Curated News: National Cancer Institute (NCI)

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Newswise: Researchers Develop Novel Test For ‘Microtentacles’ on Breast Cancer Cells
Released: 4-Aug-2020 6:45 PM EDT
Researchers Develop Novel Test For ‘Microtentacles’ on Breast Cancer Cells
University of Maryland Medical Center

Researchers at the University of Maryland School of Medicine (UMSOM) have developed a novel technology to test for the presence of thin membrane protrusions called “microtentacles” on breast cancer cells, which can help predict whether a tumor is likely to spread. They describe the TetherChip device in a new paper published today in the Royal Society of Chemistry journal Lab on a Chip.

Newswise: Scientists Develop New Models to Accelerate Progress in Preventing Drug Resistance in Lung and Pancreas Cancers
Released: 4-Aug-2020 1:05 PM EDT
Scientists Develop New Models to Accelerate Progress in Preventing Drug Resistance in Lung and Pancreas Cancers
Huntsman Cancer Institute at the University of Utah

Scientists at Huntsman Cancer Institute at the University of Utah report today the development of new models to study molecular characteristics of tumors of the lung and pancreas that are driven by mutations in a gene named NTRK1. The findings were published today in the journal Cell Reports.

Newswise: Penn Medicine Receives $4.9 Million Grant to Improve Uptake of Cancer Care Best Practices
Released: 4-Aug-2020 12:05 AM EDT
Penn Medicine Receives $4.9 Million Grant to Improve Uptake of Cancer Care Best Practices
Perelman School of Medicine at the University of Pennsylvania

A new grant awarded to the Perelman School of Medicine at the University of Pennsylvania will help identify methods to improve uptake of state-of-the-science care that can have a significant impact for patients.

Newswise: The
Released: 30-Jul-2020 10:25 AM EDT
The "M" Word
University of Kansas Cancer Center

Danny Welch, PhD, researcher at The University of Kansas Cancer Center, studies metastasis, which is responsible for more than 90% of cancer-related deaths.

Newswise: Researchers Outline Need for Further Evaluation of Gene Expression Profiling in Melanoma Patients
Released: 29-Jul-2020 1:10 PM EDT
Researchers Outline Need for Further Evaluation of Gene Expression Profiling in Melanoma Patients
Huntsman Cancer Institute at the University of Utah

A consensus statement published today in JAMA Dermatology by a group of melanoma researchers evaluates the use of prognostic genetic expression profiling within clinical treatment of patients with melanoma. The group cautioned against routine use of currently-available genetic expression profiling tests for patients with cutaneous melanoma.

Released: 29-Jul-2020 8:05 AM EDT
Study Provides New Insight on Colorectal Cancer Growth
University of Kentucky

A new study by researchers at the University of Kentucky identifies a novel function of the enzyme spermine synthase to facilitate colorectal cancer growth.

Released: 27-Jul-2020 4:40 PM EDT
Nationwide Trends Show Fewer Cancer Patients Seeking Care Since Start of Pandemic
Thomas Jefferson University

Researchers observe significant decreases nationwide in the number of patients being seen for cancer-related care as the COVID-19 pandemic progressed during the few first months of 2020.

Newswise: Cancer Care Can’t Wait
Released: 27-Jul-2020 8:00 AM EDT
Cancer Care Can’t Wait
Rutgers Cancer Institute of New Jersey

Further delaying your preventative cancer care may cause more harm than good. Expert from Rutgers Cancer Institute of New Jersey explains how most colorectal cancers can be prevented through regular screenings, and it is safe to get your screenings, even during these difficult times.

21-Jul-2020 10:55 AM EDT
New Computational Model by CHOP Researchers Identifies Noncoding Mutations Across Five Pediatric Cancers
Children's Hospital of Philadelphia

Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a new computational algorithm that has, for the first time, identified a spectrum of mutations in the noncoding portion of the human genome across five major pediatric cancers. The study, which was published today in Science Advances, used the algorithm to analyze more than 500 pediatric cancer patients’ mutations and gene expression profiles to develop a comprehensive list of potentially cancer-causing mutations.

