Scientists at La Jolla Institute for Immunology (LJI) have tracked down the rare stem cells that generate neutrophils in human bone marrow. This research, published August 18, 2020, in Immunity, gives researchers a potential path for intervening in diseases where neutrophil development goes awry.
The Coriell Institute for Medical Research has added a new collection of stem cells to its biobank offerings. The new collection is a result of a collaboration between Coriell and the Rett Syndrome Research Trust (RSRT) and consists of 10 lines of human induced pluripotent stem cells created from blood donated by individuals with Rett syndrome.
Researchers at UC San Diego School of Medicine report successfully implanting specialized grafts of neural stem cells directly into spinal cord injuries in mice, then documenting how the grafts grew and filled the injury sites, mimicking the animals’ existing neuronal network.
Researchers at the University of Maryland School of Medicine (UMSOM) have for the first time identified stem cells in the region of the optic nerve, which transmits signals from the eye to the brain. The finding presents a new theory on why the most common form of glaucoma may develop and potential for new therapies.
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have identified the process by which stem cells in the airways of the lungs switch between two distinct phases — creating more of themselves and producing mature airway cells — to regenerate lung tissue after an injury.
A team of developmental biologists at the Morgridge Institute for Research has discovered a means by which schistosomes, parasitic worms that infect more than 200 million people in tropical climates, are able to outfox the host’s immune system.
Researchers at The Ohio State University Wexner Medical Center and College of Medicine found that spinal cord injuries in mice cause an acquired bone marrow failure syndrome that may contribute to chronic immune dysfunction.
A new study suggests that communication between skeletal muscle cells and muscle fibers promotes muscle growth. Adult muscle stem cells, called satellite cells, release extracellular vesicles that are delivered to muscle fibers responsible for contraction, to promote this muscle growth. The first-of-its-kind study is published ahead of print in the journal Function.
Researchers at the UCLA Jonsson Comprehensive Cancer Center and UCLA School of Dentistry have identified a potential new combination therapy to treat advanced head and neck squamous cell carcinoma, the most common type of head and neck cancer.
Sanford Burnham Prebys Medical Discovery Institute has received an award from the California Institute for Regenerative Medicine (CIRM) to advance promising drug candidates for COVID-19. The research team will test two existing drugs against “mini lungs in a dish” that have been infected with SARS-CoV-2.
Scientists have unraveled key mechanisms behind the mysteries of aging. They isolated two paths that cells travel during aging and engineered a new way to genetically program these processes to extend life. The researchers also identified a master circuit that guides these aging processes.
Infusing umbilical cord blood – a readily available source of stem cells – safely and effectively treated 44 children born with various non-cancerous genetic disorders, including sickle cell, thalassemia, Hunter syndrome, Krabbe disease, MLD, and an array of immune deficiencies.
By inhibiting the molecule AKT, UC San Diego researchers favor the culture of human spermatogonial stem cells in the lab, a first step toward lab-produced sperm as a treatment for male infertility.
A research team is the first in Texas to investigate whether plasma from COVID-19 survivors can be used in outpatient settings to prevent the onset and progression of the virus in two new clinical trials at UTHealth.
In one of the first studies addressing the role of sex hormones’ impact on stem cells in the gut, scientists outline new insights showing how a steroidal sex hormone that is structurally and functionally similar to human steroid hormones drastically alters the way intestinal stem cells behave, ultimately affecting the overarching structure and function of this critical organ. The authors found that ecdysone, a steroid hormone produced by fruit flies, stimulates intestinal stem cell growth and causes the gut of the female fruit fly to grow in size, as well as other critical changes.
New UCLA research conducted in mice could explain why some people suffer more extensive scarring than others after a heart attack. The study, published in the journal Cell, reveals that a protein known as type 5 collagen plays a critical role in regulating the size of scar tissue in the heart.
USC Stem Cell scientists have pioneered a simpler way to generate the sensory cells of the inner ear. The study was published in the journal eLife.
A new study shows that SARS-CoV-2, the virus that causes COVID-19 (coronavirus), can infect heart cells in a lab dish, indicating it may be possible for heart cells in COVID-19 patients to be directly infected by the virus. The discovery, published today in the journal Cell Reports Medicine, was made using heart muscle cells that were produced by stem cell technology.
UC San Diego and Deerfield Management created Poseidon Innovation to support researchers working to advance disease-curing therapeutics by funding early stage projects and expediting the drug-development cycle. Poseidon announces it is funding three researchers.
Satya Dandekar, professor of microbiology and chairperson of the Department of Medical Microbiology and Immunology at UC Davis, honored by Prestigious NIH MERIT award for her illustrious journey in HIV research.
UCLA researchers and colleagues have received a $13.65 million grant from the National Institutes of Health to investigate and further develop an immunotherapy known as CAR T, which uses genetically modified stem cells to target and destroy HIV.
Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells — a type of immune cell — with measurably stronger activity against a form of leukemia, both in vivo and in vitro.
As part of the Memorial Sloan Kettering – Hackensack Meridian Health Partnership, the two organizations have formed an Immunology Research Collaboration. Through this joint initiative, researchers can apply for funding to support innovative investigations to explore the power of the immune system and ways it may be harnessed to fight cancer.
Xiaojun “Lance” Lian, assistant professor of biomedical engineering at Penn State, has received a $500,000, five-year Early Career Development Program (CAREER) grant from the National Science Foundation (NSF).
Researchers at Mount Sinai have discovered that human acute myeloid leukemia (AML) stem cells are dependent on a transcription factor known as RUNX1, potentially providing a new therapeutic target to achieve lasting remissions or even cures for a disease in which medical advances have been limited.
