Feature Channels: Drug Resistance

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Newswise: Wound Treatment Gel Fights the Battle Against Antibacterial Resistance
29-Mar-2024 11:05 AM EDT
Wound Treatment Gel Fights the Battle Against Antibacterial Resistance
American Institute of Physics (AIP)

Polymer-based hydrogels are used to treat skin ailments and in tissue engineering because of their ability to retain water, deliver drugs into wounds, and biodegrade. However, they are complicated to manufacture and not very resilient to external forces like rubbing against clothing, sheets, or wound dressings.

   
Released: 18-Mar-2024 5:05 PM EDT
UC Irvine-led research team discovers role of key enzymes that drive cancer mutations
University of California, Irvine

A research team led by the University of California, Irvine has discovered the key role that the APOBEC3A and APOBEC3B enzymes play in driving cancer mutations by modifying the DNA in tumor genomes, offering potential new targets for intervention strategies.

Newswise: Case Western Reserve University researchers report rise in global fungal drug-resistant infections
Released: 18-Mar-2024 9:00 AM EDT
Case Western Reserve University researchers report rise in global fungal drug-resistant infections
Case Western Reserve University

A global wave of infections caused by fungi growing drug-resistant has the medical community issuing precautions on how to protect yourself.

Newswise: Some lymphomas become resistant to treatment. Gene discovery may offer path to overcome it.
Released: 15-Mar-2024 3:05 PM EDT
Some lymphomas become resistant to treatment. Gene discovery may offer path to overcome it.
University of Wisconsin–Madison

Patients with some types of lymphoma that become resistant to standard treatments may benefit from a therapy that University of Wisconsin–Madison researchers are evaluating after they discovered a key process that fuels the blood cancers’ resistance to current drugs.

Newswise: Anti-vaccine conspiracies fuel divisive political discourse
Released: 26-Feb-2024 9:05 PM EST
Anti-vaccine conspiracies fuel divisive political discourse
University of Tokyo

Heightened use of social media during the coronavirus pandemic brought with it an unprecedented surge in the spread of misinformation.

   
Released: 21-Feb-2024 2:05 PM EST
Long COVID can happen to anyone. Keep up with the latest research on Long COVID on Newswise
Newswise

Stay informed! These are the latest research articles on "Long COVID" from the Coronavirus News Source on Newswise.

Newswise: RUDN pharmacists proposed ways to increase the activity of levofloxacin and overcome bacterial resistance to antimicrobial agents
Released: 21-Feb-2024 9:15 AM EST
RUDN pharmacists proposed ways to increase the activity of levofloxacin and overcome bacterial resistance to antimicrobial agents
Scientific Project Lomonosov

RUDN University pharmacists modeled derivative molecules of the antibacterial levofloxacin to find out what biological functions its individual structural fragments - pharmacophores - are responsible for. This is necessary to increase the effectiveness of the drug, as bacteria become increasingly resistant to antibiotics.

Released: 21-Feb-2024 2:05 AM EST
New model identifies drugs that shouldn’t be taken together
Massachusetts Institute of Technology (MIT)

Any drug that is taken orally must pass through the lining of the digestive tract. Transporter proteins found on cells that line the GI tract help with this process, but for many drugs, it’s unknown which of those transporters they use to exit the digestive tract.

Released: 15-Feb-2024 2:00 PM EST
UIC research helps create new antibiotic that evades bacterial resistance
University of Illinois Chicago

New drug inspired by images that captured how bacteria block antibiotic activity

   
Newswise: Mejora del proceso de evaluación de la cirugía de la epilepsia: formación y comunicación
Released: 7-Feb-2024 10:05 AM EST
Mejora del proceso de evaluación de la cirugía de la epilepsia: formación y comunicación
International League Against Epilepsy

Aunque la cirugía puede ser una opción para hasta el 40% de las personas con epilepsia resistente a los medicamentos, menos del 1% son remitidos a centros de epilepsia cada año. ¿Por qué?

Newswise: Improving the epilepsy surgery evaluation pipeline: Training and communication
Released: 7-Feb-2024 10:05 AM EST
Improving the epilepsy surgery evaluation pipeline: Training and communication
International League Against Epilepsy

Surgery may be an option for up to 40% of people with drug-resistant epilepsy, but fewer than 1% are referred to epilepsy centers each year. Why?