Newswise: Triple Negative Breast Cancer Meets Its Match
Released: 22-Jul-2020 11:05 AM EDT
Triple Negative Breast Cancer Meets Its Match
UT Southwestern Medical Center

DALLAS – July 22, 2020 – One member of a larger family of oxygen sensing enzymes could offer a viable target for triple negative breast cancer (TNBC), UTSW researchers report in a new study. The findings, published online this week in Cancer Discovery, might offer hope to this subset of patients who have few effective treatment options and often face a poor prognosis.

Newswise: Edward Chu, M.D., M.M.S., To Lead Cancer Medicine at Albert Einstein College of Medicine and Montefiore Health System
Released: 22-Jul-2020 10:30 AM EDT
Edward Chu, M.D., M.M.S., To Lead Cancer Medicine at Albert Einstein College of Medicine and Montefiore Health System
Albert Einstein College of Medicine and Montefiore Health System

Albert Einstein College of Medicine and Montefiore Health System today announced that Edward Chu, M.D., M.M.S., has been named director of the National Cancer Institute-designated Albert Einstein Cancer Center; vice president for cancer medicine at Montefiore Medicine; professor of medicine and of molecular pharmacology; and will hold the Carol and Roger Einiger Professorship of Cancer Medicine at Einstein. In these roles, Dr. Chu will unite Einstein and Montefiore’s cancer programs into a fully integrated research and clinical enterprise. The appointment will be effective October 1, 2020.

Newswise: Parents of 1 in 2 unvaccinated U.S. adolescents have no intention to initiate HPV vaccine
Released: 21-Jul-2020 7:05 PM EDT
Parents of 1 in 2 unvaccinated U.S. adolescents have no intention to initiate HPV vaccine
University of Texas Health Science Center at Houston

Study results documenting parental hesitancy to begin and complete their child's HPV vaccine series were published in The Lancet Public Health by researchers at The University of Texas Health Science Center at Houston (UTHealth).

Newswise: Huntsman Cancer Institute Receives Renewal of Prestigious Designation from the National Cancer Institute
Released: 21-Jul-2020 12:00 PM EDT
Huntsman Cancer Institute Receives Renewal of Prestigious Designation from the National Cancer Institute
Huntsman Cancer Institute at the University of Utah

The National Cancer Institute has renewed the designation of Huntsman Cancer Institute at the University of Utah as a Comprehensive Cancer Center, the highest federal rank possible for a cancer research organization. This grant awards HCI more than $29 million over seven years, an increase of 84% in annual funding from the previous award cycle.

Newswise:Video Embedded prostate-cancer-metastasis-linked-to-revival-of-dormant-molecular-program
VIDEO
19-Jul-2020 7:05 AM EDT
Prostate cancer metastasis linked to revival of dormant molecular program
Dana-Farber Cancer Institute

When prostate cancer progresses to a more-dangerous metastatic state, it does so by resurrecting dormant molecular mechanisms that had guided the fetal development of the prostate gland but had been subsequently switched off, say scientists from Dana-Farber Cancer Institute.

Newswise: Doctors motivated by both health, malpractice concerns when ordering additional tests
Released: 17-Jul-2020 8:45 PM EDT
Doctors motivated by both health, malpractice concerns when ordering additional tests
University of California, Los Angeles (UCLA), Health Sciences

A UCLA-led study has found that dermatopathologists, who specialize in diagnosing skin diseases at the microscopic level, are motivated both by patient safety concerns and by malpractice fears — often simultaneously — when ordering multiple tests and obtaining second opinions, with a higher proportion of these doctors reporting patient safety as a concern. When ordering additional microscopic tests for patients, 90% of the dermatopathologists surveyed cited patient safety as a concern and 71% of them reported malpractice fears. Similarly, when obtaining second reviews from a consulting pathologist or recommending additional surgical sampling, 91% cited safety concerns and 78% malpractice concerns.

Newswise: Huntsman Cancer Institute Announces Next Major Expansion
Released: 15-Jul-2020 6:25 PM EDT
Huntsman Cancer Institute Announces Next Major Expansion
Huntsman Cancer Institute at the University of Utah

A $4.5 million gift from the Huntsman family will fund an expansion of a unique program at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) that brings specialty cancer care directly to patients in their homes. With this major gift, HCI’s Huntsman at HomeTM will expand to rural Utah, including Carbon, Emery, and Grand Counties. The goal is to provide cancer care for patients who live far from HCI in Salt Lake City by partnering with patients and their caregivers, communities, and medical teams to deliver many aspects of cancer care in a patient’s own home as an alternative to hospital visits at a medical center or emergency department.

