… has led to the development of trophoblast stem cell lines which retain the capacity to … –OFF switch to regulate various hallmark processes of stem cell biology like self-renewal [15, 16… pools with temporal replenishment of the trophoblast stem cell hub …
Multi-drug resistance remains a critical issue in cancer treatment that hinders the effective use of chemotherapeutic drugs. The active components of traditional Chinese medicine have been applied as adjuvants to accentuate the anticancer …
Xiao-Liang Liu, Chuan-Jian Zhang, Jing-Jing Shi, Qin-Fei Ke, Yu-Wei Ge, Zhen-An Zhu, Ya-Ping Guo
This Backstory describes the development of a research article published in Cell Stem Cell that was originally submitted to Community Review, a program wherein a manuscript is simultaneously considered at multiple Cell Press journals. The article, a
… reside in the RZ, a known location for stem cells 5,11 , and that FoxA2+ cells are located in close proximity to the SOC, which is viewed as a signaling center of RZ stemness 10 , we asked whether FoxA2+ cells are different than the previously …
… stem cell … stem cell state, accompanied by altered niche requirements and a mature chief cell/secretory phenotype. Following the constitutive expression of p57 in vivo, chief cells showed an impaired injury response. Thus, p57 is a gatekeeper …
… In this issue of Cell Stem Cell, Ma et al. demonstrate that the activation of the nuclear receptor thyroid hormone receptor beta (NR1A2) improves the differentiation status of hepatocyte-like cells derived from human pluripotent stem cells. … In this …
Limited stem cells, poor stretchability and mismatched interface fusion have plagued the reconstruction of cranial defects by cell-free scaffolds. Here, we designed an instantly fixable and self-adaptive scaffold by dopamine-modified hyaluronic acid …
Lime is a very important soil amendment used to grow crops. To help ensure the correct amount is applied where it is needed most, the Clemson University Precision Agriculture Team has developed the Reverse Lime Rate Calculator.
In a paper in Academic Medicine, educators at the Renaissance School of Medicine (RSOM) at Stony Brook University highlighted the success of their three-year, elective course in biodesign that has enabled students to expand their abilities as medical device innovators.
While our planet faces many grand challenges that are impacting global food security, the Wells Fargo Innovation Incubator (IN2) is helping to bring new AgTech innovations to the table.
The honor recognizes biomaterials research that significantly benefits patient health and outcomes.
… programs maintaining stem cell integrity have been identified, safety mechanisms eliminating malignant HSPCs from the stem cell pool … HSPCs and antigen-specific CD4 + T cells, causing stem cell proliferation, differentiation, and specific exhaustion …
By developing a 3D spheroid system for hPSC-hepatocytes differentiation and combining it with genomic approaches, Jaenisch and colleagues identified a role for THRB in regulating hPSC-hepatocytes maturation through chromatin-remodeling complex pBAF.
Xu et al. demonstrated feasibility of modeling early heart failure using induced pluripotent stemcell-derived cardiomyocytes from patients with HLHS. They observed that heart failure is linked to increased apoptosis, mitochondrial dysfunction, redox
Theunissen et al. describe a methodology for deriving self-renewing 3D trophoblast organoids from naive human pluripotent stem cells. They demonstrate that stem-cell-derived trophoblast organoids model human placental development, X chromosome inact
… In order to obtain the highest yield of mesenchymal stem cell-derived nanovesicles (MSC-NVs), we employed a serial extrusion approach using polycarbonate membrane filters with 5 μm, 1 μm, 0.4 μm, and 0.2 μm pore sizes …
Cardiovascular diseases (CVDs) are globally known to be important causes of mortality and disabilities. Common treatment strategies for CVDs, such as pharmacological therapeutics impose serious challenges due to the failure of …
The high mortality rate of malignant pleural mesothelioma led to study the mechanisms for chemoresistance. The cancer stem cell (CSC) model has been proposed to explain chemoresistance. CSCs are characterized by self-renewal …
In this issue of Cell Stem Cell, Ma et al. demonstrate that the activation of the nuclear receptor thyroid hormone receptor beta (NR1A2) improves the differentiation status of hepatocyte-like cells derived from human pluripotent stem cells.
bstract: Placenta-derived stem cells (PDSCs) offer the advantages of possessing mesenchymal and embryonic traits, broad differentiation potential, large-scale availability, and no ethical constraints in their utilization in therapeutic applications. Elevated protein synthesis and consequently enhanced protein maintenance networks become necessary both due to the requirement to maintain stemness and respond to different stresses.
