With only 13 genes, human mitochondria are massively overshadowed by the 20,000 genes in the human nucleus. Nevertheless, these diminutive organelles may have a strong influence on cellular metabolism and susceptibility to metabolic diseases like heart failure or obesity.
Novembro é o mês de conscientização sobre a C. diff, um período para se concentrar em aumentar a conscientização sobre a prevenção e o tratamento de infecções causadas pela Clostridium Difficile. "A C. diff é uma infecção bacteriana que causa sintomas que vão desde a diarreia à inflamação grave do colón", diz Darrell Pardi, M.D., um gastroenterologista da Mayo Clinic.
Noviembre es el mes de concienciación sobre el Clostridium difficile (C. difficile), lo que brinda un momento para enfocarse en concienciar más a la gente acerca de la prevención y tratamiento de las infecciones por Clostridium difficile.
明尼苏达州罗切斯特— 11 月是 艰难梭状芽胞杆菌感染宣传月，其目的是提高公众对艰难梭状芽胞杆菌感染预防和治疗的认知。Mayo Clinic的胃肠病学专家 Darrell Pardi 博士表示：“艰难梭状芽胞杆菌感染是一种细菌感染，其症状多样，比如腹泻或有生命危险的结肠炎症。”
Serotonin (3A) receptors are common drug targets in the treatment of pain, gastrointestinal dysfunctions, and mood disorders yet little is known about their three-dimensional structure. Details about serotonin receptor structures could provide important clues to designing better drugs with less side effects. Now, a team of researchers from Case Western Reserve University School of Medicine have used high-powered microscopes to view serotonin activating its receptor for the first time. Images published in Nature reveal molecular details about the receptor that could improve drug design to treat a multitude of diseases.
Researchers at the University of Minnesota and the Somali, Latino, and Hmong Partnership for Health and Wellness have new evidence that the gut microbiota of immigrants and refugees rapidly Westernize after a person’s arrival in the United States. The study could provide insight into fighting obesity and diabetes.
November is C. diff awareness month, a time to focus on raising awareness about the prevention and treatment of Clostridium Difficile Infections. Mayo Clinic experts are available for interviews.
The American Society for Biochemistry and Molecular Biology announced today that Kerry-Anne Rye of the University of New South Wales Sydney and Nicholas O. Davidson of Washington University in St. Louis will be the next editors-in-chief of the Journal of Lipid Research.
Infants born at home have more diverse bacteria in their guts and feces, which may affect their developing immunity and metabolism, according to a study in Scientific Reports.
Children who are given antibiotics or antacids in their first two years of life are more likely to become obese during their childhood, according to a new study published today in the British Medical Journal, Gut.
The UNC School of Medicine is one of four clinical sites, funded by a new five-year, $10 million NIH grant, that will identify the most effective treatment options for patients with accidental bowel leakage (ABL), which is also known as fecal incontinence (FI).
Baby formula is designed to mimic human breast milk as closely as possible. A new study from Washington University School of Medicine in St. Louis finds that formula and breast milk nurture the growth of intestinal bacteria capable of producing differing metabolites. The health implications of these differences are unknown.
FSU researchers found that consuming 30 grams of protein about 30 minutes before bed appears to have a positive effect on muscle quality, metabolism and overall health. And for those who have sworn off eating at night, there is no gain in body fat.
The American College of Gastroenterology will donate $1,000 to charity for any tips that lead to the location and safe return of the stolen inflatable colon.
In a discovery that may have significant impact on the future of colon cancer treatment and research, scientists at the Helen F. Graham Cancer & Research Institute’s Center for Translational Cancer Research at Christiana Care Health System have defined a key signaling pathway that regulates colon cancer growth.
The mechanism leading to development of type 1 diabetes remains a mystery, hampering the ability to find new ways to prevent, treat or even cure this condition. With a new $3.3 million grant, University of California School of Medicine researchers hope to create a high resolution reference map of pancreatic cells that will identify molecular changes that arise during type 1 diabetes.
Researchers at The University of Texas MD Anderson Cancer Center have shed new light on why pancreatic tumors are so resistant to therapy.