Using skin cells from human volunteers, researchers at the University of Pittsburgh School of Medicine have created fully functional mini livers, which they then transplanted into rats. In this proof-of-concept experiment, the lab-made organs survived for four days inside their animal hosts.
For a while now, some plastic surgeons have been using stem cells to treat aging, sun-damaged skin. But while they’ve been getting good results, it’s been unclear exactly how these treatments – using adult stem cells harvested from the patient’s own body – work to rejuvenate “photoaged” facial skin.
In this study, researchers investigated if specific targeting of CD133+ glioblastoma with cutting-edge immunotherapy drugs could eradicate the most aggressive subpopulation of cells in the tumour. They also looked at the safety of CD133-targeting therapies on normal, non-cancerous human stem cells including hematopoietic stem cells which create blood cells and progenitor cells which can form one or more kinds of cells.
A recent study from the Mechanobiology Institute at the National University of Singapore has shown that rejuvenated fibroblasts can recover their ability to self-contract. This encouraging discovery holds great potential for applications in regenerative medicine and stem cell engineering.
Many patients with heart disease face limited treatment options. Fortunately, stem cell biology has enabled researchers to produce large numbers of cardiomyocytes, which may be used in advanced drug screens and cell-based therapies. However, current image analysis techniques don’t allow researchers to analyze heterogeneous, multidirectional, striated myofibrils typical of immature cells. In the Journal of Applied Physics, researchers showcase an algorithm that combines gradient methods with fast Fourier transforms to quantify myofibril structures in heart cells with considerable accuracy.
EpiBone’s Craniomaxillofacial, or EB-CMF, product is a living, anatomically correct bone graft made from a patient’s own fat-derived stem cells.
Oxidative stress can be pathological. Now researchers report that the other end of the redox spectrum, reductive stress, is also pathological. Reductive stress causes pathological heart enlargement and diastolic dysfunction in a mouse model.
Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve efficacy. The study was published in Cell Reports.
An interdisciplinary team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA has developed a first-of-its-kind roadmap of how human skeletal muscle develops, including the formation of muscle stem cells.
As the COVID-19 pandemic enters its third month, businesses in the United States are marketing unlicensed and unproven stem-cell-based "therapies" and exosome products that claim to prevent or treat the disease. In Cell Stem Cell on May 5, bioethicist Leigh Turner describes how these companies are "seizing the pandemic as an opportunity to profit from hope and desperation."
A new study shows how stem cells – which can contribute to creating many parts of the body, not just one organ or body part – are able to postpone their own death in order to respond to an injury that needs their attention. The study was done in planarians, which are tiny worms used as model organisms to study regeneration because of their ability to recover from any injury using stem cells.
People with the genetic condition neurofibromatosis type 1 (NF1) are prone to developing tumors on nervous system tissue. A new study from Washington University School of Medicine in St. Louis has found that the development and growth of such tumors are driven by nearby noncancerous neurons and immune cells. The findings point to potential new therapeutic targets for people with NF1.
The National Academy of Sciences today elected four UT Southwestern Medical Center scientists in the fields of biophysics, cell biology, molecular biology, and stem cell biology into its membership, one of the highest honors for American scientists.
The COVID-19 pandemic demands action on many fronts, from prevention to testing to treatment. Not content to focus its research efforts on just one, the laboratory of George Church in the Blavatnik Institute at Harvard Medical School and the Wyss Institute for Biologically Inspired Engineering at Harvard University is tackling the problem from seven different angles.
Three researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received awards to pursue treatments and vaccines for COVID-19 from the California Institute for Regenerative Medicine, the state’s stem cell agency.
اكتشف باحثو مايو كلينك (Mayo Clinic) آليات شفاء بتنشيط الخلايا الجذعية بعد نوبة قلبية حيث أعادت الخلايا الجذعية عضلة القلب إلى حالتها قبل النوبة القلبية، ما قدم مخططًا لكيفية عمل الخلايا الجذعية.
Pesquisadores da Mayo Clinic descobriram mecanismos de cura ativados por células-tronco após um ataque cardíaco. As células-tronco restauraram o músculo cardíaco devolvendo-o ao seu estado anterior ao ataque cardíaco, fornecendo um esquema sobre como as células-tronco podem funcionar.
Researchers at Washington University School of Medicine in St. Louis have used induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes, transformed the stem cells into insulin-producing cells, used the CRISPR gene-editing tool to correct a defect that caused a form of diabetes, and implanted the cells into mice to reverse diabetes in the animals.
An international team of scientists led by Camillo Ricordi, M.D., director of the Diabetes Research Institute and Cell Transplant Center at the University of Miami Miller School of Medicine, has been granted immediate FDA authorization for a 24-patient clinical trial to test the safety and exploratory efficacy of umbilical cord-derived mesenchymal stem cells to block the life-threatening lung inflammation that accompanies severe cases of COVID-19.
A study published online April 20, 2020, in Nature Immunology, led by researchers at Cincinnati Children's reports a possible new approach for treating myelodysplastic syndrome (MDS), which often can lead to leukemia.
The first COVID-19 patient in Texas has been enrolled in a stem cell therapy clinical trial for acute respiratory distress syndrome (ARDS) at The University of Texas Health Science Center at Houston (UTHealth).
Is the future of personalized medicine out of this world? Cedars-Sinai is trying to find out by launching special stem cells into space to see if they multiply better there. The Cedars-Sinai Board of Governors Regenerative Medicine Institute is partnering with Space Tango of Lexington, Kentucky, to send induced pluripotent stem cells (iPSCs) to the International Space Station. The first flight for the project, funded by a $1.5 million award from NASA, could occur as early as next year.
When adult brain cells are injured, they revert to an embryonic state, say researchers at UC San Diego School of Medicine. In their newly adopted immature state, the cells become capable of re-growing new connections that, under the right conditions, can help to restore lost function.
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