Curated News: National Cancer Institute (NCI)

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Newswise: Graphic Warning Labels on Cigarette Packaging Changes Perceptions
4-Aug-2021 8:55 AM EDT
Graphic Warning Labels on Cigarette Packaging Changes Perceptions
University of California San Diego

A Herbert Wertheim School of Public Health and Human Longevity Science at University of California San Diego clinical trial showed that graphic warning labels on cigarette packaging changes perceptions of smokers to recognize the negative consequences of tobacco and consider quitting.

Released: 3-Aug-2021 9:00 AM EDT
Moffitt Researchers Show Beta-Cutaneous HPV May Be Predictor of Squamous Cell Carcinoma
Moffitt Cancer Center

In a new article published online ahead of print in the journal Cancer Research, Moffitt Cancer Center researchers demonstrate a link between the presence of cutaneous human papillomavirus and the incidence of squamous cell carcinomas and identify key characteristics of infection that may contribute to development of the disease.

Newswise: Researchers Uncover a Way to Harness the Power of Immunotherapy for Advanced Prostate Cancer
29-Jul-2021 2:50 PM EDT
Researchers Uncover a Way to Harness the Power of Immunotherapy for Advanced Prostate Cancer
Michigan Medicine - University of Michigan

Researchers led by the University of Michigan Rogel Cancer Center identified an inhibitor that showed promise against metastatic castration-resistant prostate cancer cells.

Released: 22-Jul-2021 10:05 AM EDT
Artificial Intelligence Models to Analyze Cancer Images Can Take Shortcuts That Introduce Bias for Minority Patients
University of Chicago Medical Center

New study of artificial intelligence tools that analyze tumor images shows how they can make inaccurate predictions based on the institution that submitted the image

Newswise: FAU Nursing Faculty Member Receives NIH K01 
Grant for Breast Cancer Research
Released: 22-Jul-2021 8:30 AM EDT
FAU Nursing Faculty Member Receives NIH K01 Grant for Breast Cancer Research
Florida Atlantic University

Tarsha Jones, Ph.D., principal investigator and an assistant professor of nursing at FAU’s Christine E. Lynn College of Nursing, has received the National Institute of Health (NIH) K01 Career Development Award, a five-year, $772,525 award for a project titled, “Decision Support for Multigene Panel Testing and Family Risk Communication among Racially/Ethnically Diverse Young Breast Cancer Survivors.”

Newswise: Roswell Park Team Shows Dendritic-Cell Vaccines Can Be Paired With Standard Therapy for Breast Cancer
Released: 19-Jul-2021 5:05 PM EDT
Roswell Park Team Shows Dendritic-Cell Vaccines Can Be Paired With Standard Therapy for Breast Cancer
Roswell Park Comprehensive Cancer Center

A Roswell Park Comprehensive Cancer Center team reports new data on the promise of combining standard treatment for breast cancer with a particular form of cancer immunotherapy — dendritic-cell (DC) treatment vaccines.

Released: 15-Jul-2021 4:30 PM EDT
UM Greenebaum Comprehensive Cancer Center Earns Renewal of Highest Designation for Cancer Center Excellence from National Cancer Institute
University of Maryland Medical Center

The University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC) has earned renewal of its National Cancer Institute (NCI) designation as a Comprehensive Cancer Center for another five years. The prestigious distinction recognizes the cancer center’s high caliber of scientific leadership and robust programs in basic, clinical and population science research, placing it in the top echelon of cancer centers nationwide.

Released: 15-Jul-2021 4:00 PM EDT
Helping Working Cancer Caregivers Manage Stress
University of Colorado Cancer Center

Bradley received a nearly $4 million grant from the National Cancer Institute to study ways to lessen the impacts of stress specifically on cancer caregivers who are also employed.

Released: 15-Jul-2021 9:30 AM EDT
Moffitt Cancer Center Physician Receives NCI Cancer Clinical Investigator Team Leadership Award
Moffitt Cancer Center

Zeynep Eroglu, M.D., assistant member of the Cutaneous Oncology Department at Moffitt Cancer Center, received the 2021 Cancer Clinical Investigator Team Leadership Award from the National Cancer Institute.

Newswise: Basser Center for BRCA Awards 2021 Basser Global Prize to National Cancer Institute’s Andre Nussenzweig
Released: 15-Jul-2021 8:05 AM EDT
Basser Center for BRCA Awards 2021 Basser Global Prize to National Cancer Institute’s Andre Nussenzweig
Perelman School of Medicine at the University of Pennsylvania

The Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania, the world’s first comprehensive center aimed at advancing research, treatment, and prevention of BRCA-related cancers, has announced Andre Nussenzweig, PhD, of the National Cancer Institute (NCI) as the recipient of the ninth annual Basser Global Prize. Nussenzweig serves as branch chief of the Laboratory of Genome Integrity in the NCI’s Center for Cancer Research.