Newswise: Ludwig Cancer Research Study Finds Reprogramming of Immune Cells Enhances Effects of Radiotherapy in Preclinical Models of Brain Cancer
Released: 15-Jul-2020 3:20 PM EDT
Ludwig Cancer Research Study Finds Reprogramming of Immune Cells Enhances Effects of Radiotherapy in Preclinical Models of Brain Cancer
Ludwig Cancer Research

A Ludwig Cancer Research study has dissected how radiotherapy alters the behavior of immune cells known as macrophages found in glioblastoma (GBM) tumors and shown how these cells might be reprogrammed with an existing drug to suppress the invariable recurrence of the aggressive brain cancer.

Newswise: Yale Cancer Center Receives NCI Grant Renewal to Fund Clinical Trials
Released: 15-Jul-2020 12:05 PM EDT
Yale Cancer Center Receives NCI Grant Renewal to Fund Clinical Trials
Yale Cancer Center

The National Cancer Institute has awarded a UM1 grant renewal to Yale Cancer Center. The 6-year, $3 million a year grant will fund early phase investigator-initiated clinical trials to develop new potential therapies for treating both solid tumors and hematologic malignancies.

Released: 15-Jul-2020 10:40 AM EDT
Moffitt Researchers Identify Factors to Predict Severe Toxicities in CAR T Patients
Moffitt Cancer Center

In a new study published in Clinical Cancer Research, Moffitt Cancer Center researchers identify possible factors that could help physicians know if patients are at higher risk for severe adverse events before they receive CAR T therapy.

Newswise: Brain Cancer: UVA IDs Gene Responsible for Deadly Glioblastoma
Released: 14-Jul-2020 12:55 PM EDT
Brain Cancer: UVA IDs Gene Responsible for Deadly Glioblastoma
University of Virginia Health System

The discovery of the oncogene responsible for glioblastoma could be the brain tumor's Achilles' heel, one researcher says.

Newswise: iyer-renuka-landscape.jpg
Released: 14-Jul-2020 11:00 AM EDT
Roswell Park Studies Highlight Emerging Treatment Options for Neuroendocrine Tumors
Roswell Park Comprehensive Cancer Center

Two new studies led by Renuka Iyer, MD, Section Chief for Gastrointestinal Oncology at Roswell Park Comprehensive Cancer Center, highlight possible new treatment options for patients with neuroendocrine tumors (NETs) — a rare and hard-to-treat cancer.

Newswise: Study suggests lymphoma drug acalabrutinib might offer a potential therapeutic approach for severe COVID-19 infection
Released: 13-Jul-2020 3:45 PM EDT
Study suggests lymphoma drug acalabrutinib might offer a potential therapeutic approach for severe COVID-19 infection
Hackensack Meridian Health

The mechanisms of action of acalabrutinib led to the hypothesis it might be effective in reducing the massive inflammatory response seen severe forms of COVID19. Indeed, it did provide clinical benefit in a small group of patients by reducing their inflammatory parameters and improving their oxygenation.

Newswise: Breast Cancer Cells Can Reprogram Immune Cells to Assist in Metastasis
9-Jul-2020 10:00 AM EDT
Breast Cancer Cells Can Reprogram Immune Cells to Assist in Metastasis
Johns Hopkins Medicine

Johns Hopkins Kimmel Cancer Center investigators report they have uncovered a new mechanism by which invasive breast cancer cells evade the immune system to metastasize, or spread, to other areas of the body. They propose that therapies targeting this process could be developed to halt or prevent metastasis and reduce breast cancer deaths.

