An enzyme that helps COVID-19 (coronavirus) infect the body also plays a role in inflammation and patient outcomes in inflammatory bowel disease (IBD), according to a new study led by Cedars-Sinai. The findings raise the possibility that anti-inflammatory drug therapies for IBD may aid recovery from coronavirus.
DALLAS – Oct. 28, 2020 – Mice fed diets high in sugar developed worse colitis, a type of inflammatory bowel disease (IBD), and researchers examining their large intestines found more of the bacteria that can damage the gut’s protective mucus layer.
The American College of Gastroenterology (ACG) announces the winners of the 2020 SCOPY Awards (Service Award for Colorectal Cancer Outreach, Prevention, and Year-Round Excellence) to recognize the achievements of ACG members in their community engagement, education and awareness efforts for colorectal cancer prevention.
David A. Greenwald, MD, FACG, a gastroenterologist and the Director of Clinical Gastroenterology and Endoscopy at Mount Sinai Hospital in New York City, was elected by the membership as the 2020–2021 President of the American College of Gastroenterology (ACG), a national medical organization representing more than 15,000 clinical gastroenterologists and other specialists in digestive diseases.
More than 7,000 gastroenterologists and other health care professionals so far will convene virtually for the premier clinical gastroenterology event—the American College of Gastroenterology’s 85th Annual Scientific Meeting and Postgraduate Course (Virtual ACG 2020)—to review the latest scientific advances in gastrointestinal research, treatment of digestive diseases, and clinical practice management.
A personalized program to increase resilience in patients with inflammatory bowel disease (IBD) can substantially reduce hospitalizations and emergency room visits, Mount Sinai researchers report. The research is being unveiled on October 27th in a plenary presentation at the annual scientific meeting of the American College of Gastroenterology (ACG 2020).
An international team of researchers led by McMaster University has found that tryptophan, an amino acid present in high amounts in turkey, along with some probiotics, may help them heal and respond better to a gluten-free diet. The findings highlight the potential therapeutic value of targeting tryptophan metabolism in the gut in celiac disease to better control symptoms, despite the gluten-free diet, and accelerate intestinal healing.
Colon cancer is on the rise, especially among younger age groups and prompt diagnosis is key to improving chance of survival. Sameet Shah, M.D., gastroenterologist of Hackensack Meridian Mountainside Medical Group, shares his knowledge to educate patients on the signs and symptoms of colon cancer and how to prevent it best.
DALLAS – Oct. 7, 2020 – Endocannabinoids, signaling molecules produced in the body that share features with chemicals found in marijuana, can shut down genes needed for some pathogenic intestinal bacteria to colonize, multiply, and cause disease, new research led by UT Southwestern scientists shows.
Deirdre J. Cohen, MD, MS, an expert in pancreatic and other gastrointestinal cancers as well as an accomplished clinical trial leader has joined Mount Sinai Health System as Director of the Gastrointestinal (GI) Oncology Program and Medical Director of the Cancer Clinical Trials Office at The Tisch Cancer Institute.
UC San Diego School of Medicine researchers reported that genetic testing is cost-effective and beneficial for newly diagnosed patients with metastatic gastrointestinal stromal tumors (GIST), a rare type of cancer.
Be one of the first to read the October 2020 issue of the journal Diseases of the Colon and Rectum! Here are the editor's top picks
In a large group of patients with metastatic colorectal cancer, consumption of a few cups of coffee a day was associated with longer survival and a lower risk of the cancer worsening, researchers at Dana-Farber Cancer Institute and other organizations report in a new study.
African American men have the lowest five-year survival rate for colorectal cancer (CRC) out of any other racial group. A major factor is low adherence to recommended early detection screening. Yet published research on effective strategies to increase screening for this group specifically are minimal. These findings were published today in PLOS ONE.
What causes some people to develop chronic diseases such as rheumatoid arthritis, cancer and metabolic syndrome while others stay healthy? A major clue could be found in their gut microbiome — the trillions of microbes living inside the digestive system that regulate various bodily functions.
Many clinicians rely on self-reports from their high-risk patients about their need and proper interval for repeat surveillance colonoscopy. Researchers analyzed data over four years to explore the knowledge of these high-risk patients. Twenty-eight percent were unaware of either the need for a repeat colonoscopy or the proper surveillance interval. Of these, 16.6 percent were unaware of the proper three-year interval to obtain a follow-up surveillance colonoscopy. Also, 12 percent were not even aware that they required a follow-up surveillance colonoscopy.
Over 1,000 children from Northern Ireland, Scotland, England and Wales, known as ‘COVID Warriors’ have had their antibodies measured in the UK-wide trial called ‘Seroprevalence of SARS-Cov-2 infection in healthy children’.
Researchers at UC San Diego School of Medicine report that the lasting nature of inflammatory bowel disease may be due to a type of long-lived immune cell that can provoke persistent, damaging inflammation in the intestinal tract.
Each person’s gut virus composition is as unique as a fingerprint, according to the first study to assemble a comprehensive database of viral populations in the human digestive system.
Researchers at University of California San Diego School of Medicine report that fructose only adversely affects the liver after it reaches the intestines, where the sugar disrupts the epithelial barrier protecting internal organs from bacterial toxins in the gut.