Newswise: Proteins Suggest a Path to Reduce Drug Resistance in a Form of Cancer
Released: 2-Feb-2024 1:00 PM EST
Proteins Suggest a Path to Reduce Drug Resistance in a Form of Cancer
Pacific Northwest National Laboratory

Scientists have learned more about how drug resistance develops in patients with acute myeloid leukemia and how the process might be slowed, thanks to a study of proteins and other molecular players.

Newswise: Promising heart drugs ID'd by cutting-edge combo of machine learning, human learning
Released: 1-Feb-2024 9:05 PM EST
Promising heart drugs ID'd by cutting-edge combo of machine learning, human learning
University of Virginia Health System

University of Virginia scientists have developed a new approach to machine learning – a form of artificial intelligence – to identify drugs that help minimize harmful scarring after a heart attack or other injuries.

   
Released: 1-Feb-2024 12:05 PM EST
American Society of Anesthesiologists welcomes improvements to No Surprises Act IDR process
American Society of Anesthesiologists (ASA)

The American Society of Anesthesiologists (ASA) commends the Centers for Medicare & Medicaid Services (CMS) for taking positive steps towards returning balance to the independent dispute resolution (IDR) process of the No Surprises Act (NSA) through a recently proposed rule.

Released: 30-Jan-2024 5:05 PM EST
Using vibrator found in cell phones, researchers develop 3D tumor spheroids to screen for anti-cancer drugs
Brigham and Women’s Hospital

Depending on their location, cancer cells within a three-dimensional (3D) tumor structure can have different microenvironments.

Released: 30-Jan-2024 2:05 PM EST
Our winter of discontent: Get the latest news on the flu in the Influenza channel
Newswise

The latest research and expertise on the flue can be found in the Influenza channel on Newswise.

Newswise:Video Embedded the-fentanyl-epidemic-what-you-need-to-know-to-save-lives
VIDEO
Released: 30-Jan-2024 1:05 PM EST
The Fentanyl Epidemic: What You Need to Know to Save Lives
Cedars-Sinai

Like the rest of the country, Los Angeles County has experienced a dramatic upswing in overdoses from fentanyl, an opiate that is 100 times stronger than heroin.

Released: 30-Jan-2024 6:05 AM EST
New drug reveals a key mechanism to overcome resistance to protein degraders
Fundació Institut de Recerca Biomèdica (IRB BARCELONA)

Protein degraders offer a novel approach to targeting undruggable diseases by hijacking the cell's degradation machinery.

Released: 22-Jan-2024 1:05 PM EST
Protein discovery could help solve prostate cancer drug resistance
Washington State University

Researchers have identified a receptor protein known as CHRM1 as a key player in prostate cancer cells’ resistance to docetaxel, a commonly used chemotherapy drug to treat advanced cancer that has spread beyond the prostate.

Released: 19-Jan-2024 1:05 PM EST
Bacterial meningitis damages one in three children for life
Karolinska Institute

One in three children who suffer from bacterial meningitis live with permanent neurological disabilities due to the infection.

Released: 19-Jan-2024 1:05 PM EST
Don't wait for an emergency to get the latest emergency medicine news
Newswise

Find the latest research and features on emergency medicine in the Emergency Medicine channel on Newswise.

       
Newswise: Bioengineered approach shows promise in ulcerative colitis
Released: 16-Jan-2024 10:05 AM EST
Bioengineered approach shows promise in ulcerative colitis
UT Southwestern Medical Center

By taking advantage of mechanisms that allow cancer cells to evade immune attack, UT Southwestern Medical Center researchers have developed a new strategy in animal models that has potential for treating ulcerative colitis.

Newswise: Scientists Reveal Role of Notorious Cell Subpopulation in Antibiotic Failure
Released: 11-Jan-2024 11:05 AM EST
Scientists Reveal Role of Notorious Cell Subpopulation in Antibiotic Failure
University of North Carolina Health Care System

Antibiotic overuse can lead to antibiotic resistance, a global health problem. But UNC School of Medicine scientists with Duke School of Medicine colleagues have documented another culprit in clinical antibiotic failure: bacterial persister cells.

   
Released: 9-Jan-2024 5:05 PM EST
War on bugs can’t be won, York U researchers declare
York University

From a wartime spread of antimicrobial resistant disease in Ukraine, to superbugs in China causing “white lung” pneumonia in children, 2023 brought no shortage of new evidence that antimicrobial resistance (AMR) continues to be a pressing problem globally, and this pattern shows no sign of abating in 2024 unless a radical shift occurs.

Newswise: A new approach can address antibiotic resistance to Mycobacterium abscessus
Released: 5-Jan-2024 11:05 AM EST
A new approach can address antibiotic resistance to Mycobacterium abscessus
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital created analogs of the antibiotic spectinomycin that are significantly more effective against these highly resistant bacteria.

