Curated News: Grant Funded News

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A team of Roswell Park Comprehensive Cancer Center researchers has identified a new biomarker that could predict response to immune checkpoint inhibitors (ICI) shortly after patients with non-small cell lung cancer (NSCLC) initiate therapy. This discovery, published today in the journal Nature Communications, is not only an important step forward in lung cancer treatment, but also has implications for other malignancies, according to lead author Fumito Ito, MD, PhD, FACS.

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DHS S&T AWARDS $153K in phase 1 funding to small business for maritime object tracking technology.

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At the beginning of an immune response, a molecule known to mobilize immune cells into the bloodstream, where they home in on infection sites, rapidly shifts position, a new study shows. Researchers say this indirectly amplifies the attack on foreign microbes or the body’s own tissues.

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The Moore Center for the Prevention of Child Sexual Abuse at the Johns Hopkins Bloomberg School of Public Health has been awarded $10.3 million from Oak Foundation for the Center’s new “Global Perpetration Prevention: Translating Knowledge into Action” program.

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Women who experience an accelerated accumulation of abdominal fat during menopause are at greater risk of heart disease, even if their weight stays steady, according to a University of Pittsburgh Graduate School of Public Health-led analysis published today in the journal Menopause.

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According to the World Health Organization, one in six worldwide deaths are attributed to cancer, but not due to initial malignant tumors. They were caused by the spread of cancer cells to surrounding tissues, which consist largely of collagen. That was the focus of a recent study by Stanford University and Purdue University researchers.

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Connected, automated vehicles promise to save energy and improve safety. Michigan Tech engineers propose a modeling framework for cooperative driving. Simulation results show that the cooperative automated eco-driving algorithm saves energy — 7% under light traffic and 23% under heavy traffic.

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Researchers at the University of California San Diego School of Medicine and Massachusetts General Hospital have identified a new drug that could prevent Alzheimer’s disease by modulating, rather than inhibiting, a key enzyme involved in forming amyloid plaques in the brain. The study, which will be published March 2 in the Journal of Experimental Medicine (JEM), demonstrates that the drug is safe and effective in rodents and monkeys, paving the way for future clinical trials in humans.

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A team of researchers co-led by Michael Frohman, MD, PhD, of Stony Brook University, has identified an important cause of congenital heart disease. They discovered that certain loss of functions in the PLD1 (Phospholipase D1) gene causes congenital right-sided cardiac valve defects and neonatal cardiomyopathy.

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Duke researchers describe a new vaccination strategy that they think could re-program the body to fight off the bacteria that cause urinary tract infections.

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Scientists developed a highly efficient, targeted method for delivering gene editing machinery to specific tissues and organs, demonstrating the treatment of high cholesterol by targeting genes in the liver of mice, reducing cholesterol for over 3 months (and potentially more) with one treatment

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Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT Southwestern reports in a new study. The findings, published online in PNAS, could offer a new way to treat both Type 1 and Type 2 diabetes in people.

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Dr. Kinjyo's work Will continue to look at how combining different drug treatments can improve outcomes for women with ovarian cancer.

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By analyzing blood samples from individuals infected with SARS-CoV-2, researchers in Singapore have begun to unpack the different responses by the body’s T cells that determine whether or not an individual develops COVID-19. The study, published today in the Journal of Experimental Medicine (JEM), suggests that clearing the virus without developing symptoms requires T cells to mount an efficient immune response that produces a careful balance of pro- and anti-inflammatory molecules.

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In a study at Penn researchers found that Pennsylvania’s financial incentive policy encouraged hospitals to enact rapid changes to support treatment for opioid use disorder for patients visiting the ED, and evaluates the efficacy of the Opioid Hospital Quality Improvement Program.

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Cities around the United States could use their own biowaste from food scraps or manure to produce renewable energy for vehicles to the tune of $10 billion a year, according to a researcher at Missouri S&T. The proposed operation creates renewable natural gas (RNG) from biowaste and renewable hydrogen (RH2) from surplus electricity generated by solar or wind energy.

