A layer of cells that look like normal stomach lining on top of sites of stomach cancer can make it difficult to spot after removal of a Helicobacter pylori infection. In a recent study
In a recent Journal of Infectious Diseases study, investigators showed using two antibiotic drugs to fight P. aeruginosa in mouse models was significantly more effective than either antibiotic alone. The antibiotics were ceftazidime-avibactam
Nobel Prize-winning Directed evolution is an artificial, sped up process to make a protein perform a specified task. UNC School of Medicine scientists created a powerful new directed evolution technique for the rapid development of scientific tools and new treatments for many diseases.
KANSAS CITY, MO—Thanks to super-resolution microscopy, scientists have now been able to unambiguously identify physical associations between human chromosomes. The findings have brought to light a new understanding to a curious observation first made more than 50 years ago. The Stowers Institute for Medical Research scientists probed these physical connections between five of the chromosomes in the human karyotype in a report recently published online in the Journal of Cell Biology.
Scientists have used an optimized version of the CRISPR-Cas9 gene-editing system to prevent hearing loss in so-called Beethoven mice, which carry a genetic mutation that causes profound hearing loss in humans and mice alike The new gene-editing system successfully identified a single misspelled “letter” in the defective copy of a hearing gene and disabled the aberrant copy, sparing the healthy one DNA analyses and follow-up tests in treated animals showed no detectable off-target effects Results offer proof of principle for using the same gene-editing technique in more than 20 percent of dominantly inherited human genetic diseases
NEAT1, a noncoding RNA, appears to play a significant role in diminishing memory in the older brain, according to research publishing Tuesday from UAB. Gene editing could potentially be used to boost memory.
A new program seeks to improve community oncology providers’ knowledge of genetic testing in breast cancer patients, as well as provide tools to allow genetic counseling and testing to be incorporated in their clinical practice.
For the first time researchers have been able to completely eliminate HIV from a mouse model. It marks a critical step toward the development of a possible cure for human HIV infection.
UNC School of Medicine scientists unveiled how a particular gene helps organize the scaffolding of brain cells called radial progenitors necessary for the orderly formation of the brain. Previous studies have shown that this gene is mutated in people with autism.
One in 10 people with dilated cardiomyopathy were born with a mutation in the TTN gene, but – until now – it has been unclear whether everyone with these mutations will inevitably develop the condition. Researchers found that 95 percent of patients who had the genetic mutations did not have heart disease.
Medicare Part D enrollees may pay more out of pocket for high-priced specialty generic drugs than their brand-name counterparts, according to new research by health policy experts at Vanderbilt University Medical Center and the University of North Carolina at Chapel Hill.
A weakness in one common open source software for genomic analysis left DNA-based medical diagnostics vulnerable to cyberattacks. Researchers at Sandia National Laboratories identified the weakness and notified the software developers, who issued a patch to fix the problem. The issue has also been fixed in the latest release of the software.
A team of researchers found that DNA damaged by the widely used chemotherapy drug cisplatin is almost fully repaired in noncancerous tissue within two days. These results could inform the timing of chemotherapy strategies and improve their efficacy.
Dr. Beth Karlan, the newly appointed director of cancer population genetics at UCLA’s Jonsson Comprehensive Cancer Center, is hopeful that her research will not only help women get diagnosed with ovarian cancer at an earlier stage, but also identify the women who are most at-risk so they can intervene before the cancer even develops.
Scientists have discovered how plants create networks of air channels - the lungs of the leaf - to transport carbon dioxide (CO2) to their cells.
Study will focus on four previously identified regions in the genome of African American women that may contain undiscovered genes that contribute to hereditary breast cancer.
Ground water microbes living outside a contaminated area contain mobile genetic elements that provide them resistance to heavy metals.
The ice worm is one of the largest organisms that spends its entire life in ice and Washington State University scientist Scot Hotalilng is one of the only people on the planet studying it.
In cinema and science fiction, one small change in the past can have major, sometimes life-changing effects in the future. Using a series of snapshots, researchers recently captured such so-called “butterfly effects” in heart muscle cell development, and say this new view into the sequence of gene expression activity may lead to better understanding disease risk.
A new mathematical model of the structure of networks could help find new cancer drugs, speed up traffic flow and combat sexually transmitted disease. Although the three challenges seem diverse, they all could benefit from a theory that helps uncover information about a network by analyzing its structure. The study was published in the journal Chaos. Successful link prediction algorithms already exist for certain types of networks, but the researchers analyzed differently structured networks to come up with their alternative algorithm.
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