Overactive bladder (OAB) is a common form of urinary incontinence that is widely treated with pelvic floor muscle (PFM) training. A new laboratory study lends insights into how PFM training works: by reducing contractions of the detrusor muscle of the bladder, reports the American Journal of Physical Medicine & Rehabilitation, the official journal of the Association of Academic Physiatrists. The journal is published by Wolters Kluwer.
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health (NIH), has awarded Brian Schmidt, DDS, MD, PhD, director of the Bluestone Center for Clinical Research at New York University College of Dentistry (NYU Dentistry) and Nigel Bunnett, PhD, professor in the Departments of Surgery and Pharmacology at Columbia University, a joint $2.7 million, 3.5-year grant to study Protease-Activated Receptor 2 (PAR2) and pain signaling. The study will help determine whether PAR2 can be exploited as a therapeutic target to treat chronic pain.
Crohn’s disease (CD), a chronic inflammatory condition of the intestinal tract, has emerged as a global disease, with rates steadily increasing over the last 50 years. Experts have long suspected that CD likely represents a collection of related but slightly different disorders, but until now it has not been possible to predict accurately which subtype of CD a patient is likely to develop. In a study published Oct. 4 in the journal JCI Insight, Cornell University and University of North Carolina researchers report they have pinpointed a single molecule – microRNA-31 (miR-31) – the levels of which predict whether a patient has subtype 1 or subtype 2 of the disease.
“Every year, nearly 700,000 Americans have surgery for groin hernias.”
Women who are overweight or obese have up to twice the risk of developing colorectal cancer before age 50 as women who have what is considered a normal body mass index (BMI), according to new research led by Washington University School of Medicine in St. Louis.
Predictors of future diabetes and cardiovascular disease for a person with obesity can be found among their body's metabolites.
In studies of mouse cells, Johns Hopkins researchers have found that low levels of cellular copper appear to make fat cells fatter by altering how cells process their main metabolic fuels, such as fat and sugar.
A new study from Tufts researchers finds that two inflammatory proteins in the colon increase incrementally with weight. In individuals with obesity, this was accompanied by activation of precancerous cellular pathways.
A bacterium known for causing stomach cancer might also increase the risk of certain colorectal cancers, particularly among African Americans, according to a study led by Duke Cancer Institute researchers.
This month's tip sheet from Fred Hutch highlights research related to cancer-causing bacteria, a cancer 'escape hatch,' how sex cells sort chromosomes, cord blood's role in leukemia treatment and more.
The Maryland Proton Treatment Center (MPTC) is now offering deep-tissue external thermal therapy in combination with high-precision proton-beam radiotherapy as a potential way to boost survival chances for certain cancer patients. MPTC is the only center in the world to offer these two treatments at the same facility, an advantage to patients because these therapies are typically given within an hour of each other.
Philadelphia, PA (October 8, 2018) – More than 5,000 gastroenterologists and other health care professionals will convene at the Pennsylvania Convention Center in Philadelphia, PA for the premier clinical gastroenterology event—the American College of Gastroenterology’s 83rd Annual Scientific Meeting and Postgraduate Course (ACG 2018)—to review the latest scientific advances in gastrointestinal research, treatment of digestive diseases and clinical practice management.
Philadelphia, PA (October 8, 2018) – Sunanda V. Kane, MD, MSPH, FACG, a gastroenterologist and Professor of Medicine at Mayo Clinic Rochester, MN, was elected by the membership as the 2018-2019 President of the American College of Gastroenterology (ACG), a national medical organization representing more than 14,000 clinical gastroenterologists and other specialists in digestive diseases.
Scientists from the Cancer Science Institute of Singaporeat the National University of Singapore have discovered a new molecular pathway that controls colorectal cancer development, and their exciting findings open new therapeutic opportunities.
Philadelphia, PA (October 5, 2018) – The American College of Gastroenterology (ACG) announces the winners of the 2018 SCOPY Awards (Service Award for Colorectal Cancer Outreach, Prevention and Year-Round Excellence) to recognize the achievements of ACG members in their community engagement, education and awareness efforts for colorectal cancer prevention.