Newswise: A Promising Pathway to New Cancer Treatments
Released: 1-Jul-2021 11:55 AM EDT
A Promising Pathway to New Cancer Treatments
Argonne National Laboratory

Using Argonne National Laboratory’s Advanced Photon Source, researchers have determined the structure of an enzyme that plays a key role in the spread of cancer cells.

Newswise: Loss of Circadian Regulation Allows for Increase in Glucose Production During Lung Cancer Progression
Released: 25-Jun-2021 2:45 PM EDT
Loss of Circadian Regulation Allows for Increase in Glucose Production During Lung Cancer Progression
University of California, Irvine

New research from the University of California, Irvine reveals how the circadian regulation of glucose production in the liver is lost during lung cancer progression, and how the resulting increase in glucose production may fuel cancer cell growth.

Newswise: HER3 Gene Mutations Can Worsen Tumor Growth in Breast Cancer, Study Suggests
Released: 24-Jun-2021 12:35 PM EDT
HER3 Gene Mutations Can Worsen Tumor Growth in Breast Cancer, Study Suggests
UT Southwestern Medical Center

DALLAS – June 24, 2021 – Mutations in a gene related to HER2, a gene frequently implicated in breast cancers and a variety of other malignancies, can amplify activity that spurs tumor growth, a new study led by UT Southwestern researchers suggests. The findings, published online in Cancer Cell, could explain why many patients with HER2 mutations don’t respond to inhibitors that target this cancer driver and require other treatment.

Released: 24-Jun-2021 10:10 AM EDT
Immunotherapy May Be Effective For Subset Of Prostate Cancer
Beth Israel Deaconess Medical Center

Researchers report that about a quarter of localized prostate cancers may demonstrate immunologic traits that suggest a substantial number of patients with prostate cancer may benefit from immunotherapies.

Released: 23-Jun-2021 9:45 AM EDT
Blood test shows promise for predicting treatment response in metastatic HPV-positive throat cancer
Michigan Medicine - University of Michigan

A new blood test could signal whether treatment for metastatic HPV-positive throat cancer is working months earlier than standard imaging scans, allowing doctors to try alternatives sooner, initial results show.

Released: 23-Jun-2021 8:05 AM EDT
New study to reveal health equity impacts of flavored tobacco bans
University of Kentucky

A new University of Kentucky College of Medicine study will examine how policies that restrict the sale of flavored tobacco products including menthol cigarettes impact health disparities among vulnerable populations.

Newswise: BET Inhibitors Show Promise in Overcoming Lineage Plasticity, A Newly Recognized Form of Resistance to Prostate Cancer Drugs
Released: 18-Jun-2021 11:45 AM EDT
BET Inhibitors Show Promise in Overcoming Lineage Plasticity, A Newly Recognized Form of Resistance to Prostate Cancer Drugs
Michigan Medicine - University of Michigan

In a new study, a team of researchers uncovered new mechanisms underlying an important type of resistance to modern prostate cancer drugs called lineage plasticity, where castration-resistant prostate cancers undergo a deadly identity switch. They also outline a promising path to overcoming this form of resistance: BET bromodomain inhibitors.

Newswise: Study Adds to Evidence that Most Cancer Cells Grown in a Dish have Little in Common Genetically with Cancer Cells in People
Released: 17-Jun-2021 2:00 PM EDT
Study Adds to Evidence that Most Cancer Cells Grown in a Dish have Little in Common Genetically with Cancer Cells in People
Johns Hopkins Medicine

In a bid to find or refine laboratory research models for cancer that better compare with what happens in living people, Johns Hopkins Medicine scientists report they have developed a new computer-based technique showing that human cancer cells grown in culture dishes are the least genetically similar to their human sources.

10-Jun-2021 12:20 PM EDT
Small Numbers of Cells in a Tumor Could Be Key Enablers of Cancer Metastasis
Georgetown Lombardi Comprehensive Cancer Center

Just a small number of cells found in tumors can enable and recruit other types of cells nearby, allowing the cancer to spread to other parts of the body, report Georgetown Lombardi Comprehensive Cancer Center scientists. Working with their research collaborators, the scientists found that ‘enabler cells’ comprise about 20 percent or less of the cells in an aggressive tumor; their small numbers may account for why they are often missed when bulk tissue analyses are used to inform therapeutic decisions.

