… This review focuses on the key processes and guidelines for clinical translation of human induced pluripotent stem cell (hiPSC)derived β cells for diabetes cell therapy. Here, we discuss the (1) key considerations of manufacturing clinical-grade hiPSCs …
Researchers at UC San Diego School of Medicine report that high-frequency spinal cord stimulation proved more effective at improving perceived pain reduction than low-frequency SCS in patients studied, and that there was some variation in PPR between male and female patients.
Karin Strohmeier, Martina Hofmann, Jaroslaw Jacak, Marie-Sophie Narzt, Marlene Wahlmueller, Mario Mairhofer, Barbara Schaedl, Wolfgang Holnthoner, Martin Barsch, Matthias Sandhofer, Susanne Wolbank, Eleni Priglinger
Bao Zhang, Peng He, John E Lawrence, Shuaiyu Wang, Elizabeth Tuck, Brian A Williams, Kenny Roberts, Vitalii Kleshchevnikov, Lira Mamanova, Liam Bolt, Krzysztof Polanski, Rasa Elmentaite, Eirini S Fasouli, Martin Prete, Xiaoling He, Nadav Yayon, Yixi Fu, Hao Yang, Chen Liang, Hui Zhang, David Fitzpatrick, Helen Firth, Andrew Dean, John Marioni, Roger A Barker, Mekayla A Storer, Barbara Wold, Hongbo Zhang, Sarah Teichmann
Hiroki Kawano, Yuko Kawano, Charles O. Smith, Mark W. LaMere, Matthew J. McArthur, Michael W. Becker, Scott W. Ballinger, Satoshi Gojo, Roman A. Eliseev, Laura M. Calvi
Rui D. Alvites, Mariana Branquinho, Ana Catarina Sousa, Bruna Lopes, Patrícia Sousa, Justina Prada, Isabel Pires, Giulia Ronchi, Stefania Raimondo, Ana Lúcia Luís, Stefano Geuna, Artur S. P. Varejão, Ana Colette Maurício
Researchers share insights about the mechanisms of human embryo and create method to develop transcriptionally similar cells in tissue culture; latest discovery a step closer to finding alternative for bone marrow and other cancer treatments.
A sensor created by Johns Hopkins University graduate students to detect very early-stage lymphedema could spare thousands of patients a year, many women with breast cancer, from the painful, debilitating condition.
Researchers from Columbia Engineering and Columbia University Irving Medical Center have developed a model of human physiology in the form of a multi-organ chip consisting of engineered human heart, bone, liver, and skin that are linked by vascular flow with circulating immune cells, to allow recapitulation of interdependent organ functions. The researchers have essentially created a plug-and-play multi-organ chip, which is the size of a microscope slide, that can be customized to the patient.
In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause o
… stem cell transplantation. Endothelial cell damage may trigger the initiation of aGVHD. Methods: Endothelial damage and repair were evaluated by counting circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) in 17 …
Exosomes are known to transmit microRNAs (miRNAs) to affect human cancer progression, and miR-17-5p has been manifested to exert facilitated effects on colorectal cancer (CRC) progression, while the role of tumor stem cells-derived …
… The levels of ROS in the gut influence stem cell renewal ROS itself however is further influenced by several other factors such as the microbiota concerning the gut and immune cells which in turn also influence one another by various cross-talk …
… Mesenchymal stem cells (MSCs) are adult stem cell populations and exhibit great potential in regenerative medicine and oncology. Platelet-derived growth factors (PDGFs) are well-known to regulate MSC biology through their chemotactic and mitogenic …
Acute myeloid leukemia (AML) is characterized by poor clinical outcomes due to high rates of relapse following standard-of-care induction chemotherapy. While many pathogenic drivers have been described in AML, our understanding of the …
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), headquartered at the Rutgers Institute for Quantitative Biomedicine, announces the expansion of its data storage capacity through the Amazon Web Services (AWS) Open Data Sponsorship Program. The AWS program is providing the RCSB PDB with more than 100 terabytes of storage for no-cost delivery of Protein Data Bank information to millions of scientists, educators, and students around the world working in fundamental biology, biomedicine, bioenergy, and bioengineering/biotechnology.