Released: 8-Jul-2020 11:05 PM EDT
New Clues from Fruit Flies about the Critical Role of Sex Hormones in Stem Cell Control
Huntsman Cancer Institute at the University of Utah

In one of the first studies addressing the role of sex hormones’ impact on stem cells in the gut, scientists outline new insights showing how a steroidal sex hormone that is structurally and functionally similar to human steroid hormones drastically alters the way intestinal stem cells behave, ultimately affecting the overarching structure and function of this critical organ. The authors found that ecdysone, a steroid hormone produced by fruit flies, stimulates intestinal stem cell growth and causes the gut of the female fruit fly to grow in size, as well as other critical changes.

Newswise: A helping hand for cancer immunotherapy
7-Jul-2020 1:00 PM EDT
A helping hand for cancer immunotherapy
Sanford Burnham Prebys Medical Discovery Institute

Scientists at Sanford Burnham Prebys Medical Discovery Institute have demonstrated the therapeutic potential of PRMT5 inhibitors to sensitize unresponsive melanoma to immune checkpoint therapy. PRMT5 inhibitors are currently in clinical trials in oncology, and this research provides a strong rationale for evaluating the drugs in tumors that are not responsive to immune checkpoint therapy. The study was published in Science Translational Medicine.

Newswise: Study Suggests Method to Starve Pancreatic Cancer Cells
Released: 6-Jul-2020 11:25 AM EDT
Study Suggests Method to Starve Pancreatic Cancer Cells
Michigan Medicine - University of Michigan

Rather than attacking cancer cells directly, new cell-model research probes weaknesses in pancreatic cancer’s interactions with other cells to obtain nutrients needed for tumor growth.

Newswise: St. Jude researchers create an analytic tool that opens a new frontier of cancer discovery
2-Jul-2020 10:05 PM EDT
St. Jude researchers create an analytic tool that opens a new frontier of cancer discovery
St. Jude Children's Research Hospital

St. Jude Children’s Research Hospital scientists have developed software to identify cancer-causing mutations lurking in vast regions of the human genome

Released: 1-Jul-2020 10:25 AM EDT
Moffitt Researchers Develop Tool to Detect Patients at High Risk for Poor Lung Cancer Outcomes
Moffitt Cancer Center

In a new study published in Nature Scientific Reports, Moffitt Cancer Center researchers have shown how the use of radiomics can improve lung cancer screening by identifying early stage lung cancer patients who may be at high risk for poorer outcomes, and therefore require aggressive follow-up and/or adjuvant therapy.

Newswise: Number of Hospitalizations Can Be Important Clinical Indicator for Head, Neck Cancer Patients
Released: 30-Jun-2020 4:00 PM EDT
Number of Hospitalizations Can Be Important Clinical Indicator for Head, Neck Cancer Patients
Roswell Park Comprehensive Cancer Center

Patients who were unexpectedly hospitalized for dehydration, fever or other ailments while undergoing radiation treatment for head and neck cancers were at a higher risk for less favorable outcomes, a new study from Roswell Park Comprehensive Cancer Center reports.

Newswise: A Study of Early-Onset Colorectal Cancer in Young Adult Men Reveals “Hotspots” of Death in the United States
Released: 26-Jun-2020 12:50 PM EDT
A Study of Early-Onset Colorectal Cancer in Young Adult Men Reveals “Hotspots” of Death in the United States
Huntsman Cancer Institute at the University of Utah

A study led by Charles Rogers, PhD, examines a trend of increasing incidence and mortality among young men diagnosed with colorectal cancer. The authors identify "hotspot" areas of the U.S. where colorectal cancer is on the rise. For men with early-onset colorectal cancer, Black men are more likely to die of the disease than other racial groups.

Released: 26-Jun-2020 8:45 AM EDT
This MicroRNA Might Help Detect, Treat Ovarian Cancer
Michigan Medicine - University of Michigan

In cell and mouse models, one microRNA showed promise as a biomarker for early stage ovarian cancer and may help make immunotherapy treatment more effective.

Newswise: St. Jude creates resource for pediatric brain tumor research
Released: 23-Jun-2020 11:10 AM EDT
St. Jude creates resource for pediatric brain tumor research
St. Jude Children's Research Hospital

Researchers worldwide can access orthotopic patient-derived xenograft models to speed discovery and test novel therapies for childhood brain tumors.