Released: 2-Jan-2024 4:05 PM EST
دراسة تظهر أن الجزيئات المناعية قد يكون لها دورًا رئيسيًا في تطور مرض التصلُّب الجانبي الضموري (ALS)
Mayo Clinic

حدد الباحثون والمتعاونون في مايو كلينك بروتينًا تفرزه الخلايا المناعية والذي قد يقوم بدورٍ رئيسيٍ في ظهور مرضالتصلُّب الجانبي الضموري، المعروف أيضًا باسم مرض لو غيريغ. ووجد الفريق أيضًا أن العلاج التعديلي المناعي الذي يقوم بعملية إِحْصار للبروتين يمكنه استعادة الوظيفة الحركية في النماذج قبل السريرية. وتشير النتائج إلى أن البروتين، المعروف باسم أ5 إنتغرين (الذي يُنطق ألفا 5 إنتغرين)، هو مستهدف علاجي محتمل لعلاج مرض التصلُّب الجانبي الضموري.

Released: 2-Jan-2024 3:05 PM EST
Un estudio muestra que una molécula del sistema inmunitario puede desempeñar un rol clave en la evolución de la ELA
Mayo Clinic

Los investigadores y colaboradores de Mayo Clinic han identificado una proteína expresada en células inmunitarias que podría desempeñar un rol clave en el desarrollo de la esclerosis lateral amiotrófica (ELA), también conocida como enfermedad de Lou Gehrig. El equipo también descubrió que un tratamiento inmunomodulatorio que bloquea la proteína era capaz de restaurar la función motriz en modelos preclínicos. Los hallazgos indican que la proteína, conocida como integrina α5 (pronunciado integrina alfa 5), es un posible blanco terapéutico para la ELA.

Released: 2-Jan-2024 3:05 PM EST
Estudo mostra que molécula imunológica pode desempenhar uma função fundamental na progressão da ELA
Mayo Clinic

Pesquisadores e colaboradores da Mayo Clinic identificaram uma proteína que é expressa por células imunológicas que pode desempenhar uma função importante no desenvolvimento daesclerose lateral amiotrófica (ELA), também conhecida como doença de Lou Gehrig. A equipe também descobriu que um tratamento imunomodulador que bloqueia a proteína conseguiu restaurar a função motora em modelos pré-clínicos. As descobertas sugerem que a proteína, conhecida como integrina α5 (pronunciada como integrina alfa 5), é um possível alvo terapêutico para ELA.

Released: 20-Dec-2023 3:05 PM EST
Working with Big Data requires a lot of power! The latest research and features on Supercomputing
Newswise

With the rise in machine learning applications and artificial intelligence, it's no wonder that more and more scientists and researchers are turning to supercomputers. Supercomputers are commonly used for making predictions with advanced modeling and simulations. This can be applied to climate research, weather forecasting, genomic sequencing, space exploration, aviation engineering and more.

       
Released: 19-Dec-2023 7:05 AM EST
Breakthrough in the development of a drug for sleeping sickness
Bar-Ilan University

Damage to the protein production capacity neutralizes the trypanosome parasite, which causes sleeping sickness. Joint research by Prof.

Newswise: Medicare is Overpaying for Generic Drugs
Released: 5-Dec-2023 10:00 AM EST
Medicare is Overpaying for Generic Drugs
University of California San Diego

Researchers from at University of California San Diego, West Health, and the University of Washington have found evidence that the private insurers that sponsor Medicare Part D are artificially inflating the costs of certain generic drugs by overpaying pharmacies.

Newswise: Could Our Body’s “Bleach” Be Key to Fighting a Common Fungal Pathogen?
Released: 4-Dec-2023 1:05 PM EST
Could Our Body’s “Bleach” Be Key to Fighting a Common Fungal Pathogen?
Stony Brook University

A study that assesses the effects of hypochlorous acid (HOCI), commonly known as bleach, as it is generated during the immune response of a cell (phagocytosis) when fighting a common fungal pathogen, Candida albicans, reveals that HOCI is a potent killing agent. The laboratory finding is highlighted in the journal mBio.

Newswise: Hard to drug: Protein droplets reveal new ways to inhibit transcription factors in an aggressive form of prostate cancer
4-Dec-2023 8:00 AM EST
Hard to drug: Protein droplets reveal new ways to inhibit transcription factors in an aggressive form of prostate cancer
Fundació Institut de Recerca Biomèdica (IRB BARCELONA)

Many of the most potent human oncoproteins belong to a class of proteins called transcription factors, but designing small molecule drugs that target transcription factors is a major challenge.