Huihui Ren, Quan Wen, Qingxuan Zhao, Nan Wang, Yuming Zhao
Epigenetic modifications have been observed as a decline in miRNA-21 expression and breast cancer stem cell (CSC) population after 3 cycles of standard chemotherapy. The epigenetic response (miRNAs expression) and CSCs are also correlated in pa
The original study by Alessio et al reported that skinny people (SP) serum can promote the formation of brown adipocytes, but not the differentiation of white adipocytes. This finding may explain why SP do not often become obese, despite consum
Miji Yeo, Jung Won Yoon, Gyu Tae Park, Sung-Chan Shin, Young-Cheol Song, Yong-Il Cheon, Byung-Joo Lee, Geun Hyung Kim, Jae Ho Kim
BACKGROUNDSyringomyelia is a disease caused by the formation of a cavity inside the spinal cord and is accompanied by such symptoms as pain, paresthesia, and urination and defecation disorders, and in severe cases causes various paralyses. Curr
BACKGROUNDMesenchymal stem cells (MSC) effects on tissue regeneration are mainly mediated by their secreted substances (secretome), inducing their paracrine activity. This Conditioned medium (CM), including soluble factors (proteins, nucleic ac
… There was a statistically significant difference in the frequency of CD4+ CD95+, CD4+ CD95 Hi, and CD4+ CD95 low/med T stem cell memory (T SCM) cells between responder and nonresponder groups. However, the comparison of the …
… The child was pretreated with modified Bu/Cy plus ATG regimen for transplantation, and underwent haploid hematopoietic stem cell … , intravenous immunoglobulin (IVIG) transfusion, stem cell transfusion and other treatments, and …
Acute liver injury (ALI) is characterized by massive hepatocyte necrosis and subsequent recruitment of myeloid cells to liver. Mesenchymal stem cells (MSCs) have therapeutic potential for ALI through their immunoregulation on macrophages …
… MSC, a pluripotent stem cell, has self-renewal capability and multidirectional differentiation potential, and it can be obtained from tissues, such as the umbilical cord, bone marrow and fat [24], [25]. Many experimental and clinical studies proved …
Cell therapy using induced pluripotent stem cell (iPSC) derivatives may result in abnormal tissue generation because the cells undergo numerous cycles of mitosis before clinical application, potentially increasing the accumulation of genetic …
… stem cell sources and differentiation lineages and is therefore useful for various stem cell–… cells and extracellular matrix components, guiding stem cell fates ex vivo is generally initiated … ultimately negatively affects the guiding efficiency of the …
… d Stem cell frequency of GS5 cells treated with Cas9 and the indicated sgRNAs as determined by limiting dilution assay. e–g Representative flow cytometry images (e) and corresponding quantification (f) (n = 3 biologically independent samples, black …
… The objective of this study is to synthesise the findings of clinical studies in order to derive evidence for use of the mesenchymal stem cell (MSC) therapy in the treatment of neurodegenerative cerebellar ataxias. In order to find relevant studies …
… methylation status, which in turn compromised periodontal stem cell function including a reduction in proliferation and differentiation … co‐regulator, which plays a key role in cell proliferation, differentiation, and stem cell self‐renewal [86]. The …
Micropollutants in water often are hormones that accumulate in the environment and may have negative impacts on humans and animals. Researchers of Karlsruhe Institute of Technology (KIT) and Leibniz Institute of Surface Engineering (IOM) in Leipzig have now developed a process for the photocatalytic degradation of these pollutants when they flow through polymer membranes. It is presented in Nature Nanotechnology. Irradiation with light triggers a chemical reaction, as a result of which steroid hormones are degraded on the membranes coated with titanium dioxide. (DOI: 10.1038/s41565-022-01074-8)
… Allogeneic hematopoietic stem cell transplantation (HSCT) can be a highly effective treatment for patients with hematological malignancies and hereditary blood disorders if a suitable HSC graft can be obtained, ideally from an HLA (human leukocyte …
… hold a patent application for the investigated stem cell product “Stem cell therapy based on adipose-derived stem cells”, WO2017068140. None of the other coauthors declare conflicts of interest. LS is an advisory board member for Takeda and Kyowa …
As in younger patients, allogeneic stem cell transplantation (alloHSCT) offers the best chance for durable remission in older patients (≥60 years) with acute myeloid leukemia (AML). However, defining the best treatment strategy (and in particular …
… In this study, we generate lung cells and macrophages from the same human pluripotent stem cell (hPSC) lines and pair them to establish a co-culture system. This strategy addresses a common concern about histocompatibility when studying …
… ABCC1 encodes the ATPase cassette transporter protein multidrug resistance 1, a stem cell marker and MYCN transcriptional target conferring … 1, 2), suggesting they share a common ependymal stem cell lineage. The mismatch repair gene …
The heterogeneous nature of human CD34+ hematopoietic stem cells (HSCs) has hampered our understanding of the cellular and molecular trajectories that HSCs navigate during lineage commitment. Using various platforms including single cell …
… The objective of this study is to assess the effect of mesenchymal stem cell (MSC) therapy on SG function after radiation-induced injury. … Accumulating literature on animal studies suggests that mesenchymal stromal/stem cell (MSC) transplantation …
… We decided to focus on stem cell therapy administered within the acute phase (<2 weeks) of the timing of the TSCI, as this would be the realistic time for administration within humans. It is likely that SC therapy may involve injections within both the …
In this work, the mechanism underlying the anticancer activity of a photoactivatable Ir(III) compound of the type [Ir(CˆN) 2 (dppz)][PF 6 ] where CˆN = 1-methyl-2-(2′-thienyl)benzimidazole (complex 1) was investigated. Complex 1 photoactivated by visible light shows …
… a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms. … Taken together, our data describe one mechanism by which a transcription factor controls stem cell …
Annika M Kisch, Karin Bergkvist, Sólveig Adalsteinsdóttir, Christel Wendt, Anette Alvariza, Jeanette Winterling
Sheerien Rajput, Khurram Minhas, Iqbal Azam, Usman Shaikh, El-Nasir Lalani
Hongkui Deng, Jingyang Guan, Guan Wang, Jinlin Wang, Zhengyuan Zhang, Yao Fu, Lin Cheng, GaoFan Meng, Jialiang Zhu, Yanglu Wang, Shijia Liuyang, Zirun Yang, Huanjing He, Xinxing Zhong, Qijing Chen
Toshinobu Nakatake, Makoto Nabetani, Nanae Yutaka, Kaho Suzuki, Ryoichi Hazama, Satoshi Ohnishi, Takashi Hamazaki, Haruo Shintaku, Ran D Goldman
Yitian Lu, Jintao Zhang, Fanning Zeng, Peng Wang, Xiangna Guo, Haitao Wang, Zaisheng Qin, Tao Tao
Tadeusz J. Kaczynski, Elizabeth D. Au, Michael H. Farkas
GuoYi Dong, Xiaojing Xu, Yue Li, Wenjie Ouyang, Weihua Zhao, Ying Gu, Jie Li, Tianbin Liu, Xinru Zeng, Huilin Zou, Shuguang Wang, Sixi Liu, Hai-Xi Sun, Chao Liu
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