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Leptomeningeal disease is a rare but lethal complication faced by late-stage melanoma patients. It occurs when cancer cells spread to the membranes covering the brain and spinal cord, or the leptomeninges. This condition, which affects 5% to 8% of melanoma patients, often leads to rapid deterioration and is notoriously resistant to therapies. However, a new Moffitt Cancer Center study, published today in Cell Reports Medicine, uncovers the mechanisms that drive this drug resistance, offering new avenues for potential treatments.
Mount Sinai Health System, one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, over 400 outpatient practices, a school of nursing, and a leading school of medicine and graduate, today announced the appointment of Vincent Tammaro as the next Executive Vice President and Chief Financial Officer (CFO) joining the System in October. Tammaro will succeed Stephen Harvey, CPA, MBA, who will stay on as CFO Emeritus to support the transition.
Using tools of modern genetics, plant biochemists have produced a new high-yielding oilseed crop variety — a yellow-seeded variety of Camelina sativa, a close relative of canola, that accumulates 21.4% more oil than ordinary camelina.
Safety and Intelligent Maintenance of Offshore Structures
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At a glance:
The four scientists developed genetically engineered immune cells to combat several blood cancers.
CAR T-cell therapy has redefined the treatment of blood cancers, saving the lives of tens of thousands of people.
Researchers have demonstrated a new method that could enable the large-scale manufacturing of optical qubits. The work is a major advancement that could bring us closer to a scalable quantum computer.
As a new space race revs up, propelling humans back to the Moon and toward a Mars landing for the first time, mysteries remain about the unique pressures of spaceflight on humans – especially for those blasting off through new commercial space travel operations. For the first time, researchers have data on the physical and psychological impact of spaceflight on an all-civilian crew.
In Applied Physics Reviews, researchers from Tsinghua University work to break through the difficulties of robotic recognition of various common, yet complex, items. Their layered sensor is equipped with material detection at the surface and pressure sensitivity at the bottom, with a porous middle layer sensitive to thermal changes.
In a large clinical trial, UT Southwestern Medical Center researchers developed a robust model for testing strategies to prevent health problems in patients with multiple chronic conditions.
In a new UCLA-led study, investigators shed light on the intricate processes underlying cancer evolution and define the optimal algorithms to analyze the genetic makeup of tumors.
The Molecular Transducers of Physical Activity Consortium, of which Zhen Yan is a founding member, studied both male and female rats over eight weeks of endurance exercise and found thousands of molecular alterations. These findings, which published in May in Nature, have implications for human health, such as in liver disease, bowel disease, cardiovascular health, and tissue recovery.
Journalists who register for the fall meeting of the American Chemical Society (ACS) will have access to about 10,000 presentations on topics including agriculture and food, energy and fuels, health and medicine, sustainability, and more.
Today, researchers are developing ways to accelerate discovery by combining automated experiments, artificial intelligence and high-performance computing. A novel tool developed at Oak Ridge National Laboratory that leverages those technologies has demonstrated that AI can influence materials synthesis and conduct associated experiments without human supervision.
Scientists have developed a new efficient catalyst for the most challenging part of “water splitting,” a series of two simultaneous electrochemical reactions that generate hydrogen gas, a green energy source, from water. The new catalyst was designed based on theoretical predictions and validated in laboratory tests and industrially relevant demonstrations.
A new special issue of Frontiers of Environmental Science & Engineering presents groundbreaking research on strategies for achieving a pollution-free planet. This collection explores diverse approaches, from advanced wastewater treatment technologies to digital management systems, offering a comprehensive blueprint for a sustainable future.
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By using AI to assist with cancer contouring, the researchers found predicting the cancer size was 45 times more accurate and consistent than when physicians used only conventional clinical imaging and blood tests to predict the cancer extent.
In a significant leap for aerospace and mechanical engineering, researchers have developed a cutting-edge bidirectional energy-controlled piezoelectric shunt damping technology. This breakthrough not only significantly enhances the suppression of vibration amplitudes in mechanical systems without external power but also harnesses electrical energy, heralding a new era of self-powered solutions.
The Endocrine Society endorses the Right to IVF Act, which was introduced by Senators Cory Booker (D-NJ), Patty Murray (D-WA) and Tammy Duckworth (D-IL) to protect and expand nationwide access to fertility treatment, including in vitro fertilization (IVF), and urges the Senate to pass the Right to IVF Act on June 12th to ensure that the freedom to start and grow a family is protected and accessible to everyone in the United States.
Chulalongkorn University has once again been recognized as the No. 1 university in Thailand, and the only Thai institution to secure a spot in the world’s top 100 for Academic Reputation and Employment Outcomes, according to the QS World University Rankings (WUR) 2025, officially announced on June 5, 2024.
