RUDN Laboratory of Biology of Single Cells studied the possibilities of DNA sequencing at the level of individual cells in patients with a rare form of childhood leukemia.
Physicians and scientists from Yale Cancer Center, part of Yale School of Medicine, will present new research at the 65th American Society of Hematology (ASH) Annual Meeting and Exposition in San Diego, Calif., from December 9 to 12. This year’s ASH meeting will include oral and poster presentations, workshops, and educational sessions for hematology professionals.
A research team at The Ohio State University Wexner Medical Center and College of Medicine has been approved for a $14 million award from the Patient-Centered Outcomes Research Institute (PCORI) to study whether a higher daily dose of aspirin is more effective in decreasing the risk of dangerous blood pressure complications among some pregnant people.
Scientists at St. Jude Children’s Research Hospital identified target genes bound and regulated by HOXA9, a protein overexpressed in high-risk leukemia, extending understanding and opening new possibilities for treatment.
Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS)—two related blood diseases that disproportionally strike older adults—are notoriously difficult to treat and associated with high relapse rates.
Messenger bubbles produced by human cells can pick up bacterial products and deliver them to other cells, University of Connecticut researchers report in the Nov. 16 issue of Nature Cell Biology.
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Researchers at Washington University School of Medicine in St. Louis have found that a form of cholesterol known as cholesteryl esters builds up in the brains of mice with Alzheimer’s-like disease, and that clearing out the cholesteryl esters helps prevent brain damage and behavioral changes.
In Physics of Fluids, scientists demonstrate how bloodstains can yield valuable details by examining the protrusions that deviate from the boundaries of otherwise elliptical bloodstains. The researchers studied how these “tails” are formed using a series of high-speed experiments with human blood droplets less than a millimeter wide impacting horizontal surfaces at various angles. They found that the tail length can reflect information about the size, impact speed, and impact angle of the blood drop that formed the stain.
Published just before World Diabetes Day, work by Dr. May Faraj, director of the Research Unit on Nutrition, Lipoproteins and Cardiometabolic Diseases at the Montreal Clinical Research Institute (IRCM) and full professor at the Department of Nutrition at the University of Montreal, highlight a new mechanism and a new role for LDL – commonly called bad cholesterol – in the development of type 2 diabetes, LDL already being involved in cardiovascular diseases in the human.
Irvine, Calif., Nov. 20, 2023 — A first-of-its-kind study led by the University of California, Irvine has revealed a new culprit in the formation of brain hemorrhages that does not involve injury to the blood vessels, as previously believed. Researchers discovered that interactions between aged red blood cells and brain capillaries can lead to cerebral microbleeds, offering deeper insights into how they occur and identifying potential new therapeutic targets for treatment and prevention.
Scientists at St. Jude Children’s Research Hospital showed that a fusion oncoprotein can drive molecularly indistinguishable rhabdomyosarcomas arising from both muscle and blood vessel cells.
The story of a clinical trial that is unlocking a new, personalized treatment approach with the power to save the lives of thousands of people living with an aggressive and deadly form of leukemia was screened at the American Public Health Association Film Festival this week.
An international team has for the first time researched the longevity of neutralizing antibodies in HIV-1-infected people. Currently, it is assumed that an HIV-1 vaccine can only be effective if it produces these antibodies in vaccinated humans.
A novel assay that detects a unique molecular marker in patients with acute myeloid leukemia (AML) may revolutionize the way this disease is detected and treated according to a new report in The Journal of Molecular Diagnostics published by Elsevier.
An international clinical trial led by physician Jeffrey L. Carson, distinguished professor of medicine at Rutgers Robert Wood Johnson Medical School, found that a liberal blood transfusion given to patients who have had a heart attack and have anemia may reduce the risk of a reoccurrence and improve survival rates.
A four-year, $2.6 million grant to study circadian rhythm and novel therapies to protect the heart during a heart attack or cardiac surgery has been awarded to UTHealth Houston by the National Heart, Lung, and Blood Institute, part of the National Institutes of Health.
A multicenter study led by researchers at Sylvester Comprehensive Cancer Center shows how interactions between tumor cells and immune components of the microenvironment can impact treatment responses and outcomes in patients newly diagnosed with multiple myeloma who undergo combination treatments that include targeted immunotherapy.
