Feature Channels: Kidney Disease

• share
• favorite_border

• share
• favorite_border

• A newly developed tool assesses patients' home dialysis experience. • The 26-item Home Dialysis Care Experience instrument will be a resource for future research use, clinical care, and quality improvement initiatives among home dialysis facilities and organizations.

• share
• favorite_border

DALLAS – March 30, 2021 – UT Southwestern researchers have identified factors that put patients with childhood-onset lupus at elevated risk for poor outcomes, such as end-stage renal disease or death, as they transition from pediatric to adult health care. The findings, published online in Seminars in Arthritis and Rheumatism, emphasize the precarious nature of this period and shine a spotlight on areas prime for intervention to help protect these vulnerable patients.

• share
• favorite_border

Acute kidney injury (AKI) occurred in nearly 20 percent of patients who underwent surgery with implantation of antibiotic-loaded “spacers” and intravenous (IV) antibiotics for the treatment of deep infections after total knee arthroplasty, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

• share
• favorite_border

• An analysis of published clinical trials suggests that aerobic exercise lessens several hemodialysis-related symptoms, including restless leg syndrome, symptoms of depression, muscle cramping, and fatigue. • More research, with more diverse patients, is needed to determine the extent of benefits from aerobic exercise for individuals with kidney failure who are undergoing dialysis.

• share
• favorite_border

Research published in the AACR journal Cancer Discovery found that a protein named chemerin is present in higher quantities in the blood of obese individuals and plays an essential role in controlling fat metabolism in kidney cancer cells.

• share
• favorite_border

Only 3% of patients at high risk for primary aldosteronism (PA), a common disorder that causes high blood pressure and can lead to heart and kidney complications, are screened for the condition, according to a study that will be presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.

• share
• favorite_border

• A one-year trial found that the eKidneyCare smartphone app helped patients with chronic kidney disease take their prescribed medications properly. • The app may help to prevent adverse drug reactions and other medication errors that can endanger patients.

• share
• favorite_border

A disruption to organ rhythms caused by shift work is a key factor in injury-induced disease development, according to a new research article published in the America Journal of Physiology-Renal Physiology.

• share
• favorite_border

The Wake Forest Institute for Regenerative Medicine is investigating how cats with chronic kidney disease could someday help inform treatment for humans.

• share
• favorite_border

Jessica Davey underwent robotic surgery to treat symptoms that began on St. Patrick’s Day 2019

• share
• favorite_border

Estima-se que uma a cada dez pessoas ao redor do mundo tem doença renal crônica, mas a maioria delas não sabe disso. A falta de conhecimento é particularmente preocupante porque as pessoas com doença renal crônica que se infectarem com COVID-19 têm maior risco de apresentar a forma grave da doença.

• share
• favorite_border

Se calcula que 1 de cada 10 personas en el mundo sufre de insuficiencia renal crónica, pero la mayoría de ellas no lo saben. Ese desconocimiento es particularmente preocupante porque cuando alguien con insuficiencia renal crónica se infecta con la COVID-19, tiene mucho más riesgo de enfermar gravemente.

• share
• favorite_border

DALLAS – March 8, 2021 – A study led by UT Southwestern and Children’s Health researchers defines parameters for the number of white blood cells that must be present in children’s urine at different concentrations to suggest a urinary tract infection (UTI). The findings, published recently in Pediatrics, could help speed treatment of this common condition and prevent potentially lifelong complications.

• share
• favorite_border

An estimated 1 in 10 people worldwide have chronic kidney disease, but most of them don't know it. That lack of awareness is especially concerning because people with Chronic kidney disease who are infected with COVID-19 are at higher risk for serious illness.

• share
• favorite_border

Nearly 74,000 people will be diagnosed with kidney cancer in the United States this year according to the American Cancer Society.

• share
• favorite_border

Overweight children who were exposed to lead in utero and during their first weeks of life have the potential for poorer kidney function in adulthood, according to an Icahn School of Medicine at Mount Sinai study published in Environment International in March.

• share
• favorite_border

• Adding measures of kidney function to traditional measures of cardiovascular health could help clinicians predict an individual’s risk of developing cardiovascular disease.

• share
• favorite_border

The March 2021 issue of Toxicological Sciences includes exciting toxicology research in biotransformation, toxicokinetics, and pharmacokinetics; genetic and epigenetic toxicology; neurotoxicology; and more.

• share
• favorite_border

During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Wednesday.

• share
• favorite_border

• share
• favorite_border

• share
• favorite_border

• share
• favorite_border

• share
• favorite_border

妙佑医疗国际(Mayo Clinic) 的研究人员在《国际肾脏报告》(Kidney International Reports)中发表的一项研究表明，免疫检查点抑制剂可能会对一些患者产生负面影响，包括导致名为“间质性肾炎”的急性肾炎。免疫检查点抑制剂治疗癌症的方法是刺激免疫系统，使其攻击癌细胞。

• share
• favorite_border

Molecules called microRNAs (miRNAs) that are measurable in urine have been identified by researchers at Mount Sinai as predictors of both heart and kidney health in children without disease. The epidemiological study of Mexican children was published in February in the journal Epigenomics.

