The process, discovered in the axons of neurons, is implicated in Alzheimer’s, amyotrophic lateral sclerosis, traumatic brain injury and other diseases or injuries to the nervous system.
Johns Hopkins Medicine scientists say they have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer’s disease may be a simple imbalance in acid-alkaline—or pH—chemistry inside endosomes, the nutrient and chemical cargo shuttles in cells.
More than 90 percent of people caring for a family member with dementia experience poor sleep, according to new research by the University at Buffalo School of Nursing.
Rutgers researchers will benefit from a $250,000 grant from the Gillson Longenbaugh Foundation to help expand the team’s work on neural stem cell interactions and developing antibody therapeutics for cancer treatment.
Glaucoma Research Foundation, a national non-profit organization dedicated to finding a cure for glaucoma, today announced a team of neuroscience researchers, led by Adriana Di Polo, PhD, at University of Montreal, have made a major breakthrough in the treatment of glaucoma. The research, which was made possible by a Glaucoma Research Foundation Shaffer Grant, could also be applicable to other neurodegenerative diseases, including Alzheimer's disease.
Fujirebio Inc., a consolidated subsidiary of Miraca Holdings Inc., (Head office: Shinjuku-ku, Tokyo, President and CEO: Yoshihiro Ashihara, hereinafter “Fujirebio” or “the Company”) announced today that it has entered into an agreement with US-based Janssen Pharmaceuticals, Inc. (hereinafter “Janssen”) to develop and commercialize an AMYLOID β 42/40 RATIO assay.
A small population of brain cells called "mossy cells" deep in a memory-making region of the brain controls the production of new neurons and may have a role in common brain disorders, according to a study from scientists at the University of North Carolina School of Medicine.
People who feel faint, dizzy or lightheaded when standing up may be experiencing a sudden drop in blood pressure called orthostatic hypotension. Now a new study says middle-aged people who experience such a drop may have a greater risk of developing dementia or stroke decades later. The study is published in the July 25, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Preliminary results of the SPRINT MIND trial found that lowering one’s systolic blood pressure to 120 mm Hg reduces the risk of mild cognitive impairment and dementia.
The results of the first ever clinical trial of focused ultrasound to open the blood-brain barrier (BBB) in patients with Alzheimer’s disease were published today in Nature Communications and also presented at the Alzheimer’s Association International Conference (AAIC) in Chicago, Illinois. The pilot trial demonstrated the feasibility and preliminary safety of focally, reversibly and repetitively opening the BBB.
In a study published online July 25 in the journal Nature, University of California San Diego School of Medicine researchers identified a signaling pathway that activates the NLRP3 inflammasome implicated in several severe chronic inflammatory disorders.
Reduced levels of plasmalogens are associated with an increased risk of Alzheimer’s Disease, according to new research presented this week at AAIC 2018.
The National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site will begin making large-scale DNA sequence data available to investigators accelerate research.
Aberrant clearance activity of microglia in particular brain regions leads to changes associated with neurodegenerative diseases
A woman’s history of pregnancy may affect her risk of Alzheimer’s disease decades later, according to a study published in the July 18, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Roy Ervin Twyman, MD, PhD, an academic neurologist with nearly 20 years’ experience in neuroscience pharmaceutical drug development, will join the NeuroVision Imaging Inc. Board of Directors on July 20.
Recent articles in the journal Molecular & Cellular Proteomics investigate metabolic quirks of cancer cells, other roles for the enzyme that generates amyloid beta, and the action mechanism of a bacterial toxin.
Philanthropist Bill Gates and the Alzheimer's Drug Discovery Foundation (ADDF) co-founder Leonard Lauder have announced a new initiative, Diagnostics Accelerator, to develop novel biomarkers for the early detection of Alzheimer's disease and related dementias.
A Johns Hopkins Medicine analysis of information gathered for an ongoing and federally sponsored study of aging and disability adds to evidence that a substantial majority of older adults with probable dementia in the United States have never been professionally diagnosed or are unaware they have been.
Most people who are familiar with the term associate it with stroke (i.e., brain damage caused by disrupted blood flow to the brain). But aphasia, an impairment of language, is not always caused by stroke.
Supplementing a single protein found in the spinal cord could help prevent symptoms of Lou Gehrig’s disease, according to a new study out of Case Western Reserve University School of Medicine. Researchers found high levels of the protein—called mitofusion 2 or Mfn2—prevented nerve degeneration, muscle atrophy, and paralysis in a mouse model of the disease. Since Mfn2 is often depleted during Lou Gehrig’s, the new study suggests supplementing it could be a novel therapeutic approach for the disease.
Alzheimer’s disease is a progressive, neurodegenerative condition that often begins with mild cognitive impairment (MCI), making early and repeated assessments of cognitive change crucial to diagnosis and treatment. In a paper in Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, researchers led by scientists at the University of California San Diego School of Medicine found that repeated testing of middle-age men produced a “practice effect” which obscured true cognitive decline and delayed detection of MCI.
Older people who have higher blood pressure may have more signs of brain disease, specifically brain lesions, according to a study published in the July 11, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology. Researchers also found a link between higher blood pressure and more markers of Alzheimer’s disease, tangles in the brain.
Scientists have discovered a “Big Bang” of Alzheimer’s disease – the precise point at which a healthy protein becomes toxic but has not yet formed deadly tangles in the brain.
New research from South Australian scientists has shown that vitamin D (also commonly known as the sunshine vitamin) is unlikely to protect individuals from multiple sclerosis, Parkinson’s disease, Alzheimer’s disease or other brain-related disorders.