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Glaucoma Research Foundation (GRF) today announced a total of $1.7 million in annual research grants to support 13 investigators at prestigious colleges and universities across the United States.

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Announcement that University Hospitals has received a grant from the Robert Wood Johnson Foundation to research a model of long-term case management for Medicaid patients.

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The University of Michigan Rogel Cancer Center has named Sarah Hawley, Ph.D., M.P.H., associate director for training, education and career development. She will lead the center’s efforts to coordinate and enhance robust resources that support faculty, trainees and students interested in cancer research.

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Low blood levels of immune cells called lymphocytes, in combination with higher levels of inflammation on PET/CT scans, are indicators of active sarcoidosis — an inflammatory disease that attacks multiple organs, particularly the lungs and lymph nodes — which disproportionately affects African Americans. The discovery by researchers at the University of Illinois Chicago could help guide disease treatment.

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While the amazing regenerative power of the liver has been known since ancient times, the cells responsible for maintaining and replenishing the liver have remained a mystery. Now, research from the Children’s Medical Center Research Institute at UT Southwestern (CRI) has identified the cells responsible for liver maintenance and regeneration while also pinpointing where they reside in the liver.

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UC San Diego was awarded five COVID-19 Rapid Acceleration of Diagnostics (RADx) projects by the National Institutes of Health totaling nearly $33 million, which will fund efforts that range from managing a large data center to expanding testing in disadvantaged communities.

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Long thought a vestigial part of human cells, new genetic analysis of the primary cilium shows that it may be tied to common conditions like diabetes and kidney failure

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An animal scientist studying relationships between insulin and milk production in dairy cows has received a three-year, $500,000 grant from the U.S. Department of Agriculture National Institute of Food and Agriculture.

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A new study estimates 64% of adult COVID-19 hospitalizations in the U.S. may have been prevented if there were less obesity, hypertension, diabetes, and heart failure. The model suggests notable differences by age and race/ethnicity in COVID-19 hospitalizations related to these conditions.

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The Society for Laboratory Automation and Screening (SLAS) is pleased to announce David McIntyre, Ph.D. candidate from Boston University (Boston, MA, USA), as the 2021 SLAS Graduate Education Fellowship Grant recipient.

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Researchers have discovered a blood biomarker that predicts kidney transplant rejection with a lead time of about eight months, which could give doctors an opportunity to intervene and prevent permanent damage, potentially using an existing medication.

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Scientists at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have identified the specialized environment, known as a niche, in the bone marrow where new bone and immune cells are produced. The study, published in Nature, also shows that movement-induced stimulation is required for the maintenance of this niche, as well as the bone and immune-forming cells that it contains. Together, these findings identify a new way that exercise strengthens bones and immune function.

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Today, the Honourable Patty Hajdu, Minister of Health, and the Honourable François-Philippe Champagne, Minister of Innovation, Science and Industry, announced an investment of $3.34 million in research to understand the health impacts of extended periods of inactivity and the effectiveness of preventative measures to mitigate the impact of inactivity on our health. This investment will support eight teams of researchers whose data collection will begin in spring 2021.

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The University of Miami Miller School of Medicine was awarded a new five-year, $2 million grant from the National Institute on Deafness and Other Communication Disorders (NIDCD) for “Application of Mild Therapeutic Hypothermia for Hearing Conservation During Cochlear Implant Surgeries.” It follows a pilot grant from the CTSI, a small business innovation grant from the National Institutes of Health, and industry funding to Dr. Suhrud Rajguru, Ph.D., associate professor at the Miller School of Medicine in biomedical engineering and otolaryngology, and his laboratory.

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Debra Laefer of the NYU Tandon School of Engineering, and Rae Zimmerman of NYU Wagner win a national competition to drive research and collaborative action in urban resiliency and smart and connected communities. Their project aims to bolster the ability of NYC to respond to crises and disasters.

