A new Penn Medicine study, published today in the Annals of Internal Medicine, revealed that patients with untreated white coat hypertension not only have a heightened risk of heart disease, but they are twice as likely to die from heart disease than people with normal blood pressure.
In a study published in the Journal of Clinical Investigation, researchers show how the stress-responsive protein SIRT1 plays important roles in maintaining the regenerative potential of chronic myeloid leukemia leukemic stem cells and promoting leukemia development in CML.
A team of NIBIB-funded bioengineers at Rennselaer Polytechnic Institute developed an AI technique to rapidly convert low-dose CT scans to superior images compared to a conventional technique. Low-dose CT minimizes x-ray radiation to a patient.
Scientists at UC San Diego and Japan’s RIKEN Cluster for Pioneering Research found a way to significantly reduce the amount of energy required by organic light emitting diodes that brighten when fed with electricity. These OLEDs are attracting attention as potential replacements for popular liquid crystal diodes, or LEDs, in digital displays.
Sleeping with a television or light on in a room may be a risk factor for gaining weight or developing obesity, according to scientists at the National Institutes of Health. The research, published online June 10 in JAMA Internal Medicine, suggests that cutting off lights at bedtime could reduce women’s chances of becoming obese.
An unhealthy, inflamed gut causes breast cancer to become much more invasive and spread more quickly to other parts of the body, new research from the University of Virginia Cancer Center suggests.
Nanoengineers at UC San Diego have developed new deep learning models that can accurately predict the properties of molecules and crystals. They can enable researchers to rapidly scan the nearly-infinite universe of compounds to discover potentially transformative materials for various applications.
Some have dreamt of creating the perfect cloak to make buildings impervious to stress waves caused by bombs, earthquakes or other calamities. Sorry, researchers are now dashing the dream. But there's still hope. It is possible to make imperfect, real-world cloaks that will actually do some good.
The National Institutes of Health (NIH) has awarded a seven-year, $23 million grant to researchers at Albert Einstein College of Medicine and Montefiore Health System to study HIV and the chronic illnesses that often accompany HIV infection, including cardiovascular and lung disease, diabetes, and cancer.
Firearm injuries kill more American children and teens than anything else, except automobile crashes. But research on how those injuries happen, who’s most likely to suffer or die from one, or what steps would prevent them, has lagged behind research on other causes of death. Now, as more researchers and funders appear interested in pediatric firearm injury research, a team of experts has published the most pressing questions and called for studies to address them.
AHRQ Safety Program for Improving Surgical Care and Recovery announces its next enrollment period as it expands its perioperative care program for decreasing surgical patients’ complications and speeding their recoveries.
Study using mouse neural crest tissue reveals how primitive, undifferentiated cells choose their adult fate
Researchers at Dana-Farber Cancer Institute and the VA Boston Healthcare System have uncovered a new vital sign for gauging survival and likelihood of having an unplanned hospitalization in older patients with blood cancers: the speed at which they can walk.In a study published today in the journal Blood, the researchers report that for every 0.
To treat large gaps in long bones, like the femur, that often eventually result in amputation, researchers developed a process that partially recreates the bone growth process that occurs before birth.
Researchers at Washington University School of Medicine in St. Louis and the Africa Health Research Institute have identified a master cell that coordinates the body’s immune defenses in the crucial early days after infection. Boosting the activity of such cells could help reduce the millions of new infections that occur worldwide every year.
Addressing the psychological effects of injury can improve health and reduce the negative outcomes of injury. Yet, in a national survey, only seven percent of trauma centers incorporate routine screening for PTSD symptoms.
A multicenter team led by investigators at Washington University School of Medicine in St. Louis has taken a big step toward identifying the cysts likely to become cancerous. Testing fluid from cysts for a biomarker — an antibody called mAb Das-1 — the researchers were able to identify pancreatic cysts likely to become cancerous with 95 percent accuracy.
