… for Atg5, the stem cell loss in vivo was more pronounced than in vitro, suggesting that additional cell populations likely depend upon Atg5 function to support ileum health. We first tested whether ATG5-dependent WNT signaling was required for …
… With Select-seq, we analyse the cancer stem cell-like microniches in relation to the tumour microenvironment of triple-negative breast cancer patients. We identify alternative splice variants, perform complementarity-determining region analysis of …
Over the last 30 years, allogeneic haematopoietic stem cell transplantation (allo‐HSCT) has been adopted as a therapeutic strategy for many inborn errors of metabolism (IEM), due to the ability of donor‐derived cells to provide life‐long enzyme delivery to …
Despite advances in the understanding of the pathophysiology of cytomegalovirus (CMV) infection, it remains as one of the most common infectious complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The aim of this study …
… Also, and most importantly, when comparing results across laboratories we need to bear in mind that no embryonic stem cell line is a tabula rasa. Different cell lines have been shown to exhibit biases in differentiation potential (Ortmann et al., 2020) …
Multi-drug resistance remains a critical issue in cancer treatment that hinders the effective use of chemotherapeutic drugs. The active components of traditional Chinese medicine have been applied as adjuvants to accentuate the anticancer …
… reside in the RZ, a known location for stem cells 5,11 , and that FoxA2+ cells are located in close proximity to the SOC, which is viewed as a signaling center of RZ stemness 10 , we asked whether FoxA2+ cells are different than the previously …
Limited stem cells, poor stretchability and mismatched interface fusion have plagued the reconstruction of cranial defects by cell-free scaffolds. Here, we designed an instantly fixable and self-adaptive scaffold by dopamine-modified hyaluronic acid …
… In order to obtain the highest yield of mesenchymal stem cell-derived nanovesicles (MSC-NVs), we employed a serial extrusion approach using polycarbonate membrane filters with 5 μm, 1 μm, 0.4 μm, and 0.2 μm pore sizes …
The high mortality rate of malignant pleural mesothelioma led to study the mechanisms for chemoresistance. The cancer stem cell (CSC) model has been proposed to explain chemoresistance. CSCs are characterized by self-renewal …
Pfizer has NOT declared their COVID vaccines unsafe for pregnancy and breastfeeding women, despite misleading claims on social media, nor have they said that the real efficacy rate for their vaccine (COMIRNATY) is 12 percent.
… In this study, we demonstrated that TET2 deficiency impaired muscle stem cell proliferation and differentiation, leading to notable changes in mouse body weight and muscle morphology during development. We further assayed the genome-wide …
… related to complications of hematopoietic stem cell transplantation. This highlights a non-… The most frequent ocular complication of autologous hematopoietic stem cell transplantation is … periorbital edema in a patient after hematopoietic stem cell …
… This article provides a review of the most frequently used CSCs and stem cell markers. … of stem cells, because they play a role in stem cell pluripotency and their interactions with various co-… Indeed, the functional role of stem cell factors in …
… the multitude of stem cell types (adipose derived, bone marrow derived, embryonic and induced pluripotent) and techniques employed to induce stem cell proliferation and differentiation … Here, we curate several studies on stem cell …
… Instead, using stem cell models, it is possible to recapitulate neurodevelopment in vitro, essentially observing risk in a laboratory dish. We … The first human embryonic stem cell lines were grown in 1998, with the theoretical capability to …
PO-660-03 OPTICAL CONTROL OF ARRHYTHMIA MORPHOLOGY IN HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED … To develop a method for the induction of morphologically and physiologically defined arrhythmias in human …
Are you looking for expert commentary on the leaked opinion draft that appears to overturn Roe v. Wade? Newswise has you covered! Below are some of the latest headlines that have been added to the U.S. Supreme Court channel on Newswise.
Much has been learned about the genes and pathways that contribute to a diverse array of hematopoietic malignancies and other hematopoietic diseases. However, for many of these diseases, an allogeneic hematopoietic stem cell (HSC) transplant …
… Here, we show that a high density of ILC1s induces leukemia stem cell (LSC) apoptosis in mice. At a lower density, ILC1s prevent LSCs from differentiating into leukemia progenitors and promote their differentiation into non-leukemic cells, thus …
… In summary, our study demonstrated that NSE promoted stem cell-like characteristics of SCLC via NBL1 and the activation of the BMP2/… , which promotes stem cell-like characteristics [20, 21]. Thus, we aimed to determine …
Stem-cell-derived tissue models generated from sick people are being used to understand human development and disease, drug development, and drug screening. However, it is possible to detect disease phenotypes before a patient …
… ASCL1 is required to establish the neuronal and stem cell-like lineage … To determine whether ASCL1 is required for the development of neuronal and stem cell-like phenotype… neuronal and stem cell differentiation and functions to bias the cell fate …
… of the gut microbiota correlate with superior outcomes after hematopoietic stem cell transplantation. Correlative data support the impact of … discuss data describing the key role of microbiota in hematopoietic stem cell transplantation for …
… Stem cell quiescence is regulated by multiple factors including p53, Rb, cyclin-dependent kinase inhibitors, such as p21 and p27, and Notch signaling (5–10). How these pathways may integrate to maintain stem cell … Dysregulation or loss of quiescence …
… Human induced pluripotent stem cell (hiPSC) technology can be used for disease … Culturing hiPSC-CM or human embryonic stem cell-derived cardiomyocytes (hESC-CM) within … sufficient to induce full maturation of pluripotent stem cell-derived …
Musk's meme suggests conservatives haven't really changed. However, according to research, Republicans have moved further to the right than Democrats have to the left.
