A study led by an Oregon State University pharmaceutical sciences researcher has produced a proof of principle for a new “universal” means of treating COVID-19.
Victor Nizet, MD, Distinguished Professor of Pediatrics at UC San Diego School of Medicine and Pharmacy at Skaggs School of Pharmacy and Pharmaceutical Sciences at UC San Diego, has been elected to the National Academy of Medicine.
A large population-based study of patients with atrial fibrillation (AF) and valvular heart disease (VHD) found that use of apixaban was associated with a lower rate of ischemic stroke or systemic embolism and a lower rate of intracranial or gastrointestinal (GI) bleeding compared with rivaroxaban. The authors say clinicians should consider these findings when selecting anticoagulants in this patient population. The study is published in Annals of Internal Medicine.
A systematic review of 42 academic research articles has found that the risk-benefit balance of using opioids to treat musculoskeletal pain in the emergency department (ED) setting remains unclear. The review is published in Annals of Internal Medicine.
Psychedelic compounds found in ‘magic mushrooms’ are increasingly being recognised for their potential to treat health conditions such as depression, anxiety, compulsive disorders and addiction.
A highly innovative method using the latest technology has generated a comprehensive list of SARS-CoV-2 viral and human proteins that interact with each other, with one such interaction showing the virus directly influencing proteins that regulate the human immune system.
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The October issue of SLAS Discovery is now available open access on ScienceDirect.
Patients who have surgery to repair bone fractures typically receive a type of injectable blood thinner, low-molecular-weight heparin, to prevent life-threatening blood clots, but a new clinical trial found that over-the-counter aspirin is just as effective.
Global health has paid a deadly price for not using simple, low-cost blood pressure lowering drugs, statins and aspirin widely in the form of a single pill, also known as the polypill, say two leading cardiologists in a commentary published in The Lancet.
Michigan Medicine research suggests that administration of antibiotics with activity against anaerobic bacteria has a profound effect on the gut microbiome and, ultimately, an adverse impact on critically ill patients.
Heart disease patients with symptomatic COVID-19 are often treated with nirmatrelvir-ritonavir (Paxlovid) to prevent progression to severe disease; however, it can interact with some previously prescribed medications.
Eclipse, a venture capital firm investing in the digital transformation of the world's physical industries, and Mayo Clinic today announced the creation and seed funding of Nucleus RadioPharma, a new company built to ensure cancer patients can access potentially lifesaving radiopharmaceuticals by developing technologies to modernize the clinical development, manufacturing and supply chain of these promising new therapies.
In the article published in the prestigious scientific journal Science, a group of international researchers, including Gorka Orive, Doctor of Pharmacy and researcher in the UPV/EHU’s NanoBioCel group, and Unax Lertxundi of the Bioaraba Institute for Health Research, have issued a warning about the increase in pharmaceutical contamination.
Cleveland Clinic researchers have identified a common diabetes medication, metformin, as a possible treatment for atrial fibrillation. The study, published in Cell Reports Medicine, built on ongoing collaborative Cleveland Clinic research to support further investigation into metformin as a drug repurposing candidate. Researchers used advanced computation and genetic sequencing to determine that metformin’s targets overlap significantly with genes dysregulated in atrial fibrillation.
The growing threat of antimicrobial resistance has led researchers to search for new compounds everywhere. This week in mBio, a multinational team of researchers in Europe report the discovery of a new antifungal antibiotic named solanimycin.
The American Medical Association (AMA), Association of American Publishers (AAP), Counsel of Medical Specialty Societies (CMSS), American Society for Clinical Pharmacology & Therapeutics (ASCPT), and Foundation for Individual Rights and Expression (FIRE), filed amicus briefs in support of the American Society of Anesthesiologists (ASA) after Pacira Biosciences Inc., appealed its dismissed lawsuit filed against ASA, the editor-in-chief of Anesthesiology, ASA’s official peer-reviewed medical journal – and 11 contributing authors.
UC Davis Comprehensive Cancer Center has launched a Center for Experimental Therapeutics in Cancer to accelerate promising cancer therapies from the lab to the bedside. The idea is to advance precision medicine that leads to more effective, less toxic cancer therapies.
A research team led by a University of Massachusetts Amherst scientist has made a significant genetic discovery that sheds light on the use of the drug caspofungin to treat a deadly fungal infection, Aspergillus fumigatus, which kills some 100,000 severely immunocompromised people each year.
Finding new ways to treat the novel coronavirus and its ever-changing variants has been a challenge for researchers, especially when the traditional drug development and discovery process can take years. A Michigan State University researcher and his team are taking a hi-tech approach to determine whether drugs already on the market can pull double duty in treating new COVID variants.
The drug tofacitinib was well tolerated among patients with early scleroderma, primarily affecting the protein interferon both in fibroblasts and keratinocytes. Researchers say the drug is safe and can possibly be repurposed for systemic sclerosis treatment.
Study results showed that by prescribing a combination of three non-opioid painkillers to patients, researchers successfully reduced approximately tenfold the amounts of opioids consumed over a six-week post-operative period, without altering their pain levels. Co-principal investigator Olufemi Ayeni and his team gleaned their results by enrolling 193 patients between March 2021 and March 2022 from three Hamilton hospitals including HHS’ McMaster University Medical Centre and Hamilton General Hospital, and St. Joseph’s Healthcare Hamilton. The patients were randomly assigned to either a control group of 98 receiving standard opioid-based painkillers or an opioid-free group (93) receiving a combination therapy of naproxen, acetaminophen and pantoprazole and a patient educational infographic. The opioid-free group did have access to opioid medication if required for pain. Each patient undergoing outpatient knee or shoulder arthroscopic surgery was monitored for six weeks
Acetaminophen use during pregnancy is associated with sleep and behavior problems consistent with attention deficit hyperactivity disorder (ADHD), according to a study by Penn State College of Medicine researchers.