Released: 22-Jun-2020 9:00 AM EDT
Smokers good at math are more likely to want to quit
Ohio State University

For smokers who are better at math, the decision to quit just adds up, a new study suggests. Researchers found that smokers who scored higher on a test of math ability were more likely than others to say they intended to quit smoking.

Released: 15-Jun-2020 9:20 AM EDT
Drug with new approach on impeding DNA repair shows promise in first clinical trial
Dana-Farber Cancer Institute

Berzosertib, an ATR-targeting drug, improves progression-free survival in combination with chemotherapy in patients with high-grade serous ovarian cancer

Newswise: Researchers Identify a Moving Target in Small Cell Lung Tumors
Released: 1-Jun-2020 4:05 PM EDT
Researchers Identify a Moving Target in Small Cell Lung Tumors
Huntsman Cancer Institute at the University of Utah

About 15 percent of lung cancers are classified as small cell lung cancer. Recent studies have indicated that four major subtypes of small cell lung cancer exist, yet approaches to tailor treatment of these subtypes have not yet become standard of care. Today in the journal Cancer Cell, scientists outline new findings about the origins of these lung cancer subtypes, paving the way for a new foundation to study this disease.

Released: 20-May-2020 6:05 PM EDT
$5.75M grant to help researchers study role of obesity in development of pancreatic cancer
University of California, Los Angeles (UCLA), Health Sciences

A team of researchers from the UCLA Jonsson Comprehensive Cancer Center and peer institutions has been awarded a $5.75 million grant from the National Cancer Institute to study the correlation between obesity, inflammation and pancreatic cancer. The scientists hope their findings may help people avoid getting this cancer.

Released: 20-May-2020 10:35 AM EDT
New Liver Cancer Research Targets Non-Cancer Cells to Blunt Tumor Growth
Perelman School of Medicine at the University of Pennsylvania

“Senotherapy,” a treatment that uses small molecule drugs to target “senescent” cells, or those cells that no longer undergo cell division, blunts liver tumor progression in animal models according to new research from a team led by Celeste Simon, PhD, a professor of Cell and Developmental Biology in the Perelman School of Medicine at the University of Pennsylvania and scientific director of the Abramson Family Cancer Research Institute. The study was published in Nature Cell Biology.

Newswise: New Study Confirms Important Clues to Fight Ovarian Cancer
Released: 19-May-2020 11:55 AM EDT
New Study Confirms Important Clues to Fight Ovarian Cancer
Pacific Northwest National Laboratory

A new study comparing cancerous tissue with normal fallopian tube samples advances important insights about the rogue cellular machinery that drives a majority of ovarian cancers.

Newswise: Cervical precancer identified by fluorescence, in a step toward bedside detection
18-May-2020 6:05 AM EDT
Cervical precancer identified by fluorescence, in a step toward bedside detection
Tufts University

Researchers developed a method using fluorescence to detect precancerous metabolic and physical changes in individual epithelial cells lining the cervix. The method, which can detect precancerous lesions non-invasively and non-destructively, opens the door to early-stage bedside diagnostics.

Released: 18-May-2020 10:30 AM EDT
Creating a Vaccine against COVID-19
University of New Mexico Comprehensive Cancer Center

David Peabody, PhD, and Bryce Chackerian, PhD, are creating vaccines from particles that are the opposite of Trojan Horses: they look deadly on the outside but are harmless on the inside. Their virus-like particles may rouse the immune system into combatting COVID-19. The idea is to trick the body into believing it’s been infected with a microscopic foe.

Newswise: Roswell Park Team Proposes Strategy for Making Pancreatic Tumors Respond to Checkpoint Inhibition
Released: 18-May-2020 10:15 AM EDT
Roswell Park Team Proposes Strategy for Making Pancreatic Tumors Respond to Checkpoint Inhibition
Roswell Park Comprehensive Cancer Center

A possible new strategy for treating pancreatic cancer highlights the promise of collaboration between experts in both precision medicine and immunology. The findings from a team led by Agnieszka Witkiewicz, MD, and Erik Knudsen, PhD, at Roswell Park Comprehensive Cancer Center and published today in the journal Gut suggest a combination treatment approach that can make some breakthrough immunotherapy drugs effective for more patients with pancreatic cancer.