Nearly all major neurodegenerative diseases are defined by the presence of one of four proteins that have gone rogue. As such, investigational drugs aimed at preventing or slowing the disease often hone in on just one of these proteins. However, targeting multiple proteins at once may be the real key, according to a recent Penn Medicine study.
A first-of-its-kind study has found that “skinny fat” – the combination of low muscle mass and strength in the context of high fat mass – may be an important predictor of cognitive performance in older adults. Results show that sarcopenic obesity or “skinny fat” was associated with the lowest performance on global cognition.
A regimen of low-dose aspirin potentially may reduce plaques in the brain, which will reduce Alzheimer’s disease pathology and protect memory, according to neurological researchers at Rush University Medical Center, who published the results of their study today in the July issue of The Journal of Neuroscience.
Researchers at Johns Hopkins have added to evidence that rising and chronic inflammation as measured by a biomarker in the blood in middle and late age are linked to visible structural changes in the brains of people with poor cognition and dementia.
Deep brain stimulation (DBS) may slow the progression of tremor for early-stage Parkinson’s disease patients, according to a Vanderbilt University Medical Center study released in the June 29 online issue of Neurology®, the medical journal of the American Academy of Neurology.
A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.
A new study suggests that when a high-fat, high-sugar diet that leads to obesity is paired with normal aging, it may contribute to the development of Alzheimer’s disease. In addition, researchers discovered that certain areas of the brain respond differently to risk factors associated with Alzheimer’s. The study is published in Physiological Reports.
Researchers at Indiana University have found early evidence that tiny snippets of genetic material called microRNA may help with early of conditions such as Alzheimer's disease.
Researchers from Queen’s University Belfast have shown that the eye could be a surrogate for brain degeneration like Alzheimer’s disease (AD).
Two strains of human herpesvirus—human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) —are found in the brains of people with Alzheimer’s disease at levels up to twice as high as in those without Alzheimer’s, researchers from the Icahn School of Medicine at Mount Sinai report.
Alzheimer’s disease could be better treated, thanks to a breakthrough discovery of the properties of the metals in the brain involved in the progression of the neurodegenerative condition, by an international research collaboration including the University of Warwick.Dr Joanna Collingwood, from Warwick’s School of Engineering, was part of a research team which characterised iron species associated with the formation of amyloid protein plaques in the human brain – abnormal clusters of proteins in the brain.
An age group analysis of data from the ADvance trial has shown that participants over the age of 65 continue to derive the most benefit from Deep Brain Stimulation of the fornix (DBS-f), as observed in the data from the phase 2 findings (12 – 24 months) of the Phase II trial.
When seniors experience memory problems, they may start worrying that they have Alzheimer’s disease. Indeed, Alzheimer’s is the most common cause of memory loss in the elderly – but sometimes an entirely different diagnosis is to blame.
A research team at Wayne State University hopes to give clinicians tools for identifying the early signs of impending disease by measuring subtle deviations in the way the brain modulates its chemistry during the formation of new memories. Their research project, “Task-related modulation of hippocampal glutamate, subfield volumes and associative memory in younger and older adults: a longitudinal ¹H FMRS study,” was recently awarded a two-year, $423,500 grant from the National Institute on Aging of the National Institutes of Health.
The Alzheimer’s Foundation of America (AFA) is awarding $206,184 over the next three years to Stony Brook Medicine to support an innovative Positron Emission Tomography (PET) imaging research project that will compare neurons from healthy controls and those with Alzheimer’s disease in an effort to improve drug development.
Copper exposure’s link Alzheimer’s disease, the effects of consumer microbials on the colon, a potential prostate-based activation of a carcinogen in cooked meat, and the impact of hydraulic fracturing mixtures on the immune system featured in latest issue of Toxicological Sciences.
Research from the University of Illinois at Chicago has found that some of the genes affected by alcohol and inflammation are also implicated in processes that clear amyloid beta — the protein that forms globs of plaques in the brain and which contributes to neuronal damage and the cognitive impairment associated with Alzheimer’s disease.
Approximately 47 million people worldwide are living with Alzheimer’s disease (AD) and other dementias. One of the most prominent neuroscientists in the country has developed eight myths and truths about AD to shed light on this form of dementia that causes problems with memory, thinking and behavior.
The latest research and features in cell biology in the Cell Biology News Source
The UCLA Alzheimer’s and Dementia Care Program has been producing a series of online videos aimed at helping caregivers understand how to care for persons with dementia. They utilize actors who portray both dementia patients and their caregivers and cover a wide range of issues facing caregivers.
Recently published research from Iowa State University plant scientists maps the stress response detected by the endoplasmic reticulum, an organelle in cells of corn seedlings. The study shows how cells transition from adaptation to death when faced with persistent stress and could help plant breeders develop stress-resistant crop varieties.
In a paper to be published in the June 1 issue of the Journal of Biological Chemistry, researchers at Washington University in St. Louis provide the first report of an enzyme that breaks down plasmalogens, a breakthrough in understanding the molecular processes that occur during Alzheimer’s and other diseases.
Researchers look at the promising role played by the BMI1 gene, which could someday help mitigate or even reverse the disease.
In the ongoing quest for a successful treatment for Alzheimer’s disease, a team of scientists from several leading research institutions have created a map of the molecular network in the aging brain.
New research from The Ohio State University has found that young people with subtle hearing loss – the kind they aren’t even aware of – are putting demands on their brains that typically wouldn’t be seen until later in life.
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