A team of researchers led by the University of California San Diego have discovered what’s responsible for making the teeth of the deep-sea dragonfish transparent. This unique adaptation, which helps camouflage the dragonfish from their prey, results from their teeth having an unusually crystalline nanostructure mixed with amorphous regions. The findings could provide “bioinspiration” for researchers looking to develop transparent ceramics.
Researchers in Japan have discovered that the Plasmodium parasites responsible for malaria rely on a human liver cell protein for their development into a form capable of infecting red blood cells and causing disease. The study, which will be published June 12 in the Journal of Experimental Medicine, suggests that targeting this human protein, known as CXCR4, could be a way to block the parasite’s life cycle and prevent the development of malaria.
A theory that proposes the existence of a dynamic interface between the environment and human physiology over someone’s lifetime has earned a leading Mount Sinai researcher the prestigious Outstanding Investigator Award from the National Institute of Environmental Health Sciences (NIEHS). Manish Arora, PhD, will receive a total of $8 million over eight years to complete research into his theory, known as the Biodynamic Interface.
By participating in organized physical activity from the age of 6, children will have less risk of emotional difficulties by the time they're 12, a new Canadian study finds.
Migraine sufferers who used a smartphone-based relaxation technique at least twice a week experienced on average four fewer headache days per month, a new study shows.
J. Mark Meacham and Minji Kim in his lab studied cilia in an acoustic trap that allows them to analyze hundreds of cells in minutes.
Tuberculosis is the most lethal infectious disease in the world. Researchers at Washington University School of Medicine in St. Louis and Umea University in Sweden have found a compound that can prevent and even reverse antibiotic resistance in TB bacteria.
Researchers at Washington University School of Medicine in St. Louis found that wristwatch-like motion detectors can help identify in children signs of motor impairments that might otherwise be missed.
Researchers at Washington University School of Medicine in St. Louis have shown that lithium improves muscle size and strength in mice with a rare form of muscular dystrophy. The findings, published April 18 in Neurology Genetics, could lead to a drug for the disabling condition.
As part of a program called the Congressionally Directed Medical Research Program, the DOD is awarding Texas Biomedical Research Institute $2 million over the next three years to study a promising experimental Zika vaccine.
By examining brain tumors in mice, researchers at Washington University School of Medicine in St. Louis discovered that immune cells that should be defending the body against disease sometimes can be enticed into providing aid and comfort to tumor cells instead. The more immune cells a tumor can recruit to its side, the faster the tumor grows, the researchers found.
A team at Washington University School of Medicine in St. Louis has snapped high-resolution pictures of chikungunya virus latched onto a protein found on the surface of cells in the joints. The structures, published May 9 in the journal Cell, shows in atomic-level detail how the virus and cell-surface protein fit together – data that promises to accelerate efforts to design drugs and vaccines to prevent or treat arthritis caused by chikungunya or related viruses.
Georgetown University Medical Center announces the launch of the only known therapeutic (disease modifying) clinical trial for Lewy body dementia, a neurological disorder that affects a million people in the United States for which there are no approved medications that modify the disease.
Growing up in poverty and experiencing traumatic events like a bad accident or sexual assault were linked to accelerated puberty and brain maturation, abnormal brain development, and greater mental health disorders, such as depression, anxiety, and psychosis, according to a new Penn Medicine study published this week in JAMA Psychiatry.
In a study in Metabolism, Ganesh Halade details the profound lipidomic and metabolic signatures and the modified leukocyte profiling that delay heart failure progression and provide improved survival in 12/15 lipoxygenase-deficient mice. Heart failure after a heart attack is a global epidemic.
A collaborative study led by archaeologists, geneticists and museum curators is providing answers to previously unsolved questions about life in sub-Saharan Africa thousands of years ago.
Johns Hopkins Medicine researchers say mysterious, previously unseen “X cell” may be cause of type 1 diabetes
Even a short stay for travelers in cities with high levels of air pollution leads to breathing problems that can take at least a week from which to recover, a new study shows.
