In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute have shown their drug candidates can target biological pathways involved in the destruction of brain cells in Parkinson's disease.
Researchers found that – when it comes to the ability to regulate emotions – brain activity in autistic people is significantly different than brain activity in people without autism. Researchers showed that symptoms including tantrums, irritability, and anxiety have a biological, mechanistic basis.
43% of surveyed female meningioma survivors aged 25–44 yrs stated they were warned that pregnancy was a risk factor for meningioma recurrence. Nevertheless, these women were more likely to want a baby (70% vs 54%) and intend to have a baby (27% vs 12%) than same-age women in the general population.
Tens of millions of people worldwide have abnormal, leak-prone sproutings of blood vessels in the brain called cerebral cavernous malformations. These abnormal growths can lead to seizures, strokes, and hemorrhages, yet their precise molecular cause has never been determined. Now, cardiovascular scientists have studied this pathway in heart development to discover an important set of molecular signals, triggered by CCM-linked gene defects, that potentially could be targeted to treat the disorder.
Howard Hughes Medical Institute scientists have identified a circuit in the brains of mice that regulates thirst. When a subset of cells in the circuit is switched on, mice immediately begin drinking water, even if they are fully hydrated. A second set of cells suppresses the urge to drink.
Neurons that trigger our sense of thirst—and neurons that turn it off—have been identified by Columbia University Medical Center neuroscientists. The paper was published today in the online edition of Nature.
Scorpions can teach us a lot about the benefits of prolonging nerve impulses, and we might now be better students. The results of a new study could pave the way for easier identification of drugs that function similarly to scorpion venom, but with happier results for the recipient.
Five genetic variants that influence the size of structures within the human brain have been discovered by an international team that included a Georgia State University researcher.
A novel pathway buried deep within a region of the brain produces a brain hormone that acts as a crucial sensor of blood glucose levels. Understanding how the hormone orchestrates the body's response to low blood sugar offers hope for treating hypoglycemia.
Inflammation has long been studied in Alzheimer’s, but in a counterintuitive finding reported in a new paper, University of Florida researchers have uncovered the mechanism by which anti-inflammatory processes may trigger the disease.
An international research team led by scientists at McGill University has found that excessive salt intake “reprograms” the brain, interfering with a natural safety mechanism that normally prevents the body’s arterial blood pressure from rising.
Pelizaeus Merzbacher disease, or PMD, is a devastating neurological condition that, in its most severe form, kills infants weeks after birth. Thirty years ago, UW-Madison neuroscientist Ian Duncan noticed a genetic mutation in dogs that was practically identical to the disease in humans. Now, in the online edition of the journal Neurobiology of Disease, Duncan has laid out the results of his marathon pursuit of PMD.
In a discovery that could dramatically affect the treatment of brain and spinal cord injuries, researchers have identified a previously unknown, beneficial immune response that occurs after injury to the central nervous system.
Scientists have identified a gene that helps regulate how well nerves of the central nervous system are insulated, researchers at Washington University School of Medicine in St. Louis report.
New research shows that stomach sleepers with epilepsy may be at higher risk of sudden unexpected death, drawing parallels to sudden infant death syndrome in babies. The study is published in the January 21, 2015, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The International Neuromodulation Society 12th World Congress in Montreal June 6 - 11, 2015 features traditional and cutting-edge ways to address chronic disease through interfacing with the body’s nervous system.
Epigenetic changes are implicated in a host of neural conditions, from Alzheimer's-related memory loss to depression. Now, a revolutionary set of molecular editing tools is allowing scientists to alter the epigenome like never before. UAB neuroscientist Jeremy Day, Ph.D., explains how he uses these techniques in his lab, and why they could lead to an entirely new kind of therapy.
Researchers at The Saban Research Institute of Children’s Hospital Los Angeles now reveal an unexpected role for ghrelin in early brain development and show its long-term impact on appetite regulation. Their study will be published online January 20 by The Journal of Clinical Investigation.
The January issue of the American Headache Society journal Headache provides an updated assessment of the best treatments to use when a migraine attack occurs. The assessment will form the basis of new AHS treatment guidelines. The paper was authored for the AHS by leading headache specialists Michael J. Marmura, MD and Stephen D. Silberstein, MD, FACP, both of the Jefferson Headache Center of Thomas Jefferson University, and by Todd J. Schwedt, MD, MSCI, of the Department of Neurology, Mayo Clinic Arizona.
Our existence depends on a bit of evolutionary genius aptly nicknamed “fight or flight.” But where in our brain does the alarm first go off, and what other parts of the brain are mobilized to express fear and remember to avoid danger in the future?
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