Feature Channels: Vaccines

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The SARS-CoV-2 virus is continuously evolving and structural changes to the virus may impact the efficacy of antibody therapies and vaccines. A study publishing February 17th in PLOS Pathogens by Anshumali Mittal at the University of Pittsburgh, USA and colleagues describes the structural and functional landscape of neutralizing antibodies against SARS-CoV-2 spike protein and discuss the effects of mutations on the virus spike protein that may allow it to evade antibody responses.

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Using powerful tools and techniques developed in the field of structural biology, researchers at the University of Washington and The Scripps Research Institute have discovered new details about the human immunodeficiency virus, HIV.

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Researchers at Mayo Clinic, along with colleagues in the Netherlands and Germany, may have a viable, less risky alternative to regenerate bone: messenger RNA. This well-known platform for vaccines has already proven to be safe in human use by the FDA.

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A future vaccine providing protection against a wide range of coronaviruses that jump from their original animal hosts to humans — including SARS-CoV-2, the cause of COVID-19 — may be possible, say Johns Hopkins Medicine researchers, based on findings from their recent study.

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Next generation mRNA vaccines. A new PSMA-targeted approach for prostate cancer. A novel treatment for reducing LDL cholesterol. These are some of the innovations that will optimize and change healthcare in the coming year, according to an expert panel of clinicians and researchers. Cleveland Clinic has announced the Top 10 Medical Innovations for 2022. The list of breakthrough technologies was selected by a committee of Cleveland Clinic subject matter experts, led by D. Geoffrey Vince, Ph.D., executive director of Innovations and chair of Biomedical Engineering at Cleveland Clinic.

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Researchers reporting in ACS Infectious Diseases have developed a new type of cholera vaccine consisting of polysaccharides displayed on virus-like particles. The vaccine generated long-lasting antibody responses against V. cholerae in mice.

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Medication against the nonhuman primate version of HIV given two weeks after infection helped keep tuberculosis in check.

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African children and adolescents hospitalized with COVID-19 experience much higher mortality rates than Europeans or North Americans, according to a study conducted by the Institute of Human Virology at the University of Maryland School of Medicine and the Institute of Human Virology Nigeria.

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Researchers at the Tufts University School of Engineering are building a reputation for precision targeting in drug delivery. Their tools: tiny lipid-based nanoparticles (LNPs) that can be fine tuned to latch on to specific tissues, organs, even cell types within the body. Their latest creation: LNPs that carry genetic instructions directly into the lungs.

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Asymptomatic COVID infection in generally healthy unvaccinated adults is likely much less common than previously reported, according to a new study published Feb. 14 in Open Forum Infectious Diseases by researchers at the Uniformed Services University of the Health Sciences (USU).

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Antibodies elicited by COVID-19 vaccination become steadily more powerful for at least six months after vaccination, according to a study by researchers at Washington University School of Medicine in St. Louis that involved the Pfizer-BioNTech COVID-19 vaccine.

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Georgia Tech researchers develop species agnostic lipid nanoparticle screening system to accelerate creation of cutting edge mRNA therapies.

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Chulalongkorn University reaffirms its commitment to “Innovations for Society”, which aims at developing innovations that address social issues and creating a better society in all aspects, including health, well-being and knowledge in order to move society forward. Let’s find out more about Chulalongkorn University’s amazing innovations.

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Cancer patients undergoing active treatment were more likely to believe misinformation related to COVID-19 than those without a history of cancer, according to a new study led by researchers at Virginia Commonwealth University.

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Participants in the study who cycled on a stationary bike or took a brisk walk for an hour-and-a-half after getting a flu shot or COVID-19 jab produced more antibodies in the following four weeks compared to participants who sat or continued with their daily routine post-immunization.

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• Results from a study from France suggest that both individual and herd vaccine-induced immunity protect against severe forms of COVID-19 in patients on dialysis. • A U.S. study found that antibody responses following COVID-19 vaccination wane over time across vaccine types in patients on dialysis.

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A number of existing strains of SARS-CoV-2, as well as other future variants that could arise, have the potential to escape the immune system’s cytotoxic T cell response in some portion of the population. That’s the conclusion of a new modeling study publishing February 10th in PLOS Computational Biology.

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Conservative activist Charlie Kirk suggested that COVID-19 vaccines are contributing to higher mortality rates in the U.S. over the last few years.

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Scientists at McMaster University who have developed an inhaled form of COVID vaccine have confirmed it can provide broad, long-lasting protection against the original strain of SARS-CoV-2 and variants of concern. The research, recently published in the journal Cell, reveals the immune mechanisms and significant benefits of vaccines being delivered directly into the respiratory tract, rather than by traditional injection.

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A new study by UCLA researchers and colleagues demonstrates that the Ebola vaccine known as rVSVΔG-ZEBOV-GP results in a robust and enduring antibody response among vaccinated individuals in areas of the Democratic Republic of Congo (DRC) that are experiencing outbreaks of the disease. Among the more than 600 study participants, 95.6% demonstrated antibody persistence six months after they received the vaccine. The study is the first published research examining post–Ebola-vaccination antibody response in the DRC, a nation of nearly 90 million. While long-term analyses of the study cohort continue, the findings will help inform health officials’ approach to vaccine use for outbreak control, the researchers said.