1-Dec-2023 11:00 AM EST
One in Six Patients with Opioid Use Disorder Leaving the Hospital Before Completing Treatment, Potentially Due to Untreated Withdrawal Symptoms
Perelman School of Medicine at the University of Pennsylvania

The number of patients admitted with opioid use disorder (OUD) and injection-related infections who left the hospital before completing treatment increased significantly between 2016 and 2020 (from 9.3 percent to 17 percent) according to analysis from researchers at the Perelman School of Medicine at the University of Pennsylvania.

Released: 29-Nov-2023 10:05 AM EST
Drugs already licensed could be trialled to potentially treat secondary brain cancer, new research finds
University of Bristol

The largest review of papers for brain cancer that has spread from the lungs has found abnormalities in the brain cancer and for which licensed drugs could be clinically trialled to find out if they could treat the disease.

Newswise: Turning Drug Resistance Against Itself
Released: 26-Nov-2023 11:00 AM EST
Turning Drug Resistance Against Itself
Stony Brook University

A team of Stony Brook University researchers led by Gábor Balázsi, PhD, have been testing drug resistance with mammalian cell lines. Their latest investigation reveals that by taking a part of a DNA amplification from a cell, which causes resistance, and placing it back in, actually stops the drug resistance. Their findings will be published this week in PNAS.

Newswise: Making sense of bacterial Babel
Released: 23-Nov-2023 5:05 AM EST
Making sense of bacterial Babel
Aalto University

Researchers tease apart the relationships between bacterial languages

Newswise: ASPET Welcomes the 2023 FASPET Class
Released: 21-Nov-2023 4:00 PM EST
ASPET Welcomes the 2023 FASPET Class
Federation of American Societies for Experimental Biology (FASEB)

The American Society for Pharmacology and Experimental Therapeutics (ASPET) has selected 16 individuals as 2023 ASPET Fellows.

Released: 21-Nov-2023 3:45 PM EST
It's not over until it's over. Keep up with the latest COVID research in the Coronavirus channel.
Newswise

Stay informed! Keep up with the latest research on the COVID-19 virus in the Coronavirus channel on Newswise.

Released: 20-Nov-2023 7:05 PM EST
Genomic study links cannabis abuse to multiple health problems
Yale University

A Yale-led analysis of the genomes of more than 1 million people has shed light on the underlying biology of cannabis use disorder and its links to psychiatric disorders, abuse of other substances such as tobacco, and possibly even an elevated risk of developing lung cancer.

Released: 18-Nov-2023 1:05 PM EST
Study reveals surprising link between malnutrition and rising antibiotic resistance
University of British Columbia

University of B.C. researchers have uncovered startling connections between micronutrient deficiencies and the composition of gut microbiomes in early life that could help explain why resistance to antibiotics has been rising across the globe.

Newswise: First human clinical trial for pill-sized device that monitors breathing from the gut
Released: 18-Nov-2023 1:05 PM EST
First human clinical trial for pill-sized device that monitors breathing from the gut
Cell Press

Scientists have developed an ingestible device that can safely monitor vital signs like breathing and heart rate from inside humans. The tool, described November 17 in the journal Device, has the potential to provide accessible and convenient care for people at risk of opioid overdose.

Newswise: Cheap medicines prevented migraine as well as expensive ones
Released: 18-Nov-2023 1:05 PM EST
Cheap medicines prevented migraine as well as expensive ones
University of Bergen

Migraine is more than just a headache. Often the pain is accompanied by nausea, vomiting, light sensitivity, and sound sensitivity. Chronic migraine can be disabling and may prevent many, especially women, from contributing to working life.

Released: 15-Nov-2023 11:20 AM EST
From Farm to Newsroom: The Latest Research and Features on Agriculture
Newswise

The world’s total population is expected to reach 9.9 billion by 2050. This rapid increase in population is boosting the demand for agriculture to cater for the increased demand. Below are some of the latest research and features on agriculture and farming in the Agriculture channel on Newswise.

Released: 15-Nov-2023 10:05 AM EST
Pain Scores, Age Can Help Identify Patients More Likely to Use Few or No Opioids After Surgery
Perelman School of Medicine at the University of Pennsylvania

A study showed that patient pain scores were a good predictor for opioid use, but younger patients and those who hadn’t used opioids before were less likely to take them



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