Rotator cuff (RC) attaches to humerus across a triphasic yet continuous tissue zones (bone-fibrocartilage-tendon), termed “enthesis”. Regrettably, rapid and functional enthesis regeneration is challenging after RC tear. The existing grafts bioengineered …
Advances in molecular technologies accelerated investigations of the hematopoietic stem cell (HSC) compartment in aplastic anemia (AA). Initially, stem cell biology approaches indicated a profound depletion of HSC pool, while studies of paroxysmal …
Dental stem cells (DSCs), an important source of mesenchymal stem cells (MSCs), can be easily obtained by minimally invasive procedures and have been used for the treatment of various diseases. Classic paradigm attributed the mechanism of their …
Since the first bone marrow transplant was performed in the 1950s, stem cell-based therapies have offered the potential to treat many chronic, degenerative conditions, and multiple sclerosis (MS) is no exception. Over the last decade, autologous …
Pancreatic β cell dysfunction is a central component of diabetes progression. During the last decades, the genetic basis of several monogenic forms of diabetes has been recognized. Genome-wide association studies (GWAS) have also facilitated the …
The Wnt/β-catenin pathway plays an important role in tumor progression and chemotherapy resistance and seems to be essential for the maintenance of cancer stem cells (CSC) in several tumor types. However, the interplay of these factors has …
Mesenchymal stem cells (MSCs) are stem cells with the potential ability to differentiate into various cells and the ability to self-renew and resemble fibroblasts. These cells can adhere to plastic to facilitate the culture process. MSCs can be used …
The role of hematopoietic stem cell transplantation (HSCT) in pediatric acute lymphoblastic leukemia (ALL) is evolving. The indications for transplant in first complete remission (CR1) has decreased over the last decade; however, it continues …
… Over the past 25 years, scientific advancements in stem cell technologies have led to a new hope of fertility restoration for those at risk or who have lost their fertility. Though some couples diagnosed with infertility are successfully able to conceive by …
The significance of cancer stem cells (CSCs) in initiation and progression of colon cancer (CC) has been established. In this study, we investigated the utility of measuring mRNA expression levels of CSC markers EpCAM, LGR5 and LGR4 for …
Simple Summary Aquaculture is expanding due to the high demand of fish for human consumption. However, since carnivorous fish are fed using fish-derived proteins and lipids, the sustainability of this food-producing sector is debated. Therefore, feed …
Histone variants and the associated post-translational modifications that govern the stemness of haematopoietic stem cells (HSCs) and differentiation thereof into progenitors (HSPCs) have not been well defined. H3. 3 is a replication-independent …
Irrespective of the labyrinth of fastidiously woven artificial scaffolds, the lack of biocompatibility hampers effective clinical translation, which is the definitive purpose of any biomedical system or device. Hence, the current exploration deals with the …
Hyaluronic acid-based hydrogels (Hyal-Gels) have the potential to reduce wrinkles by physically volumizing the skin. However, they have limited ability to stimulate collagen generation, thus warranting repeated treatments to maintain their …
Introduction Genital chronic graft‐versus‐host disease (cGvHD) is a common late effect after allogeneic stem cell transplantation. In a previous cross‐sectional study, prevalence, signs and symptoms of genital and extra‐genital cGvHD were accounted …
Porous polymer scaffolds are essential materials for tissue engineering because they can be easily processed to deliver stem cells or bioactive factors. However, scaffolds made of synthetic polymers normally lack a bioactive cell-material interface and …
Abstract According to World Health Organization, over 50,000 hematopoietic stem cell transplants (HSCTs) are performed annually worldwide. Though HSCT can extend life-expectancy and improve disease-related health burdens, it is not without …
Osteoarthritis (OA) had a high incidence in people over 65 years old, and there is currently no drug that could completely cure it. This study is aimed at studying the role of exosomes in regulating glutamine metabolism in the treatment of OA. First, we …
Introduction Cigarette smoking is the main risk factor for lung cancer. MSCs in the TME promoting tumor angiogenesis, growth, and metastasis. SIBLING proteins enable cancer cells to extend, invade and metastasize. Objectives Cigarette smoke …
Regenerative medicine aims to replace damaged tissues by stimulating endogenous tissue repair or by transplanting autologous or allogeneic cells. Due to their capacity to produce unlimited numbers of cells of a given cell type, pluripotent stem cells …
… Aldehyde dehydrogenase 1(ALDH1) is a stem cell marker, expressed in many different solid tumors of bladder, pancreas, colon, and kidney. … This stem cell marker is expressed in a number of different solid tumors of bladder,13 pancreas,14 …
Materials and Methods This experimental study consists of designing a recombinant protein by bioinformatic softwares and the laboratory part of the study. The indices of interest for designing of the protein structures were analysed by various softwares …
Promising outcomes of kidney transplantation following hematopoeitic stem cell transplantation has been reported. Data from some centers have demonstrated stable graft function without long term immunosuppression. We present our …
Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene‐edited human‐induced pluripotent stem cell‐ derived cardiomyocytes and preclinical drug screening-El‐Battrawy-2021-Clinical …
Background. Griscelli syndrome (GS) is a rare disorder characterized by partial albinism and silver hair with alteration in genes necessary for melanin transport. Type 2 GS is fatal due to severe immunodeficiency without curative stem cell …
Hematopoietic stem cell transplantation (HSCT) from haploidentical donors is a viable option for patients lacking HLA-matched donors. Here we report the results of a prospective multicenter phase I/II trial of transplantation of TCRαβ and CD19 …
Since the first patients received autologous hematopoietic stem cell transplantation (auto-HSCT) more than 60 years ago, therapeutic developments in the field have been substantial. Mobilized peripheral blood cells has replaced bone marrow as …
… We previously demonstrated that the cancer stem cell marker Musashi-1 (MSI1) is an RNA binding protein that promotes radioresistance … In addition, miR-671-5p could attenuate tumor migration and cancer stem cell (CSC) characteristics by …
Antifungal prophylaxis can reduce morbidity and mortality from invasive fungal disease (IFD). However, its use needs to be optimised and appropriately targeted to patients at highest risk to derive the most benefit. In addition to established risks for …
Stem cell transplantation has been applied to treat spinal cord injury (SCI) in clinical trials for many years. However, the clinical efficacies of stem cell transplantation in SCI have been quite diverse. The purpose of our study was to systematically …
Simple Summary Due to its graft-versus-myeloma effect, allogeneic hematopoietic stem cell transplantation (allo-SCT) can enable long-term survival or even cure in carefully selected patients with multiple myeloma (MM), but remains controversial …
… The purpose of this research was to confirm the use of patient-specific induced pluripotent stem cell (iPSC)-derived hepatocyte-like cells (HLCs) as an applicable tool to model ARH disorder. Using Sendai viral vectors, fibroblasts of an ARH patient …
In a widely shared newsletter, Steve Kirsch, a man who promotes himself as an entrepreneur and technology expert, stated that "they've now killed close to twice as many kids from the vaccine as have died from COVID." He's also repeated this claim in an interview on The New American, a conservative news site. We find this claim false. There is no confirmed evidence of a COVID-19 vaccine causing the death of even one child.
The inhibition of voltage-gated sodium (Na V) channels in somatosensory neurons presents a promising novel modality for the treatment of pain. However, the precise contribution of these channels to neuronal excitability, the cellular correlate of pain, is …
Human pluripotent stem cells can differentiate into any cell type given appropriate signals and hence have been used to research early human development of many tissues and diseases. Here, we review the major biological factors that regulate …
The heart is a highly complex, multicellular solid organ with energy-demanding processes that require a dense vascular network, extensive cell-cell interactions, and extracellular matrix (ECM)-mediated crosstalk among heterogeneous cell …
Stem cells have been utilized as'living drugs'in clinics for decades. Their self- renewal, differentiation, and immunomodulating properties provide potential solutions for a variety of malignant diseases and disorders. However, the …
Although most patients with hepatitis E virus (HEV) infection are asymptomatic or have mild symptoms, its infection is generally underdiagnosed and overlooked. In immunocompromised patients, HEV infection can lead to acute liver failure and …
Maintaining genomic integrity and stability is crucial for life; yet, no tissue-driven mechanism that robustly safeguards the epithelial genome has been discovered. Epidermal stem cells (EpiSCs) continuously replenish the stratified layers of …
Cytochrome P45011A1, encoded by Cyp11a1, converts cholesterol to pregnenolone (P5), the first and rate-limiting step in steroidogenesis. In zebrafish, cyp11a1 is maternally expressed and cyp11a2 is considered the ortholog of Cyp11a1 in …
The simultaneous generation of multiple tissues and their functional assembly into complex tissues remains a critical challenge for regenerative medicine. The tissue-to- tissue interface connecting two adjacent tissues is vital in effective tissue function …
The goal of the current study was to investigate the therapeutic effects of exosomes derived from mesenchymal stem cells (MSCs-Exo) and copper sulfide nanoparticles (CuSNPs) as biomaterials in order to understand the mechanisms that contribute to …
Osteosarcoma is a high-grade bone-forming neoplasm, with a complex genome. Tumours frequently show chromothripsis, many deletions, translocations and copy number alterations. Alterations in the p53 or Rb pathway are the most common …
Rapid percutaneous coronary intervention for acute myocardial infarction (AMI) reduces acute mortality, but there is an urgent need for treatment of left ventricular dysfunction and remodeling after AMI to improve the prognosis. The myocardium …
Human pluripotent stem cells (hPSCs) grow as colonies with epithelial-like features including cell polarity and position-dependent features that contribute to symmetry breaking during development. Our study provides evidence that hPSC colonies …
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