Feature Channels: Alzheimer's and Dementia

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Study shows seniors with dementia are on the rise. Dr. Yves Joanette is available to speak about the disease.

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Is it possible to prevent dementia from happening in the first place? That’s what a leading FAU neuroscientist plans to prove using an innovative approach that defies the idea that “one-size-fits-all” when it comes to battling Alzheimer’s disease, Lewy Body Dementia, Parkinson’s disease and other related disorders. Using a personalized approach and precision medicine to reduce risk, this center is one of only a handful of centers in the world that focuses on dementia prevention.

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The Mediterranean diet, rich in plant-based foods, is associated with a variety of health benefits, including a lower incidence of dementia.

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The discovery hints that microglia, rather than neurons, may control much of a person’s genetic susceptibility to Alzheimer’s disease.

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Professor Matthew Disney of the Department of Chemistry on the Florida campus of The Scripps Research Institute (TSRI), together with scientists from Mayo Clinic’s Florida campus and Johns Hopkins School of Medicine, has been awarded $7.2 million from the National Institute of Neurological Disorders and Stroke of The National Institutes of Health to create new RNA-based treatments for the most common form of amyotrophic lateral sclerosis (ALS), as well as a type of frontotemporal dementia (FTD).

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A new study shows that people with a protective Aβ mutation have less of the peptide in their blood all through their lives, likely explaining why they do not get Alzheimer's. It suggests ways to prevent the disease in the vast majority of people who don’t have the mutation.

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Hand over hand. That's how new, near-atomic resolution, 3-D snapshots show that a key biological machine unfolds a ribbon of protein through its central channel.

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A new, high-resolution view of the structure of Hsp104 (heat shock protein 104), a natural yeast protein nanomachine with six subunits, may show news ways to dismantle harmful protein clumps in disease.

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Duke University researchers have identified a potential new mechanism for Parkinson's disease in both mice and human endocrine cells that populate the small intestines.

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The rate of death from Alzheimer’s disease in the United States increased by more than 50 percent in the past 15 years. In part, it’s because Americans are living longer – age is one of the biggest risk factors for developing Alzheimer’s. But it’s also because medical professionals can identify risk factors.

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At a glance: Most frequent genetic cause of ALS and a form of dementia (FTD) is known to produce toxic peptides that interfere with RNA splicing—an intermediary step in generating functional proteins from genes. New Harvard Medical School study finds these toxic peptides block assembly of the cellular machinery responsible for RNA splicing. This blockage leads to splicing errors for genes that regulate the workings of mitochondria and neurons and the expression of other genes. Restoring normal splicing function may be a therapeutic strategy for averting or treating the development of ALS, FTD or both.

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Profs. Michal Schwartz and Ido Amit at the Weizmann Institute of Science have discovered a unique immune cell type whose regulated activation may form the foundation of a future treatment for Alzheimer’s disease

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According to research reported online today in Neurology, the international Dementia with Lewy Bodies Consortium issued new guidelines about diagnosing and treating the disease and called for more clinical trials into the illness.

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The milestone Imaging Dementia – Evidence for Amyloid Scanning (IDEAS) Study is working with government and academic researchers to launch three add-on studies to expand the impact of the core study where more than 18,000 people with cognitive decline but an unclear diagnosis will receive an amyloid PET scan.

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/PRNewswire-USNewswire/ -- The Alzheimer's Drug Discovery Foundation (ADDF), the only public charity solely focused on funding the development of drugs for Alzheimer's, and Science Exchange today announced the launch of ADDF ACCESS, a first-of-its-kind online platform designed to match scientists working on central nervous system (CNS) diseases with a vetted network of contract research organizations (CROs).

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Memory loss, language problems and other symptoms of cognitive decline are strongly associated with diseases of the small blood vessels in the brain, according to a study published in the International Journal of Geriatric Psychiatry.

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A founder of U.S. Alzheimer’s research, Robert D. Terry, has died at 93. He first showed what plaques and tangles look like in the electron microscope, and linked failing cognition to withering synapses in the brain.

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At a meeting in Leuven, Belgium, a coherent picture began to emerge for how fluid pockets of proteins and RNAs contribute to health and disease.

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Mayo Clinic Monthly News Tips — May 2017

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Cognitive tests can detect early Alzheimer’s disease in older adults without symptoms according to a new Keck School of Medicine of USC study.