Feature Channels: Women's Health

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In the past several years, myocarditis has been of public interest because of cases associated with vaccines for SARS-CoV2 or related conditions. Another form of myocarditis has been linked to immune checkpoint inhibitors (ICIs) used in cancer care. ICI-induced myocarditis is a potentially fatal side effect of ICI usage, and it appears that the adverse cardiac effects may disproportionally impact female patients. This finding is in contrast to other forms of myocarditis, with more cases reported in male patients.

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A new preclinical study from researchers at The University of Texas MD Anderson Cancer Center and the University of California San Francisco (UCSF) has discovered the underlying cause of gender differences in immunotherapy-associated myocarditis after immune checkpoint inhibitor (ICI) treatment. Their findings point to possible treatment strategies for this side effect, which disproportionately affects female patients.

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Vaginal progesterone, a hormone treatment considered the standard of care for preventing preterm birth in at-risk pregnant women, may not be effective, according to UT Southwestern Medical Center researchers.

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UT Southwestern researchers have identified a causative signaling pathway in breast cancer, providing potential new targets for treatment of the most common type of cancer in women.

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Pregnant teens in the U.S. have long been known to face increased health risks and pregnancy complications, but a new study for the first time finds that girls ages 13 or younger who get pregnant face even greater risks. These very young girls are significantly more likely to experience preterm birth, cesarean delivery, and admission to the intensive care unit (ICU) compared to older pregnant teens.

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A Roundup of the Latest Medical Discoveries and Faculty News at Cedars-Sinai

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If women want to lean in to work, they may first want to lay down for a good night’s rest.

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A drug approved to treat breast cancer patients with mutations in the BRCA1 or BRCA2 genes may also benefit people who have other genetic mutations.

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New research from Yale Cancer Center reveals for the first time ever a differential clinical response to pembrolizumab in Lynch-like (mutated) vs methylated microsatellite instability-high (MSI-H) uterine cancer patients, increasing our understanding about the proportion of patients that derive benefit from immune checkpoint blockade.

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Cecilia Lindestam Arlehamn, Ph.D., aims to shed light on how sex-based immune system differences may affect the development and progression of these neurodegenerative diseases in men versus women.

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Rates of one type of stroke called subarachnoid hemorrhage have increased in older people and men in recent years, and such strokes occur in Black people at a disproportionately higher rate compared to people of other races and ethnicities, according to a study published in the October 26, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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The LJI team plans to use their new map of the Lassa virus surface glycoprotein to design a much-needed vaccine.

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UW Medicine researchers compared vaginal samples collected from 95 young women or adolescent study participants in Kenya before or after they began having sexual intercourse. They found a sharp increase in proteins that control the immune response, including IL-1β, IL-2, and CXCL8, during the first year after becoming sexually active.

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Researchers publish data on the effects of intermittent fasting on women's hormones

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尊敬的妙佑医疗国际：我的偏头痛断断续续发作已有五年了，为此我饱受折磨。最近，我发现自己平时服用的口服药物似乎也没那么有效了。我知道市面上有一些更新型的药物，但一位朋友建议我试一试Botox注射。她很认真地告诉我，正是这种药物使她的慢性头痛得到了控制。我想请问一下，Botox注射的安全性怎么样？是如何起作用的？这种药物的治疗方案是什么？需要结合使用其他头痛药物吗？答：Botox又名A型肉毒杆菌毒素，其于2010年经美国食品药品管理局批准用于治疗慢性偏头痛。这种药物并不能根治此病。使用Botox注射治疗头痛的患者通常需要每三个月接受一次注射。

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ESTIMADA MAYO CLINIC: venho sofrendo com enxaquecas intermitentes há mais ou menos cinco anos. Recentemente, a terapia oral que venho usando parece não estar mais fazendo efeito. Apesar de saber que novos medicamentos estão disponíveis, uma amiga sugeriu que eu experimentasse injeções de Botox. Ela jura que as injeções deixaram seus níveis de dores de cabeça sob controle. Essas injeções são seguras e como o Botox funciona? Qual é o cronograma de tratamento e eu também precisaria tomar outros medicamentos para dor de cabeça? RESPOSTA: a toxina Onabotulínica A, ou Botox, foi aprovada pela Food and Drug Administration (Administração de Alimentos e Medicamentos dos Estados Unidos) em 2010 para tratar enxaquecas. Não se trata de uma cura. As pessoas que recebem injeções de Botox para dores de cabeça geralmente recebem o tratamento mais ou menos a cada três meses.

