University of Minnesota medical researchers and engineers have developed a way to study cancer cells which could lead to new and improved treatment. They have developed a new way to study these cells in a 3D in vitro model (i.e. in a culture dish rather than in a human or animal).
Researchers at the University of Pittsburgh School of Medicine have identified a brain protein at the root of how the brain recovers from stroke. The finding offers a promising avenue for developing therapies that could work even when given beyond the first few hours after a stroke.
A detailed analysis of blood samples from Ebola patients is providing clues about the progression of the effects of the virus in patients and potential treatment pathways. The findings point to a critical role for a molecular pathway that relies on the common nutrient choline, as well as the importance of cellular bodies known as microvesicles.
Using super-sensitive microscopic imaging, a team of scientists made a fundamental biological discovery that explains the structure of the nuclear envelope and gives tantalizing clues as to how cells squish through narrow openings without springing a leak.
Director of the Southwest National Primate Research Center Professor Deepak Kaushal, Ph.D. says research he collaborated on is pinpointing a possible new avenue of protection for HIV/AIDS patients. The study, published this month in the journal Cell Reports helps scientists better understand how HIV promotes deadly cases of tuberculosis (TB).
A new Johns Hopkins study found that rats’ ability to recalibrate learned relationships among time, speed and distance is ever-evolving, moment-by-moment.
A drop of rainwater that falls on a cassava field in Uganda takes a different path than one that falls 500 miles east in Somalia. Knowing where rain comes from now, and where it might come from under future climate scenarios, is important for the millions of people who rely on subsistence agriculture to survive. Research from Washington University in St Louis offers a new tool for tracking the rainwater race.
UC San Diego’s Alison Coil and colleagues James Aird (University of Leicester, UK) and Antonis Georgakakis (National Observatory of Athens) recently published research findings to reveal how supermassive black holes are growing at the center of galaxies, and how that growth relates to the growth of galaxies themselves.
Results from a large, multi-center study suggest that cardiac magnetic resonance, or CMR, has potential as a non-invasive, non-toxic alternative to stress echocardiograms, catheterizations and stress nuclear exams in identifying the severity of coronary artery disease.
Researchers at Beth Israel Deaconess Medical Center found that higher sodium intake, when studied in the context of the DASH-Sodium trial (Dietary Approaches to Stop Hypertension), increases lightheadedness. These findings challenge traditional recommendations to increase sodium intake to prevent lightheadedness.
Blood cells could hold the key to aging, according to new research out of Case Western Reserve University School of Medicine. In a study published in Aging Cell, researchers found human blood cells have an intrinsic clock that remains steady even after transplant. The researchers say the clock could control human aging and may underlie blood cancers.
The first study of the immunotherapy drug pembrolizumab as the initial treatment for patients with a rare but aggressive form of skin cancer known as Merkel cell carcinoma reports better responses and longer survival than expected with conventional chemotherapy.
Researchers at the University of Michigan Rogel Cancer Center have cataloged circular RNA in multiple cancers and conducted initial research that suggests these stable structures could serve as cancer biomarkers in blood or urine.
In experiments with mice, researchers at Johns Hopkins Medicine report a promising advance in the search for a new class of drugs to treat major depression. A compound developed by the Johns Hopkins Drug Discovery Group targets a chemical in specific cells of the mammalian brain, and eases signs of social avoidance and depression in rodents, without some of the toxic side effects that have bedeviled its parent compound.
New findings published in “Nature Communications” could apply to the manufacture of self-assembling nanomaterials and the creation of environmentally responsive sensors. This could lead to new methods for making nanoscale devices and more economical medical, point-of-care diagnostics.
Each year, some 600 million people around the world come down with strep throat. Yet, it was unclear why some kids are prone to repeated bouts of strep throat while others appear to be more or less immune. The latest study by researchers at La Jolla Institute for Immunology (LJI) provides the first clues why some children are more susceptible than others to contracting recurrent strep throat.
