home—equipped with a new heart and liver—after nearly eight months at Cedars-Sinai.

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UC San Francisco’s Cardiovascular team is welcoming two highly regarded cardiac surgeons to its renowned program. The specialists will join the newly formed Advanced Heart Failure Comprehensive Care Center (AHF CCC).

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Patients with multiple myeloma who have been treated with a three-drug combination therapy have a growing number of choices for subsequent treatment. Results of a new study led by researchers at Dana-Farber Cancer Institute can help patients and their physicians weigh benefits and risks of each option.

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Cedars-Sinai clinicians and scientists, including anti-rejection therapy pioneer Stanley Jordan, MD, will share their latest advances in research at the American Transplant Congress (ATC), June 4-8, 2022, in Boston. The ATC is the joint annual meeting of the American Society of Transplant Surgeons and the American Society of Transplantation.

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The Liver4Life research team owes its perfusion machine, which was developed in house, to the fact that it became possible to implant a human organ into a patient after a storage period of three days outside a body.

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MedStar Heart & Vascular Institute has named Thomas E. MacGillivray, MD, as its physician executive director of Cardiac Surgery at MedStar Health, and chairman of Cardiac Surgery at MedStar Washington Hospital Center, effective September 1, 2022.

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A multicenter study performed by a large international consortium that includes UT Southwestern has outlined a set of risk factors and outcomes for patients with autoimmune hepatitis (AIH) that recurs after liver transplantation. The findings, published in the Journal of Hepatology, represent a first step toward better managing and potentially preventing this uncommon condition.

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A national policy change to facilitate the broader sharing of donor livers through “acuity circles” has resulted in procurement delays, according to a researcher at the University of Miami Miller School of Medicine.

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Hackensack University Medical Center surgeon performs kidney donor procedure using a single-incision laparoscopic approach — marking the first time the surgical technique has been used at the hospital.

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A study presented today at the AATS 102nd Annual Meeting reports that intentionally prolonging the cold static preservation (CSP) of a donor lung at 10°C (12-24h) is clinically safe and feasible.

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Stanley C. Jordan, MD, director of the Cedars-Sinai Nephrology and Transplant Immunology programs in the Cedars-Sinai Comprehensive Transplant Center, has been elected to the Association of American Physicians (AAP).

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Researchers at Washington University School of Medicine in St. Louis have received a $6 million grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) to harness new understandings of the immune system to develop innovative therapies for heart failure and the prevention of organ rejection following heart transplantation.

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Young adults who received organ transplants as children may not be regularly attending their doctor appointments after leaving their pediatric providers. Missing these appointments is associated with longer and more frequent hospitalizations and poorer medication adherence, according to a new study.

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Cardiologists and cardiothoracic surgeons from the Smidt Heart Institute at Cedars-Sinai are available to discuss the latest advances in research, clinical care, transcatheter procedures and cardiothoracic surgery throughout the International Society for Heart and Lung Transplantation (ISHLT) Scientific Sessions 2022 and Heart Rhythm 2022.

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“The only way out of this is with new lungs.” That’s what Andy Wilkins and his wife Michelle were told after Andy was hospitalized with COVID-19.

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The risk of major complications for people who donate a kidney via laparoscopic surgery is minimal. That is the conclusion of a 20-year Mayo Clinic study of more than 3,000 living kidney donors. Only 2.5% of patients in the study experienced major complications, and all recovered completely.

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The 2022 Annual Report from the Smidt Heart Institute at Cedars-Sinai is available now, detailing the latest research and medical achievements by the expert team ranked No. 1 for cardiology and cardiac surgery in California by U.S. News & World Report.

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A new initiative called Pluralist will challenge the current paradigm and pursue equity in organ transplantation. The effort will place particular emphasis on communities of color in Sacramento and throughout California by using education intervention tools like social networks and digital media.

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Rutgers Cancer Institute of New Jersey and RWJBarnabas Health have appointed Ira Braunschweig, MD, as chief, Section of Transplant and Cell Therapy at Rutgers Cancer Institute, chief of the Transplant and Cell Therapy Service of the RWJBarnabas Health Oncology Service Line, and director for Cell Therapy and Bone Marrow Transplantation at Robert Wood Johnson University Hospital, an RWJBarnabas facility.

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Development of an implantable artificial heart that operates wirelessly and reliably for 10 years is the goal of an ongoing Penn State College of Medicine project.

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This Donate Life Month, the Nettleton and Conklin families are celebrating nearly 16 years of being family.

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Black kidney transplant recipients have a faster clearance rate of the immunosuppressive drug tacrolimus than white recipients, according to a new study led by the University at Buffalo. The study, published earlier this year in Pharmacotherapy, is one of the first to examine how both race and sex influence tacrolimus pharmacokinetics.

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去年早些时候，Veronica Ciudad-Real被诊断出患有多发性骨髓瘤，一种她从未听说过的血癌，这让她感到非常惊讶和困惑。她才40岁，比该疾病的大多数患者都要年轻。随后她又了解到，在她的祖国萨尔瓦多无法获得她所需的治疗。

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Quando Veronica Ciudad-Real foi diagnosticada no começo do ano passado com mieloma múltiplo, um câncer do sangue do qual ela nunca tinha ouvido falar, ela teve mais perguntas do que respostas. Aos 40 anos, ela era mais jovem do que a maioria das pessoas com essa doença.

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Cuando Verónica Ciudad-Real recibió a principios del año el diagnóstico de mieloma múltiple, cáncer de la sangre del cual ella nunca había escuchado hablar, tuvo muchas preguntas y pocas respuestas. A sus 40 años, era más joven que la mayoría de las personas que sufren de esta enfermedad.

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Due to COVID-19 and a rapidly expanding list of conditions for which lung transplantation can be lifesaving, the need for new organs is growing. However, there’s a global shortage of donated lungs, which results in numerous deaths among patients on the waitlist. To help expand the donor pool, Northwestern Medicine is now using a device from XVIVO called XPS™ which is used for ex vivo lung perfusion (EVLP) – nicknamed “lungs in a box” – to rescue potentially viable lungs and those initially deemed “unacceptable” for transplant. Out of all solid organs, lungs have the lowest utilization, with only one in five donated lungs getting transplanted.

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Since the start of the COVID-19 pandemic, alcohol use has been on the rise ― and so is alcohol-associated liver disease. Two Penn State Health doctors discuss what alcohol does to the liver and when it’s time for a transplant in this week’s Medical Minute.

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Throughout the month of April—Donate Life Month—experts from Cedars-Sinai Comprehensive Transplant Center and the Smidt Heart Institute are available for interviews on issues related to transplantation, immunology and organ donation.

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While 2021 proved to be a record-breaking year for organ donation in the U.S., many people are still hesitant to register to become a donor. Nationwide, only about 48% of people are registered to be organ donors, according to LifeSource. That's despite surveys showing that 95% of people in the U.S. support organ donation.

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