Computed tomography (CT) is used at a higher rate than ultrasound in children with developmental and cognitive impairments to diagnose appendicitis, even though CT scans increase radiation risk in smaller bodies.
Mountainside Medical Group announced today that Sameet Shah, D.O., has joined the practice to serve the community’s growing need in the field of gastroenterology.
B cells are white blood cells that develop to produce antibodies.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have uncovered a novel drug target, a protein called PPP1R1B, that stops the deadly spread of pancreatic cancer, called metastasis, when inhibited in mice. Published in Gastroenterology, the findings are a first step toward a potential treatment for one of the deadliest cancers known today.
We may not think about it often, but our gut is home to a complex ecosystem of microorganisms that play a critical role in how we function.
"Because it affects them in their childbearing years, women need to know when it is safe to get pregnant," says Dr. Jacqueline Wolf, a national expert on IBD and pregnancy and a physician in the Division of Gastroenterology, Hepatology and Nutrition at Beth Israel Deaconess Medical Center, shares her expertise on Crohn's disease and pregnancy.
A team of developmental biologists at the Morgridge Institute for Research has discovered a means by which schistosomes, parasitic worms that infect more than 200 million people in tropical climates, are able to outfox the host’s immune system.
Although rates of surgery for Crohn’s disease have decreased over the years, many patients still require surgical treatment – due to inadequate responses to medical therapy, severe attacks of acute colitis, and many other situations. Reflecting the latest research evidence and clinical practice, an updated set of recommendations for surgery in patients with Crohn’s disease have been published in Diseases of the Colon & Rectum (DC&R), the official journal of the American Society of Colon and Rectal Surgeons (ASCRS). The journal is published by Wolters Kluwer.
Cedars-Sinai announced a $25 million gift from Martha L. Karsh and Bruce A. Karsh, and the Karsh Family Foundation, to support the treatment of digestive and liver diseases and the advancement of innovative research. The current division of Digestive and Liver Diseases will be renamed the Karsh Division of Gastroenterology and Hepatology.
UC Davis researchers have found that combining a Western-style high-fat diet with antibiotic use significantly increases the risk of developing pre- inflammatory bowel disease. This combination shuts down the mitochondria in cells of the colon lining, leading to gut inflammation. Mesalazine can help restart the mitochondria and treat pre-IBD condition.
A new study from Washington University School of Medicine in St. Louis has found that mice infected with Chikungunya virus get less sick and are less likely to transmit the virus to mosquitoes if they have healthy gut microbiomes.
Findings from an online survey of more than 53,000 American adults suggest that using heartburn medications known as proton pump inhibitors (PPIs) once or twice daily significantly increases the odds of a positive test for COVID-19 compared to those who do not take PPIs. This research appeared online July 7, 2020 in pre-print format in The American Journal of Gastroenterology.
Milestone for therapeutic development of peptides against gastrointestinal disordersThe fascinating family of trefoil factor peptides brings hope to both research and industry to improve the treatment of chronic disorders such as Crohn’s disease. For the first time, a team led by ERC awardee Markus Muttenthaler from the Faculty of Chemistry of the University of Vienna succeeded in the synthesis and folding of the peptide TFF1, a key player in mucosal protection and repair.
In a newly published experimental study, the consumption of dietary fibre from oat and rye brans supported the growth of beneficial gut microbiota, which in turn ameliorated cholesterol metabolism, enhanced gut barrier function and reduced hepatic inflammation.
A new study finds antibiotic exposure during crucial developmental periods in early childhood alters digestive tract nerve function and bacterial colonies. The study is published in the American Journal of Physiology-Gastrointestinal and Liver Physiology.
A new study published in Clinical Gastroenterology and Hepatology led by Maria T. Abreu, M.D., professor of medicine and professor of microbiology and immunology at the University of Miami Miller School of Medicine, found that eating diets low in fat and high in fiber may improve the quality of life of patients with ulcerative colitis (UC) — even those in remission.
After one consumes food or a beverage containing fructose, the gut helps to shield the liver from damage by breaking down the sugar. However, the consumption of too much fructose can overwhelm the gut, causing fructose to “spill over” into the liver, where it wreaks havoc and causes fatty liver, researchers discovered.
The 2020 Warren Alpert Foundation Prize has been awarded to a trio of researchers for seminal discoveries about the function of key intestinal hormones, their effects on metabolism and the subsequent design of treatments for type 2 diabetes, obesity and short bowel syndrome.
A new study describes how poor oral health may worsen gut inflammation.
DALLAS – June 9, 2020 – Serotonin, a chemical known for its role in producing feelings of well-being and happiness in the brain, can reduce the ability of some intestinal pathogens to cause deadly infections, new research by UT Southwestern scientists suggests. The findings, publishing online today in Cell Host & Microbe, could offer a new way to fight infections for which few truly effective treatments currently exist.
For children and young adults with Crohn’s disease, steroid-sparing therapies may help reduce the risk of developing a severe and common complication of the inflammatory bowel condition, a new study suggests.
A study led by University of Kentucky Markey Cancer Center researchers showed that patients who already used opioids, sedatives or antidepressants prior to colorectal surgery experience significantly more complications post-surgery.
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