Mayo Clinic Laboratories, a leading global reference laboratory, and Progentec Diagnostics, a digital health and biomarker technology-based company focused on autoimmune conditions, today announced a strategic collaboration to bring Progentec’s suite of proprietary biomarker blood tests for the proactive management of autoimmune diseases to market.
CAR-T cell therapy is a last hope for many patients with blood, bone marrow or lymph gland cancer when other treatments such as chemotherapy are unsuccessful. A limiting factor of this otherwise very effective and safe therapy is that the cells used in the process quickly reach a state of exhaustion.
Multiple sclerosis patients whose blood tests reveal elevated NfL, a biomarker of nerve damage, could see worsening disability one to two years later, according to a new study spearheaded by researchers at UC San Francisco.
A new targeted drug, studied by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James), may offer a new treatment option for patients with blood cancers, including chronic lymphocytic leukemia and Non-Hodgkin lymphoma whose disease has stopped responding to standard treatments.
Measuring blood pressure while patients are standing rather than sitting may improve the accuracy of readings, UT Southwestern Medical Center researchers report. Their findings, published in Scientific Reports, could lead to significant improvements in early detection of high blood pressure in healthy adults.
Research in mice shows that the anti-inflammatory properties of exercise may arise from immune cells mobilized to counter exercise-induced inflammation. Immune cells prevent muscle damage by lowering levels of interferon, a key driver of chronic inflammation, inflammatory diseases, and aging.
A species of exotic tick arrived in Ohio in 2021 in such huge numbers that their feeding frenzy on a southeastern farm left three cattle dead of what researchers believe was severe blood loss.
Phenylketonuria (PKU) is a rare newborn genetic disease that impacts between 1 in 10,000 to 1 in 20,000 people, depending on the individuals’ genetic ancestry. PKU causes an amino acid—called phenylalanine (Phe)—to build up in the bloodstream.
The Mount Sinai Health System has received a $7 million grant from the Multiple Myeloma Research Foundation for a three-year project that aims to fast-track novel translational concepts to improve outcomes for people with high risk myeloma, the second most common blood cancer in the United States.
Urinary biomarkers have the potential to surpass serum biomarkers in disease diagnosis and monitoring. This review highlights their non-invasive, stable, and specific nature. It explores a range of urinary biomarkers, such as proteins, genes, metabolites, electrolytes, and extracellular vesicles, showing their superiority.
Rheumatoid arthritis is an inflammatory disease that can cause severe pain and swelling of the joints. But a novel exercise intervention could help improve physical function and quality of life in people struggling with this debilitating condition.
As people age, the DNA in their cells begins to accumulate genetic mutations. Mosaic chromosomal alterations (mCAs), a category of mutations acquired in blood cells, are linked with a 10-fold increased risk of developing blood cancer. mCAs hold promise as a tool to identify people at high risk of developing certain cancers and diseases, but they have not yet been studied among a large, diverse cohort of people – a critical step required before such testing can be developed. University of Kentucky Markey Cancer Center researcher Yasminka A. Jakubek, Ph.D., has led the first large-scale effort to understand the co-occurrence of mCAs among individuals of diverse ancestries. The study was published in Nature Genetics Oct. 30.
Over the past decades, Brazil has become the world’s leading soybean producer, as well as the leading consumer of pesticides. Despite concerns about potential public health consequences, little is known about the effects of pesticide exposure in the general population.
Adults exposed to lead at work can unintentionally bring it home, exposing their families to the highly toxic substance. While preventing lead exposure is always important, Michigan State University and other organizations are urging increased awareness during National Lead Poisoning Prevention Week, Oct. 22 to 28, designated by the U.S. Centers for Disease Control and Prevention.
Post COVID-19 condition does not appear to be linked to direct viral invasion of the brain or active brain damage. This has been shown by a study at the University of Gothenburg. Searching for abnormal biomarkers among the participants yielded no hits in either blood or cerebrospinal fluid samples
Representatives from the American College of Surgeons STOP THE BLEED® program, along with Massachusetts state legislators, will host a news conference on Monday, October 23, in support of recent STOP THE BLEED® legislation.
Women with a high genetic predisposition for blood clots are six times more likely to develop a blood clot during the first two years of using contraceptive pills according to a new study from Uppsala University. The results have been published in the American Journal of Obstetrics and Gynaecology