Newswise: Study Finds Dosing Strategy May Affect Immunotherapy Outcomes
Released: 14-Jun-2021 11:05 AM EDT
Study Finds Dosing Strategy May Affect Immunotherapy Outcomes
UT Southwestern Medical Center

DALLAS – June 14, 2021 – Overweight cancer patients receiving immunotherapy treatments live more than twice as long as lighter patients, but only when dosing is weight-based, according to a study by cancer researchers at UT Southwestern Medical Center.

Newswise: Huntsman Cancer Institute Researchers Yield New Insights into the Origins of Synovial Sarcoma
Released: 2-Jun-2021 5:40 PM EDT
Huntsman Cancer Institute Researchers Yield New Insights into the Origins of Synovial Sarcoma
Huntsman Cancer Institute at the University of Utah

A new study published today in Cancer Discovery, a journal of the American Association for Cancer Research, reports findings that may change the understanding of how synovial sarcoma develops and spreads. The study was led by Kevin B. Jones, MD and Bradley R. Cairns, PhD from Huntsman Cancer Institute.

Newswise: LJI launches new global cancer immunology resource
Released: 2-Jun-2021 1:55 PM EDT
LJI launches new global cancer immunology resource
La Jolla Institute for Immunology

The National Cancer Institute (NCI) of the National Institutes of Health has granted over $4.2 million to launch the Cancer Epitope Database and Analysis Resource (CEDAR), led by La Jolla Institute for Immunology (LJI) Professors Alessandro Sette, Dr. Biol. Sci., and Bjoern Peters, Ph.D.

Released: 21-May-2021 6:00 AM EDT
Perlmutter Cancer Center at NYU Langone Health Joins Call for Urgent Action to Get Cancer-Preventing HPV Vaccination Back on Track
NYU Langone Health

Perlmutter Cancer Center at NYU Langone Health is collaborating with more than 70 other National Cancer Institute (NCI)-designated cancer centers and partner organizations to issue a joint statement urging the nation’s physicians, parents and young adults to get the human papillomavirus (HPV) vaccination back on track.

Newswise: Sanford Burnham Prebys and other top U.S. cancer centers call for urgent action to get cancer-preventing HPV vaccination back on track
Released: 20-May-2021 5:05 PM EDT
Sanford Burnham Prebys and other top U.S. cancer centers call for urgent action to get cancer-preventing HPV vaccination back on track
Sanford Burnham Prebys Medical Discovery Institute

Sanford Burnham Prebys has joined doctors & scientists across America at National Cancer Institute (NCI)-designated cancer centers & other organizations to issue a joint statement urging the nation’s physicians, parents & young adults to get the human papillomavirus (HPV) vaccination back on track.

Newswise: Top Cancer Centers Call for Urgent Action to Get Cancer-Preventing HPV Vaccination Back on Track
Released: 20-May-2021 2:05 PM EDT
Top Cancer Centers Call for Urgent Action to Get Cancer-Preventing HPV Vaccination Back on Track
Roswell Park Comprehensive Cancer Center

As part of a unanimous effort on the part of the nation’s 71 National Cancer Institute (NCI)-designated cancer centers, Roswell Park Comprehensive Cancer Center is urging the nation’s physicians, parents and young adults to get cancer-preventing human papillomavirus (HPV) vaccination back on track.

Released: 20-May-2021 12:55 PM EDT
Mayo Clinic Cancer Center joins national call to get HPV vaccinations back on track
Mayo Clinic

Mayo Clinic Cancer Center has joined 71 National Cancer Institute-designated comprehensive cancer centers in calling on the nation's health care providers, parents and young adults to help get HPV vaccinations back on track. HPV causes several types of cancers, and nearly everyone gets infected with HPV by age 50.

Released: 20-May-2021 12:25 PM EDT
The University of Kansas Cancer Center joins other top US cancer centers in urgent call to get HPV vaccination back on track
University of Kansas Cancer Center

The University of Kansas Cancer Center has partnered with 70 other National Cancer Institute (NCI)-designated cancer centers and partner organizations to issue a joint statement urging the nation’s physicians, parents and young adults to get the human papillomavirus (HPV) vaccination back on track.

Newswise: NCI-designated cancer centers call for urgent action to get cancer-preventing HPV vaccination back on track
Released: 20-May-2021 12:20 PM EDT
NCI-designated cancer centers call for urgent action to get cancer-preventing HPV vaccination back on track
St. Jude Children's Research Hospital

The COVID-19 pandemic has interrupted delivery of key health services for children and adolescents, including HPV vaccination for cancer prevention.