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Researchers at Fox Chase Cancer Center conducted the largest published, peer-reviewed, study to-date examining the short-term adverse effects of mRNA COVID-19 vaccination in patients with cancer—finding they experienced no more, and no different, side effects compared to non-cancer patients.

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在整个2019冠状病毒病（COVID-19）大流行期间，存在一个普遍的误解，那就是COVID-19对儿童的影响不大，即使他们生病，症状也很轻微。然而，大流行病正在以多种方式影响着儿童的身心健康。

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Ao longo da pandemia de COVID-19, um erro comum é que as crianças não são afetadas pela doença, e que se elas ficassem doentes, os sintomas seriam leves. Porém, a pandemia está afetando as crianças de maneiras diversas, física e mentalmente.

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Researchers at the University of Chicago Medicine found that when searching for vaccine information online, Spanish language resources took extra clicks to access compared to English language resources.

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CSUDH is partnering with Rite Aid to bring this vaccination clinic to campus to make it easier for everyone to get vaccinated and stop the spread of COVID-19.

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Roswell Park Comprehensive Cancer Center is the first center to treat patients in a newly opened advanced-stage clinical trial utilizing the brain cancer vaccine SurVaxM, offering a new treatment option for patients who are dealing with a rare but deadly form of the disease. The multicenter randomized clinical trial is sponsored by MimiVax LLC, a company spun off from Roswell Park in 2012.

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A one-year, $10.3 million dollar grant from the U.S. Health Resources and Services Administration (HRSA) was awarded to increase COVID-19 vaccinations through the development and mobilization of existing community-based health and outreach workforces in the state by The University of Texas Health Science Center at Houston (UTHealth Houston).

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Wistar Institute scientists take a promising step in the direction of developing an HIV vaccine that uses a unique native-like trimer to develop Tier-2 neutralizing antibodies—the kind that matter for combatting HIV—in mice for the first time.

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On July 15, 2021, the U.S. Surgeon General issued an urgent plea for all Americans to take part in slowing a serious threat to public health. He wasn’t talking about the COVID-19 pandemic but rather the harmful effects on personal and public health caused by the infodemic – the creation and spread of an excessive amount of unreliable and false health information.

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Theodore Beauchaine and his colleagues break down the cognitive shortcuts that can affect how we assess risk and decide to behave in the face of the pandemic in a recent paper in the journal Brain, Behavior, and Immunity.

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As COVID-19 edges from pandemic to endemic status, there is a growing need for antiviral therapies. A team of UF researchers has identified dozens of therapeutic targets that could feed the drug development pipeline.

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Fathers older than age 34 were more open to having their child vaccinated against COVID-19, while younger Black and white mothers were the least open to it, finds a new survey of Medicaid recipients from the Brown School at Washington University in St. Louis.

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Researchers at McMaster University have found that children who receive years of season-specific flu vaccines develop antibodies that also provide broader protection against new strains, including those capable of causing pandemics.

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The COVID-19 vaccine does not impair the body’s physiological response to exercise, according to a new study at The University of Arizona.

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The Innovative Genomics Institute, founded by Nobel Laureate Jennifer Doudna, is partnering with Mobility Health to bring rapid PCR-based testing to migrant workers and their families in the Salinas Valley region of Northern California. Mobile service will provide COVID testing, vaccines and wraparound services.

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For several hours on Monday, January 31, 2022, a misleading article from news agency Reuters lead to many readers sharing the report on social media as conclusive evidence of ivermectin’s effectiveness against COVID-19, and proof of the alleged conspiracy of suppressed research to blame for the anti-parasite drug’s current lack of approval by the United States Food & Drug Administration.

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The February 2022 issue of Toxicological Sciences features manuscripts in the areas of developmental and reproductive toxicology, environmental toxicology, and more.

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The first generation of COVID-19 vaccines have been highly effective, but also have limitations. Now Wistar scientists have developed a more targeted vaccine that, in animal studies, shows stronger, broader, and more durable protection in a single, low dose.

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One recent obstacle to drug delivery research is an observed weak correlation between in vitro and in vivo performance. When nanoparticles are applied intravenously, they face several obstacles that differ from in vitro situations. Nanoparticles are usually covered by a biomolecular multilayer (a protein corona), which alters the physiochemical properties, pharmacokinetics, and toxicity profile of the nanoparticles. In Biophysics Reviews, researchers provide a cutting-edge characterization of the protein corona formed around nanoparticles and its impact on the physiochemical and biological properties of these nanoparticles.

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Durante toda la pandemia de la COVID-19, a menudo y erróneamente se ha creído que la enfermedad no afecta mucho a los niños y que de llegar a contraerla, los síntomas serían leves. Sin embargo, la pandemia afecta a los niños de muchas maneras físicas y mentales.

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When the FDA announced it was no longer authorizing two COVID-19 monoclonal antibody drugs in the U.S., Governor DeSantis, along with a many Republicans objected, saying they did this without data. However, recent lab studies strongly suggest the treatments will not help omicron-infected people.