Released: 14-May-2020 1:00 PM EDT
Moffitt Researchers Develop Model to Predict Prostate Cancer Aggressiveness
Moffitt Cancer Center

Researchers in the Center of Excellence for Evolutionary Therapy at Moffitt Cancer Center want to better understand what is happening in the tumor microenvironment to drive prostate cancer to become aggressive and grow rapidly. In a new article published in Nature Ecology & Evolution, the research team provides a closer look at a multiscale mathematical model they developed to analyze integrated biologic and pathologic data to determine tumor aggressiveness.

Released: 14-May-2020 8:30 AM EDT
Moffitt Cancer Center Study Suggests More Could Benefit from CAR T-Cell Therapy
Moffitt Cancer Center

Moffitt Cancer Center organized a consortium of 16 cancer treatment facilities across the U.S. that offer Yescarta as a standard-of-care therapy for patients with relapsed/refractory large B cell lymphoma. They wanted to determine if the safety and effectiveness seen in the ZUMA-1 clinical trial were similar for patients treated with the now commercially available CAR T therapy. Their findings were published in the Journal of Clinical Oncology.

Released: 11-May-2020 2:30 PM EDT
Researchers connect matrix fiber structure and cell behavior
Cornell University

A Cornell-led collaboration investigated how differences in these collagen fibers are responsible for influencing the behavior of myofibroblasts – findings that could have implications for preventing and treating fibrotic diseases such as cancer.

Released: 6-May-2020 11:05 AM EDT
Latest $2.5 Million Grant Accelerates Advances in Bioimaging at Rensselaer
Rensselaer Polytechnic Institute (RPI)

In order to effectively address intractable challenges like cancer, researchers, drug developers, and clinicians need to be able to see how a potential therapeutic works within a living system, ideally in real time. That type of vision and insight is being made possible by engineers at Rensselaer Polytechnic Institute. A new $2.5 million grant from the National Institutes of Health’s National Cancer Institute (NCI) underscores the influence of Rensselaer researchers in this area, as they continue to develop new and innovative bioimaging techniques that also harness the power of machine learning methods.

Newswise: Researchers Find New Insights Linking Cell Division to Cancer
Released: 29-Apr-2020 11:45 AM EDT
Researchers Find New Insights Linking Cell Division to Cancer
Huntsman Cancer Institute at the University of Utah

Scientists at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) and collaborators at the University of California, San Francisco (UCSF) published research in the journal Nature extending our understanding of cell division. They discovered the protein LEM2 has two important functions during cell division.

Newswise: Researchers receive $2.8 million grant to develop blood-based test for liver transplant candidate selection
Released: 27-Apr-2020 1:55 PM EDT
Researchers receive $2.8 million grant to develop blood-based test for liver transplant candidate selection
University of California, Los Angeles (UCLA), Health Sciences

Researchers from the UCLA Jonsson Comprehensive Cancer Center received a $2.8 million, five-year grant from the National Cancer Institute to help develop a blood-based test to improve the selection and prioritization for patients with liver cancer who need a liver transplantation.

Newswise: Boosting the immune system's appetite for cancer
Released: 23-Apr-2020 4:10 PM EDT
Boosting the immune system's appetite for cancer
UT Southwestern Medical Center

A combination of immunotherapy agents that encourages some immune cells to eat cancer cells and alert others to attack tumors put mice with a deadly type of brain cancer called glioblastoma into long-term remission.

Released: 23-Apr-2020 2:20 PM EDT
Game theory suggests more efficient cancer therapy
Cornell University

Cornell mathematicians are using game theory to model how this competition could be leveraged, so cancer treatment – which also takes a toll on the patient’s body – might be administered more sparingly, with maximized effect.

Newswise: Diabetes reversed in mice with genetically edited stem cells derived from patients
21-Apr-2020 8:50 AM EDT
Diabetes reversed in mice with genetically edited stem cells derived from patients
Washington University in St. Louis

Researchers at Washington University School of Medicine in St. Louis have used induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes, transformed the stem cells into insulin-producing cells, used the CRISPR gene-editing tool to correct a defect that caused a form of diabetes, and implanted the cells into mice to reverse diabetes in the animals.


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