Newswise: New AI-based tool can find rare cell populations in large single-cell datasets
19-May-2021 3:55 PM EDT
New AI-based tool can find rare cell populations in large single-cell datasets
University of Texas M. D. Anderson Cancer Center

MD Anderson researchers have developed a first-of-its-kind AI tool to identify rare groups of biologically important cells from the noise of large, complex single-cell datasets. The new tool, called SCMER, can help reserachers gain new insights across many applications.

Newswise: Tumor marker may help overcome endocrine treatment-resistant breast cancer
Released: 19-May-2021 12:35 PM EDT
Tumor marker may help overcome endocrine treatment-resistant breast cancer
Sanford Burnham Prebys Medical Discovery Institute

A study led by scientists at Sanford Burnham Prebys Medical Discovery Institute has identified a tumor marker that may be used to predict which breast cancer patients will experience resistance to endocrine therapy. The research offers a new approach to selecting patients for therapy that targets HER2, a protein that promotes the growth of cancer cells, to help avoid disease relapse or progression of endocrine-sensitive disease.

Released: 17-May-2021 11:15 AM EDT
Researchers Discover First Immune Stimulating Long Noncoding RNA Involved in Body's Response to Cancer
Michigan Medicine - University of Michigan

U-M researchers have discovered the first immune stimulating long noncoding RNA Involved in the body's response to cancer, suggesting potential approaches to improve immunotherapy treatment.

Released: 12-May-2021 1:05 PM EDT
Mutation Profile of Acral Nevi Differs from Acral Melanoma, Moffitt Researchers Say
Moffitt Cancer Center

In a new study published in JAMA Dermatology, Moffitt Cancer Center researchers report on the mutation profile of acral nevi and describe differences between acral nevi and acral melanoma.

Newswise: New Research Outlines a Critical Driver in an Immune Cell’s Defense against Melanoma
Released: 11-May-2021 12:25 PM EDT
New Research Outlines a Critical Driver in an Immune Cell’s Defense against Melanoma
Huntsman Cancer Institute at the University of Utah

Researchers at Huntsman Cancer Institute have found critical new insights into how cells defend against melanoma. In a report published in Nature Communications, the team describes how an enzyme called nicotinamide phosphoribosyltransferase, or NAMPT, initiates antitumor activity. The researchers suggest that new therapies strengthening this pathway in immune cells could be the foundation for more effective treatments against melanoma.

Released: 11-May-2021 11:15 AM EDT
Moffitt Researchers Discover Regulatory Pathway That Blocks Immune Response Against Cancer
Moffitt Cancer Center

In a new article published in the journal Immunity, Moffitt Cancer Center researchers show that TIM-3 inhibits the STING signaling pathway in dendritic cells, thereby blocking their ability to elicit an immune response.

Newswise: Researchers identify potential combination therapy for aggressive lung cancer
Released: 4-May-2021 12:30 PM EDT
Researchers identify potential combination therapy for aggressive lung cancer
University of California, Los Angeles (UCLA), Health Sciences

The combination approach uses immune checkpoint inhibitors with ATRA, a safe medication that is widely used to treat leukemia.

Newswise: Cancer Researchers Study Cognitive Dysfunction after Chemo
Released: 4-May-2021 8:40 AM EDT
Cancer Researchers Study Cognitive Dysfunction after Chemo
Health Sciences at the University of Pittsburgh

Following chemo, survivors suffer with memory dysfunction. The first large-scale study underway on cognitive behavioral therapy.

Newswise: $9 Million Contract from National Cancer Institute Awarded for NJ State Cancer Registry
Released: 27-Apr-2021 8:45 AM EDT
$9 Million Contract from National Cancer Institute Awarded for NJ State Cancer Registry
Rutgers Cancer Institute of New Jersey

The New Jersey State Cancer Registry (NJSCR), under the direction of the State Department of Health in partnership with Rutgers Cancer Institute of New Jersey, has been awarded a seven-year, $9,085,109 contract (75N91021D00009) from the National Cancer Institute (NCI) to support core infrastructure and research activities as part of the Surveillance, Epidemiology, and End Results (SEER) Program, the most authoritative source of information on cancer incidence and survival in the United States. The funding will support ongoing cancer surveillance activities at the NJSCR, as well as support enhancements to New Jersey’s electronic reporting systems such as electronic pathology and medical claims data transmissions.

Released: 26-Apr-2021 10:00 AM EDT
ACR DSI Links Use Cases to NCI Archive Datasets to Streamline Artificial Intelligence Development
American College of Radiology (ACR)

The American College of Radiology® (ACR®) Data Science Institute® (DSI) and the Cancer Imaging Archive (TCIA), funded by the National Cancer Institute (NCI), have teamed up to connect use cases and datasets to speed medical imaging artificial intelligence (AI) development.