New computer machine learning techniques can be now be used in crowdsourcing projects to deal with massively increasing amounts of data—making computers a surprising new partner in citizen science projects.
Treatment with the NSAID carprofen triggers subtle low-grade inflammation in the heart and kidneys. The combination of carprofen pretreatment and heart attack magnifies this impact by dysregulating the acute inflammatory response, amplifying inflammation and intensifying the cardiorenal syndrome.
Building a circle of trusted adults around a suicidal teen, to support them during vulnerable times, may have long-term effects that reduce their risk of dying young, a new study suggests. About 12 years after the teens were hospitalized for suicidal behaviors, far more of the young people who got standard care had died, compared with young adults in the group that had received the extra adult support.
Pilot study shows ‘LevelCheck’ program may prevent operating on wrong spinal segment
In what they consider a surprise finding, Johns Hopkins Medicine researchers have demonstrated a key role for male sex hormone “signaling” in inducing—rather than suppressing—allergic lung inflammation in a mouse model of asthma.
Researchers in Germany have discovered why sleep can sometimes be the best medicine. Sleep improves the potential ability of some of the body’s immune cells to attach to their targets, according to a new study that will be published February 12 in the Journal of Experimental Medicine. The study, led by Stoyan Dimitrov and Luciana Besedovsky at the University of Tübingen, helps explain how sleep can fight off an infection, whereas other conditions, such as chronic stress, can make the body more susceptible to illness.
Women's brains appear to be three years younger than men's of the same age, according to a study of brain metabolism by researchers at Washington University School of Medicine in St. Louis. The findings could explain why women maintain their cognitive skills longer than men.
An international team of collaborators found that the CD4 surface protein, which is used by HIV and SIV as the receptor to enter immune cells, is highly variable among wild chimpanzees.
The United Nations Children’s Fund (UNICEF) has been working with researchers at the San Diego Supercomputer Center (SDSC) and other parts of UC San Diego to determine the location of existing Liberian schools to provide them with resources and work with policy makers to plan for future schools.
Following a California Institute for Regenerative Medicine (CIRM) Independent Citizens Oversight Committee meeting held last week, University of California, Irvine (UCI) researchers learned they will receive $6 million in funding to support the continued development of a promising new treatment for Huntington’s disease (HD).
While oral appliances such as splints and bite guards are the most common treatment for facial pain from temporomandibular disorders (TMD), patients rate them as less helpful than self-care treatments, such as jaw exercises or warm compresses, finds a new study by researchers at NYU College of Dentistry.
Researchers at Washington University School of Medicine in St. Louis may have found a path toward improving the effectiveness of chemotherapy in people with breast or ovarian cancer caused by defects in one of the BRCA genes. The researchers identified a pair of genes that operate in parallel to BRCA and may increase susceptibility to chemotherapy drugs.
Researchers from Weill Cornell Medicine have used human embryonic stem cells to create a new model system that allows them to study the initiation and progression of small cell lung cancer (SCLC). The study, which will be published February 8 in the Journal of Experimental Medicine, reveals the distinct roles played by two critical tumor suppressor genes that are commonly mutated in these highly lethal cancers.
. In an exhaustive search of microbes from more than 1,400 insects collected from diverse environments across North and South America, a UW-Madison research team found that insect-borne microbes often outperformed soil bacteria in stopping some of the most common and dangerous antibiotic-resistant pathogens.
NASA’s Curiosity Rover may have been ambling around the Gale Crater on Mars for nearly seven years but scientists have found a way to use it for something new: making the first surface gravity measurements on a planet other than Earth.
In a study of over 12,000 lines of fruit flies, researchers from the Perelman School of Medicine at the University of Pennsylvania have found a single gene, called nemuri, that increases the need for sleep.
Researchers at University of Utah Health and University of Washington found an FDA-approved cancer drug--paclitaxel--offers protection to mice after experiencing mild traumatic brain injuries.