Some people suffer unpredictable bouts of abdominal pain and constipation. A new study in mice, from Washington University School of Medicine in St. Louis, shows that viruses that target the nervous system can kill neurons in the gut that coordinate the process of moving waste along. Such viruses may be involved in causing people's digestive woes.
A new study led by UNC School of Medicine researchers has found that a set of biomolecules known as microRNAs, specifically microRNA-31 (miR-31), can help predict which patients with Crohn’s disease are at higher risk for the development of severe problems that may require surgical removal of the large intestine.
Los pacientes obesos que se sometieron simultáneamente a los procedimientos salvadores del trasplante hepático y de la cirugía para reducción de peso pudieron mantener mejor el peso a largo plazo y tuvieron menos complicaciones metabólicas que quienes perdieron peso por su cuenta.
Drinking an additional 1.5 liters of water daily can reduce recurring bladder infections in premenopausal women by nearly half, a yearlong study of otherwise healthy women with a history of repeated infections has found.
Peter Wiklund, MD, PhD, a world-renowned surgeon who pioneered robot-assisted cystectomy, has been appointed Director of the Bladder Cancer Program at the Mount Sinai Health System and Professor of Urology in the Department of Urology at the Icahn School of Medicine at Mount Sinai.
Gary Patti, the Michael and Tana Powell Associate Professor of Chemistry in Arts & Sciences at Washington University in St. Louis, has been awarded $4.8 million in two separate National Institutes of Health (NIH) grants focused on improving the accessibility of metabolomics — the study of the biochemical reactions that underlie metabolism.
Extreme dieting causes short-term body changes that may have long-term health consequences, according to a new study. The findings will be presented today at the American Physiological Society’s (APS) Cardiovascular, Renal and Metabolic Diseases: Sex-Specific Implications for Physiology conference in Knoxville, Tenn.
Fixing or replacing faulty genes has emerged as a key to unlocking cures for numerous devastating diseases. But if the new, engineered genes can’t find their way into the patient’s genomic sequence, they won’t help.
Deep space bombardment by galactic cosmic radiation could significantly damage gastrointestinal tissue leading to long-term functional alterations, according to a study by investigators at Georgetown University Medical Center, which also raises concerns about high risk of tumor development in the stomach and colon.
Exercise may reduce the risk of osteoporosis associated with the loss of ovarian function, but fitness may not protect against related metabolic changes and weight gain, a new study reports. The findings will be presented today at the American Physiological Society’s (APS) Cardiovascular, Renal and Metabolic Diseases: Sex-Specific Implications for Physiology conference in Knoxville, Tenn.
Drinking an additional 1.5 liters of water daily can reduce recurring bladder infections in premenopausal women by nearly half, a yearlong study of otherwise healthy women with a history of repeated infections has found.
The American Thyroid Association (ATA) announces with pleasure that the 2018 John B. Stanbury Thyroid Pathophysiology Medal will be awarded to Dr. Marvin C. Gershengorn at the ATA Annual Meeting this week. Dr. Gershengorn is Chief of the Clinical Endocrinology Branch (formerly the Laboratory of Endocrinology and Receptor Biology) at the National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, Maryland.
Saint Louis University researchers reviewed data for patients with a rare type of bladder cancer, examining treatments and survival rates.
In a study published in the Journal of Controlled Release, University of Kentucky Markey Cancer Center researchers used nanoparticles to deliver powerful chemotherapy drugs directly to lungs affected by metastatic disease while avoiding toxicity elsewhere in the body.
Driver genes in different metastases from the same patient are remarkably similar, providing optimism for the success of future targeted therapies, according to a published study by Science.
UC Davis Comprehensive Cancer Center has received a $6.3 million grant from the National Cancer Institute’s (NCI) Center to Reduce Cancer Health Disparities for a 5-year study to tease out why some ethnic and racial minority groups fare worse than whites when they get cancer and to find more precise treatments to improve their chances of survival.
The family’s hope for Willow stems from a gene therapy center at UT Southwestern Medical Center where leading experts are engineering innovative treatments for some of the world’s rarest brain diseases.
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