In this issue of Cell Stem Cell, a new study by Rostovskaya et al. (2022) uses human stem cells to understand the formation of the amnion, a vital extraembryonic tissue that encircles the fetus during gestation. They provide insight into human amnio
In this review, Shao and Fu outline recent progress in reconstructing multiscale structural orders in embryoids and organoids and discuss conceptual and technological frameworks useful for innovating bioengineering-directed approaches to achieve next
The intrahepatic bile ducts consist of a complex branching morphology. Here, Roos et al. demonstrate that a branching tubular architecture can be induced in human adult intrahepatic cholangiocyte organoids. These BRCOs faithfully recapitulate aspect
In this review, Qazi et al. describe advances in the engineering of hydrogels to explore complex biological processes, such as development, disease, and wound healing. They specifically highlight the spatiotemporal control over hydrogel biochemical
In this issue of Cell Stem Cell, Xu et al. demonstrate that induced pluripotent stem cell-derived cardiomyocytes from patients with hypoplastic left heart syndrome exhibit mitochondrial dysfunction and can be used for disease modeling. In addition,
Antigen presentation is typically regarded as the domain of immune cells such as dendritic cells and B cells. Hernandez-Malmierca et al. (2022) upend this notion by observing that hematopoietic stem and progenitor cells process and present antigen v
The success of stem cell transplantation depends upon the coordinated sequence of stem cell renewal, differentiation, assembly, and maintenance of long-term function. Advances in biomaterials can improve pre-/post-transplantation outcomes by integrat
Haas and colleagues show that hematopoietic stem cells (HSCs) act as antigen-presenting cells. The presentation of immunogenic antigens triggers a bidirectional interaction with antigen-specific CD4+ T cells, resulting in the rapid exhaustion of dis
Shirley Pomponi, Ph.D., an ocean explorer, aquanaut and marine biotechnologist, will receive the Society for In Vitro Biology’s (SIVB) highest award – the 2022 “Lifetime Achievement Award.” She has made pioneering, scientific advances and contributions to marine invertebrate biotechnology, biological oceanography and national marine policy.
Industry produces acetone and isopropanol using processes that release carbon dioxide and other greenhouse gases. Researchers have now developed a new fermentation process that efficiently converts waste carbon oxide gases into acetone and isopropanol. This use of engineered bacteria advances progress on “carbon-negative” biomanufacturing for more sustainable industrial production and reduced greenhouse gas emissions.
Zhongyue Lv, Ying Li, Yachen Wang, Fengyu Cong, Xiaoyan Li, Wanming Cui, Chao Han, Yushan Wei, Xiaojun Hong, Yong Liu, Luyi Ma, Yang Jiao, Chi Zhang, Huanjie Li, Mingyan Jin, Liang Wang, Shiwei Ni, Jing Liu
Xiaowei Gu, Anna Heinrich, Tony DeFalco
Isaline Bontemps, Celine Lallemand, Denis Biard, Nathalie Dechamps, Thierry Kortulewski, Emmanuelle Bourneuf, Capucine Siberchicot, Francois Boussin, Sylvie Chevillard, Anna Campalans, Jerome Lebeau
In this paper, we describe a platform for modeling LGMD based on the use of human induced pluripotent stem cells (hiPSC).
latelets are a uniquely mammalian physiologic attribute. As the only non-marine vertebrate class to experience menopause, humans have a substantial post-reproductive lifespan and are believed to have a limited, non-renewable oocyte supply. Ovarian reserve typically declines after about age 35yrs, marking losses which cannot be recovered by available fertility medications.
Yizhuo Zhou, Ying Yang, Jun Qian, Jian Ge, Debora I Sinner, Hongxu Ding, Andrea Califano, Wellington V Cardoso
Yoshitaka Tamaki, Jay P Ross, Paria Alipour, Helene Catoire, Daniel Rochefort, Makoto Urushitani, Ryosuke Takahashi, Joshua A Sonnen, Stefano Stifani, Patrick A Dion, Guy A Rouleau
… In this study, we demonstrated that TET2 deficiency impaired muscle stem cell proliferation and differentiation, leading to notable changes in mouse body weight and muscle morphology during development. We further assayed the genome-wide …
Bryce LaFoya, Ken Prehoda
Congjuan Luo, Feng Luo, Lin Che, Long Zhao, Hui Zhang, Xiaofei Man, Quandong Bu, Haiyan Zhou, Yan Xu
Wout J. Weuring, Nina Dirkx, Els De Vriendt, Noor Smal, Bobby P.C. Koeleman, Joep van de Vondervoort, Martijn Koetsier, Sarah Weckhuysen
… related to complications of hematopoietic stem cell transplantation. This highlights a non-… The most frequent ocular complication of autologous hematopoietic stem cell transplantation is … periorbital edema in a patient after hematopoietic stem cell …
… This article provides a review of the most frequently used CSCs and stem cell markers. … of stem cells, because they play a role in stem cell pluripotency and their interactions with various co-… Indeed, the functional role of stem cell factors in …
… the multitude of stem cell types (adipose derived, bone marrow derived, embryonic and induced pluripotent) and techniques employed to induce stem cell proliferation and differentiation … Here, we curate several studies on stem cell …
… Instead, using stem cell models, it is possible to recapitulate neurodevelopment in vitro, essentially observing risk in a laboratory dish. We … The first human embryonic stem cell lines were grown in 1998, with the theoretical capability to …
PO-660-03 OPTICAL CONTROL OF ARRHYTHMIA MORPHOLOGY IN HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED … To develop a method for the induction of morphologically and physiologically defined arrhythmias in human …
Ying Yang, Ming Zhang, Mengqi Li, Yingchun Li, Wei Yang, Zhuogang Liu, Hongtao Wang
Chuyu Li, Jiazi Xie, Juan Dong, Chao Gao, Meng Xia, Yuting Lin, Yugui Cui, Lianju Qin, Wei Wu
Yajuan Shi, Hyosung Kim, Catherine A Hamann, Elizabeth M Rhea, Jonathan M Brunger, Ethan S Lippmann
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right