The exhaust heat generated by a fusing plasma in a commercial-scale reactor may not be as damaging to the vessel’s innards as once thought, according to new research about escaping plasma particles made by researchers at the Princeton Plasma Physics Laboratory, Oak Ridge National Laboratory and ITER Organization (ITER).
Intensive fishing and habitat degradation from urbanization and climate change have caused queen conch populations to significantly dwindle. “eConch,” a free online training program to grow queen conch, is easy to follow, allows users to move at their own pace, includes high-quality video and provides access to expert advice.
A new study by an international team of researchers, published today in Nature Climate Change, has revealed significant progress in the drive to reduce atmospheric levels of chemicals that destroy the Earth’s protective ozone layer, confirming the success of historic regulations limiting their production and use. Empa scientists contributed to this study with measurements from the high-alpine research station at Jungfraujoch.
Today, researchers are developing ways to accelerate discovery by combining automated experiments, artificial intelligence and high-performance computing. A novel tool developed at Oak Ridge National Laboratory that leverages those technologies has demonstrated that AI can influence materials synthesis and conduct associated experiments without human supervision.
The hearts of pregnant rats with high blood pressure increase in size more than rats experiencing a normal pregnancy, according to new computer model predictions.
Researchers have developed a new excitation modality for studying tiny molecules in super detail. The technique, known as MINFLUX, works by shining a patterned light on the molecule. This new method uses a simpler device to create the light pattern, making it faster, cheaper, and easier for future scientific discoveries.
Researchers have developed a novel cell culturing technique that reveals the hidden biomechanics of breast cancer — the end goal, “radical improvement” in the laborious process of screening chemotherapeutics.
The Hong Kong Institute for Advanced Study (HKIAS) at City University of Hong Kong (CityUHK) welcomed Professor Enge Wang from June 3 to June 7, 2024. Prof. Wang, a Senior Fellow of HKIAS and University Chair Professor of Physics at Peking University, is a distinguished member of the Chinese Academy of Sciences.
A new study has revealed significant progress in the drive to reduce levels in the atmosphere of chemicals that destroy Earth’s ozone layer, confirming the success of historic regulations limiting their production.
Using an advanced artificial intelligence tool, researchers at the Icahn School of Medicine at Mount Sinai have identified rare coding variants in 17 genes that shed light on the molecular basis of coronary artery disease (CAD), the leading cause of morbidity and mortality worldwide. The discoveries, detailed in the June 11 online issue of Nature Genetics, reveal genetic factors impacting heart disease that open new avenues for targeted treatments and personalized approaches to cardiovascular care. The investigators used an in silico, or computer-derived, score for coronary artery disease (ISCAD) that holistically represents CAD, as described in a previous paper by the team in The Lancet. The ISCAD score incorporates hundreds of different clinical features from the electronic health record, including vital signs, laboratory test results, medications, symptoms, and diagnoses. To build the score, they trained machine learning models on the electronic health records of 604,914 individuals
In a new study published this week, researchers at the University of South Australia highlight the urgency of ensuring young victims of serious child abuse or neglect get the support they need prior to school commencement so that that can be as close to developmentally on track as possible.
A study led by linguists from the NUS Faculty of Arts and Social Sciences has found that early linguistic signs of dementia can be detected through the study of the natural speech of senior Singaporeans. The novel study revealed that participants with memory-related mild cognitive impairment spoke less and used fewer, but more abstract, nouns that is consistent with the speech pattern of Alzheimer’s patients.
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A collaboration between the SA Department for Education and the University of South Australia, the five-year study will engage 4000 students in years two, four and six, across 57 South Australian primary schools to determine the benefits of teaching self-regulated learning.
Fourteen teams from 11 schools, including seven schools new to the competition, gathered at Argonne to race. They also learned about teamwork, competition, engineering and problem-solving.
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Jinghui Yuan, an R&D staff member in the Applied Research for Mobility Systems group at the Department of Energy’s Oak Ridge National Laboratory, has been elevated to a senior member of the Institute of Electrical and Electronics Engineers, or IEEE.
Karen Innocent, DNP, RN, CRNP, ANP-BC, CMSRN, has been named to the American Nurses Credentialing Center's Commission on Accreditation in Nursing Continuing Professional Development
The MOLLER experiment has received Critical Decision 2 “Approve Performance Baseline” and Critical Decision 3 “Approve Start of Construction” from the Department of Energy, which provides clearance to move forward with all procurements and equipment construction.
A new study published in Medical Care today showed that substituting registered nurses (RN) with lower-wage staff (e.g. licensed practical nurses, unlicensed assistive personnel) in hospital care is linked with more deaths, readmissions, longer hospital stays, poorer patient satisfaction, and higher costs of care.