BK polyomavirus is harbored in most humans; in kidney transplant patients, immune suppression drugs to help the kidney can reactivate the virus and instead cause kidney failure. Research shows a way to reduce BK polyomavirus levels in patients without reducing immunosuppressing drugs.
For environmental monitoring, precision agriculture, infrastructure maintenance and certain security applications, slow and energy efficient can be better than fast and always needing a recharge. That’s where “SlothBot” comes in.
A new paper explores the genetic signatures of a pair of wolves isolated on Isle Royale, a remote national park in Lake Superior. The pair are father-daughter and share the same mother. Such close inbreeding leads to genetic anomalies, which likely are the main driver behind the wolf population crash over the past decade. Less extreme genetics help guide conservation decisions around the world.
BRCA, the DNA-repair protein family, interacts with a multipart, molecular complex that is also responsible for regulating the immune system. When certain players in this pathway go awry, autoimmune disorders, like lupus, can arise. Researchers have now deciphered the structure of the complex and have found new molecular targets for fighting autoimmunity.
Researchers at the Johns Hopkins Kimmel Cancer Center have developed a simple new blood test that can detect the presence of seven different types of cancer by spotting unique patterns in the fragmentation of DNA shed from cancer cells and circulating in the bloodstream.
In patients with chronic lymphocytic leukemia, the rate of disease growth is apt to follow one of three trajectories: relentlessly upward, steadily level, or something in between, scientists at Dana-Farber Cancer Institute, the Broad Institute of MIT and Harvard, Massachusetts General Hospital, and the University of Washington report in a new study.
The cardiorespiratory fitness of survivors of childhood acute lymphoblastic leukemia is 22 per cent worse than that general Canadian population,and genetics might play a role, an UdeM researcher finds.
La Jolla Institute Professor Erica Ollmann Saphire, Ph.D., will lead a five-year global effort totaling up to $35 million that brings together experts from around the world to streamline and accelerate the development of immunotherapeutics against emerging and re-emerging viral threats. The international consortium is funded through the Centers of Excellence for Translational Research (CETR) program at the National Institute of Allergy and Infectious Disease), part of the National Institutes of Health (NIH).
Aging adults often show signs of slowing when it comes to managing their finances, such as calculating their change when paying cash or balancing an account ledger. But trouble managing money can also be a harbinger of dementia and, according to new Duke research in The Journal of Prevention of Alzheimer’s Disease, could be correlated to the amount of protein deposits built up in the brain.
Bioengineers have developed a 3D printing technique that creates the interacting networks for transport of air, blood, and other bodily fluids—a major step toward 3D printed replacement organs.
Scientists have long sorted cells into different varieties based on their appearance under a microscope or, for differences that are more visually subtle, based on the behavior of a handful of genes. But in a bid to reveal even more distinctive differences and similarities, researchers from the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins Institute for Genetic Medicine and the Johns Hopkins Department of Neuroscience developed two new artificial intelligence methods that decipher complex gene activity controlling cell fate decisions in retina development and relate this gene activity to what occurs in other tissues and across different species.
Researchers at The Johns Hopkins University and other institutions report that a new laboratory test that induces cancer cells to squeeze through narrow spaces has the potential to accurately predict which breast cancers and other solid tumors are likely to spread, or metastasize, to other sites. The test, they say, might also help clinicians select the best drugs to prevent cancer’s spread.
In this paper, the authors demonstrate a significant association between pedicle screw loosening and the presence of low-virulent pathogens on spinal implants.
A decade ago researchers announced development of a cancer immunotherapy called CAR (for chimeric antigen receptor)-T, in which a patient is re-infused with their own genetically modified T cells equipped to mount a potent anti-tumor attack.
A mouse model called experimental autoimmune encephalomyelitis, or EAE, is used to discover disease mechanisms in multiple sclerosis. Researchers now report how dysregulated neutrophils cause damage in a severe, mouse model form of EAE called atypical EAE, which attacks cerebellum brain tissue.
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