… stem cell niche. Here, we hypothesized that regulation of cell-cell interactions using a polymeric scaffold as synthetic extracellular matrix (ECM) could be critical in creating a hematopoietic stem cell … and cell-instructive characteristics for stem cell …
Hepatic sinusoidal obstruction syndrome (SOS) is a serious complication after allogeneic stem cell transplantation (allo-HCT). However, there is no uniform consensus on the optimal strategy for SOS prevention. Ursodeoxycholic acid is the …
… In this study, we found that the PDMS substrate coated with a combination of polydopamine (PDA) and laminin-511 E8 fragments (PDA + LME8-coated PDMS) can support human-induced pluripotent stem cell (hiPSC) attachment and growth for …
… Its impact in any cancer stem cell (CSC) subtype remained elusive. In a recent study, we characterized the expression of LAMP2A and CMA activity in glioblastoma revealing its enrichment in a glioma stem cell (GSC) subpopulation. LAMP2A …
Benzophenones are widely used in industry and commonly added in many personal care products. However, the neurotoxicity, in particular neurodevelopmental toxicity, of benzophenone family chemicals and metabolites has not been fully elucidated …
… Human neuronal models range from various neuroblastoma cell lines to stem cell–derived systems, including those derived from mesenchymal stem/stromal cells (hMSC). hMSCs exhibit numerous advantages, including the fact that they can be obtained in …
… This review focuses on the key processes and guidelines for clinical translation of human induced pluripotent stem cell (hiPSC)derived β cells for diabetes cell therapy. Here, we discuss the (1) key considerations of manufacturing clinical-grade hiPSCs …
It’s been 50 years since the Tuskegee Study was disclosed to the American public. In May, a new riveting account of the Study, when government doctors intentionally withheld effective therapy for syphilis for 40 years in 400 African American men, will be published in the American Journal of Respiratory and Critical Care Medicine. The article explains the deeper everlasting lessons of the study.
… stem cell transplantation. Endothelial cell damage may trigger the initiation of aGVHD. Methods: Endothelial damage and repair were evaluated by counting circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) in 17 …
Exosomes are known to transmit microRNAs (miRNAs) to affect human cancer progression, and miR-17-5p has been manifested to exert facilitated effects on colorectal cancer (CRC) progression, while the role of tumor stem cells-derived …
… Mesenchymal stem cells (MSCs) are adult stem cell populations and exhibit great potential in regenerative medicine and oncology. Platelet-derived growth factors (PDGFs) are well-known to regulate MSC biology through their chemotactic and mitogenic …
Acute myeloid leukemia (AML) is characterized by poor clinical outcomes due to high rates of relapse following standard-of-care induction chemotherapy. While many pathogenic drivers have been described in AML, our understanding of the …
… There was a statistically significant difference in the frequency of CD4+ CD95+, CD4+ CD95 Hi, and CD4+ CD95 low/med T stem cell memory (T SCM) cells between responder and nonresponder groups. However, the comparison of the …
… The child was pretreated with modified Bu/Cy plus ATG regimen for transplantation, and underwent haploid hematopoietic stem cell … , intravenous immunoglobulin (IVIG) transfusion, stem cell transfusion and other treatments, and …
Acute liver injury (ALI) is characterized by massive hepatocyte necrosis and subsequent recruitment of myeloid cells to liver. Mesenchymal stem cells (MSCs) have therapeutic potential for ALI through their immunoregulation on macrophages …
… MSC, a pluripotent stem cell, has self-renewal capability and multidirectional differentiation potential, and it can be obtained from tissues, such as the umbilical cord, bone marrow and fat [24], [25]. Many experimental and clinical studies proved …
Cell therapy using induced pluripotent stem cell (iPSC) derivatives may result in abnormal tissue generation because the cells undergo numerous cycles of mitosis before clinical application, potentially increasing the accumulation of genetic …
… stem cell sources and differentiation lineages and is therefore useful for various stem cell–… cells and extracellular matrix components, guiding stem cell fates ex vivo is generally initiated … ultimately negatively affects the guiding efficiency of the …
… The objective of this study is to synthesise the findings of clinical studies in order to derive evidence for use of the mesenchymal stem cell (MSC) therapy in the treatment of neurodegenerative cerebellar ataxias. In order to find relevant studies …
… d Stem cell frequency of GS5 cells treated with Cas9 and the indicated sgRNAs as determined by limiting dilution assay. e–g Representative flow cytometry images (e) and corresponding quantification (f) (n = 3 biologically independent samples, black …
… methylation status, which in turn compromised periodontal stem cell function including a reduction in proliferation and differentiation … co‐regulator, which plays a key role in cell proliferation, differentiation, and stem cell self‐renewal [86]. The …
… Allogeneic hematopoietic stem cell transplantation (HSCT) can be a highly effective treatment for patients with hematological malignancies and hereditary blood disorders if a suitable HSC graft can be obtained, ideally from an HLA (human leukocyte …
As in younger patients, allogeneic stem cell transplantation (alloHSCT) offers the best chance for durable remission in older patients (≥60 years) with acute myeloid leukemia (AML). However, defining the best treatment strategy (and in particular …
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