UAH computer science Ph.D. candidate Truong Xuan Tran and his advisor, UAH associate professor Dr. Ramazan Aygun, have developed an else-tree classifier with the potential to generate zero percent error without overfitting by separating hard-to-classify data as undecided.
New rules recently went into effect, seeking to protect patients who donate tissue samples for research in the age of genetic sequencing. But this rule could have unintended consequences for certain critical types of biospecimens.
Three ultrasound measurements moderately, but significantly, predict successful arteriovenous fistula maturation. Mature fistulas are vital for hemodialysis, but half fail to mature. This information can facilitate decisions by the clinician, like new surgery or abandonment of the fistula.
Hospitalizations for cardiovascular disease rose precipitously in Orleans and Jefferson parishes after Hurricane Katrina. The increase in rates lasted for more than one month after landfall and rates were higher among the older black population, compared to the older white population.
Organic compounds from perfume, food, fabrics and soaps coat indoor surfaces. The film commonly found in our homes can impact the air we breathe and our health. Yet the details of how these compounds interact microscopically with indoor surfaces are not fully known. Researchers are learning more.
A scientific team from Case Western Reserve University School of Medicine and Cleveland Clinic has developed a new way to identify second-line antibiotics that may be effective in killing germs already resistant to a first-line antibiotic – potentially helping overcome antibiotic resistance. This new research provides an approach clinicians could consult when deciding which antibiotic treatment courses will be most effective for patients.
Experimenting with mice, Johns Hopkins Medicine researchers report that a low-calorie diet prevented asthma symptoms regardless of the diet’s fat and sugar content. The researchers also say they found that obesity resulting from a high-calorie diet led to asthma symptoms in the animals by causing lung inflammation, and a drug that blocks inflammation eased those symptoms.
In a first-of-its-kind study, researchers at Beth Israel Deaconess Medical Center (BIDMC) used imaging data to determine the underlying anatomical cause of schizophrenia’s negative symptoms and then applied non-invasive brain stimulation to ameliorate them.
Nearly 1 percent of high school seniors report using Flakka, a highly potent and potentially dangerous synthetic drug, according to a study by researchers at NYU School of Medicine, the Center for Drug Use and HIV/HCV Research (CDUHR) at NYU College of Global Public Health, and Columbia University Mailman School of Public Health.
Computer-based guide aims to help families with life-and-death treatment decisions
A team of researchers led by the University of California San Diego has identified a genetic pathway that causes some individuals to develop an abnormal heart rhythm, or arrhythmia, after experiencing a heart attack. They have also identified a drug candidate that can block this pathway.
A collaboration of scientists including Professor Jean Patterson, Ph.D., of Texas Biomedical Research Institute, is working on a new way to detect Zika virus that will help guide clinicians in their treatment of patients with the disease. The test uses optofluidic chips to screen bodily fluids (blood, urine, semen) for the presence of the virus. This new approach will also help pinpoint the stage of the disease. Researchers at the University of California at Santa Cruz, Brigham Young University, and the University of California at Berkeley developed the technology being tested.
Around the country, women physician researchers make 7 to 8 percent less per year than men. At the Johns Hopkins University School of Medicine, efforts to eliminate such a gender disparity have cut the difference in salaries from 2.6 percent in 2005 to a statistically insignificant 1.9 percent in 2016.
A multi-institutional research team will develop and evaluate a pregnancy-specified Artificial Pancreas
Nearly 1 in 5 fifth-graders has received violent injuries, the majority delivered by guns or knives, according to recently published research by The University of Texas Health Science Center at Houston (UTHealth).
A study in mice and people from Washington University School of Medicine in St. Louis shows that sleep deprivation causes tau levels to rise and tau tangles to spread through the brain. Tau tangles are associated with Alzheimer's disease and brain damage.
Scientists at the Unviersity of Kentucky have assembled the entire genome of the Mexican Axolotl, the key to unlocking the secrets of regeneration with potential for life-changing clinical applications down the road.
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