• share
• favorite_border

• Patients with kidney failure associated with sickle cell disease benefit from kidney transplants, but they’re less likely than other patients to receive them.

• share
• favorite_border

Washington, DC (February 25, 2021) —The American Society of Nephrology (ASN) is spearheading efforts to secure direct federal allocation of COVID-19 vaccines to dialysis patients and frontline dialysis workers. This allocation would improve access for a vulnerable patient population, more than half of whom are Black, Hispanic, Asian, Native American, and Native Hawaiian or other Pacific Islanders (NHPIs).

• share
• favorite_border

• share
• favorite_border

Long thought a vestigial part of human cells, new genetic analysis of the primary cilium shows that it may be tied to common conditions like diabetes and kidney failure

• share
• favorite_border

A web-based tool developed by Jefferson researchers predicts individualized risk for stroke, other grave post-surgical complications

• share
• favorite_border

An artificial intelligence-enabled in vitro diagnostics company and the University of Utah today announced a partnership to improve kidney health and reduce the risk of kidney failure for large scale populations in the earliest stages of kidney disease.

• share
• favorite_border

Researchers have discovered a blood biomarker that predicts kidney transplant rejection with a lead time of about eight months, which could give doctors an opportunity to intervene and prevent permanent damage, potentially using an existing medication.

• share
• favorite_border

UCLA researchers found that patients’ decision-making about how and when to seek treatment for kidney stones was driven by logistical barriers and patients’ reluctance to risk exposure to COVID-19 in health care facilities.

• share
• favorite_border

• Racial disparities in access to kidney transplantation persist in the United States. New research indicates that registering Black patients on the kidney transplant waitlist at a slightly higher level of kidney function compared with white patients might lessen racial inequality in patients’ wait time prior to kidney failure onset, and ultimately improve racial equity in access to kidney transplantation.

• share
• favorite_border

A recommendation for more intensive blood pressure management from an influential global nonprofit that publishes clinical practice guidelines in kidney disease could, if followed, benefit nearly 25 million Americans.

• share
• favorite_border

Around 80% of the UK population is currently infected with human cytomegalovirus (HCMV) and in developing countries this can be as high as 95%.

• share
• favorite_border

• Veterans who receive all of their post–kidney transplant care within the Veterans Health Administration (VA) have a lower risk of death than those who receive care outside the VA through Medicare coverage, according to a recent study.

• share
• favorite_border

The Cardio-Renal Pediatric Dialysis Emergency Machine (CARPEDIEM) is a new system for patients with acute kidney injury or kidney failure requiring dialysis. This ground-breaking technology is intended to provide continuous renal replacement therapy (CRRT) to patients weighing between 5 and 20 pounds.

• share
• favorite_border

Un estudio dirigido por investigadores de Mayo Clinic y publicado en Kidney International Reports (Informes Internacionales sobre el Riñón) descubrió que los inhibidores de los puntos de control inmunitario pueden tener consecuencias negativas en algunos pacientes, incluida una inflamación aguda del riñón conocida como nefritis intersticial.

• share
• favorite_border

Patients with advanced kidney cancer, who received a targeted drug combined with a checkpoint-blocker immunotherapy agent had longer survival than patients treated with the standard targeted drug, said an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial.

• share
• favorite_border

• Despite wide recognition, policy reforms, and extensive research to address barriers in patients’ access to kidney transplantation, investigators found no improvement in rates of wait list placement and transplantation over 2 decades. • Moreover, rates among vulnerable populations are especially low.

• share
• favorite_border

People undergoing long-term dialysis are almost 4 times more likely to die from COVID-19 and should be prioritized for vaccination, found a new Ontario study published in CMAJ (Canadian Medical Association Journal).

• share
• favorite_border

— The American Society of Nephrology (ASN) re- affirms its support for the Organ Procurement Organizations (OPOs) Conditions for Coverage final rule issued on November 20, 2020. The society calls for the Biden-Harris administration to implement this final policy as expediently as possible. By bringing objective and verifiable standards to assess the performance of OPOs, this final rule will increase the number of organs available for transplant and reduce racial inequity in the U.S. transplant system.

• share
• favorite_border

A study by Mayo Clinic researchers published in Kidney International Reports finds that immune checkpoint inhibitors, may have negative consequences in some patients, including acute kidney inflammation, known as interstitial nephritis. Immune checkpoint inhibitors are used to treat cancer by stimulating the immune system to attack cancerous cells.

• share
• favorite_border

Rheoscan (model: Rheoscan-And300, Rheoscan-D300) system is an in vitro diagnostic device that tests the erythrocyte deformability, aggregation, and critical shear stress used as a POC device.

• share
• favorite_border

• Race and social determinants of health were associated with the likelihood of undergoing kidney transplantation among US adults with kidney failure. • Interventions that target social determinants of health may improve access to kidney transplantation.

• share
• favorite_border

New research suggests the toxic effects of nicotine on the kidneys’ filtering function are partly responsible for the progression of diabetes-related kidney disease in people who smoke. The study is published ahead of print in the American Journal of Physiology-Renal Physiology.