Feature Channels: Vaccines

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Immunotherapy using LEAPS peptide technology may be able to reduce COVID-19 viral load and tissue damage resulting from infection in the lungs.

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A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.

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Harvard University scientists will collaborate with Chinese colleagues to elucidate the basic biology of the novel coronavirus (COVID-19), and the resulting disease, toward new diagnostic tools, vaccine development and antiviral therapies. The collaboration is part of a $115 million research initiative funded by China Evergrande Group.

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John Theurer Cancer Center at Hackensack University Medical Center is the only site in New Jersey and one of just 17 in the country participating in a multicenter international Phase II study of an innovative personalized cancer vaccine being evaluated in combination with pembrolizumab immunotherapy in patients with melanoma that has been surgically removed but has a high risk of coming back. The hope is that the vaccine can prime a patient's immune system to be more responsive to immunotherapy and reduce the risk of cancer recurrence.

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From working to develop one of the first nonhuman primate models for the 2019 novel coronavirus disease (COVID-19) to designing new nanotechnology-based tests to rapidly diagnose infections, researchers at Tulane University are responding across disciplines to the emerging coronavirus epidemic.

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Data scientists analyzing genetic sequences of the COVID-19 coronavirus have identified potential vulnerabilities that could help in vaccine development and further study of the infectious disease now spreading worldwide.

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By: Bill Wellock | Published: February 14, 2020 | 3:35 pm | SHARE: As an outbreak of a new coronavirus makes headlines across the world, another more common infectious disease is spreading across the United States and beyond — the flu.About 8 percent of the U.S. population gets sick from the flu each season, according to the Centers for Disease Control and Prevention.

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Robert Stahelin studies some of the world’s deadliest viruses. Filoviruses, including Ebola virus and Marburg virus, cause viral hemorrhagic fever with high fatality rates. Stahelin, professor at Purdue University, examines how these viruses take advantage of human host cells.

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Young sexual minority men — including those who are gay, bisexual, queer or straight-identified men who have sex with men — do not fully understand their risk for human papillomavirus (HPV) due to a lack of information from health care providers, according to Rutgers researchers.

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Pneumococcal conjugate vaccines (PCVs) have been highly effective in reducing pneumonia and other invasive infections caused by Streptococcus pneumoniae bacteria. But rates of meningitis have shown little change, as pneumococcal strains not targeted by PCVs emerge as more important causes of meningitis, reports a paper in The Pediatric Infectious Disease Journal, the official journal of The European Society for Paediatric Infectious Diseases. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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A Rutgers-led team has developed a tool to monitor influenza A virus mutations in real time, which could help virologists learn how to stop viruses from replicating. The gold nanoparticle-based probe measures viral RNA in live influenza A cells, according to a study in The Journal of Physical Chemistry C. It is the first time in virology that experts have used imaging tools with gold nanoparticles to monitor mutations in influenza, with unparalleled sensitivity.

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VICC is the first cancer center to enroll a patient in a clinical trial for this new technology developed by SQZ Biotechnologies of Watertown, Massachusetts. The investigational product is generated from the company’s technology that uses high-speed cell deformation to squeeze cells, creating a temporary disruption of their membranes and offering a window for the insertion of tumor antigens.

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Wearing a surgical mask is unlikely to protect healthy people from the novel coronavirus that originated in China, and influenza likely poses a much greater threat to Americans, according to José Cordero, professor of epidemiology and biostatistics in the University of Georgia’s College of Public Health.

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By figuring out how a common virus hides from the immune system, scientists have identified a potential vaccine to prevent sometimes deadly respiratory infections in humans.

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The Women’s Heart Fund, a philanthropic arm of Hackensack Meridian Health Meridian Health Foundation, has announced that for its newest venture, the organization will sponsor ‘Community Conversations with the CDI,’ a women-focused, three-year lecture series featuring researchers from Hackensack Meridian Health’s Center for Discovery and Innovation (CDI). The lectures will focus on topics relevant to community members throughout the state, including heart disease, breast and ovarian cancer, vaccines, Alzheimer’s Disease and diabetes.

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As the world nears poliovirus eradication, the vaccines themselves have become the greatest threat. In response to a global demand for an effective, safer-to-handle and less costly polio vaccine, scientists at the Uniformed Services University (USU) have developed a new one that could help secure a polio-free world.

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– Over the past year, at least seven children have died from diseases including influenza while being detained by the U.S. Department of Homeland Security’s Customs and Border Protection (CBP) agency. Infectious disease experts at the University of Maryland School of Medicine (UMSOM) called for protections like influenza vaccinations to prevent serious outbreaks.

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The HPV vaccine protects against some of the deadliest, most disfiguring and hard-to-treat cancers. Here is what parents of teens and pre-teens should know about the HPV vaccine.