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ESTIMADA MAYO CLINIC: He sufrido migraña de forma intermitente durante aproximadamente cinco años. En el último tiempo, la terapia oral que he recibido pareciera ser menos eficaz. Si bien sé que existen medicamentos más nuevos, una amiga me sugirió que pruebe las inyecciones de bótox. Mi amiga jura que el bótox controló sus dolores de cabeza crónicos. ¿Cuán seguras son estas inyecciones? ¿Cómo funciona el bótox? ¿Cuál es el plan de tratamiento? ¿También tendría que tomar otro medicamento para el dolor de cabeza? RESPUESTA: La onabotulinumtoxina A, o el bótox, fue aprobada por la Administración de Alimentos y Medicamentos en el 2010 para el tratamiento de los dolores de cabeza por migraña crónicos. No es una cura. Las personas que reciben inyecciones de bótox para los dolores de cabeza suelen recibir el tratamiento aproximadamente cada tres meses.

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Here are some of the latest articles that have been added to the Drugs and drug abuse channel.

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A three-week course of radiation therapy is as safe and effective as four to six weeks of treatment for patients with early-stage breast cancer who have a higher risk of having their tumors recur, results of a randomized phase III clinical trial show. Delivering fewer, but higher, doses of radiation following lumpectomy, while concurrently delivering a radiation boost to the surgical site, led to similar outcomes as a longer course of treatment.

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On Wednesday, November 2, 2022, MacNeal Hospital will host an interactive demonstration in which members of the community can observe and try out the da Vinci surgical system. The event will be held from 11 am to 4 pm at the Oak Park lobby entrance. Acquired by Loyola Medicine in 2021, the da Vinci robots are used for minimally invasive procedures at MacNeal. In this interactive experience, members of the community have an opportunity to learn first-hand how MacNeal physicians perform urologic, gynecologic and general surgeries using this advanced technology.

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A new study finds that sexual side effects of cancer treatment are discussed far less frequently with female patients than with male patients, even when the treatment directly affects sex organs.

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The latest articles that have been added to the Environmental Health channel.

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Women at risk of pregnancy loss who need a specialist surgical procedure could benefit from a single-stranded suture thread to reduce risk of infection, results from the C-STICH clinical trial found.

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A new study may prompt medical experts to rethink when to start mammograms for women who have a mother, sister or daughter diagnosed with breast cancer.

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A team of researchers from Mayo Clinic Comprehensive Cancer Center has been awarded a five-year, $12.1 million Specialized Program of Research Excellence (SPORE) grant in breast cancer from the National Cancer Institute (NCI). This is the third renewal of Mayo Clinic's breast cancer SPORE grant.

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Rates of prenatal care among foreign-born Latinx pregnant people decreased below expected levels during the 2016 presidential campaign – likely reflecting the effects of harmful anti-immigrant rhetoric, reports a study in the November issue of Medical Care. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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It’s not your mom’s mammogram. Take a look inside a 3-D exam room in this week’s Medical Minute.

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While hormone therapy was associated with higher self-reported quality of life in white women, Black women actually experienced lower overall quality of life under the same treatment.

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A Ludwig Cancer Research study has developed a strategy to noninvasively track immune cells known as macrophages within brain and breast tumors in living mice.

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The American College of Radiology is set to launch the Contrast-Enhanced Mammography Imaging Screening Trial (CMIST) with the Breast Cancer Research Foundation (BCRF) and GE Healthcare. CMIST will determine if contrast-enhanced mammography improves breast cancer detection and reduces false-positive exams in women with dense breasts.

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A recent survey showed that family and friends who care for dependent adults are at increased risk of health-related socioeconomic vulnerabilities compared to non-caregivers.

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Yuan Yuan, MD, PhD, a breast medical oncologist and physician scientist who specializes in triple-negative breast cancer and breast cancer immunotherapy, has joined Cedars-Sinai Cancer as director of Breast Oncology. Yuan will treat patients at Cedars-Sinai and at Huntington Cancer Center, an affiliate of Cedars-Sinai Cancer.

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妙佑医疗国际(Mayo Clinic) 研究人员发现，借助人工智能(AI)算法来分析临产妇女的变化模式，可以帮助确定产妇能否顺利进行阴道分娩，以及阴道分娩能否确保母婴平安。这些研究结果已发表在《PLOS ONE》期刊上。