How psychedelic drugs affect a rat’s brain
Lund UniversityResearchers at Lund University have developed a technique for simultaneously measuring electrical signals from 128 areas of the brain in awake rats.
Researchers at Lund University have developed a technique for simultaneously measuring electrical signals from 128 areas of the brain in awake rats.
New and rapidly developing technologies, such as cryo-electron (cryo-EM) and artificial intelligence, are providing the tools to revolutionize biomedical research, but you need scientists who know how to use them
For the first time in Thailand, lecturers at Chulalongkorn University’s Faculty of Pharmaceutical Sciences have successfully developed antibody from tobacco plants with inhibitory effects on the growth of cancer cells in laboratory animals. This signals hope for access to effective cancer medication and treatment at a lower cost.
A new study led by Lorraine Kelley-Quon, MD, MSHS, pediatric surgeons at Children’s Hospital Los Angeles shows that methadone use in babies after surgery can lead to longer hospital stays.
An antibody in single-chain fragment variable (scFv) format that binds to the powerful opioid carfentanil was shown to reverse signs of carfentanil overdose in preclinical tests conducted by scientists at Scripps Research.
JNCCN study sheds light on a rapid shift in practice evolution by oncologists treating people with colon cancer adjuvantly after primary surgery, following publications from the IDEA collaboration.
Research from Saint Louis University School of Medicine finds that among patients 65 and older, a diagnosis of anxiety was significantly associated with an increased risk of dementia diagnosis, and benzodiazepine exposure was associated with a 28% increased risk of dementia.
The key to understanding proteins — such as those that govern cancer, COVID-19, and other diseases — is quite simple. Identify their chemical structure and find which other proteins can bind to them. But there’s a catch.
Since its inception in 2014, Insilico Medicine has developed multiple AI models for predicting the probability of success of clinical trials focusing on Phase II to Phase III transition probabilities.
Dr. Santiago Mazuera, head of Sinai Hospital's Headache Clinic, shares how Botox treatments can drastically improve quality of life for those who experience chronic migraines.
A recent study reveals that Metformin, a common drug used to manage Type 2 Diabetes, could offer new hope for treating periodontitis, a chronic inflammatory disease affecting oral tissues. The study explored the effects of Metformin on HMGB1 (High Mobility Group Box 1), an inflammation mediator implicated in oxidative stress during periodontitis.
Huntsman Cancer Institute investigators find a way to reduce infection after pancreatic surgery, discover the best treatment combination that’s cost effective for prostate cancer patients, and learn lung cancer patients receiving chemotherapy have more emergency department visits. They also found a genetic mutation that makes anemia more likely after chemotherapy, and a non-invasive way to remove brain tumors.
Corticosteroids are used to increase very preterm infant survival rates and reduce health issues, however the effects on the infant’s long-term health have not been well understood, particularly in infants who exceed expectations and are born at term. The research suggests that many babies exposed to steroids avoid preterm birth, but new risks for other future health complications are introduced
The cardiovascular polypill, developed by the Spanish National Centre for Cardiovascular Research (CNIC) and the pharmaceutical company Ferrer, has been included by the World Health Organization (WHO) in its List of Essential Medicines.
Waters Corporation (NYSE:WAT) introduced the first in a new line of size exclusion chromatography (SEC) columns aimed at improving the analysis while lowering the cost of gene therapies, specifically adeno-associated viral (AAV) vectors.
Ion channels play a crucial role in many cellular processes, including neuronal communication, muscle contraction or cell proliferation. Most multi subunit ion channels exist in two functional states, either closed or open. During gating, one should expect that all subunits undergo conformational changes. The absence of intermediate conduction levels is surprising and asks for an explanation. A team of researchers from the University of Vienna and the Washington University in St. Louis created a smart model system to answer this important question. The study is currently published in Nature Communications.
Postpartum prescriptions for oxycodone were not associated with increased risk of longer-term opioid use compared to codeine prescriptions, according to new research published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.221351.
A team including University of Pittsburgh researchers uses computer modeling and new ways of employing enzymes to create never-before-seen amino acids.
Systemic sclerosis is the scaring of multiple organs within the body resulting in difficulty in functioning for these organs. The disease can become deadly if the organ scaring isn’t treated properly. Researchers at the University of Michigan Health System have identified a protein in the disease that may be a new target for treatment.