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University of Chicago Medicine associate professor and infectious disease expert Dr. Emily Landon explains what public health officials know about new coronavirus virus from Wuhan, China and how to stay safe.

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The results of the B Part of It study – the largest meningococcal B herd immunity study ever conducted – are published today in the New England Journal of Medicine.

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Fully vaccinating children reduces the risk of hospitalization associated with influenza by 54%, according to a study by researchers at the University of Michigan, the Clalit Research Institute, and Ben-Gurion University in Israel.

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The virus appears to be less dangerous than SARS, but there are still concerns of a wider outbreak in Asia.

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Two different UC San Diego research teams identified the same molecule — αvβ5 integrin — as Zika virus’ key to brain cell entry. They found ways to take advantage of the integrin to both block Zika virus from infecting cells and turn it into something good: a way to shrink brain cancer stem cells.

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A vaccine is available to protect against human papillomavirus (HPV). HPV is the most common sexually transmitted infection and can cause diseases such as genital warts and cancer. The HPV vaccine now protects against nine strains of HPV. Research shows that the HPV vaccine is safe and effective. The HPV vaccine is approved for men and women between the ages of 9 to 45. The HPV vaccine can protect adults from HPV-related diseases, however it provides the most protection when it is given in childhood before someone becomes sexually active. Parents should talk with their child’s pediatrician about the HPV vaccine. Adult men should ask their primary care provider about the HPV vaccine, and adult women should speak with their gynecologist.

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Sharon Wright,MD, MPH, BIDMC’s Senior Medical Director of Infection Control/Hospital Epidemiology at Beth Israel Deaconess Medical Center shares everything you need to know about the flu.

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Dr. Kathy Monroe has seen her share of the flu in Alabama's busiest emergency department for kids. She shares important tips on who should get the flu vaccine, when to get it, and what to do when your child shows signs and symptoms.

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A new study at the University of Georgia has found a way to attack cancer cells that is potentially less harmful to the patient.

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Diarrheal diseases are a leading cause of death for young children, accounting for nine percent of all deaths worldwide in children under five years of age, with most occurring in children under two years of age. Now, researchers at the University of Maryland School of Medicine (UMSOM) found that even milder cases of diarrheal diseases can lead to death in young children.

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A new Penn Medicine study puts researchers within closer reach of vaccines that can protect infants against infections by overcoming a mother’s antibodies, which are known to shut down immune defenses initiated by conventional vaccines. That hurdle largely explains why vaccinations for infectious diseases like influenza and measles not given until six to 12 months of age. Findings from the preclinical study were published online today in Science Translational Medicine.

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-Newborn mice derive protective antibodies from their mothers’ microbiota -Antibodies derived from mothers’ microbiota ward off both localized and widespread systemic infections by the bacterium E. coli -Study points to the role of maternal microbes in offspring protection and neonatal immunity -Findings can inform development of microbe-based therapies against infectious diarrhea in infants

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An isoelectric point is a common way to characterize viruses. However, it’s not easy. To improve manufacturing for vaccines and gene therapy, a Michigan Tech team uses surface charge to determine the isoelectric point of different viruses. Specifically, they use a single-particle method with atomic force microscopy (AFM).

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Weizmann Institute scientists created a decoy molecule that successfully recruits the immune system to fight arenaviruses. It also appears to be heat-resistant and stable, meaning it could be delivered to the remote areas where these diseases are endemic.

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Building on its illustrious landmark-achieving history in the field of immunology, NYU Langone Health announced today the launch of a Vaccine Center that combines basic research, clinical studies and public health outreach to prevent the spread of infectious diseases and other immunological disorders.

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Worldwide, more people die from tuberculosis than any other infectious disease, even though the vast majority were vaccinated. The vaccine just isn’t that reliable. But a new Nature study finds that simply changing the way the vaccine is administered could dramatically boost its protective power.

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A new study revealed that one dose of the HPV vaccine may prevent infection from the potential cancer-causing virus, according to research published in JAMA Network Open from The University of Texas Health Science Center at Houston (UTHealth).

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A study from Washington University School of Medicine in St. Louis may help explain why previous attempts to develop a staph vaccine have failed, while also suggesting a new approach to vaccine design that focuses on activating an untapped set of immune cells, as well as immunizing against staph within the first few days after birth.

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How successfully a person can fend off the flu depends not only on the virus' notorious ability to change with the season, but also on the strain first encountered during childhood, according to new research published in the open-access journal PLoS Pathogens.

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Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way to move precision immunotherapy forward by using genomics to inform immunotherapy for multiple myeloma, a blood cancer, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research, in December.

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According to the American College of Obstetricians and Gynecologist, girls should have their first gynecologic visit between the ages of 13 and 15. Here's what parents need to know about when to take teens to an adolescent gynecologist.