22-Apr-2021 8:40 AM EDT
Less is More for the Next Generation of CAR T Cells
Perelman School of Medicine at the University of Pennsylvania

Penn Medicine researchers discovered that less is more when it comes to the length of what is known as the single-chain variable fragment in CAR T cells.

Released: 21-Apr-2021 11:20 AM EDT
Insurance isn’t Enough for Women at High Risk of Breast Cancer
Ohio State University

Women at high risk of breast cancer face cost-associated barriers to care even when they have health insurance, a new study has found. The findings suggest the need for more transparency in pricing of health care and policies to eliminate financial obstacles to catching cancer early.

Newswise: Roswell Park, Wilmot Cancer Institute Collaborate on First Large Study of Immunotherapy in Black Cancer Patients
Released: 20-Apr-2021 3:45 PM EDT
Roswell Park, Wilmot Cancer Institute Collaborate on First Large Study of Immunotherapy in Black Cancer Patients
Roswell Park Comprehensive Cancer Center

A new collaboration between two Western New York cancer research leaders will help oncologists learn whether Black and white cancer patients respond differently to a game-changing immunotherapy treatment, and seeks to improve the safety and effectiveness of these newer drugs in diverse populations.

Newswise: ‘Information Theory’ Recruited to Help Scientists Find Cancer Genes
Released: 20-Apr-2021 1:00 PM EDT
‘Information Theory’ Recruited to Help Scientists Find Cancer Genes
Johns Hopkins Medicine

Using a widely known field of mathematics designed mainly to study how digital and other forms of information are measured, stored and shared, scientists at Johns Hopkins Medicine and Johns Hopkins Kimmel Cancer Center say they have uncovered a likely key genetic culprit in the development of acute lymphoblastic leukemia (ALL).

Newswise: Exploring a New Therapeutic Strategy for T-cell Acute Lymphoblastic Leukemia
Released: 20-Apr-2021 6:05 AM EDT
Exploring a New Therapeutic Strategy for T-cell Acute Lymphoblastic Leukemia
Rutgers Cancer Institute of New Jersey

Researchers from Rutgers Cancer Institute of New Jersey, recently discovered that a mitochondrial uncoupling drug is toxic against leukemic cells, revealing a potential therapeutic strategy against T-ALL.

Newswise: Researchers Discover Common Mechanism Causing Autoimmune Disease and Blood Cancers
19-Apr-2021 8:00 AM EDT
Researchers Discover Common Mechanism Causing Autoimmune Disease and Blood Cancers
Yale Cancer Center

In a study by Yale Cancer Center, researchers report on the discovery of a common mechanism that promotes both autoimmune diseases and blood cancers, including the blood diseases Acute Lymphoblastic Leukemia (ALL), Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL).

Released: 14-Apr-2021 11:40 AM EDT
UChicago Medicine enrolling patients in LymphBridge™ clinical study for surgical treatment of breast cancer-related lymphedema
University of Chicago Medical Center

The University of Chicago Medicine is enrolling patients in LymphBridge™, a randomized clinical study to evaluate a novel surgical treatment for addressing breast cancer-related lymphedema.

Released: 12-Apr-2021 9:00 AM EDT
Case Western Reserve awarded $3 million National Cancer Institute grant to apply AI to immunotherapy in lung cancer patients
Case Western Reserve University

Medical researchers from Case Western Reserve University, New York University (NYU), and University Hospitals have been awarded a five-year, $3 million National Cancer Institute grant to develop and apply artificial intelligence (AI) tools for predicting which lung cancer patients will respond to immunotherapy.

Released: 8-Apr-2021 8:05 AM EDT
Moffitt Investigators Identify Sting Gene Methylation That Allows Melanoma to Evade the Immune System
Moffitt Cancer Center

A dysfunctional immune system significantly contributes to the development of cancer. Several therapeutic strategies to activate the immune system to target cancer cells have been approved to treat different types of cancer, including melanoma.

Released: 5-Apr-2021 4:00 PM EDT
Researchers Identify Genes Behind Uterine Leiomyosarcoma Which May Be Treated Using Precision Medicine
Yale Cancer Center

In a new study, Yale Cancer Center researchers have defined the genetic landscape of uterine leiomyosarcomas (uLMS).

Released: 5-Apr-2021 9:00 AM EDT
Cancer Discovery Could Revive Failed Treatments for Solid Tumors
University of Virginia Health System

New research from the UVA Cancer Center could rescue once-promising immunotherapies for treating solid cancer tumors, such as ovarian, colon and triple-negative breast cancer, that ultimately failed in human clinical trials.


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