A new demonstrates that the National Institutes of Health (NIH) spent $950 million on basic or applied research associated with patents that provided manufacturers with market exclusivity.
Two studies featured today at the 2023 AACC Annual Scientific Meeting & Clinical Lab Expo highlight advances that could boost the accuracy of marijuana tests and provide vital information for addressing the opioid epidemic.
MD Anderson and Nexo announced a strategic research collaboration to rapidly advance new cancer therapies against previously undruggable targets.
Scientists at the University of Colorado Anschutz Medical Campus have discovered what they believe to be the central mechanism behind cognitive decline associated with normal aging.
The mass and composition of our bodies can significantly affect the way medications are metabolized and absorbed. Investigators at Cedars-Sinai found that inflammatory bowel disease (IBD) patients with higher levels of intra-abdominal visceral adipose tissue– a distinctive type of fat inside the abdomen −had lower rates of remission when treated with certain anti-inflammatory medications.
Antibody therapies are only effective if the antibodies do what we want them to do. This research can help scientists determine if an antibody is likely to stick to something other than the intended target, which should lessen the amount of time wasted with overly sticky antibodies.
The Association for Diagnostics & Laboratory Medicine (ADLM) is pleased to announce the recipients of its 2023 Top Corporate Supporter Award.
You might not think of diabetes when you think of muscle function. But a common diabetes drug that regulates blood sugar can also prevent muscle atrophy and muscular fibrosis—which can help the elderly bounce back faster from injury or illness.
A team of researchers led by Rensselaer Polytechnic Institute’s Jonathan S. Dordick, Ph.D., Institute Professor of Chemical and Biological Engineering, has illuminated a new possibility for the treatment and prevention of COVID-19 in research published in Communications Biology.
Base editing technology invented at Rutgers, The State University of New Jersey, and exclusively licensed to Revvity, Inc. subsidiary Horizon Discovery, has been sub-licensed to biopharmaceutical company AstraZeneca to support its creation of cell therapies for the treatment of cancer and immune-mediated diseases.
AACC, a global scientific and medical professional organization dedicated to better health through laboratory medicine, is pleased to announce a name change to the Association for Diagnostics & Laboratory Medicine.
The secret to protecting your memory may be a staple of a bodybuilder’s diet. RUSH researchers recently discovered that a muscle-building supplement called beta-hydroxy beta-methylbutyrate, also called HMB, may help protect memory, reduce plaques and ultimately help prevent the progression of Alzheimer’s disease.
A medication commonly used for abortion or miscarriage management is only available at six per cent of Hamilton, Ont. pharmacies, according to a McMaster University-led survey.
Researchers at the University of Illinois Chicago have identified a process by which enzymes can help prevent heart damage in chemotherapy patients
The latest research in psychology and psychiatry on Newswise.
The July 2023 issue of SLAS Discovery, the open access journal focused on research progressing drug discovery, is now available.
The first study in the world to compare cholesterol-lowering medications on a range of diseases has good and bad news for more than 200 million people.
The American Chemical Society will honor researchers and companies as Heroes of Chemistry for developing products that have led to significant advancements in improving health and the environment.
People who start taking medication soon after the first signs of multiple sclerosis (MS) may have a lower risk of disability later, according to a study published in the July 19, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Researchers at Indiana University have identified a new method of reversing the effects of fentanyl. Their study could lead to a new way to reverse overdoses either through a new product or working synchronously with naloxone.
The discovery of antibiotics in 1928 was a major turning point in the history of medicine. For the first time since the dawn of human civilization, doctors had gained access to an extremely powerful and effective tool to fight against a wide variety of bacterial infections.
Drs. Jinwook Cha and Jinsoo Park of the Natural Product Informatics Research Center at the Korea Advanced Institute of Science and Technology (KIST) announced that they have developed the first NMR method (Ultraselective Heteronuclear Polarization Transfer Method, or UHPT) that can selectively measure the information of carbon atom nuclei linked to specific hydrogen in a single measurement.
Vanderbilt University Medical Center has received a $7 million, five-year funding award from PCORI (Patient-Centered Outcomes Research Institute) to compare two sedatives used to place breathing tubes in the emergency department (ED) or intensive care unit (ICU). To provide support with a breathing machine, doctors must place a breathing tube into a patient’s mouth and throat, and they are given a medication to make them sleep during this procedure.