Feature Channels: Autoimmune Diseases

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The immune system relies on B cells and their ability to make antibodies against an extremely broad range of pathogens. This broad responsiveness bears some risk, as B cells can also turn against healthy tissue - a phenomenon called autoimmunity. Scientists from the lab of Meinrad Busslinger now reported in the journal "Nature Immunology" how the protein lkaros orchestrates the fine balance between B cell silencing and activation - and thereby controls autoimmunity.

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Below are summaries of recent Fred Hutch research findings, with links for additional background and media contacts.

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A team of college interns at Sandia National Laboratories has built autonomous drones to try out new navigation, guidance and control, and target recognition techniques ultimately bound for autonomous hypersonic vehicles.

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A study largely validates that immunoglobulin IgG is a crucial part of the pathogenic immunodeposits in kidneys of patients with IgA nephropathy. The routine clinical test that identifies the presence of IgA in all cases of IgA nephropathy fails to show IgG in 50 to 80 percent of biopsies.

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Grammy® Nominated Songwriter and Singer Dayna Caddell to Lead 5th Annual Los Angeles Autoimmune Walk on November 3. Former NFL Dallas Cowboys Player Darryl Clack is the Featured Speaker. The Walk is part of AARDA's "Linking Together for a Cure" campaign to raise awareness and funding for research.

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Named a major women’s health issue by the National Institutes of Health’s Office of Research on Women’s Health, it is no surprise that the number of celebrities impacted by autoimmune disease is on the rise. Kim Kardashian West recently opened up about the impact of autoimmune disease on her life. Other celebrities with autoimmune disease diagnoses include Venus Williams, Selena Gomez, and Missy Elliott.

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The American Autoimmune Related Diseases Association (AARDA) partners with AHN Autoimmunity Institute to present a free public forum on autoimmune disease and the inaugural Pittsburgh Autoimmune Walk.

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Researchers have found a synergistic connection, or crosstalk, between two rare but potentially deadly blood-clotting diseases — thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. The linkage may provide a rationale for a more targeted therapeutic intervention in patients.

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A children’s book published by Hospital for Special Surgery for youngsters with lupus not only explains the illness, but offers a message of encouragement and hope. The book, written by a hospital volunteer with lupus, has received excellent reviews from health professionals around the country.

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The American Neuromuscular Foundation has a new chronic inflammatory demyelinating polyneuropathy development grant award recipient, Dr. Karissa Gable.

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AARDA presents a free health and wellness event focused on autoimmune patients and families

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Sanford Burnham Prebys Medical Discovery Institute today announced a three-year extension to its existing collaboration with Eli Lilly and Company (Lilly) to discover and develop immunological therapies. The goals of the agreement are to advance ongoing projects—including a Phase 1 clinical trial of an immune therapy that arose from the research collaboration—and to expand the previous scope to include omics-based target identification studies.

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Using advanced technology, scientists at Chan Zuckerberg (CZ) Biohub, Mayo Clinic and UC San Francisco, have discovered an autoimmune disease that appears to affect men with testicular cancer.

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A surprising new discovery in mouse models reveals a previously unknown role for pain in immunity and has implications for treating autoimmune diseases

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The American Autoimmune Related Diseases Association (AARDA) announced today a strategic alliance with iMD Health Global that will help evolve communications between physicians and patients to improve health outcomes, focused on autoimmune and related diseases, which is estimated to affect over 50 million Americans.

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Results suggest some forms of PD are an autoimmune disease triggered years before noticeable symptoms

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The ideal treatment for any autoimmune disease such as multiple sclerosis (MS) would preserve the immune system’s ability to protect the body. In July, a team of researchers published a study in The Journal of Neuroinflammation reporting progress toward this goal. After ‘knocking out’ a transcription factor called Oct1, investigators saw a significant reduction in symptoms in mice with MS-like disease. More importantly, the mice preserved most of their ability to clear viral infections.

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Irvine, Calif., June 5, 2019 — A nanotechnology treatment derived from bone marrow stem cells has reversed multiple sclerosis symptoms in mice and could eventually be used to help humans, according to a new study led by University of California, Irvine researchers.  “Until now, stem cell therapies for autoimmune and neurodegenerative diseases have produced mixed results in clinical trials, partly because we don’t know how the treatments work,” said corresponding author Weian Zhao, an associate professor of pharmaceutical sciences and biomedical engineering who is affiliated with the Sue & Bill Gross Stem Cell Research Center.

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A previously unknown autoimmune muscle disease involving sudden onset of debilitating muscle pain and weakness has been identified by researchers at Washington University School of Medicine in St. Louis. The syndrome easily could be mistaken for other muscle diseases that require different treatment, so the findings are expected to help physicians treat patients appropriately, the researchers said.