A cost-effectiveness study of sodium–glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP1) receptor agonists has found that the use of these medications as first-line treatment for type-2 diabetes would improve outcomes, but their costs would need to decrease by at least 70 percent to be cost-effective. The study is published in Annals of Internal Medicine.
Women with severe preeclampsia (severe high blood pressure) during pregnancy may be treated with extended-release nifedipine, a blood pressure-lowering medicine, daily during the labor and delivery process, according to new research published today in Hypertension, an American Heart Association journal.
The White House has sounded the alarm about vulnerabilities in the pharmaceutical supply chain. But new research from the Center for Analytics and Business Insights at Olin Business School found that the U.S. actually has the capacity to make the nation’s most essential and critical drugs — yet it's mostly sitting idle.
Mayo Clinic researchers have discovered that people with major depressive disorder and a history of attempted suicide have distinct biomarkers that correlate with their response to antidepressant therapy. The new findings, published in Frontiers Pharmacology, are key to individualized treatment strategies and early identification of patients who are at the highest risk for suicide.
Each day, millions of biological processes occur in our body at a cellular level. Studying these processes can help us learn more about how cells function, a field that has continued to intrigue researchers.
RUDN University chemists have created the first derivatives of chitin and chitosan with selenium. The new compounds showed antibacterial and catalytic activity. A simple procedure for obtaining does not require harsh conditions.
Combined oral contraceptives (COCs) containing both estrogen and progestin do not contribute to the development of enlarged breasts (macromastia) – nor do they increase the risk of breast regrowth in adolescents and young women following breast-reduction surgery, reports a study in the October issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). The journal is published in the Lippincott portfolio by Wolters Kluwer.
The common, inexpensive supplement was linked with a 44% reduction in suicide attempts and self-harm.
Published in Nature, this research in animal models show it’s possible to create a compound that hits the same exact target as psychedelic drugs hit – the 5-HT2A serotonin receptors on the surface of specific neurons – but does not cause the same psychedelic effects when given to mice.
In the first known study of its type, an international team of researchers evaluated whether high research and development costs explain high drug prices in the United States. They found no such association for 60 new drugs approved from 2009 to 2018.
Researchers in Japan have succeeded in inhibiting cancer cell growth using pyrrolizidine alkaloid, a component of plant origin previously thought to be too toxic to administer.
An experimental drug to fight aggressive brain cancer has proved so successful in the first trial on humans that University of South Australia scientists will fast-track the second stage. The development provides a glimmer of hope for glioblastoma patients, who face a survival time of only 12 to 18 months after diagnosis.
For the first time, researchers have shown that a class of anti-fibrotic drugs slows the progression of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA).
UC San Diego engineers have developed microscopic robots, called microrobots, that can swim around in the lungs, deliver medication and be used to clear up life-threatening cases of bacterial pneumonia. In mice, the microrobots safely eliminated pneumonia-causing bacteria in the lungs and resulted in 100% survival. By contrast, untreated mice all died within three days after infection.
How do the hundreds of individual pieces that make up viruses assemble into shapes capable of spreading disease from cell to cell?
An international phase 3 clinical trial for a rare, inherited form of ALS led by Washington University School of Medicine in St. Louis, showed that an investigational drug, known as tofersen, reduced molecular signs of the fatal disease, but at six months did not improve motor control and muscle strength. However, the trial, which was sponsored by the pharmaceutical company Biogen, found evidence that longer-term use of the drug may help stabilize muscle strength and control.
Melatonin use among children and teenagers is on the rise. Today, the American Academy of Sleep Medicine released a health advisory encouraging parents to talk to a health care professional before giving melatonin or any supplement to children.
During the pandemic, physicians used infusions of monoclonal antibodies to help patients fight off COVID-19 infections. Now, in response to the U.S. opioid crisis, researchers at UC Davis are trying to create monoclonal antibodies that can help fight chronic pain.
New discoveries in anesthesiology and pain management are being made every day, and ANESTHESIOLOGY® 2022 (Oct. 21-25) is the best place to be in-the-know about these important findings.
Apremilast (brand name Otezla) has helped psoriasis patients achieve clearer skin and ease the symptoms of their psoriatic arthritis. Now, new data from researchers at the Perelman School of Medicine at the University of Pennsylvania shows it could also help people with psoriasis shed unhealthy body fat and therefore improve cardiovascular health, a well-known vulnerability for those with psoriasis.
Adolescent and young adult women who were diagnosed with cancer and received chemotherapy treatment prior to pregnancy did not have a higher risk of stillbirth, according to research led by Caitlin C. Murphy, PhD, MPH, with UTHealth Houston.
Researchers in China have discovered that inhibiting a protein called the GABAA receptor can protect intestinal stem cells from the toxic effects of chemotherapy and radiotherapy. The study, published September 20 in the Journal of Experimental Medicine (JEM), suggests that the FDA-approved anti-sedative flumazenil, which targets GABAA receptors, could alleviate some of the common gastrointestinal side effects, such as diarrhea and vomiting, induced by many cancer treatments.
Early intervention with rituximab, a drug used in the treatment of rheumatoid arthritis (RA), can reduce the risk of deterioration in myasthenia gravis, an autoimmune disease that causes loss of muscle control.
Thank the rare crested ibis for a clue that could someday help our bodies make better drugs.
When patients who are on a commonly prescribed blood thinner stop taking aspirin, their risk of bleeding complications drops significantly (more than 30%), a new study finds. Researchers say aspirin should only be taken under the direction of a physician to review if the expected benefit outweighs the risk.
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