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A materials engineer at the University of California San Diego is leading the development of a new research platform for studying high-performance materials, in particular new materials that melt above 4000 degrees Celsius (C). UC San Diego nanoengineering professor Kenneth Vecchio is leading the project, which is funded by a new $800,000 grant from the US Office of Naval Research (ONR), through the Defense University Research Instrumentation Program (DURIP).

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A recommendation for more intensive blood pressure management from an influential global nonprofit that publishes clinical practice guidelines in kidney disease could, if followed, benefit nearly 25 million Americans.

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DHS S&T and CISA are jointly announcing the inaugural research and development (R&D) awards for the newly-launched Secure and Resilient Mobile Network Infrastructure (SRMNI) project.

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An experimental treatment can essentially reverse type 1 diabetes in certain types of laboratory mice, according to a series of studies led by University of Utah Health scientists. An injection of the therapeutic agent converts cells that normally control glucose production into ones that generate insulin.

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A team of researchers at Beth Israel Deaconess Medical Center (BIDMC) has developed a mathematical means of assessing tests’ false-negative rate.

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The changes, which mainly affect the left ventricle of the heart, may predispose some women to ischemic heart disease and heart failure later in life.

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In a statewide study of adults over 60 with osteoarthritis, researchers found that effective treatment for insomnia can be delivered in a few short phone calls.

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New York City's Memorial Sloan Kettering Cancer Center (MSK) announces the following awards and appointments for February 2021.

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Located in the Sheila and Eric Samson Pavilion at the Health Education Campus of Case Western Reserve University and Cleveland Clinic, the Marian K. Shaughnessy Nurse Leadership Academy will offer a collaborative, welcoming and high-tech space for students and faculty to deepen their learning and research.

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Kahan S. Dhillon, Jr. and Emergent Medical Solutions, LLC donates generous gift to benefit Hackensack Meridian Health Foundation's network-wide celebration

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A child’s first influenza infection shapes their immunity to future airborne flu viruses – including emerging pandemic strains. But not all flu strains spur the same initial immune defense, according to new findings published today by University of Pittsburgh virologists.

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The transatlantic, not-for-profit medical accelerator, Harrington Discovery Institute (HDI) at University Hospitals, has collaborated with leading venture investor, Advent Life Sciences (‘Advent’) in the launch of the Advent-Harrington Impact Fund. Advent’s new impact fund, structured alongside Advent Life Sciences Fund III, brings a total of $215 million to advance breakthrough discoveries into novel treatments for the benefit of patients and society.

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HHMI announces the selection of 21 exceptional early career scientists as 2020 Hanna Gray Fellows to support diversity in biomedical research. The 2022 Hanna H. Gray Fellows Program competition will open later this year.

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Irregular sleep schedules can affect mood and risk of developing symptoms of depression according to a study of first-year medical residents that used Fitbits and smartphones.

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DALLAS – Feb. 18, 2021 – Inhalation of depleted uranium from exploding munitions did not lead to Gulf War illness (GWI) in veterans deployed in the 1991 Persian Gulf War, a new study co-authored by a leading researcher of the disease at UT Southwestern suggests. The findings, published today in Scientific Reports, help eliminate a long-suspected cause of GWI that has attracted international concern for three decades.

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Recommendations designed to address the under-representation of African Americans in clinical trials for multiple myeloma (MM), a blood cancer that is twice as deadly in this demographic as in whites.

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Looking to take a bite out of COVID-19 losses and rebuild a suffering segment of the economy, The Inclusivity Project, led by Humboldt State University’s Northern California Small Business Development Center, launched with the goal of securing $100 million for 1,000 Black-owned businesses.

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Basic biology finding on thyroid hormone function could lead to new treatments for obesity, diabetes and related disorders

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The National Institutes of Health (NIH) has awarded a $2.1 million, four-year research grant to Anirban Sen Gupta at Case Western Reserve University in Cleveland, Ohio, and collaborators at the University of Michigan and University of North Carolina, to advance the design of artificial platelets that can promote and stabilize clots to stop bleeding.